The potential of liquid biopsy in the management of cancer patients

Detection of circulating tumour cells before and following adjuvant chemotherapy and long-term prognosis of early breast cancer

(2022) Alexios Matikas et al.   BRITISH JOURNAL OF CANCER

The Use of Serial Circulating Tumor DNA to Detect Resistance Alterations in Progressive Metastatic Breast Cancer

(2021) Saya Jacob et al.   CLINICAL CANCER RESEARCH

Dynamic changes of CTCs in patients with metastatic HR(+)/HER2(−) breast cancer receiving salvage treatment with everolimus/exemestane

(2021) Maria Spiliotaki et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

ESR1 NAPA Assay: Development and Analytical Validation of a Highly Sensitive and Specific Blood-Based Assay for the Detection of ESR1 Mutations in Liquid Biopsies

(2021) Dimitra Stergiopoulou et al.   Cancers

Platelets and tumor-associated RNA transfer

(2021) Silvia D'Ambrosi et al.   BLOOD

Genomic profile of advanced breast cancer in circulating tumour DNA

(2021) Belinda Kingston et al.   Nature Communications

RNA-Based CTC Analysis Provides Prognostic Information in Metastatic Breast Cancer

(2021) Areti Strati et al.   Diagnostics

Clinical validation of a targeted methylation-based multi-cancer early detection test using an independent validation set

(2021) E.A. Klein et al.   ANNALS OF ONCOLOGY

Circulating tumor cells, circulating tumor DNA, and disease characteristics in young women with metastatic breast cancer

(2021) Ami N. Shah et al.   BREAST CANCER RESEARCH AND TREATMENT

Detection of EGFR Mutations in Plasma cfDNA and Paired CTCs of NSCLC Patients before and after Osimertinib Therapy Using Crystal Digital PCR

(2021) Aliki Ntzifa et al.   Cancers

Circulating tumor cell number and endocrine therapy index in ER positive metastatic breast cancer patients

(2021) Costanza Paoletti et al.   npj Breast Cancer

Can Circulating Tumor DNA Support a Successful Screening Test for Early Cancer Detection? The Grail Paradigm

(2021) Oscar D. Pons-Belda et al.   Diagnostics

Feasibility of blood testing combined with PET-CT to screen for cancer and guide intervention

(2020) Anne Marie Lennon et al.   SCIENCE

Genetic characterization of a unique neuroendocrine transdifferentiation prostate circulating tumor cell-derived eXplant model

(2020) Vincent Faugeroux et al.   Nature Communications

Sensitive and specific multi-cancer detection and localization using methylation signatures in cell-free DNA

(2020) M.C. Liu et al.   ANNALS OF ONCOLOGY

Precision Prevention and Cancer Interception: The New Challenges of Liquid Biopsy

(2020) Maria Jose Serrano et al.   Cancer Discovery

High Sensitivity of Circulating Tumor Cells Derived from a Colorectal Cancer Patient for Dual Inhibition with AKT and mTOR Inhibitors

(2020) Daniel J. Smit et al.   Cells

Understanding the organ tropism of metastatic breast cancer through the combination of liquid biopsy tools

(2020) Lorenzo Gerratana et al.   EUROPEAN JOURNAL OF CANCER

Brief report on the clinical characteristics of patients whose samples generate small cell lung cancer circulating tumour cell derived explants

(2020) Alexander J. Vickers et al.   LUNG CANCER

Circulating platelets as liquid biopsy sources for cancer detection

(2020) Mafalda Antunes‐Ferreira et al.   Molecular Oncology

Clinical utility of circulating tumor cells: an update

(2020) Antoine Vasseur et al.   Molecular Oncology

Circulating tumor DNA analysis in breast cancer: is it ready for prime-time?

