PCBP2 maintains antiviral signaling homeostasis by regulating cGAS enzymatic activity via antagonizing its condensation
Published 2022 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
PCBP2 maintains antiviral signaling homeostasis by regulating cGAS enzymatic activity via antagonizing its condensation
Authors
Keywords
-
Journal
Nature Communications
Volume 13, Issue 1, Pages -
Publisher
Springer Science and Business Media LLC
Online
2022-03-23
DOI
10.1038/s41467-022-29266-9
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- PCBP1 modulates the innate immune response by facilitating the binding of cGAS to DNA
- (2020) Chen-Yang Liao et al. Cellular & Molecular Immunology
- Phosphorylation of cGAS by CDK1 impairs self-DNA sensing in mitosis
- (2020) Li Zhong et al. Cell Discovery
- Regulation and Consequences of cGAS Activation by Self-DNA
- (2020) Christian Zierhut et al. TRENDS IN CELL BIOLOGY
- KAT5 acetylates cGAS to promote innate immune response to DNA virus
- (2020) Ze-Min Song et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Rapid and direct control of target protein levels with VHL-recruiting dTAG molecules
- (2020) Behnam Nabet et al. Nature Communications
- Apoptotic Caspases Suppress Type I Interferon Production via the Cleavage of cGAS, MAVS, and IRF3
- (2019) Xiaohan Ning et al. MOLECULAR CELL
- Acetylation Blocks cGAS Activity and Inhibits Self-DNA-Induced Autoimmunity
- (2019) Jiang Dai et al. CELL
- eIF4G2 balances its own mRNA translation via a PCBP2-based feedback loop
- (2019) Victoria V Smirnova et al. RNA
- Structure of the Human cGAS–DNA Complex Reveals Enhanced Control of Immune Surveillance
- (2018) Wen Zhou et al. CELL
- Attenuation of cGAS‐STING signaling is mediated by a p62/SQSTM1‐dependent autophagy pathway activated by TBK1
- (2018) Thaneas Prabakaran et al. EMBO JOURNAL
- DNA-induced liquid phase condensation of cGAS activates innate immune signaling
- (2018) Mingjian Du et al. SCIENCE
- Gasdermin D Restrains Type I Interferon Response to Cytosolic DNA by Disrupting Ionic Homeostasis
- (2018) Ishita Banerjee et al. IMMUNITY
- Inflammasome Activation Triggers Caspase-1-Mediated Cleavage of cGAS to Regulate Responses to DNA Virus Infection
- (2017) Yutao Wang et al. IMMUNITY
- A novel fluorescent reporter detects plastic remodeling of mitochondria–ER contact sites
- (2017) Zhaoying Yang et al. JOURNAL OF CELL SCIENCE
- SENP7 Potentiates cGAS Activation by Relieving SUMO-Mediated Inhibition of Cytosolic DNA Sensing
- (2017) Ye Cui et al. PLoS Pathogens
- The cGAS-STING Defense Pathway and Its Counteraction by Viruses
- (2016) Zhe Ma et al. Cell Host & Microbe
- Sumoylation Promotes the Stability of the DNA Sensor cGAS and the Adaptor STING to Regulate the Kinetics of Response to DNA Virus
- (2016) Ming-Ming Hu et al. IMMUNITY
- TRIM14 Inhibits cGAS Degradation Mediated by Selective Autophagy Receptor p62 to Promote Innate Immune Responses
- (2016) Meixin Chen et al. MOLECULAR CELL
- Glutamylation of the DNA sensor cGAS regulates its binding and synthase activity in antiviral immunity
- (2016) Pengyan Xia et al. NATURE IMMUNOLOGY
- The STRING database in 2017: quality-controlled protein–protein association networks, made broadly accessible
- (2016) Damian Szklarczyk et al. NUCLEIC ACIDS RESEARCH
- Mycobacterium tuberculosis Differentially Activates cGAS- and Inflammasome-Dependent Intracellular Immune Responses through ESX-1
- (2015) Ruth Wassermann et al. Cell Host & Microbe
- The Poly(C) binding protein Pcbp2, and its retrotransposed derivative Pcbp1, are independently essential to mouse development.
- (2015) Louis R. Ghanem et al. MOLECULAR AND CELLULAR BIOLOGY
- 2016 update of the PRIDE database and its related tools
- (2015) Juan Antonio Vizcaíno et al. NUCLEIC ACIDS RESEARCH
- Akt Kinase-Mediated Checkpoint of cGAS DNA Sensing Pathway
- (2015) Gil Ju Seo et al. Cell Reports
- Innate Immune Sensing and Signaling of Cytosolic Nucleic Acids
- (2014) Jiaxi Wu et al. Annual Review of Immunology
- Crosstalk between the cGAS DNA Sensor and Beclin-1 Autophagy Protein Shapes Innate Antimicrobial Immune Responses
- (2014) Qiming Liang et al. Cell Host & Microbe
- Improved vectors and genome-wide libraries for CRISPR screening
- (2014) Neville E Sanjana et al. NATURE METHODS
- The Cytosolic DNA Sensor cGAS Forms an Oligomeric Complex with DNA and Undergoes Switch-like Conformational Changes in the Activation Loop
- (2014) Xu Zhang et al. Cell Reports
- Cyclic GMP-AMP Synthase Is Activated by Double-Stranded DNA-Induced Oligomerization
- (2013) Xin Li et al. IMMUNITY
- SAINTexpress: Improvements and additional features in Significance Analysis of INTeractome software
- (2013) Guoci Teo et al. Journal of Proteomics
- Pivotal Roles of cGAS-cGAMP Signaling in Antiviral Defense and Immune Adjuvant Effects
- (2013) X.-D. Li et al. SCIENCE
- COX5B Regulates MAVS-mediated Antiviral Signaling through Interaction with ATG5 and Repressing ROS Production
- (2013) Yuanyuan Zhao et al. PLoS Pathogens
- Cyclic GMP-AMP Is an Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA
- (2012) J. Wu et al. SCIENCE
- Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway
- (2012) L. Sun et al. SCIENCE
- ProHits: integrated software for mass spectrometry–based interaction proteomics
- (2010) Guomin Liu et al. NATURE BIOTECHNOLOGY
- SAINT: probabilistic scoring of affinity purification–mass spectrometry data
- (2010) Hyungwon Choi et al. NATURE METHODS
- The STRING database in 2011: functional interaction networks of proteins, globally integrated and scored
- (2010) D. Szklarczyk et al. NUCLEIC ACIDS RESEARCH
- PCBP2 mediates degradation of the adaptor MAVS via the HECT ubiquitin ligase AIP4
- (2009) Fuping You et al. NATURE IMMUNOLOGY
- The Adaptor Protein MITA Links Virus-Sensing Receptors to IRF3 Transcription Factor Activation
- (2008) Bo Zhong et al. IMMUNITY
- Identification of PCBP2, a facilitator of IRES-mediated translation, as a novel constituent of stress granules and processing bodies
- (2008) K. Fujimura et al. RNA
- Protein–RNA tethering: The role of poly(C) binding protein 2 in poliovirus RNA replication
- (2008) Allyn Spear et al. VIROLOGY
Add your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload NowBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started