Mutations in the KIF21B kinesin gene cause neurodevelopmental disorders through imbalanced canonical motor activity

Gli2 Rescues Delays in Brain Development Induced by Kif3a Dysfunction

(2018) Jia-Long Chen et al.   CEREBRAL CORTEX

Biallelic variants in KIF14 cause intellectual disability with microcephaly

(2018) Periklis Makrythanasis et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Nuclear PTEN deficiency causes microcephaly with decreased neuronal soma size and increased seizure susceptibility

(2018) Atsushi Igarashi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autoinhibition of kinesin-1 is essential to the dendrite-specific localization of Golgi outposts

(2018) Michael T. Kelliher et al.   JOURNAL OF CELL BIOLOGY

KIF20A/MKLP2 regulates the division modes of neural progenitor cells during cortical development

(2018) Anqi Geng et al.   Nature Communications

Neurobeachin and the Kinesin KIF21B Are Critical for Endocytic Recycling of NMDA Receptors and Regulate Social Behavior

(2018) Kira V. Gromova et al.   Cell Reports

Reconstituting Corticostriatal Network on-a-Chip Reveals the Contribution of the Presynaptic Compartment to Huntington’s Disease

(2018) Amandine Virlogeux et al.   Cell Reports

The Molecular Motor KIF21B Mediates Synaptic Plasticity and Fear Extinction by Terminating Rac1 Activation

(2018) Momo Morikawa et al.   Cell Reports

Kinesin Family of Proteins Kif11 and Kif21B Act as Inhibitory Constraints of Excitatory Synaptic Transmission Through Distinct Mechanisms

(2018) Supriya Swarnkar et al.   Scientific Reports

Mutations in Kinesin family member 6 reveal specific role in ependymal cell ciliogenesis and human neurological development

(2018) Mia J. Konjikusic et al.   PLoS Genetics

Ciliogenesis and cell cycle alterations contribute to KIF2A-related malformations of cortical development

(2017) Loïc Broix et al.   HUMAN MOLECULAR GENETICS

WD40-repeat 47, a microtubule-associated protein, is essential for brain development and autophagy

(2017) Meghna Kannan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Kinesin-4 KIF21B is a potent microtubule pausing factor

(2017) Wilhelmina E van Riel et al.   eLife

Regulation of neural stem cell proliferation and differentiation by Kinesin family member 2a

(2017) Dong Sun et al.   PLoS One

mTORC1 signaling and primary cilia are required for brain ventricle morphogenesis

(2016) Philippe Foerster et al.   DEVELOPMENT

KIF1A inhibition immortalizes brain stem cells but blocks BDNF-mediated neuronal migration

(2016) Aurelie Carabalona et al.   NATURE NEUROSCIENCE

Recurrent KIF2A mutations are responsible for classic lissencephaly

(2016) Mara Cavallin et al.   NEUROGENETICS

Activity-Dependent Regulation of Distinct Transport and Cytoskeletal Remodeling Functions of the Dendritic Kinesin KIF21B

(2016) Amy E. Ghiretti et al.   NEURON

Structural basis for misregulation of kinesin KIF21A autoinhibition by CFEOM1 disease mutations

(2016) Sarah Bianchi et al.   Scientific Reports

The Kinesin KIF21B Regulates Microtubule Dynamics and Is Essential for Neuronal Morphology, Synapse Function, and Learning and Memory

(2016) Mary Muhia et al.   Cell Reports

Autoinhibition of a Neuronal Kinesin UNC-104/KIF1A Regulates the Size and Density of Synapses

(2016) Shinsuke Niwa et al.   Cell Reports

A patient with lissencephaly, developmental delay, and infantile spasms, due to de novo heterozygous mutation ofKIF2A

(2016) Guoling Tian et al.   Molecular Genetics & Genomic Medicine

Kinesin superfamily proteins (KIFs): Various functions and their relevance for important phenomena in life and diseases

(2015) Nobutaka Hirokawa et al.   EXPERIMENTAL CELL RESEARCH

Clinical application of whole-exome sequencing across clinical indications

(2015) Kyle Retterer et al.   GENETICS IN MEDICINE

GeneMatcher: A Matching Tool for Connecting Investigators with an Interest in the Same Gene

(2015) Nara Sobreira et al.   HUMAN MUTATION

De novo KIF1A mutations cause intellectual deficit, cerebellar atrophy, lower limb spasticity and visual disturbance

(2015) Chihiro Ohba et al.   JOURNAL OF HUMAN GENETICS

Kinesin-12 influences axonal growth during zebrafish neural development

(2014) Man Xu et al.   Cytoskeleton

The kinesin KIF21B participates in the cell surface delivery of γ2 subunit-containing GABAA receptors

