Preventing erosion of X-chromosome inactivation in human embryonic stem cells

De novo DNA methyltransferases DNMT3A and DNMT3B are essential for XIST silencing for erosion of dosage compensation in pluripotent stem cells

(2021) Atsushi Fukuda et al.   Stem Cell Reports

X chromosome inactivation in human development

(2020) Catherine Patrat et al.   DEVELOPMENT

Single-Cell Analysis Reveals Partial Reactivation of X Chromosome instead of Chromosome-wide Dampening in Naive Human Pluripotent Stem Cells

(2020) Susmita Mandal et al.   Stem Cell Reports

Overcoming Autocrine FGF Signaling-Induced Heterogeneity in Naive Human ESCs Enables Modeling of Random X Chromosome Inactivation

(2020) Chenrui An et al.   Cell Stem Cell

Generation of induced pluripotent stem cell GZHMCi001-A and GZHMCi001-B derived from peripheral blood mononuclear cells of epileptic patients with KCNC1 mutation

(2020) Liu Nengqing et al.   Stem Cell Research

Transcriptional Heterogeneity in Naive and Primed Human Pluripotent Stem Cells at Single-Cell Resolution

(2019) Tobias Messmer et al.   Cell Reports

Wnt/Beta-Catenin Signaling Regulation and a Role for Biomolecular Condensates

(2019) Kristina N. Schaefer et al.   DEVELOPMENTAL CELL

Epigenetic aberrations in human pluripotent stem cells

(2019) Shiran Bar et al.   EMBO JOURNAL

Global Characterization of X Chromosome Inactivation in Human Pluripotent Stem Cells

(2019) Shiran Bar et al.   Cell Reports

Comparison of two different culture conditions for derivation of early hiPSC

(2018) Caroline A. B. Hey et al.   CELL BIOLOGY INTERNATIONAL

Transcriptome variations among human embryonic stem cell lines are associated with their differentiation propensity

(2018) Changbin Sun et al.   PLoS One

Sex-specific gene expression differences are evident in human embryonic stem cells and during in vitro differentiation of human placental progenitor cells

(2018) Camille Syrett et al.   STEM CELLS AND DEVELOPMENT

The Pleiotropic Effects of the Canonical Wnt Pathway in Early Development and Pluripotency

(2018) Anchel de Jaime-Soguero et al.   Genes

Towards a Unified Understanding of Lithium Action in Basic Biology and its Significance for Applied Biology

(2017) Eric Jakobsson et al.   JOURNAL OF MEMBRANE BIOLOGY

Regulation of X-chromosome dosage compensation in human: mechanisms and model systems

(2017) Anna Sahakyan et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Screen for reactivation of MeCP2 on the inactive X chromosome identifies the BMP/TGF-β superfamily as a regulator of XIST expression

(2017) Smitha Sripathy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human Embryonic Stem Cells Do Not Change Their X Inactivation Status during Differentiation

(2017) Sanjeet Patel et al.   Cell Reports

Early X chromosome inactivation during human preimplantation development revealed by single-cell RNA-sequencing

(2017) Joana C. Moreira de Mello et al.   Scientific Reports

Single-Cell RNA-Seq Reveals Lineage and X Chromosome Dynamics in Human Preimplantation Embryos

(2016) Sophie Petropoulos et al.   CELL

Single-cell analyses of X Chromosome inactivation dynamics and pluripotency during differentiation

(2016) Geng Chen et al.   GENOME RESEARCH

Female human pluripotent stem cells rapidly lose X chromosome inactivation marks and progress to a skewed methylation pattern during culture

(2016) M. Geens et al.   MOLECULAR HUMAN REPRODUCTION

Dynamic stem cell states: naive to primed pluripotency in rodents and humans

(2016) Leehee Weinberger et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Dosage compensation of the sex chromosomes and autosomes

(2016) Christine M. Disteche   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

The dynamic changes of X chromosome inactivation during early culture of human embryonic stem cells

(2016) Pingyuan Xie et al.   Stem Cell Research

Systematic Discovery of Xist RNA Binding Proteins

(2015) Ci Chu et al.   CELL

Erosion of X Chromosome Inactivation in Human Pluripotent Cells Initiates with XACT Coating and Depends on a Specific Heterochromatin Landscape

(2015) Céline Vallot et al.   Cell Stem Cell

The Xist lncRNA interacts directly with SHARP to silence transcription through HDAC3

(2015) Colleen A. McHugh et al.   NATURE

Glycogen synthase kinase-3 (GSK3): Regulation, actions, and diseases

(2015) Eleonore Beurel et al.   PHARMACOLOGY & THERAPEUTICS

A comprehensive Xist interactome reveals cohesin repulsion and an RNA-directed chromosome conformation

(2015) A. Minajigi et al.   SCIENCE

X Inactivation Lessons from Differentiating Mouse Embryonic Stem Cells

(2015) Greta Pintacuda et al.   Stem Cell Reviews and Reports

A Pooled shRNA Screen Identifies Rbm15, Spen, and Wtap as Factors Required for Xist RNA-Mediated Silencing

(2015) Benoit Moindrot et al.   Cell Reports

Identification of Spen as a Crucial Factor for Xist Function through Forward Genetic Screening in Haploid Embryonic Stem Cells

(2015) Asun Monfort et al.   Cell Reports

A Primary Role for the Tsix lncRNA in Maintaining Random X-Chromosome Inactivation

(2015) Srimonta Gayen et al.   Cell Reports

X Inactivation Lessons from Differentiating Mouse Embryonic Stem Cells

(2015) Greta Pintacuda et al.   Stem Cell Reviews and Reports

Stable X Chromosome Reactivation in Female Human Induced Pluripotent Stem Cells

(2015) Tahsin Stefan Barakat et al.   Stem Cell Reports

Resetting Transcription Factor Control Circuitry toward Ground-State Pluripotency in Human

(2014) Yasuhiro Takashima et al.   CELL

Reorganization of Enhancer Patterns in Transition from Naive to Primed Pluripotency

(2014) Christa Buecker et al.   Cell Stem Cell

Systematic Identification of Culture Conditions for Induction and Maintenance of Naive Human Pluripotency

(2014) Thorold W. Theunissen et al.   Cell Stem Cell

Derivation of naive human embryonic stem cells

(2014) C. B. Ware et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aberrant Patterns of X Chromosome Inactivation in a New Line of Human Embryonic Stem Cells Established in Physiological Oxygen Concentrations

(2014) Juliana Andrea de Oliveira Georges et al.   Stem Cell Reviews and Reports

Differentiation-dependent requirement of Tsix long non-coding RNA in imprinted X-chromosome inactivation

(2014) Emily Maclary et al.   Nature Communications

Wnt-Mediated Repression via Bipartite DNA Recognition by TCF in the Drosophila Hematopoietic System

(2014) Chen U. Zhang et al.   PLoS Genetics

X Chromosome of Female Cells Shows Dynamic Changes in Status during Human Somatic Cell Reprogramming

(2014) Kun-Yong Kim et al.   Stem Cell Reports

featureCounts: an efficient general purpose program for assigning sequence reads to genomic features

(2013) Y. Liao et al.   BIOINFORMATICS

Derivation of novel human ground state naive pluripotent stem cells

(2013) Ohad Gafni et al.   NATURE

XACT, a long noncoding transcript coating the active X chromosome in human pluripotent cells

(2013) Céline Vallot et al.   NATURE GENETICS

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

Reconciling the different roles of Gsk3β in “naïve” and “primed” pluripotent stem cells

(2012) Amar M. Singh et al.   CELL CYCLE

Derivation Conditions Impact X-Inactivation Status in Female Human Induced Pluripotent Stem Cells

(2012) Kiichiro Tomoda et al.   Cell Stem Cell

Molecular Signatures of Human Induced Pluripotent Stem Cells Highlight Sex Differences and Cancer Genes

(2012) Montserrat C. Anguera et al.   Cell Stem Cell

Recurrent Variations in DNA Methylation in Human Pluripotent Stem Cells and Their Differentiated Derivatives

(2012) Kristopher L. Nazor et al.   Cell Stem Cell

Erosion of Dosage Compensation Impacts Human iPSC Disease Modeling

(2012) Shila Mekhoubad et al.   Cell Stem Cell

Tracking the progression of the human inner cell mass during embryonic stem cell derivation

(2012) Thomas O'Leary et al.   NATURE BIOTECHNOLOGY

Inhibition of GSK3 by lithium, from single molecules to signaling networks

(2012) Laure Freland et al.   Frontiers in Molecular Neuroscience

Reconstitution of the Mouse Germ Cell Specification Pathway in Culture by Pluripotent Stem Cells

(2011) Katsuhiko Hayashi et al.   CELL

Unexpected X Chromosome Skewing during Culture and Reprogramming of Human Somatic Cells Can Be Alleviated by Exogenous Telomerase

(2011) Oz Pomp et al.   Cell Stem Cell

Derivation of new human embryonic stem cell lines reveals rapid epigenetic progression in vitro that can be prevented by chemical modification of chromatin

(2011) Silvia V. Diaz Perez et al.   HUMAN MOLECULAR GENETICS

Eutherian mammals use diverse strategies to initiate X-chromosome inactivation during development

(2011) Ikuhiro Okamoto et al.   NATURE

The Demoiselle of X-Inactivation: 50 Years Old and As Trendy and Mesmerising As Ever

(2011) Céline Morey et al.   PLoS Genetics

GSK-3 Inhibitors: Preclinical and Clinical Focus on CNS

(2011) Hagit Eldar-Finkelman et al.   Frontiers in Molecular Neuroscience

Derivation of Pre-X Inactivation Human Embryonic Stem Cells under Physiological Oxygen Concentrations

(2010) Christopher J. Lengner et al.   CELL

Female Human iPSCs Retain an Inactive X Chromosome

(2010) Jason Tchieu et al.   Cell Stem Cell

Induced pluripotency: history, mechanisms, and applications

(2010) M. Stadtfeld et al.   GENES & DEVELOPMENT

Comparison of defined culture systems for feeder cell free propagation of human embryonic stem cells

(2010) Veronika Akopian et al.   IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL

Variations of X Chromosome Inactivation Occur in Early Passages of Female Human Embryonic Stem Cells

(2010) Tamar Dvash et al.   PLoS One

Human embryonic stem cells with biological and epigenetic characteristics similar to those of mouse ESCs

(2010) J. Hanna et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Matrigel: A complex protein mixture required for optimal growth of cell culture

(2010) Chris S. Hughes et al.   PROTEOMICS

Naive and Primed Pluripotent States

(2009) Jennifer Nichols et al.   Cell Stem Cell

Evidence of Xist RNA-independent initiation of mouse imprinted X-chromosome inactivation

(2009) Sundeep Kalantry et al.   NATURE

X-inactivation reveals epigenetic anomalies in most hESC but identifies sublines that initiate as expected

(2008) Lisa L. Hall et al.   JOURNAL OF CELLULAR PHYSIOLOGY

X-chromosome inactivation and epigenetic fluidity in human embryonic stem cells

(2008) S. S. Silva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

X-inactivation in female human embryonic stem cells is in a nonrandom pattern and prone to epigenetic alterations

(2008) Y. Shen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA