MicroRNA-214 Reduces Insulin-like Growth Factor-1 (IGF-1) Receptor Expression and Downstream mTORC1 Signaling in Renal Carcinoma Cells

MicroRNA Expression Profiling of Oral Carcinoma Identifies New Markers of Tumor Progression

(2017) L. Scapoli et al.   INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY

microRNA-21-induced dissociation of PDCD4 from rictor contributes to Akt-IKKβ-mTORC1 axis to regulate renal cancer cell invasion

(2014) Amit Bera et al.   EXPERIMENTAL CELL RESEARCH

TGFβ-Induced Deptor Suppression Recruits mTORC1 and Not mTORC2 to Enhance Collagen I (α2) Gene Expression

(2014) Falguni Das et al.   PLoS One

NFκB-mediated cyclin D1 expression by microRNA-21 influences renal cancer cell proliferation

(2013) Amit Bera et al.   CELLULAR SIGNALLING

Comprehensive molecular characterization of clear cell renal cell carcinoma

(2013)   NATURE

microRNA-21 Governs TORC1 Activation in Renal Cancer Cell Proliferation and Invasion

(2012) Nirmalya Dey et al.   PLoS One

microRNA-214 contributes to melanoma tumour progression through suppression of TFAP2C

(2011) Elisa Penna et al.   EMBO JOURNAL

Unrestrained Mammalian Target of Rapamycin Complexes 1 and 2 Increase Expression of Phosphatase and Tensin Homolog Deleted on Chromosome 10 to Regulate Phosphorylation of Akt Kinase

(2011) Falguni Das et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Simvastatin Prevents Skeletal Metastasis of Breast Cancer by an Antagonistic Interplay between p53 and CD44

(2011) Chandi Charan Mandal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MicroRNA-21 Orchestrates High Glucose-induced Signals to TOR Complex 1, Resulting in Renal Cell Pathology in Diabetes

(2011) Nirmalya Dey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of mRNA Translation and Stability by microRNAs

(2010) Marc Robert Fabian et al.   Annual Review of Biochemistry

MicroRNA-7 targets IGF1R (insulin-like growth factor 1 receptor) in tongue squamous cell carcinoma cells

(2010) Lu Jiang et al.   BIOCHEMICAL JOURNAL

The VHL-dependent regulation of microRNAs in renal cancer

(2010) Calida S Neal et al.   BMC Medicine

Treatment of kidney cancer

(2010) William G. Kaelin   CANCER

The mammalian target of rapamycin pathway is widely activated without PTEN deletion in renal cell carcinoma metastases

(2010) Tamer Abou Youssif et al.   CANCER

Phase 3 trial of everolimus for metastatic renal cell carcinoma

(2010) Robert J. Motzer et al.   CANCER

MicroRNA Biogenesis Takes Another Single Hit from Microsatellite Instability

(2010) Helge Großhans et al.   CANCER CELL

FoxOs Enforce a Progression Checkpoint to Constrain mTORC1-Activated Renal Tumorigenesis

(2010) Boyi Gan et al.   CANCER CELL

A Genetic Defect in Exportin-5 Traps Precursor MicroRNAs in the Nucleus of Cancer Cells

(2010) Sonia A. Melo et al.   CANCER CELL

Downregulation of p53-inducible microRNAs 192, 194, and 215 Impairs the p53/MDM2 Autoregulatory Loop in Multiple Myeloma Development

(2010) Flavia Pichiorri et al.   CANCER CELL

PRAS40 acts as a nodal regulator of high glucose-induced TORC1 activation in glomerular mesangial cell hypertrophy

(2010) Nirmalya Dey et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Dysregulation of miR-15a and miR-214 in human pancreatic cancer

(2010) Xing J Zhang et al.   Journal of Hematology & Oncology

mTOR: from growth signal integration to cancer, diabetes and ageing

(2010) Roberto Zoncu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

MicroRNAs contribute to the chemoresistance of cisplatin in tongue squamous cell carcinoma lines

(2010) Zhi-wei Yu et al.   ORAL ONCOLOGY

mTORC1-Mediated Cell Proliferation, But Not Cell Growth, Controlled by the 4E-BPs

(2010) R. J. O. Dowling et al.   SCIENCE

New oral treatment for kidney cancer approved

(2009) K. Traynor   AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY

Activation of the PI3K/AKT Pathway Induces Urothelial Carcinoma of the Renal Pelvis: Identification in Human Tumors and Confirmation in Animal Models

(2009) C.-N. Qian et al.   CANCER RESEARCH

MicroRNAs: Target Recognition and Regulatory Functions

(2009) David P. Bartel   CELL

IGF-1 stimulates protein synthesis by enhanced signaling through mTORC1 in bovine mammary epithelial cells

(2009) S.A. Burgos et al.   DOMESTIC ANIMAL ENDOCRINOLOGY

Evolution under canalization and the dual roles of microRNAs--A hypothesis

(2009) C.-I Wu et al.   GENOME RESEARCH

TSC2 Deficiency Increases PTEN via HIF1α

(2009) Lenin Mahimainathan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differential expression of miRNA patterns in renal cell carcinoma and nontumorous tissues

(2009) Zhengjun Yi et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

MicroRNA profiling of clear cell renal cell cancer identifies a robust signature to define renal malignancy

(2009) Monika Jung et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Reduction of Lobe leads to TORC1 hypoactivation that induces ectopic Jak/STAT signaling to impair Drosophila eye development

(2009) Ying-Hsuan Wang et al.   MECHANISMS OF DEVELOPMENT

MicroRNA Expression Profiling in Human Ovarian Cancer: miR-214 Induces Cell Survival and Cisplatin Resistance by Targeting PTEN

(2008) H. Yang et al.   CANCER RESEARCH

Targeting the Eukaryotic Translation Initiation Factor 4E for Cancer Therapy

(2008) J. R. Graff et al.   CANCER RESEARCH

Resveratrol inhibits PDGF receptor mitogenic signaling in mesangial cells: role of PTP1B

(2008) Balachandar Venkatesan et al.   FASEB JOURNAL

Systemic IGF‐I administration stimulates thein vivogrowth of early, but not advanced, renal cell carcinoma

(2008) Ann H. Rosendahl et al.   INTERNATIONAL JOURNAL OF CANCER

Isolation of Hyperactive Mutants of Mammalian Target of Rapamycin

(2008) Yoichiro Ohne et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Alterations in RNA-binding activities of IRES-regulatory proteins as a mechanism for physiological variability and pathological dysregulation of IGF-IR translational control in human breast tumor cells

(2008) Zheng Meng et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Efficacy of everolimus in advanced renal cell carcinoma: a double-blind, randomised, placebo-controlled phase III trial

(2008) Robert J Motzer et al.   LANCET

Early drug development of inhibitors of the insulin-like growth factor-I receptor pathway: Lessons from the first clinical trials

(2008) J. Rodon et al.   MOLECULAR CANCER THERAPEUTICS

VHL loss actuates a HIF-independent senescence programme mediated by Rb and p400

(2008) Arthur P. Young et al.   NATURE CELL BIOLOGY

MicroRNAs Make Big Impression in Disease After Disease

(2008) J. Couzin   SCIENCE

Raptor-rictor axis in TGFβ-induced protein synthesis

(2007) Falguni Das et al.   CELLULAR SIGNALLING