(2019) Giuseppe Buono et al.   CANCER TREATMENT REVIEWS

Liquid biopsy and minimal residual disease — latest advances and implications for cure

(2019) Klaus Pantel et al.   Nature Reviews Clinical Oncology

Prospective Multicenter Validation of Androgen Receptor Splice Variant 7 and Hormone Therapy Resistance in High-Risk Castration-Resistant Prostate Cancer: The PROPHECY Study

(2019) Andrew J. Armstrong et al.   JOURNAL OF CLINICAL ONCOLOGY

Plasma HER2 (ERBB2) Copy Number Predicts Response to HER2-targeted Therapy in Metastatic Colorectal Cancer

(2019) Giulia Siravegna et al.   CLINICAL CANCER RESEARCH

Establishment and characterization of a patient-derived circulating lung tumor cell line in vitro and in vivo

(2019) Zujun Que et al.   Cancer Cell International

Liver-derived Cell-free Nucleic Acids in Plasma: Biology and Applications in Liquid Biopsies

(2019) Peiyong Jiang et al.   JOURNAL OF HEPATOLOGY

Utility of ctDNA to support patient selection for early phase clinical trials: the TARGET study

(2019) Dominic G. Rothwell et al.   NATURE MEDICINE

Alpelisib for PIK3CA-Mutated, Hormone Receptor–Positive Advanced Breast Cancer

(2019) Fabrice André et al.   NEW ENGLAND JOURNAL OF MEDICINE

Analysis of Plasma Cell-Free DNA by Ultradeep Sequencing in Patients With Stages I to III Colorectal Cancer

(2019) Thomas Reinert et al.   JAMA Oncology

Circulating Tumor Cell Clusters in Metastatic Breast Cancer Patients: a SWOG S0500 Translational Medicine Study.

(2019) Costanza Paoletti et al.   CLINICAL CANCER RESEARCH

PIK3CA hotspot mutations in circulating tumor cells and paired circulating tumor DNA in breast cancer: a direct comparison study

(2019) Eleni Tzanikou et al.   Molecular Oncology

Circulating tumor cell as the functional aspect of liquid biopsy to understand the metastatic cascade in solid cancer

(2019) Luis Enrique Cortés-Hernández et al.   MOLECULAR ASPECTS OF MEDICINE

DYNAMIC insights into MRD responses early after resection of NSCLC

(2019) David Killock   Nature Reviews Clinical Oncology

Personalized circulating tumor DNA analysis to detect residual disease after neoadjuvant therapy in breast cancer

(2019) Bradon R. McDonald et al.   Science Translational Medicine

How liquid biopsies can change clinical practice in oncology

(2019) G Siravegna et al.   ANNALS OF ONCOLOGY

Detection of ESR1 Mutations in Single Circulating Tumor Cells on Estrogen Deprivation Therapy but Not in Primary Tumors from Metastatic Luminal Breast Cancer Patients

(2019) André Franken et al.   JOURNAL OF MOLECULAR DIAGNOSTICS

Monitoring treatment efficacy and resistance in breast cancer patients via circulating tumor DNA genomic profiling

(2019) Zhanhong Chen et al.   Molecular Genetics & Genomic Medicine

Clinical applications of the CellSearch platform in cancer patients

(2018) Sabine Riethdorf et al.   ADVANCED DRUG DELIVERY REVIEWS

Targeted methylation sequencing of plasma cell-free DNA for cancer detection and classification

(2018) L Liu et al.   ANNALS OF ONCOLOGY

Potential of quantitative SEPT9 and SHOX2 methylation in plasmatic circulating cell-free DNA as auxiliary staging parameter in colorectal cancer: a prospective observational cohort study

(2018) Julia Bergheim et al.   BRITISH JOURNAL OF CANCER

Targeting USP7 identifies a metastasis-competent state within bone marrow-resident melanoma CTCs

(2018) Monika Vishnoi et al.   CANCER RESEARCH

Early Assessment of Lung Cancer Immunotherapy Response via Circulating Tumor DNA

(2018) Sarah B. Goldberg et al.   CLINICAL CANCER RESEARCH

RNA Profiles of Circulating Tumor Cells and Extracellular Vesicles for Therapy Stratification of Metastatic Breast Cancer Patients

(2018) Corinna Keup et al.   CLINICAL CHEMISTRY

Serial circulating tumour DNA analysis during multimodality treatment of locally advanced rectal cancer: a prospective biomarker study

(2018) Jeanne Tie et al.   GUT

Osimertinib As First-Line Treatment of EGFR Mutation–Positive Advanced Non–Small-Cell Lung Cancer

(2018) Suresh S. Ramalingam et al.   JOURNAL OF CLINICAL ONCOLOGY

Detection and localization of surgically resectable cancers with a multi-analyte blood test

(2018) Joshua D. Cohen et al.   SCIENCE

Identifying Circulating Tumor DNA Mutation Profiles in Metastatic Breast Cancer Patients with Multiline Resistance

