NADPH metabolism determines the leukemogenic capacity and drug resistance of AML cells

Identification of leukemic and pre-leukemic stem cells by clonal tracking from single-cell transcriptomics

(2021) Lars Velten et al.   Nature Communications

Oxidative phosphorylation enhances the leukemogenic capacity and resistance to chemotherapy of B cell acute lymphoblastic leukemia

(2021) Chiqi Chen et al.   Science Advances

Endothelial E-selectin inhibition improves acute myeloid leukaemia therapy by disrupting vascular niche-mediated chemoresistance

(2020) Valerie Barbier et al.   Nature Communications

Treatment of Relapsed Acute Myeloid Leukemia

(2020) Felicitas Thol et al.   CURRENT TREATMENT OPTIONS IN ONCOLOGY

Mitochondrial ubiquinol oxidation is necessary for tumour growth

(2020) Inmaculada Martínez-Reyes et al.   NATURE

Bone Marrow Mesenchymal Stem Cells Support Acute Myeloid Leukemia Bioenergetics and Enhance Antioxidant Defense and Escape from Chemotherapy

(2020) Dorian Forte et al.   Cell Metabolism

Reductive TCA cycle metabolism fuels glutamine- and glucose-stimulated insulin secretion

(2020) Guo-Fang Zhang et al.   Cell Metabolism

Mutant and wild-type isocitrate dehydrogenase 1 share enhancing mechanisms involving distinct tyrosine kinase cascades in cancer

(2019) Dong Chen et al.   Cancer Discovery

Direct stimulation of NADP+ synthesis through Akt-mediated phosphorylation of NAD kinase

(2019) Gerta Hoxhaj et al.   SCIENCE

Energy metabolism is co-determined by genetic variants in chronic lymphocytic leukemia and influences drug sensitivity

(2019) Junyan Lu et al.   HAEMATOLOGICA

Inhibition of Amino Acid Metabolism Selectively Targets Human Leukemia Stem Cells

(2019) Courtney L. Jones et al.   CANCER CELL

Vulnerabilities in mIDH2 AML confer sensitivity to APL-like targeted combination therapy

(2019) Vera Mugoni et al.   CELL RESEARCH

Activated stromal cells transfer mitochondria to rescue acute lymphoblastic leukemia cells from oxidative stress

(2019) Richard Burt et al.   BLOOD

B-Cell-Specific Diversion of Glucose Carbon Utilization Reveals a Unique Vulnerability in B Cell Malignancies

(2018) Gang Xiao et al.   CELL

Spatiotemporal compartmentalization of hepatic NADH and NADPH metabolism

(2018) Russell P. Goodman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Clonal evolution mechanisms in NT5C2 mutant-relapsed acute lymphoblastic leukaemia

(2018) Gannie Tzoneva et al.   NATURE

Analysis of redox landscapes and dynamics in living cells and in vivo using genetically encoded fluorescent sensors

(2018) Yejun Zou et al.   Nature Protocols

Mitochondrial One-Carbon Pathway Supports Cytosolic Folate Integrity in Cancer Cells

(2018) Yuxiang Zheng et al.   CELL

Metabolic Imaging Reveals a Unique Preference of Symmetric Cell Division and Homing of Leukemia-Initiating Cells in an Endosteal Niche

(2018) Xiaoxin Hao et al.   Cell Metabolism

Venetoclax with azacitidine disrupts energy metabolism and targets leukemia stem cells in patients with acute myeloid leukemia

(2018) Daniel A. Pollyea et al.   NATURE MEDICINE

High mTORC1 activity drives glycolysis addiction and sensitivity to G6PD inhibition in acute myeloid leukemia cells

(2017) L Poulain et al.   LEUKEMIA

Genetically encoded fluorescent sensors reveal dynamic regulation of NADPH metabolism

(2017) Rongkun Tao et al.   NATURE METHODS

Rapid immunopurification of mitochondria for metabolite profiling and absolute quantification of matrix metabolites

(2017) Walter W Chen et al.   Nature Protocols

The natural product carolacton inhibits folate-dependent C1 metabolism by targeting FolD/MTHFD

(2017) Chengzhang Fu et al.   Nature Communications

Sticking It to the Niche: CD98 Mediates Critical Adhesive Signals in AML

(2016) Andreas Reinisch et al.   CANCER CELL

Absolute Quantification of Matrix Metabolites Reveals the Dynamics of Mitochondrial Metabolism

(2016) Walter W. Chen et al.   CELL

In vivo monitoring of cellular energy metabolism using SoNar, a highly responsive sensor for NAD+/NADH redox state

(2016) Yuzheng Zhao et al.   Nature Protocols

mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle

(2016) I. Ben-Sahra et al.   SCIENCE

SoNar, a Highly Responsive NAD+/NADH Sensor, Allows High-Throughput Metabolic Screening of Anti-tumor Agents

(2015) Yuzheng Zhao et al.   Cell Metabolism

Redox Modulation by Reversal of the Mitochondrial Nicotinamide Nucleotide Transhydrogenase

(2015) Michael P. Murphy   Cell Metabolism

NOX4-driven ROS formation mediates PTP inactivation and cell transformation in FLT3ITD-positive AML cells

(2015) A K Jayavelu et al.   LEUKEMIA

Oxidative stress inhibits distant metastasis by human melanoma cells

(2015) Elena Piskounova et al.   NATURE

Cell-State-Specific Metabolic Dependency in Hematopoiesis and Leukemogenesis

(2014) Ying-Hua Wang et al.   CELL

Nuclear Enrichment of Folate Cofactors and Methylenetetrahydrofolate Dehydrogenase 1 (MTHFD1) Protectde NovoThymidylate Biosynthesis during Folate Deficiency

(2014) Martha S. Field et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lysine Acetylation Activates 6-Phosphogluconate Dehydrogenase to Promote Tumor Growth

(2014) Changliang Shan et al.   MOLECULAR CELL

Tracing Compartmentalized NADPH Metabolism in the Cytosol and Mitochondria of Mammalian Cells

(2014) Caroline A. Lewis et al.   MOLECULAR CELL

Quantitative flux analysis reveals folate-dependent NADPH production

(2014) Jing Fan et al.   NATURE

The pentose phosphate pathway and cancer

(2014) Krushna C. Patra et al.   TRENDS IN BIOCHEMICAL SCIENCES

Overproduction of NOX-derived ROS in AML promotes proliferation and is associated with defective oxidative stress signaling

(2013) P. S. Hole et al.   BLOOD

Myeloproliferative Neoplasia Remodels the Endosteal Bone Marrow Niche into a Self-Reinforcing Leukemic Niche

(2013) Koen Schepers et al.   Cell Stem Cell

Reciprocal regulation of p53 and malic enzymes modulates metabolism and senescence

(2013) Peng Jiang et al.   NATURE

Clonal evolution and devolution after chemotherapy in adult acute myelogenous leukemia

(2012) B. Parkin et al.   BLOOD

Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis

(2011) Gina M. DeNicola et al.   NATURE

Separation of flavins and nicotinamide cofactors in Chinese hamster ovary cells by capillary electrophoresis

(2008) Ye Li et al.   BIOMEDICAL CHROMATOGRAPHY

Genomic instability in myeloid malignancies: Increased reactive oxygen species (ROS), DNA double strand breaks (DSBs) and error-prone repair

(2008) Annahita Sallmyr et al.   CANCER LETTERS