Malaria artemisinin resistance: an extracellular vesicles export hypothesis

Artemisinin resistance in the malaria parasite, Plasmodium falciparum, originates from its initial transcriptional response

(2022) Lei Zhu et al.   Communications Biology

Artemisinin-resistant K13 mutations rewire Plasmodium falciparum’s intra-erythrocytic metabolic program to enhance survival

(2021) Sachel Mok et al.   Nature Communications

Implicating extracellular vesicles in Plasmodium falciparum artemisinin resistance development

(2021) Kwesi Z. Tandoh et al.   TRAFFIC

The ESCRT-III machinery participates in the production of extracellular vesicles and protein export during Plasmodium falciparum infection

(2021) Yunuen Avalos-Padilla et al.   PLoS Pathogens

The apicoplast link to fever-survival and artemisinin-resistance in the malaria parasite

(2021) Min Zhang et al.   Nature Communications

Plasmodium falciparum resistance to ACTs: Emergence, mechanisms, and outlook

(2021) Faiza Amber Siddiqui et al.   International Journal for Parasitology-Drugs and Drug Resistance

A Kelch13-defined endocytosis pathway mediates artemisinin resistance in malaria parasites

(2020) Jakob Birnbaum et al.   SCIENCE

Role of Plasmodium falciparum Kelch 13 Protein Mutations in P. falciparum Populations from Northeastern Myanmar in Mediating Artemisinin Resistance

(2020) Faiza Amber Siddiqui et al.   mBio

Insights into the intracellular localization, protein associations and artemisinin resistance properties of Plasmodium falciparum K13

(2020) Nina F. Gnädig et al.   PLoS Pathogens

Decreased K13 Abundance Reduces Hemoglobin Catabolism and Proteotoxic Stress, Underpinning Artemisinin Resistance

(2019) Tuo Yang et al.   Cell Reports

Remodeling of the malaria parasite and host human red cell by vesicle amplification that induces artemisinin resistance

(2018) Souvik Bhattacharjee et al.   BLOOD

Oxidative stress and protein damage responses mediate artemisinin resistance in malaria parasites

(2018) Frances Rocamora et al.   PLoS Pathogens

Artemisinin kills malaria parasites by damaging proteins and inhibiting the proteasome

(2018) Jessica L. Bridgford et al.   Nature Communications