(2018) Zhe-Yu Hu et al.   EBioMedicine

Longitudinal Liquid Biopsy and Mathematical Modeling of Clonal Evolution Forecast Time to Treatment Failure in the PROSPECT-C Phase II Colorectal Cancer Clinical Trial

(2018) Khurum H. Khan et al.   Cancer Discovery

A Digital RNA Signature of Circulating Tumor Cells Predicting Early Therapeutic Response in Localized and Metastatic Breast Cancer

(2018) Tanya T. Kwan et al.   Cancer Discovery

The genetic landscape and clonal evolution of breast cancer resistance to palbociclib plus fulvestrant in the PALOMA-3 trial

(2018) Ben O'Leary et al.   Cancer Discovery

A Phase II Trial of Osimertinib in the Second-Line Treatment of Non-small Cell Lung Cancer with the EGFR T790M Mutation, Detected from Circulating Tumor DNA: LiquidLung-O-Cohort 2

(2018) Cheol-Kyu Park et al.   Cancer Research and Treatment

Dynamics of tumor and immune responses during immune checkpoint blockade in non-small cell lung cancer

(2018) Valsamo Anagnostou et al.   CANCER RESEARCH

Association of clinical outcomes in metastatic breast cancer patients with circulating tumour cell and circulating cell-free DNA

(2018) Zhong Ye et al.   EUROPEAN JOURNAL OF CANCER

CTCs‐derived xenograft development in a triple negative breast cancer case

(2018) Tais Pereira‐Veiga et al.   INTERNATIONAL JOURNAL OF CANCER

New insights into the mechanisms of epithelial–mesenchymal transition and implications for cancer

(2018) Anushka Dongre et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Circulating tumor DNA in advanced prostate cancer: transitioning from discovery to a clinically implemented test

(2018) Enrique González-Billalabeitia et al.   PROSTATE CANCER AND PROSTATIC DISEASES

Homophilic CD44 Interactions Mediate Tumor Cell Aggregation and Polyclonal Metastasis in Patient-Derived Breast Cancer Models

(2018) Xia Liu et al.   Cancer Discovery

The clinical use of circulating tumor cells (CTCs) enumeration for staging of metastatic breast cancer (MBC): International expert consensus paper

(2018) Massimo Cristofanilli et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Single CpG site methylation controls estrogen receptor gene transcription and correlates with hormone therapy resistance

(2017) Kouki Tsuboi et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Microfluidic isolation of platelet-covered circulating tumor cells

(2017) Xiaocheng Jiang et al.   LAB ON A CHIP

Phylogenetic ctDNA analysis depicts early-stage lung cancer evolution

(2017) Christopher Abbosh et al.   NATURE

Analysis of Plasma Epstein–Barr Virus DNA to Screen for Nasopharyngeal Cancer

(2017) K.C. Allen Chan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Direct detection of early-stage cancers using circulating tumor DNA

(2017) Jillian Phallen et al.   Science Translational Medicine

Molecular characterization of breast cancer CTCs associated with brain metastasis

(2017) Debasish Boral et al.   Nature Communications

Early Detection of Molecular Residual Disease in Localized Lung Cancer by Circulating Tumor DNA Profiling

(2017) Aadel A. Chaudhuri et al.   Cancer Discovery

Tumourigenic non-small-cell lung cancer mesenchymal circulating tumour cells: a clinical case study

(2016) C. J. Morrow et al.   ANNALS OF ONCOLOGY

Molecular Portrait of Metastasis-Competent Circulating Tumor Cells in Colon Cancer Reveals the Crucial Role of Genes Regulating Energy Metabolism and DNA Repair

(2016) Catherine Alix-Panabières et al.   CLINICAL CHEMISTRY

PlasmaESR1Mutations and the Treatment of Estrogen Receptor–Positive Advanced Breast Cancer

(2016) Charlotte Fribbens et al.   JOURNAL OF CLINICAL ONCOLOGY

Gene expression profiling and DNA methylation analyses of CTCs

(2016) Evi S. Lianidou   Molecular Oncology

Early dissemination seeds metastasis in breast cancer

(2016) Hedayatollah Hosseini et al.   NATURE

Organoid culture systems for prostate epithelial and cancer tissue

(2016) Jarno Drost et al.   Nature Protocols

Circulating tumor DNA analysis detects minimal residual disease and predicts recurrence in patients with stage II colon cancer

(2016) Jeanne Tie et al.   Science Translational Medicine

The Long and Short of Circulating Cell-Free DNA and the Ins and Outs of Molecular Diagnostics

(2016) Peiyong Jiang et al.   TRENDS IN GENETICS

Vasculogenic mimicry in small cell lung cancer

(2016) Stuart C. Williamson et al.   Nature Communications

Circulating tumour DNA profiling reveals heterogeneity of EGFR inhibitor resistance mechanisms in lung cancer patients

(2016) Jacob J. Chabon et al.   Nature Communications

Clinical Applications of Circulating Tumor Cells and Circulating Tumor DNA as Liquid Biopsy

(2016) C. Alix-Panabieres et al.   Cancer Discovery

Establishment of a multimarker qPCR panel for the molecular characterization of circulating tumor cells in blood samples of metastatic breast cancer patients during the course of palliative treatment

(2016) Maren Bredemeier et al.   Oncotarget

Multiplexed methylation profiles of tumor suppressor genes and clinical outcome in oligodendroglial tumors

(2016) Lu-Ting Kuo et al.   Cancer Medicine

Genomic Alterations in Cell-Free DNA and Enzalutamide Resistance in Castration-Resistant Prostate Cancer

(2016) Alexander W. Wyatt et al.   JAMA Oncology

First-line erlotinib versus gemcitabine/cisplatin in patients with advancedEGFRmutation-positive non-small-cell lung cancer: analyses from the phase III, randomized, open-label, ENSURE study

(2015) Y.-L. Wu et al.   ANNALS OF ONCOLOGY

Establishment and Characterization of a Cell Line from Human Circulating Colon Cancer Cells

(2015) L. Cayrefourcq et al.   CANCER RESEARCH

Epigenetic Alteration by DNA Methylation of ESR1, MYOD1 and hTERT Gene Promoters is Useful for Prediction of Response in Patients of Locally Advanced Invasive Cervical Carcinoma Treated by Chemoradiation

(2015) S. Sood et al.   CLINICAL ONCOLOGY

Sera DNA Methylation of CDH1, DNMT3b and ESR1 Promoters as Biomarker for the Early Diagnosis of Hepatitis B Virus-Related Hepatocellular Carcinoma

(2015) Cheng-Yun Dou et al.   DIGESTIVE DISEASES AND SCIENCES

Analysis of circulating DNA and protein biomarkers to predict the clinical activity of regorafenib and assess prognosis in patients with metastatic colorectal cancer: a retrospective, exploratory analysis of the CORRECT trial

(2015) Josep Tabernero et al.   LANCET ONCOLOGY

Estrogen receptor alpha mediates epithelial to mesenchymal transition, expression of specific matrix effectors and functional properties of breast cancer cells

(2015) Panagiotis Bouris et al.   MATRIX BIOLOGY

Cell-free circulating tumour DNA as a liquid biopsy in breast cancer

(2015) Leticia De Mattos-Arruda et al.   Molecular Oncology

Mutation tracking in circulating tumor DNA predicts relapse in early breast cancer

(2015) Isaac Garcia-Murillas et al.   Science Translational Medicine

Predicting Radiotherapy Responses and Treatment Outcomes Through Analysis of Circulating Tumor DNA

(2015) Aadel A. Chaudhuri et al.   SEMINARS IN RADIATION ONCOLOGY

Tumor Heterogeneity and Lesion-Specific Response to Targeted Therapy in Colorectal Cancer

(2015) M. Russo et al.   Cancer Discovery

New findings on primary and acquired resistance to anti-EGFR therapy in metastatic colorectal cancer: do all roads lead to RAS?

