Review
Pharmacology & Pharmacy
Andrea Cunha, Patricia M. A. Silva, Bruno Sarmento, Odilia Queiros
Summary: The Warburg effect is a metabolic shift that leads to acidification of the tumor microenvironment and increased drug resistance. The metabolic differences between cancer and normal cells provide a strategy for new therapies, and nanodrug delivery systems can overcome multidrug resistance.
Article
Pharmacology & Pharmacy
Linyi Li, Huijuan Ma, Dan Li, Qi Shu, Tingqian Wang, Xiaodong Song, Huan Xu
Summary: In this study, it was discovered that Myricetin can attenuate the Warburg effect in tumor cells induced by formaldehyde through the inhibition of HIF-1α signaling. Animal experiments also demonstrated that oral administration of Myricetin can alleviate the tumor-promoting effects of formaldehyde.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Komal Tyagi, Supratim Mandal, Adhiraj Roy
Summary: Epithelial ovarian cancer, a deadly gynecological malignancy that is often diagnosed at advanced stages, displays resistance to standard chemotherapeutic regimens. Recent studies have shown that the 'Warburg effect', where ovarian cancer cells consume glucose via glycolysis even in aerobic conditions, contributes significantly to disease progression and chemoresistance, making it a potential novel drug target for intervention.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2021)
Article
Oncology
Saratchandra Singh Khumukcham, Vasudevarao Penugurti, Anita Soni, Veena Uppala, Kishore Hari, Mohit Kumar Jolly, Anju Dwivedi, P. K. Abdul Salam, Chiranjeevi Padala, Srinivasulu Mukta, Triveni Bhopal, Bramanandam Manavathi
Summary: The study reveals a reciprocal positive feedback loop between HPIP and HIF-1 alpha in breast cancer cells, influencing phenotypic diversity and clinical prognosis in response to hypoxic and normoxic microenvironments. This pathway could be considered as a potential therapeutic target in breast cancer.
Review
Medicine, Research & Experimental
Majid Ghanavat, Mehdi Shahrouzian, Zeinab Deris Zayeri, Sara Banihashemi, Seyedeh Maryam Kazemi, Najmaldin Saki
Summary: Glucose metabolism enzymes and transporters play a significant role in cancer development and metastasis. Aerobic glycolysis is observed as the most favorable mechanism for glucose metabolism in cancer cells. Lactate, lactate dehydrogenase, and monocarboxylic transporter serve as potential biomarkers, therapeutic targets, and diagnostic tools for cancer and metastasis.
Review
Biochemistry & Molecular Biology
Antonino B. D'Assoro, Roberto Leon-Ferre, Eike-Benjamin Braune, Urban Lendahl
Summary: The Notch signaling pathway is important for normal development, but dysregulation of this pathway is associated with various types of tumors. In addition to its role in tumor cells, Notch signaling also affects non-mutated cells in the tumor microenvironment and their interactions with tumor cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Oncology
Chang Liu, Ying Jin, Zhimin Fan
Summary: This review discusses the role of glycolysis in chemoresistance, exploring the mechanisms from glycolysis processes, signaling pathways, tumor microenvironment, and their interactions. Understanding how glycolysis induces chemoresistance may offer new molecular targets and concepts for cancer therapy.
