SARS-CoV-2 NSP13 helicase suppresses interferon signaling by perturbing JAK1 phosphorylation of STAT1

Toward wide-spectrum antivirals against coronaviruses: Molecular characterization of SARS-CoV-2 NSP13 helicase inhibitors

(2022) Gustavo R. Perez-Lemus et al.   Science Advances

K18-hACE2 mice develop respiratory disease resembling severe COVID-19

(2021) Claude Kwe Yinda et al.   PLoS Pathogens

Genomic monitoring of SARS-CoV-2 uncovers an Nsp1 deletion variant that modulates type I interferon response

(2021) Jing-wen Lin et al.   Cell Host & Microbe

Impact of high dose of baricitinib in severe COVID-19 pneumonia: a prospective cohort study in Bangladesh

(2021) Md. Jahidul Hasan et al.   BMC INFECTIOUS DISEASES

SARS-CoV-2 non-structural protein 1 inhibits the interferon response by causing depletion of key host signaling factors.

(2021) Anil Kumar et al.   JOURNAL OF VIROLOGY

Clofazimine broadly inhibits coronaviruses including SARS-CoV-2

(2021) Shuofeng Yuan et al.   NATURE

Structural basis for backtracking by the SARS-CoV-2 replication–transcription complex

(2021) Brandon Malone et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Systematic functional analysis of SARS-CoV-2 proteins uncovers viral innate immune antagonists and remaining vulnerabilities

(2021) Manuel Hayn et al.   Cell Reports

SARS-CoV-2 drives JAK1/2-dependent local complement hyperactivation

(2021) Bingyu Yan et al.   Science Immunology

Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp13 helicase

(2021) Jingkun Zeng et al.   BIOCHEMICAL JOURNAL

An atomistic model of the coronavirus replication-transcription complex as a hexamer assembled around nsp15

(2021) Jason K. Perry et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Discovering potential inhibitors against SARS-CoV-2 by targeting Nsp13 Helicase

(2021) Rajat Nandi et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Type I, II, and III Interferon Signatures Correspond to Coronavirus Disease 2019 Severity

(2021) Myung-Ho Kim et al.   JOURNAL OF INFECTIOUS DISEASES

Tofacitinib in Patients Hospitalized with Covid-19 Pneumonia

(2021) Patrícia O. Guimarães et al.   NEW ENGLAND JOURNAL OF MEDICINE

SARS-CoV-2 viral proteins NSP1 and NSP13 inhibit interferon activation through distinct mechanisms

(2021) Christine Vazquez et al.   PLoS One

Structure, mechanism and crystallographic fragment screening of the SARS-CoV-2 NSP13 helicase

(2021) Joseph A. Newman et al.   Nature Communications

A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster

(2020) Jasper Fuk-Woo Chan et al.   LANCET

Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study

(2020) Nanshan Chen et al.   LANCET

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

(2020) Chaolin Huang et al.   LANCET

A pneumonia outbreak associated with a new coronavirus of probable bat origin

(2020) Peng Zhou et al.   NATURE

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

(2020) Markus Hoffmann et al.   CELL

Ruxolitinib in treatment of severe coronavirus disease 2019 (COVID-19): A multicenter, single-blind, randomized controlled trial

(2020) Yang Cao et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Severe Covid-19

(2020) David A. Berlin et al.   NEW ENGLAND JOURNAL OF MEDICINE

Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients

(2020) Jérôme Hadjadj et al.   SCIENCE

Targeting JAK-STAT Signaling to Control Cytokine Release Syndrome in COVID-19

(2020) Wei Luo et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Activation and evasion of type I interferon responses by SARS-CoV-2

(2020) Xiaobo Lei et al.   Nature Communications

SARS-CoV-2 Orf6 hijacks Nup98 to block STAT nuclear import and antagonize interferon signaling

(2020) Lisa Miorin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metallodrug ranitidine bismuth citrate suppresses SARS-CoV-2 replication and relieves virus-associated pneumonia in Syrian hamsters

(2020) Shuofeng Yuan et al.   Nature Microbiology

SARS-CoV-2 N protein antagonizes type I interferon signaling by suppressing phosphorylation and nuclear translocation of STAT1 and STAT2

(2020) Jingfang Mu et al.   Cell Discovery

Cryo-EM Structure of an Extended SARS-CoV-2 Replication and Transcription Complex Reveals an Intermediate State in Cap Synthesis

(2020) Liming Yan et al.   CELL

Delicate structural coordination of the Severe Acute Respiratory Syndrome coronavirus Nsp13 upon ATP hydrolysis

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Enzymatic Characterization of Wild-Type and Mutant Janus Kinase 1

(2019) Nicholas P. D. Liau et al.   Cancers

Selective Activation of Type II Interferon Signaling by Zika Virus NS5 Protein

(2017) Vidyanath Chaudhary et al.   JOURNAL OF VIROLOGY

Zika virus evades interferon-mediated antiviral response through the co-operation of multiple nonstructural proteins in vitro

(2017) Yaoxing Wu et al.   Cell Discovery

The JAK-STAT Pathway: Impact on Human Disease and Therapeutic Intervention

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Evaluation of SSYA10-001 as a Replication Inhibitor of Severe Acute Respiratory Syndrome, Mouse Hepatitis, and Middle East Respiratory Syndrome Coronaviruses

(2014) Adeyemi O. Adedeji et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

I B kinase   (IKK ) regulates the balance between type I and type II interferon responses

(2011) S.-L. Ng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Severe Acute Respiratory Syndrome Coronavirus M Protein Inhibits Type I Interferon Production by Impeding the Formation of TRAF3·TANK·TBK1/IKKϵ Complex

(2009) Kam-Leung Siu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differential Inhibitory Activities and Stabilisation of DNA Aptamers against the SARS Coronavirus Helicase

(2008) Ka To Shum et al.   CHEMBIOCHEM

Isolation of inhibitory RNA aptamers against severe acute respiratory syndrome (SARS) coronavirus NTPase/Helicase

(2007) Kyoung Jin Jang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS