Article
Cell Biology
Gemma Fabozzi, Paola Rebuzzini, Danilo Cimadomo, Mariachiara Allori, Marica Franzago, Liborio Stuppia, Silvia Garagna, Filippo Maria Ubaldi, Maurizio Zuccotti, Laura Rienzi
Summary: The gut microbiota plays an important role in both male and female fertility, and dysbiosis of the gut microbiota may contribute to reproductive issues. Exposure to endocrine-disrupting chemicals is a major cause of gut microbiota dysbiosis and can have significant effects on host health and potential transgenerational effects.
Review
Environmental Sciences
Laura Calero-Medina, Maria Jose Jimenez-Casquet, Leticia Heras-Gonzalez, Javier Conde-Pipo, Alejandro Lopez -Moro, Fatima Olea-Serrano, Miguel Mariscal-Arcas
Summary: Endocrine disrupting chemicals (EDCs) can interfere with hormonal actions and have been associated with a higher incidence of metabolic disorders. They affect numerous physiological, biochemical, and endocrinal activities, including reproduction, metabolism, immunity, and behavior. The purpose of this review was to elucidate the association of EDCs in food with the gut microbiota and with metabolic disorders. EDC exposure induces changes that can lead to microbial dysbiosis, and the microbial metabolites can affect the host metabolism.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Review
Pharmacology & Pharmacy
Amer H. Asseri, Tahani Bakhsh, Samah Sulaiman Abuzahrah, Sajad Ali, Irfan A. Rather
Summary: The human gut microbiota consists of over 100 trillion organisms, mainly bacteria, outnumbering the host body cells by a factor of ten. The gastrointestinal tract, housing a large number of immune cells, plays a crucial role in maintaining immune homeostasis. However, dysbiosis of the gut microbiota can lead to inflammation and tumorigenesis. This review explores the impact of gut microbiota dysbiosis on cancer development and discusses the potential of manipulating the gut microbiota for cancer therapies.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Microbiology
Aditya Enjeti, Harindra Darshana Sathkumara, Andreas Kupz
Summary: Tuberculosis (TB) has been a global infectious disease problem for a long time. Efforts to eliminate TB have been hindered by factors such as the complexity of Mycobacterium tuberculosis (Mtb), the emergence of antibiotic resistant strains, and the impact of the COVID-19 pandemic. Studying the immunomodulatory role of gastrointestinal microbiota offers a new direction for TB research.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Gratiela Gradisteanu Pircalabioru, Janie Liaw, Ozan Gundogdu, Nicolae Corcionivoschi, Iuliana Ilie, Luciana Oprea, Madalina Musat, Mariana-Carmen Chifiriuc
Summary: This study aims to investigate the role of gut microbiota in the development of metabolic syndrome (MetSyn) and type 2 diabetes mellitus (T2DM). The findings show that MetSyn patients have reduced microbial diversity and loss of butyrate producers in their gut microbiome. Furthermore, T2DM patients with MetSyn exhibit distinct gut microbiota signatures. The study also highlights the impact of metformin treatment on the gut microbiome.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nutrition & Dietetics
Daniela Ratto, Elisa Roda, Marcello Romeo, Maria Teresa Venuti, Anthea Desiderio, Giuseppe Lupo, Enrica Capelli, Anna Sandionigi, Paola Rossi
Summary: This study investigated the effects of physiological aging on gut microbiome composition and the relationship between cognitive frailty and gut microbiome composition. The results showed that physiological aging significantly affected the overall gut microbiome composition and the relative abundance of specific bacterial taxa. Additionally, several amplicon sequence variants were found to be significantly associated with the Cognitive Frailty Index.
Article
Gastroenterology & Hepatology
Van T. Pham, Sophie Fehlbaum, Nicole Seifert, Nathalie Richard, Maaike J. Bruins, Wilbert Sybesma, Ateequr Rehman, Robert E. Steinert
Summary: Recent research suggests that vitamins, particularly vitamin C, B2, and D, may modulate the human gut microbiome in terms of metabolic activity and bacterial composition. In a study involving human clinical trials and fermentation experiments, vitamin C was found to significantly increase microbial alpha diversity and fecal short-chain fatty acids compared to placebo, indicating a potential role of vitamins in regulating gut microbiota.