FRONTIERS IN ONCOLOGY
(2021)
Review
Medicine, Research & Experimental
Maura Lima Pereira Bueno, Sara Teresinha Olalla Saad, Fernanda Marconi Roversi
Summary: The investigation of tumor microenvironment is crucial for cancer diagnosis, prognosis, and treatment. WNT5A plays a critical role in tumorigenesis by regulating multiple signaling pathways and affecting cell growth, migration, and invasiveness.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Immunology
Raefa Abou Khouzam, Rania Faouzi Zaarour, Klaudia Brodaczewska, Bilal Azakir, Goutham Hassan Venkatesh, Jerome Thiery, Stephane Terry, Salem Chouaib
Summary: Hypoxia is an environmental stressor that affects tumor microenvironment and immune cell functions, and may have an impact on the effectiveness of immune checkpoint inhibitors.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Pharmacology & Pharmacy
He Fang, Hanyang Li, Hang Zhang, Shu Wang, Shuang Xu, Li Chang, Yongsheng Yang, Ranji Cui
Summary: This article summarises the significance of HADH expression in tumors and its potential mechanisms of action in the onset and progression of certain cancers. It also describes the possible roles of HADH as a target and/or biomarker for the detection and treatment of various malignancies.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Chemistry, Medicinal
Ioana-Ecaterina Pralea, Alina-Maria Petrache, Adrian Bogdan Tigu, Diana Gulei, Radu-Cristian Moldovan, Maria Ilies, Raul Nicoara, Simona-Codruta Heghes, Alina Uifalean, Cristina-Adela Iuga
Summary: The complex nature of cancer poses many challenges, but plant-derived compounds show promise in anticancer therapy. This review provides an overview of how these compounds can affect tumor glycolysis and HIF-1 pathways, emphasizing the importance of cell culture-based metabolomics in understanding the response of cancer cells to phytochemicals.
Review
Biochemistry & Molecular Biology
Da Young Lee, Jung Nyeo Chun, Minsoo Cho, Insuk So, Ju-Hong Jeon
Summary: E2F8 is a multifaceted transcription factor that is involved in various aspects of cancer development and progression. It has the ability to promote cancer cell proliferation and survival while also exhibiting tumor-suppressing activity. This review highlights the recent progress in understanding the role of E2F8 in human cancers and its implications for developing therapeutic strategies.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2023)
Review
Oncology
Xinyang Zhong, Xuefeng He, Yaxian Wang, Zijuan Hu, Huixia Huang, Senlin Zhao, Ping Wei, Dawei Li
Summary: Colorectal cancer is a common and deadly cancer, and the Warburg effect plays a significant role in promoting cancer metastasis and altering the tumor microenvironment. Understanding the mechanisms of the Warburg effect in colorectal cancer and identifying new therapeutic targets is a promising approach.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2022)
Review
Immunology
Saerok Shim, Siyoung Lee, Yasmin Hisham, Sinae Kim, Tam T. Nguyen, Afeisha S. Taitt, Jihyeong Hwang, Hyunjhung Jhun, Ho-Young Park, Youngmin Lee, Su Cheong Yeom, Sang-Yeob Kim, Yong-Gil Kim, Soohyun Kim
Summary: IL-32 plays a contradictory role in cancer development, with its high expression typically associated with tumor proliferation and progression. However, different isoforms of IL-32 may have different effects in cancer, such as IL-32 beta promoting cancer expansion and IL-32 theta inhibiting epithelial-mesenchymal transition. Further research is needed to understand the role of IL-32 in cancer therapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Jiaojiao Peng, Feng Liu, Hong Zheng, Qi Wu, Shixi Liu
Summary: The study revealed that ZFAS1 contributes to radioresistance of NPC cells by regulating the miR-7-5p/ENO2 axis, potentially making it a therapeutic target for addressing radioresistance in NPC cells.
