Osmotic stress activates RIPK3/MLKL-mediated necroptosis by increasing cytosolic pH through a plasma membrane Na + /H + exchanger

The regulation of necroptosis by post-translational modifications

(2021) Yanxiang Meng et al.   CELL DEATH AND DIFFERENTIATION

Location, location, location: A compartmentalized view of TNF-induced necroptotic signaling

(2021) André L. Samson et al.   Science Signaling

The death-inducing activity of RIPK1 is regulated by the pH environment

(2020) Kenta Moriwaki et al.   Science Signaling

Pyrazine ring-based Na+/H+ exchanger (NHE) inhibitors potently inhibit cancer cell growth in 3D culture, independent of NHE1

(2020) Michala G. Rolver et al.   Scientific Reports

The molecular machinery of regulated cell death

(2019) Daolin Tang et al.   CELL RESEARCH

The Na+/H+-Exchanger NHE1 Regulates Extra- and Intracellular pH and Nimodipine-sensitive [Ca2+]i in the Suprachiasmatic Nucleus

(2019) Pi-Cheng Cheng et al.   Scientific Reports

Estrogen-Related Hormones Induce Apoptosis by Stabilizing Schlafen-12 Protein Turnover

(2019) Dianrong Li et al.   MOLECULAR CELL

The SLC9A-C Mammalian Na+/H+ Exchanger Family: Molecules, Mechanisms, and Physiology

(2019) S. F. Pedersen et al.   PHYSIOLOGICAL REVIEWS

RIP kinases as modulators of inflammation and immunity

(2018) Sudan He et al.   NATURE IMMUNOLOGY

Mixed Lineage Kinase Domain-like Protein MLKL Breaks Down Myelin following Nerve Injury

(2018) Zhengxin Ying et al.   MOLECULAR CELL

Necroptosis and RIPK1-mediated neuroinflammation in CNS diseases

(2018) Junying Yuan et al.   NATURE REVIEWS NEUROSCIENCE

Selective knockout of astrocytic Na+ /H+ exchanger isoform 1 reduces astrogliosis, BBB damage, infarction, and improves neurological function after ischemic stroke

(2017) Gulnaz Begum et al.   GLIA

Programmed necrosis in inflammation: Toward identification of the effector molecules

(2016) D. Wallach et al.   SCIENCE

Inhibition of NA+/H+Exchanger 1 Attenuates Renal Dysfunction Induced by Advanced Glycation End Products in Rats

(2016) Peng Li et al.   Journal of Diabetes Research

Receptor-Interacting Protein Homotypic Interaction Motif-Dependent Control of NF- B Activation via the DNA-Dependent Activator of IFN Regulatory Factors

(2014) W. J. Kaiser et al.   JOURNAL OF IMMUNOLOGY

Toll-like Receptor 3-mediated Necrosis via TRIF, RIP3, and MLKL

(2013) William J. Kaiser et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NHE-1: Still a viable therapeutic target

(2013) Morris Karmazyn   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase

(2012) Liming Sun et al.   CELL

DAI/ZBP1/DLM-1 Complexes with RIP3 to Mediate Virus-Induced Programmed Necrosis that Is Targeted by Murine Cytomegalovirus vIRA

(2012) Jason W. Upton et al.   Cell Host & Microbe

Phosphorylation and Activation of the Plasma Membrane Na+/H+ Exchanger (NHE1) during Osmotic Cell Shrinkage

(2011) Robert R. Rigor et al.   PLoS One

Toll-like receptors activate programmed necrosis in macrophages through a receptor-interacting kinase-3-mediated pathway

(2011) S. He et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amiloride inhibits macropinocytosis by lowering submembranous pH and preventing Rac1 and Cdc42 signaling

(2010) Mirkka Koivusalo et al.   JOURNAL OF CELL BIOLOGY

Phosphorylation-Driven Assembly of the RIP1-RIP3 Complex Regulates Programmed Necrosis and Virus-Induced Inflammation

(2009) YoungSik Cho et al.   CELL

Receptor Interacting Protein Kinase-3 Determines Cellular Necrotic Response to TNF-α

(2009) Sudan He et al.   CELL

Physiology of Cell Volume Regulation in Vertebrates

(2009) Else K. Hoffmann et al.   PHYSIOLOGICAL REVIEWS

RIP3, an Energy Metabolism Regulator That Switches TNF-Induced Cell Death from Apoptosis to Necrosis

(2009) D.-W. Zhang et al.   SCIENCE

Sodium-Hydrogen Exchange Inhibition by Cariporide to Reduce the Risk of Ischemic Cardiac Events in Patients Undergoing Coronary Artery Bypass Grafting: Results of the EXPEDITION Study

(2008) Robert M. Mentzer et al.   ANNALS OF THORACIC SURGERY

Kinetic Analysis of the Regulation of the Na+/H+Exchanger NHE-1 by Osmotic Shocks†

(2008) Jérôme Lacroix et al.   BIOCHEMISTRY