Review
Nutrition & Dietetics
Jasmine Carter, Jeffery Bettag, Sylvia Morfin, Chandrashekhara Manithody, Aakash Nagarapu, Aditya Jain, Hala Nazzal, Sai Prem, Meghan Unes, Matthew McHale, Chien-Jung Lin, Chelsea Hutchinson, Grace Trello, Arti Jain, Edward Portz, Arun Verma, Marzena Swiderska-Syn, Daniel Goldenberg, Kento Kurashima
Summary: Short bowel syndrome (SBS) is a condition caused by a reduction in the length or functional capacity of the intestine. The gut microbiome plays a significant role in modulating disease progression in SBS patients. The composition and shifts of gut bacteria in SBS and the resulting systemic effects have been extensively studied, revealing the variability and dependence on multiple factors. The bidirectional communication between the gut and the brain, regulated by the microbiome, known as the gut-brain axis (GBA), also has implications in SBS.
Editorial Material
Microbiology
Marc D. Cook, Taylor Hogue
Summary: This article aims to explore the mechanisms of how exercise affects gut microbial characteristics and vascular health outcomes, as well as provide insights into future research directions.
Review
Cell Biology
Heloise Tudela, Sandrine P. Claus, Maya Saleh
Summary: The gut microbiota, a diverse community of microorganisms in the gastrointestinal tract, has a significant impact on health and disease. Keystone species, essential microbes for microbiota balance, play crucial roles in maintaining essential functions and their identification is crucial for the development of microbiome-based therapeutics. Understanding the functions of keystone species is a major step towards comprehending microbiome dynamics in disease.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Geriatrics & Gerontology
Emily M. Klann, Upuli Dissanayake, Anjela Gurrala, Matthew Farrer, Aparna Wagle Shukla, Adolfo Ramirez-Zamora, Volker Mai, Vinata Vedam-Mai
Summary: Parkinson's disease is a chronic neurodegenerative disease characterized by the accumulation of misfolded alpha-synuclein protein in certain neurons. Recent research suggests a potential relationship between gut bacteria and the brain, known as the microbiome-gut-brain axis, which may play a role in the development of Parkinson's disease. This review provides an overview of the current knowledge on the relationship between gut microbiota and Parkinson's disease, discussing the role of alpha-synuclein and potential interventions.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Gastroenterology & Hepatology
Barbara Olendzki, Vanni Bucci, Caitlin Cawley, Rene Maserati, Margaret McManus, Effie Olednzki, Camilla Madziar, David Chiang, Doyle Ward, Randall Pellish, Christine Foley, Shakti Bhattarai, Beth A. McCormick, Ana Maldonado-Contreras
Summary: This study aims to investigate the impact of specific foods on the intestinal microbiome in patients with IBD and explore the interactions between diet and immunity to provide personalized nutrition guidance for IBD patients with dysbiosis-related conditions.
Article
Nutrition & Dietetics
Priyanka Sharma, Guojun Wu, Deeptha Kumaraswamy, Natalie Burchat, Hong Ye, Yongjia Gong, Liping Zhao, Yan Y. Lam, Harini Sampath
Summary: DHF supplementation in female mice significantly reduces fat mass, hepatic lipid accumulation, and adipose tissue inflammation, while in male mice, it does not provide protection against adiposity and may worsen hepatic lipid accumulation and adipose tissue inflammation. The effects of DHF on the female gut microbiome precede changes in body weight and play a crucial role in mediating the sexually dimorphic effects of DHF on body weight.
Review
Nutrition & Dietetics
Eleuterio A. Sanchez Romero, Erika Melendez Oliva, Jose Luis Alonso Perez, Sebastian Martin Perez, Silvia Turroni, Lorenzo Marchese, Jorge Hugo Villafane
Summary: This study aimed to review the association between gut microbiome and pain in OA patients and found only three out of 2084 studies supported a relationship, but the results were not conclusive. It also highlighted the lack of high-quality studies and significant technique disparities, making it impossible to draw firm conclusions on the topic.
Article
Environmental Sciences
Yi Huang, Yuhang Hong, Shu Wu, Xiaozhen Yang, Qiang Huang, Yanzhen Dong, Dayong Xu, Zhiqiu Huang
Summary: The present study investigated the toxic effects of IMI on the brain and gut of zebrafish by analyzing the transcriptome and microbiome. The results showed that prolonged darkness improved survival rate and attenuated oxidative stress induced by IMI exposure. Microbiome analysis also revealed changes in gut bacterial community structure and tryptophan metabolism pathway inhibition, which were alleviated in the prolonged darkness group.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Rehabilitation
Elien Van der Gucht, Lore Dams, Koen Bernar, Tessa De Vrieze, Vincent Haenen, An De Groef, Lode Godderis, Bart Morlion, Mira Meeus, Nele Devoogdt
Summary: This study assessed the psychometric properties of the PDI-DLV questionnaire after breast cancer surgery. The results showed good relative reliability, internal consistency, content validity, and construct validity of the PDI-DLV. Therefore, the PDI-DLV questionnaire can effectively assess pain-related disability 1 year after breast cancer surgery.
PHYSIOTHERAPY THEORY AND PRACTICE
(2023)
Article
Medicine, General & Internal
N. Fraeyman, D. De Bacquer, T. Fiers, L. Godderis, R. Verhaeghe, K. Eeckloo, P. Gemmel, L. Viaene, E. Mortier
Summary: This study aimed to analyze the relationship between BMI and ergonomic accidents. The study found that factors such as gender, age, and functional status of employees influenced the incidence of ergonomic accidents, but BMI was not independently associated. Furthermore, the type and severity of accidents were also unrelated to BMI.
ACTA CLINICA BELGICA
(2023)
Editorial Material
Public, Environmental & Occupational Health
Vivi Schlunssen, Jean Baptist du Prel, Martie van Tongeren, Lode Godderis, Michelle C. Turner, Damien McElvenny
Summary: Harmonized tools and approaches for data collection can help detect similarities and differences in COVID-19 across countries and support the development of effective preventive strategies. The open source occupational questionnaires on COVID-19 provide comprehensive coverage of key aspects related to the pandemic. However, the general questionnaire has a limited number of questions for each domain.
ANNALS OF WORK EXPOSURES AND HEALTH
(2023)
Article
Environmental Sciences
Imane Berni, Aziza Menouni, Matteo Creta, Ibrahim El Ghazi, Radu-Corneliu Duca, Lode Godderis, Samir El Jaafari
Summary: This study aimed to evaluate the levels of glyphosate and its metabolite AMPA in Moroccan children, identify predictors, and conduct a risk assessment. The study found that glyphosate and AMPA were detected in the urine of 73% and 75% of children, respectively, with higher concentrations in younger children and those living near pesticide spraying fields. Factors such as drinking water source and household income were also associated with AMPA concentration. The health risk assessment showed low risk for the target population.
ENVIRONMENTAL RESEARCH
(2023)
Article
Environmental Sciences
Ilana Struys, Eline Verscheure, Liesbeth Lenaerts, Frederic Amant, Lode Godderis, Manosij Ghosh
Summary: Due to the genotoxic consequences of antineoplastic agents on non-cancerous tissue, it is crucial to understand their effects. This study aimed to characterize the genotoxic profile of different classes of antineoplastic drugs using a cell line assay. The results showed increased micronucleus formation with all tested drugs, as well as specific abnormalities for each drug class. These findings can aid in interpreting genotoxic aberrations in patients treated with these drugs.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2023)
Article
Health Care Sciences & Services
Lode Godderis, Loic Lerouge, Yogindra Samant, Peter Noone
Summary: Synergies and collaboration between occupational and public health professionals are crucial in preventing community-acquired infections, as demonstrated during the COVID-19 pandemic. Public health professionals should define and set health and healthcare goals in various multi-stakeholder contexts such as work, school, home, and leisure. These goals can be achieved through collaboration with local communities and relevant OSH stakeholders.
JOURNAL OF PUBLIC HEALTH POLICY
(2023)
Article
Anesthesiology
Lore Dams, Elien Van der Gucht, Nele Devoogdt, Ann Smeets, Koen Bernar, Bart Morlion, Lode Godderis, Vincent Haenen, Tessa De Vrieze, Steffen Fieuws, Niamh Moloney, Paul Van Wilgen, Mira Meeus, An De Groef
Summary: Pain is a common and long-lasting side effect in women who have undergone surgical treatment for breast cancer. Pain neuroscience education (PNE) is an effective educational intervention that not only explains pain from a biomedical perspective but also considers psychological and social factors. In a randomized controlled trial, PNE showed similar results to providing a biomedical explanation for pain in terms of reducing pain-related disability and improving secondary outcomes.