Editorial Material
Oncology
Rob A. Cairns, Tak W. Mak
Article
Oncology
Satoshi Inoue, Wanda Y. Li, Alan Tseng, Isabel Beerman, Andrew J. Elia, Sean C. Bendall, Francois Lemonnier, Ken J. Kron, David W. Cescon, Zhenyue Hao, Evan F. Lind, Naoya Takayama, Aline C. Planello, Shu Yi Shen, Alan H. Shih, Dana M. Larsen, Qinxi Li, Bryan E. Snow, Andrew Wakeham, Jillian Haight, Chiara Gorrini, Christian Bassi, Kelsie L. Thu, Kiichi Murakami, Alisha R. Elford, Takeshi Ueda, Kimberly Straley, Katharine E. Yen, Gerry Melino, Luisa Cimmino, Iannis Aifantis, Ross L. Levine, Daniel D. De Carvalho, Mathieu Lupien, Derrick J. Rossi, Garry P. Nolan, Rob A. Cairns, Tak W. Mak
Editorial Material
Biochemistry & Molecular Biology
Rob A. Cairns, Tak W. Mak
CELL DEATH AND DIFFERENTIATION
(2017)
Article
Multidisciplinary Sciences
Jing Ye, Yu Gu, Feng Zhang, Yuanlin Zhao, Yuan Yuan, Zhenyue Hao, Yi Sheng, Wanda Y. Li, Andrew Wakeham, Rob A. Cairns, Tak W. Mak
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2017)
Article
Oncology
Rob A. Cairns, Tak W. Mak
EXPERIMENTAL CELL RESEARCH
(2017)
Letter
Hematology
Francois Lemonnier, Elsa Poullot, Aurelie Dupuy, Lucile Couronne, Nadine Martin, Laurianne Scourzic, Virginie Fataccioli, Julie Bruneau, Rob A. Cairns, Tak W. Mak, Olivier A. Bernard, Laurence de Leval, Philippe Gaulard
Letter
Hematology
Francois Lemonnier, Elsa Poullot, Aurelie Dupuy, Lucile Couronne, Nadine Martin, Laurianne Scourzic, Virginie Fataccioli, Julie Bruneau, Rob A. Cairns, Tak W. Mak, Olivier A. Bernard, Laurence de Leval, Philippe Gaulard
Article
Multidisciplinary Sciences
Ivano Amelio, Mara Mancini, Varvara Petrova, Rob A. Cairns, Poling Vikhreva, Sara Nicolai, Alberto Marini, Alexey A. Antonov, John Le Quesne, Juvenal D. Baena Acevedo, Kate Dudek, Gabriella Sozzi, Ugo Pastorino, Richard A. Knight, Tak W. Mak, Gerry Melino
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2018)
Letter
Oncology
Zhuo Ren, Mariusz Shrestha, Takashi Sakamoto, Tali Melkman, Li Meng, Rob A. Cairns, Eldad Zacksenhaus, Tak W. Mak, Vuk Stambolic, Mark D. Minden, Jiance Atom Wang
Article
Oncology
Kathy Han, Anthony Fyles, Tina Shek, Jennifer Croke, Neesha Dhani, David D'Souza, Ting-Yim Lee, Naz Chaudary, Jeffrey Bruce, Melania Pintilie, Rob Cairns, Douglass Vines, Sara Pakbaz, David Jaffray, Ur Metser, Marjan Rouzbahman, Michael Milosevic, Marianne Koritzinsky
Summary: This study found that metformin can reduce tumor hypoxia in cervical cancer and improve the tumor's response to radiation therapy. After using metformin, the hypoxic volume decreased and the disease-free survival rate of the patients increased.
CLINICAL CANCER RESEARCH
(2022)
Correction
Oncology
Sameer Agnihotri, Brian Golbourn, Xi Huang, Marc Remke, Susan Younger, Rob A. Cairns, Alan Chalil, Christian A. Smith, Stacey-Lynn Krumholtz, Danielle Mackenzie, Patricia Rakopoulos, Vijay Ramaswamy, Michael S. Taccone, Paul S. Mischel, Gregory N. Fuller, Cynthia Hawkins, William Stanford, Michael D. Taylor, Gelareh Zadeh, James T. Rutka
Meeting Abstract
Oncology
Kathy Han, Anthony Fyles, Tina Shek, Jennifer Croke, Neesha Dhani, David D'Souza, Ting-Yim Lee, Naz Chaudary, Rob Cairns, Melania Pintilie, Douglass Vines, David Jaffray, Ur Metser, Michael Milosevic, Marianne Koritzinsky
RADIOTHERAPY AND ONCOLOGY
(2021)
Meeting Abstract
Oncology
Jelena Lukovic, Melania Pintilie, Jeffrey Bruce, Kathy Han, Rob Cairns, Trevor Pugh, Michael Milosevic
RADIOTHERAPY AND ONCOLOGY
(2020)
Meeting Abstract
Oncology
Aesha Patel, Rob Cairns, Brad Wouters
RADIOTHERAPY AND ONCOLOGY
(2020)
Article
Oncology
Eric Leung, Rob A. Cairns, Naz Chaudary, Ravi N. Vellanki, Tuula Kalliomaki, Eduardo H. Moriyama, Hilda Mujcic, Brian C. Wilson, Bradly G. Wouters, Richard Hill, Michael Milosevic