Epistasis at the SARS-CoV-2 Receptor-Binding Domain Interface and the Propitiously Boring Implications for Vaccine Escape

Prospective mapping of viral mutations that escape antibodies used to treat COVID-19

(2021) Tyler N. Starr et al.   SCIENCE

Comprehensive mapping of mutations in the SARS-CoV-2 receptor-binding domain that affect recognition by polyclonal human plasma antibodies

(2021) Allison J. Greaney et al.   Cell Host & Microbe

mRNA vaccine-elicited antibodies to SARS-CoV-2 and circulating variants

(2021) Zijun Wang et al.   NATURE

Prevalent, protective, and convergent IgG recognition of SARS-CoV-2 non-RBD spike epitopes

(2021) William N. Voss et al.   SCIENCE

Structural impact on SARS-CoV-2 spike protein by D614G substitution

(2021) Jun Zhang et al.   SCIENCE

Alpha, Beta, Delta, Gamma: What’s important to know about SARS-CoV-2 variants of concern?

(2021) Diana Duong   CANADIAN MEDICAL ASSOCIATION JOURNAL

Experimental Evidence for Enhanced Receptor Binding by Rapidly Spreading SARS-CoV-2 Variants

(2021) Charlie Laffeber et al.   JOURNAL OF MOLECULAR BIOLOGY

Ongoing global and regional adaptive evolution of SARS-CoV-2

(2021) Nash D. Rochman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mapping mutations to the SARS-CoV-2 RBD that escape binding by different classes of antibodies

(2021) Allison J. Greaney et al.   Nature Communications

Potent and protective IGHV3-53/3-66 public antibodies and their shared escape mutant on the spike of SARS-CoV-2

(2021) Qi Zhang et al.   Nature Communications

Where did ‘weird’ Omicron come from?

(2021) Kai Kupferschmidt   SCIENCE

Covid-19: Omicron is causing more infections but fewer hospital admissions than delta, South African data show

(2021) Owen Dyer   BMJ-British Medical Journal

Template switching and duplications in SARS-CoV-2 genomes give rise to insertion variants that merit monitoring

(2021) Sofya K. Garushyants et al.   Communications Biology

SARS-CoV-2 Vaccines: Status Report

(2020) Fatima Amanat et al.   IMMUNITY

Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor

(2020) Jun Lan et al.   NATURE

Neutralizing Antibodies against SARS-CoV-2 and Other Human Coronaviruses

(2020) Shibo Jiang et al.   TRENDS IN IMMUNOLOGY

Deep mutational scanning of SARS-CoV-2 receptor binding domain reveals constraints on folding and ACE2 binding

(2020) Tyler N. Starr et al.   CELL

Analysis of a SARS-CoV-2-Infected Individual Reveals Development of Potent Neutralizing Antibodies with Limited Somatic Mutation

(2020) Emilie Seydoux et al.   IMMUNITY

Lost in deletion: The enigmatic ORF8 protein of SARS-CoV-2

(2020) Luca Zinzula   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Immune life history, vaccination, and the dynamics of SARS-CoV-2 over the next 5 years

(2020) Chadi M. Saad-Roy et al.   SCIENCE

Deep phylogeny of cancer drivers and compensatory mutations

(2020) Nash D. Rochman et al.   Communications Biology

Complete Mapping of Mutations to the SARS-CoV-2 Spike Receptor-Binding Domain that Escape Antibody Recognition

(2020) Allison J. Greaney et al.   Cell Host & Microbe

No evidence for increased transmissibility from recurrent mutations in SARS-CoV-2

(2020) Lucy van Dorp et al.   Nature Communications

Flex ddG: Rosetta Ensemble-Based Estimation of Changes in Protein–Protein Binding Affinity upon Mutation

(2018) Kyle A. Barlow et al.   JOURNAL OF PHYSICAL CHEMISTRY B

GISAID: Global initiative on sharing all influenza data – from vision to reality

(2017) Yuelong Shu et al.   Eurosurveillance

The Rosetta All-Atom Energy Function for Macromolecular Modeling and Design

(2017) Rebecca F. Alford et al.   Journal of Chemical Theory and Computation

Epistasis as the primary factor in molecular evolution

(2012) Michael S. Breen et al.   NATURE

RosettaScripts: A Scripting Language Interface to the Rosetta Macromolecular Modeling Suite

(2011) Sarel J. Fleishman et al.   PLoS One

Alternate States of Proteins Revealed by Detailed Energy Landscape Mapping

(2010) Michael D. Tyka et al.   JOURNAL OF MOLECULAR BIOLOGY

Secondary mutations as a mechanism of cisplatin resistance in BRCA2-mutated cancers

(2008) Wataru Sakai et al.   NATURE