(2014) Dorthe Labonté et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Involvement of the kinesin family membersKIF4AandKIF5Cin intellectual disability and synaptic function

(2014) Marjolein H Willemsen et al.   JOURNAL OF MEDICAL GENETICS

Human CFEOM1 Mutations Attenuate KIF21A Autoinhibition and Cause Oculomotor Axon Stalling

(2014) Long Cheng et al.   NEURON

Somatic Mutations in Cerebral Cortical Malformations

(2014) Saumya S. Jamuar et al.   NEW ENGLAND JOURNAL OF MEDICINE

Terminal Axon Branching Is Regulated by the LKB1-NUAK1 Kinase Pathway via Presynaptic Mitochondrial Capture

(2013) Julien Courchet et al.   CELL

Vesicular Glycolysis Provides On-Board Energy for Fast Axonal Transport

(2013) Diana Zala et al.   CELL

Exome sequencing identifies mutations inKIF14as a novel cause of an autosomal recessive lethal fetal ciliopathy phenotype

(2013) I. Filges et al.   CLINICAL GENETICS

Polarity in Migrating Neurons Is Related to a Mechanism Analogous to Cytokinesis

(2013) Aditi Falnikar et al.   CURRENT BIOLOGY

The vertebrate-specific Kinesin-6, Kif20b, is required for normal cytokinesis of polarized cortical stem cells and cerebral cortex size

(2013) K. M. Janisch et al.   DEVELOPMENT

CFEOM1-Associated Kinesin KIF21A Is a Cortical Microtubule Growth Inhibitor

(2013) Babet van der Vaart et al.   DEVELOPMENTAL CELL

Ablation of the mTORC2 component rictor in brain or Purkinje cells affects size and neuron morphology

(2013) Venus Thomanetz et al.   JOURNAL OF CELL BIOLOGY

Mutations in TUBG1, DYNC1H1, KIF5C and KIF2A cause malformations of cortical development and microcephaly

(2013) Karine Poirier et al.   NATURE GENETICS

TRIM3 Regulates the Motility of the Kinesin Motor Protein KIF21B

(2013) Dorthe Labonté et al.   PLoS One

Mutations in KIF11 Cause Autosomal-Dominant Microcephaly Variably Associated with Congenital Lymphedema and Chorioretinopathy

(2012) Pia Ostergaard et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Micro-duplications of 1q32.1 associated with neurodevelopmental delay

(2012) H.E. Olson et al.   European Journal of Medical Genetics

KCTD13 is a major driver of mirrored neuroanatomical phenotypes of the 16p11.2 copy number variant

(2012) Christelle Golzio et al.   NATURE

Motor Protein KIF1A Is Essential for Hippocampal Synaptogenesis and Learning Enhancement in an Enriched Environment

(2012) Makoto Kondo et al.   NEURON

Molecular Motor KIF5A Is Essential for GABAA Receptor Transport, and KIF5A Deletion Causes Epilepsy

(2012) Kazuo Nakajima et al.   NEURON

Primary cilia and Gli3 activity regulate cerebral cortical size

(2011) Sandra L. Wilson et al.   Developmental Neurobiology

Mutations in KIF7 link Joubert syndrome with Sonic Hedgehog signaling and microtubule dynamics

(2011) Claudia Dafinger et al.   JOURNAL OF CLINICAL INVESTIGATION

Kinesin-5, a mitotic microtubule-associated motor protein, modulates neuronal migration

(2011) Aditi Falnikar et al.   MOLECULAR BIOLOGY OF THE CELL

Deep sequencing reveals 50 novel genes for recessive cognitive disorders

(2011) Hossein Najmabadi et al.   NATURE

A conditional knockout resource for the genome-wide study of mouse gene function

(2011) William C. Skarnes et al.   NATURE

KIF7 mutations cause fetal hydrolethalus and acrocallosal syndromes

(2011) Audrey Putoux et al.   NATURE GENETICS

Neurogenin2 regulates the initial axon guidance of cortical pyramidal neurons projecting medially to the corpus callosum

(2011) Randal Hand et al.   Neural Development

The Translocation Selectivity of the Kinesins that Mediate Neuronal Organelle Transport

(2011) Chun-fang Huang et al.   TRAFFIC

Kinesin-12, a Mitotic Microtubule-Associated Motor Protein, Impacts Axonal Growth, Navigation, and Branching

(2010) M. Liu et al.   JOURNAL OF NEUROSCIENCE

Kinesin 3 and cytoplasmic dynein mediate interkinetic nuclear migration in neural stem cells

(2010) Jin-Wu Tsai et al.   NATURE NEUROSCIENCE