(2015) Giuseppe Bronte et al.   Oncotarget

Aberrant DNA methylation profiles of inherited and sporadic colorectal cancer

(2015) Nora Sahnane et al.   Clinical Epigenetics

Characterization of DNA Methylation in Circulating Tumor Cells

(2015) Constantin Pixberg et al.   Genes

ESR1gene promoter region methylation in free circulating DNA and its correlation with estrogen receptor protein expression in tumor tissue in breast cancer patients

(2014) Joaquina Martínez-Galán et al.   BMC CANCER

Circulating Tumor Cell Clusters Are Oligoclonal Precursors of Breast Cancer Metastasis

(2014) Nicola Aceto et al.   CELL

PIK3CA Mutational Status in Circulating Tumor Cells Can Change During Disease Recurrence or Progression in Patients with Breast Cancer

(2014) A. Markou et al.   CLINICAL CANCER RESEARCH

Circulating Tumor DNA as a Liquid Biopsy for Cancer

(2014) E. Heitzer et al.   CLINICAL CHEMISTRY

Circulating tumor cells as promising novel biomarkers in solid cancers

(2014) Evi S. Lianidou et al.   CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES

Methylation patterns of estrogen receptor α promoter correlate with estrogen receptor α expression and clinicopathological factors in hepatocellular carcinoma

(2014) Binghua Dai et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Estrogen receptor promoter methylation predicts survival in low-grade ovarian carcinoma patients

(2014) Verena Kirn et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Liquid Biopsies: Genotyping Circulating Tumor DNA

(2014) Luis A. Diaz et al.   JOURNAL OF CLINICAL ONCOLOGY

Circulating Tumor Cells Predict Survival in Early Average-to-High Risk Breast Cancer Patients

(2014) Brigitte Rack et al.   JNCI-Journal of the National Cancer Institute

Clinical validity of circulating tumour cells in patients with metastatic breast cancer: a pooled analysis of individual patient data

(2014) François-Clément Bidard et al.   LANCET ONCOLOGY

Tumorigenicity and genetic profiling of circulating tumor cells in small-cell lung cancer

(2014) Cassandra L Hodgkinson et al.   NATURE MEDICINE

DNA methylation and gene deletion analysis of brain metastases in melanoma patients identifies mutually exclusive molecular alterations

(2014) D. M. Marzese et al.   NEURO-ONCOLOGY

AR-V7 and Resistance to Enzalutamide and Abiraterone in Prostate Cancer

(2014) Emmanuel S. Antonarakis et al.   NEW ENGLAND JOURNAL OF MEDICINE

Ex vivo culture of circulating breast tumor cells for individualized testing of drug susceptibility

(2014) M. Yu et al.   SCIENCE

Capture of Viable Circulating Tumor Cells in the Liver of Colorectal Cancer Patients

(2013) E. Deneve et al.   CLINICAL CHEMISTRY

Heterogeneity of Estrogen Receptor Expression in Circulating Tumor Cells from Metastatic Breast Cancer Patients

(2013) Anna Babayan et al.   PLoS One

The Identification and Characterization of Breast Cancer CTCs Competent for Brain Metastasis

(2013) L. Zhang et al.   Science Translational Medicine

CST6 promoter methylation in circulating cell-free DNA of breast cancer patients

(2012) Maria Chimonidou et al.   CLINICAL BIOCHEMISTRY

SOX17 Promoter Methylation in Circulating Tumor Cells and Matched Cell-Free DNA Isolated from Plasma of Patients with Breast Cancer

(2012) M. Chimonidou et al.   CLINICAL CHEMISTRY

Circulating tumour cells in non-metastatic breast cancer: a prospective study

(2012) Anthony Lucci et al.   LANCET ONCOLOGY

Gene expression profile of circulating tumor cells in breast cancer by RT-qPCR

(2011) Areti Strati et al.   BMC CANCER

Molecular Characterization of Circulating Tumor Cells in Breast Cancer by a Liquid Bead Array Hybridization Assay

(2011) A. Markou et al.   CLINICAL CHEMISTRY

DNA Methylation of Tumor Suppressor and Metastasis Suppressor Genes in Circulating Tumor Cells

(2011) M. Chimonidou et al.   CLINICAL CHEMISTRY

Circulating Methylated SEPT9 DNA in Plasma Is a Biomarker for Colorectal Cancer

(2009) T. deVos et al.   CLINICAL CHEMISTRY

Circulating tumour cells as prognostic markers in progressive, castration-resistant prostate cancer: a reanalysis of IMMC38 trial data

(2009) Howard I Scher et al.   LANCET ONCOLOGY

Circulating mutant DNA to assess tumor dynamics

(2008) Frank Diehl et al.   NATURE MEDICINE

Epigenetics in Cancer

(2008) Manel Esteller   NEW ENGLAND JOURNAL OF MEDICINE