Article
Public, Environmental & Occupational Health
Ella Parsons, Sheryl L. Rifas-Shiman, Anne K. Bozack, Andrea A. Baccarelli, Dawn L. DeMeo, Marie-France Hivert, Lode Godderis, Radu-Corneliu Duca, Emily Oken, Andres Cardenas
Summary: The prenatal environment may program health and disease susceptibility via epigenetic mechanisms. This study found associations between maternal trimester-specific intake of micronutrients and global DNA methylation and 5-hydroxymethylation in cord blood, with some associations persisting into early childhood.
JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE
(2023)
Review
Medicine, General & Internal
Arne Wyns, Jolien Hendrix, Astrid Lahousse, Elke De Bruyne, Jo Nijs, Lode Godderis, Andrea Polli
Summary: Stress has negative impacts on physical and mental health, especially for patients with chronic pain who experience stress intolerance. This paper summarizes the role of the autonomic nervous system and hypothalamus-pituitary-adrenal axis in stress intolerance based on clinical and preclinical studies. The (epi)genetic mechanisms influencing these stress systems are also explored. Understanding the connection between stress, HPA axis, ANS, and chronic health conditions like chronic pain is crucial for improving public health and well-being.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Public, Environmental & Occupational Health
Octavio Jimenez-Garza, Manosij Ghosh, Timothy M. Barrow, Lode Godderis
Summary: This review summarizes the findings of DNA methylation studies in blood cells of workers exposed to toxicants. The results suggest that DNA methylation changes are associated with disease development in occupational exposures, but the heterogeneity in genes studied and the lack of longitudinal studies limit their use as biomarkers in occupational settings.
FRONTIERS IN PUBLIC HEALTH
(2023)
Review
Health Care Sciences & Services
Geertruida E. Bekkering, Marleen Corremans, Marco Gemignani, Nancy Gerber, Lode Godderis, Sumuttana Kaewma, Adchara Khammathit, Jonas Steel, Karin Hannes
Summary: The objective of this review is to investigate the effects of culture-based prescribing on improving mental health and well-being. Although culture-based prescribing shows promise as a community-based source of support, there is heterogeneity in the field regarding definition, underlying hypotheses, and cultural activity, which hinders further development and implementation.
JBI EVIDENCE SYNTHESIS
(2023)
Article
Health Care Sciences & Services
Deborah Seys, Massimiliano Panella, Sophia Russotto, Reinhard Strametz, Jose Joaquin Mira, Astrid Van Wilder, Lode Godderis, Kris Vanhaecht
Summary: This review examines the impact of patient safety incidents on healthcare professionals and the support that can be provided to them. The findings suggest that second victims may experience psychosocial, professional, and physical reactions. Support can be provided at five levels, including prevention, self-care, support by peers, professional support, and clinical support.
BMC HEALTH SERVICES RESEARCH
(2023)
Article
Public, Environmental & Occupational Health
Paulien Cleys, Emilie Hardy, Yu Ait Bamai, Giulia Poma, Adam Cseresznye, Govindan Malarvannan, Paul T. J. Scheepers, Susana Viegas, Simo P. Porras, Tiina Santonen, Lode Godderis, Jelle Verdonck, Katrien Poels, Carla Martins, Maria Joao Silva, Henriqueta Louro, Inese Martinsone, Lasma Akulova, An van Nieuwenhuyse, Martien Graumans, Selma Mahiout, Radu Corneliu Duca, Adrian Covaci
Summary: The aim of this study was to assess the exposure of e-waste workers to phthalates and alternative plasticizers. The results showed that e-waste workers had higher urinary concentrations of phthalates and metabolites compared to non-occupationally exposed controls. However, no significant differences were found between pre-and post-shift concentrations in the e-waste workers.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2024)
Article
Public, Environmental & Occupational Health
Evelien Nys, Sara Pauwels, Balazs Adam, Joao Amaro, Athanasios Athanasiou, Osnat Bashkin, Tatjana Kofol Bric, Petar Bulat, Cigdem Caglayan, Irina Guseva Canu, Serghei Cebanu, Barbara Charbotel, Jolanta Cirule, Stefania Curti, Nadav Davidovitch, Keren Dopelt, Metoda Dodic Fikfak, Heikki Frilander, Per Gustavsson, Anje Christina Hoeper, Sibel Kiran, Manolis Kogevinas, Ferenc Kudasz, Henrik A. Kolstad, Sanja Brekalo Lazarevic, Jelena Macan, Nicole Majery, Alessandro Marinaccio, Dana Mates, Stefano Mattioli, Damien Martin Mcelvenny, Zakia Mediouni, Ingrid Sivesind Mehlum, Eda Merisalu, Dragan Mijakoski, Evangelia Nena, Peter Noone, Marina Ruxandra Otelea, Daniela Pelclova, Nurka Pranjic, Mark Rosso, Consol Serra, Lesley Rushton, Abdulsamet Sandal, Eva S. Schernhammer, Sasho Stoleski, Michelle C. Turner, Henk F. van der Molen, Marek Varga, Jolanta Walusiak-Skorupa, Kurt Straif, Lode Godderis
Summary: Based on responses from experts in 38 countries in Europe, COVID-19 can be recognized as occupational disease or injury in 94% of the countries surveyed, with differences in social security and occupational health systems.
OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
(2023)
Meeting Abstract
Biochemistry & Molecular Biology
Ilana Struys, Manosij Ghosh, Carolina Velazquez, Kristel Van Calsteren, Lode Godderis, Thierry Voet, Ruben van Boxtel, Liesbeth Lenaerts, Frederic Amant
EUROPEAN JOURNAL OF HUMAN GENETICS
(2023)
Article
Environmental Sciences
Toshimi Nakajima, Mao Kuragano, Makoto Yamada, Ryo Sugimoto
Summary: This study compared the contribution of submarine groundwater discharge (SGD) to river nutrient budgets at nearshore and embayment scales, and found that SGD-derived nutrients become more important at larger spatial scales.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Fan Liu, Lei Zhang, Chongyang Zhang, Ziguang Chen, Jingguang Li
Summary: NO2 emissions from wall-mounted gas stoves used for household heating have become a significant source of indoor pollution in Chinese urban areas. The high indoor concentration of NO2 poses potential health risks to residents. It is urgently necessary to establish relevant regulations and implement emission reduction technologies to reduce NO2 emissions from wall-mounted gas stoves.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Letter
Environmental Sciences
Hans Peter H. Arp, Raoul Wolf, Sarah E. Hale, Sivani Baskaran, Juliane Gluege, Martin Scheringer, Xenia Trier, Ian T. Cousins, Harrie Timmer, Roberta Hofman-Caris, Anna Lennquist, Andre D. Bannink, Gerard J. Stroomberg, Rosa M. A. Sjerps, Rosa Montes, Rosario Rodil, Jose Benito Quintana, Daniel Zahn, Herve Gallard, Tobias Mohr, Ivo Schliebner, Michael Neumann
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Philomina Onyedikachi Peter, Binessi Edouard Ifon, Francois Nkinahamira, Kayode Hassan Lasisi, Jiangwei Li, Anyi Hu, Chang-Ping Yu
Summary: This study investigates the relationship between dissolved organic matter (DOM) and Rare Earth Elements (REEs) in sediments from Yundang Lagoon, China. The results show four distinct fluorescent components, with protein-like substances being the most prevalent. Additionally, the total fluorescence intensity and LREE concentrations exhibit a synchronized increase from Outer to Inner to Songbai Lake core sediments. The findings demonstrate a strong correlation between DOM content and pollution levels.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Surya Gupta, Pasquale Borrelli, Panos Panagos, Christine Alewell
Summary: The objective of this study is to incorporate soil hydraulic properties into the erodibility factor (K) of USLE-type models. By modifying and improving the existing equations for soil texture and permeability, the study successfully included information on saturated hydraulic conductivity (Ksat) into the calculation of K factor. Using the Random Forest machine learning algorithm, two independent K factor maps with different spatial resolutions were generated. The results show that the decrease in K factor values has a positive impact on the modeling of soil erosion rates.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Jesmin Akter, Wendy J. M. Smith, Yawen Liu, Ilho Kim, Stuart L. Simpson, Phong Thai, Asja Korajkic, Warish Ahmed
Summary: The choice of workflow in wastewater surveillance has a significant impact on SARS-CoV-2 concentrations, while having minimal effects on HF183 and no effect on HAdV 40/41 concentrations. Certain components in the workflow can be interchangeable, but factors such as buffer type, chloroform, and homogenization speed can affect the recovery of viruses and bacteria.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Yu Luo, Xueting Yang, Diwei Wang, Hongmei Xu, Hongai Zhang, Shasha Huang, Qiyuan Wang, Ningning Zhang, Junji Cao, Zhenxing Shen
Summary: Atmospheric PM2.5, which can generate reactive oxygen species (ROS), is associated with cardiorespiratory morbidity and mortality. The study found that both the mass concentration of PM2.5 and the DTT activity were higher during the heating season than during the nonheating season. Combustion sources were the primary contributors to DTT activity during the heating season, while secondary formation dominated during the nonheating season. The study also revealed that biomass burning had the highest inherent oxidation potential among all sources investigated.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Erin L. Murphy, Leah R. Gerber, Chelsea M. Rochman, Beth Polidoro
