The RBPJ/DAPK3/UBE3A signaling axis induces PBRM1 degradation to modulate the sensitivity of renal cell carcinoma to CDK4/6 inhibitors

Targeting Aberrant FGFR Signaling to Overcome CDK4/6 Inhibitor Resistance in Breast Cancer

(2021) Navid Sobhani et al.   Cells

Metastatic Renal Cell Carcinoma Management: From Molecular Mechanism to Clinical Practice

(2021) Michela Roberto et al.   Frontiers in Oncology

USP22‐mediated deubiquitination of PTEN inhibits pancreatic cancer progression by inducing p21 expression

(2021) Dianyun Ren et al.   Molecular Oncology

The HECT E3 Ligase E6AP/UBE3A as a Therapeutic Target in Cancer and Neurological Disorders

(2020) Asia Owais et al.   Cancers

Combination therapy in metastatic renal cell carcinoma: Back to the future?

(2020) L. Cerbone et al.   SEMINARS IN ONCOLOGY

Palbociclib induces DNA damage and inhibits DNA repair to induce cellular senescence and apoptosis in oral squamous cell carcinoma

(2020) Tong-Hong Wang et al.   JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION

Disruption of NOTCH signaling by a small molecule inhibitor of the transcription factor RBPJ

(2019) Cecilia Hurtado et al.   Scientific Reports

Regulation of PRMT5–MDM4 axis is critical in the response to CDK4/6 inhibitors in melanoma

(2019) Shatha AbuHammad et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PES1 promotes BET inhibitors resistance and cells proliferation through increasing c-Myc expression in pancreatic cancer

(2019) Xin Jin et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

PBRM1 acts as a p53 lysine-acetylation reader to suppress renal tumor growth

(2019) Weijia Cai et al.   Nature Communications

Prognostic and Predictive Value of PBRM1 in Clear Cell Renal Cell Carcinoma

(2019) Lucía Carril-Ajuria et al.   Cancers

Palbociclib as single agent or in combination with the endocrine therapy received before disease progression for estrogen receptor-positive, HER2-negative metastatic breast cancer: TREnd trial

(2018) L Malorni et al.   ANNALS OF ONCOLOGY

Proteotranscriptomic Measurements of E6-Associated Protein (E6AP) Targets in DU145 Prostate Cancer Cells

(2018) Twishi Gulati et al.   MOLECULAR & CELLULAR PROTEOMICS

Genomic Biomarkers of a Randomized Trial Comparing First-line Everolimus and Sunitinib in Patients with Metastatic Renal Cell Carcinoma

(2017) James J. Hsieh et al.   EUROPEAN UROLOGY

E6AP promotes prostate cancer by reducing p27 expression

(2017) Dinesh Raghu et al.   Oncotarget

Renal cancer

(2016) Umberto Capitanio et al.   LANCET

An Autism-Linked Mutation Disables Phosphorylation Control of UBE3A

(2015) Jason J. Yi et al.   CELL

Molecular Genetics of Clear-Cell Renal Cell Carcinoma

(2014) James Brugarolas   JOURNAL OF CLINICAL ONCOLOGY

Renal cell carcinoma

(2014) E. Jonasch et al.   BMJ-British Medical Journal

Phase II Trial of the CDK4 Inhibitor PD0332991 in Patients With Advanced CDK4-Amplified Well-Differentiated or Dedifferentiated Liposarcoma

(2013) Mark A. Dickson et al.   JOURNAL OF CLINICAL ONCOLOGY

Murine gammaherpesvirus 68 ORF75c contains ubiquitin E3 ligase activity and requires PML SUMOylation but not other known cellular PML regulators, CK2 and E6AP, to mediate PML degradation

(2013) Jaturong Sewatanon et al.   VIROLOGY

E6AP ubiquitin ligase regulates PML-induced senescence in Myc-driven lymphomagenesis

(2012) K. Wolyniec et al.   BLOOD

Zipper-interacting Protein Kinase (ZIPK) Modulates Canonical Wnt/β-Catenin Signaling through Interaction with Nemo-like Kinase and T-cell Factor 4 (NLK/TCF4)

(2011) Sumihito Togi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pharmacological Inhibition of Cyclin Dependent Kinases Causes p53 Dependent Apoptosis in Renal Cell Carcinoma

(2010) Tatsuto Ishimaru et al.   JOURNAL OF UROLOGY

Polybromo-associated BRG1-associated factor components BRD7 and BAF180 are critical regulators of p53 required for induction of replicative senescence

(2010) A. E. Burrows et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

UBE3A/E6-AP regulates cell proliferation by promoting proteasomal degradation of p27

(2009) Amit Mishra et al.   NEUROBIOLOGY OF DISEASE

BAF180 Is a Critical Regulator of p21 Induction and a Tumor Suppressor Mutated in Breast Cancer

(2008) W. Xia et al.   CANCER RESEARCH

E3 ubiquitin ligase E6AP-mediated TSC2 turnover in the presence and absence of HPV16 E6

(2008) Li Zheng et al.   GENES TO CELLS