Summary: Plastic pollution has devastating consequences for marine organisms. This study uses a trait-based framework to develop a vulnerability index for marine mammals, seabirds, and sea turtles in Hawai'i. The index ranks 63 study species based on their vulnerability to macroplastic pollution, providing valuable information for species monitoring and management priorities.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Kenji Maurice, Amelia Bourceret, Sami Youssef, Stephane Boivin, Liam Laurent-Webb, Coraline Damasio, Hassan Boukcim, Marc-Andre Selosse, Marc Ducousso
Summary: Growing pressure from climate change and agricultural land use is destabilizing soil microbial community interactions. Little is known about microbial community resistance and adaptation to disturbances, hindering our understanding of recovery latency and implications for ecosystem functioning. This study found that anthropic disturbance and natural disturbance have different effects on the topology and stability of soil microbial networks.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Yunhao Li, Yali Feng, Haoran Li, Yisong Yao, Chenglong Xu, Jinrong Ju, Ruiyu Ma, Haoyu Wang, Shiwei Jiang
Summary: Deep-sea mining poses a serious threat to marine ecosystems and human health by disturbing sediment and transmitting metal ions through the food chain. This study developed a new regenerative adsorption material, OMN@SA, which effectively removes metal ions. The adsorption mechanism and performance of the material for metal ion fixation were investigated.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Antonio Medici, Margherita Lavorgna, Marina Isidori, Chiara Russo, Elena Orlo, Giovanni Luongo, Giovanni Di Fabio, Armando Zarrelli
Summary: Valsartan, a widely used antihypertensive drug, has been detected in high concentrations in surface waters due to its unchanged excretion and incomplete degradation in wastewater treatment plants. This study investigated the degradation of valsartan and identified 14 degradation byproducts. The acute and chronic toxicity of these byproducts were evaluated in key organisms in the freshwater trophic chain.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Jiang Lin, Lianbao Chi, Qing Yuan, Busu Li, Mingbao Feng
Summary: This study investigated the photodegradation behavior and product formation of two representative pharmaceuticals in simulated estuary water. The study found that the formed transformation products of these pharmaceuticals have potential toxicity on marine organisms, including oxidative stress and damage to cellular components.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Hua Fang, Dongdong Jiang, Ye He, Siyi Wu, Yuehong Li, Ziqi Zhang, Haoting Chen, Zixin Zheng, Yan Sun, Wenxiang Wang
Summary: This study revealed that exposure to lower levels of air pollutants led to decreased pregnancy rates, with PM10, NO2, SO2, and CO emerging as the four most prominent pollutants. Individuals aged 35 and above exhibited heightened susceptibility to pollutants.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Ali Shaan Manzoor Ghumman, Rashid Shamsuddin, Amin Abbasi, Mohaira Ahmad, Yoshiaki Yoshida, Abdul Sami, Hamad Almohamadi
Summary: In this study, inverse vulcanized polysulfides (IVP) were synthesized by reacting molten sulfur with 4-vinyl benzyl chloride, and then functionalized using N-methyl D-glucamine (NMDG). The functionalized IVP showed a high mercury adsorption capacity and a machine learning model was developed to predict the amount of mercury removed. Furthermore, the functionalized IVP can be regenerated and reused, providing a sustainable and cost-effective adsorbent.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Rita Bonfiglio, Renata Sisto, Stefano Casciardi, Valeria Palumbo, Maria Paola Scioli, Erica Giacobbi, Francesca Servadei, Gerry Melino, Alessandro Mauriello, Manuel Scimeca
Summary: This study investigated the presence of aluminum in human colon cancer samples and its potential association with biological processes involved in cancer progression. Aluminum was found in tumor areas of 24% of patients and was associated with epithelial to mesenchymal transition (EMT) and cell death. Additional analyses revealed higher tumor mutational burden and mutations in genes related to EMT and apoptosis in aluminum-positive colon cancers. Understanding the molecular mechanisms of aluminum toxicity may improve strategies for the management of colon cancer patients.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)