Article
Pharmacology & Pharmacy
Jonathan D. Diedrich, Romina Gonzalez-Pons, Hyllana C. D. Medeiros, Elliot Ensink, Karen T. Liby, Elizabeth A. Wellberg, Sophia Y. Lunt, Jamie J. Bernard
Summary: Anti-hormone therapies are ineffective for reducing the incidence of triple negative breast cancer. Visceral obesity is a strong risk factor for this aggressive subtype, and it is unclear how excessive deposition of visceral adipose tissue promotes the malignant transformation. The activation of AhR by factors released from VAT may drive the malignant transformation of breast epithelial cells.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
Yanbo Chen, Tong-Tong Liu, Mengxia Niu, Xiaoting Li, Xinwei Wang, Tong Liu, Yan Li
Summary: The mutation of the Drosophila prickle gene causes epileptic seizures and abnormal glial wrapping in insects, suggesting a crucial role of this gene in both neurons and glia. It regulates cell adhesion between neurons and ensheathing glia, ensuring neuron-glial interaction within neuropils. Dysregulation of this process may contribute to PRICKLE1-associated epilepsy.
Article
Environmental Sciences
Ling He, Xiangjun Zhou, Jia Liu, Yina Yao, Junyuan Lin, Jialong Chen, Shizhen Qiu, Zeyu Liu, Yingzheng He, Yujie Yi, Xueqiong Zhou, Fei Zou
Summary: Esophageal cancer is a significant global public health problem. Nitrosamines exposure increases the risk of esophageal cancer. This study found that Ribonucleic acid export 1 (RAE1) is upregulated in the early stage of nitrosamine-induced esophageal carcinogenesis and EC tissues. RAE1 plays a role in regulating the cell cycle and proliferation, with its knockdown leading to cell cycle blockade and inhibition of proliferation, while its overexpression has the opposite effect. Additionally, RAE1 regulates lipid metabolism by maintaining the stability of PPAR alpha mRNA.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Immunology
Ji Wang, Yilin Zhao, Xin Zhang, Wei Tu, Rongjun Wan, Yingchun Shen, Yan Zhang, Ruchik Trivedi, Peisong Gao
Summary: The study found that AhR in type II alveolar epithelial cells protects against allergic airway inflammation by regulating cellular autophagy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biology
Yevgeniya Gartshteyn, Anca. D. Askanase, Ruijiang Song, Shoiab Bukhari, Matthew Dragovich, Kieran Adam, Adam Mor
Summary: SLAMF6 clustering with the CD3 complex enhances T cell activity and shares downstream signaling pathways. Bispecific antibodies can modulate T cell responses.
LIFE SCIENCE ALLIANCE
(2022)
Article
Genetics & Heredity
Nanami Akai, Shizue Ohsawa, Yukari Sando, Tatsushi Igaki
Summary: The study found that in Drosophila Minute mutants, both cell death and compensatory cell proliferation are significantly increased during development, highlighting the essential role of cell-turnover in robust tissue growth.
Article
Cell Biology
Arthur Boutillon, Sophie Escot, Amelie Elouin, Diego Jahn, Sebastian Gonzalez-Tirado, Joern Starruss, Lutz Brusch, Nicolas B. David
Summary: During zebrafish gastrulation, the migration of polster cells guides the extension of the embryonic axis, and each cell is oriented by its followers through mechanotransduction.
DEVELOPMENTAL CELL
(2022)
Article
Immunology
Adam K. Wade-Vallance, Zhiyong Yang, Jeremy B. Libang, Marcus J. Robinson, David M. Tarlinton, Christopher D. C. Allen
Summary: Wade-Vallance et al. demonstrate that the binding of antigen or antibody to the B cell receptor triggers apoptosis in IgE plasma cells. This mechanism is relevant to allergic disease and its treatment through endogenous IgE regulation.
JOURNAL OF EXPERIMENTAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Suhrid Ghosh, Weihua Leng, Michaela Wilsch-Braeuninger, Mariana Barrera-Velazquez, Pierre Leopold, Suzanne Eaton
Summary: The study investigates the local uptake and storage of insulin-like peptides Dilps in the endocrine organ CC in Drosophila, and how activation of IGF signaling pathway promotes steroid hormone secretion to accelerate developmental progression in response to nutrient shortage.
Article
Biochemistry & Molecular Biology
Deguang Kong, Hengbo Zhou, Deepika Neelakantan, Connor J. Hughes, Jessica Y. Hsu, Ramakrishnan Rajaram Srinivasan, Michael T. Lewis, Heide L. Ford
Summary: VEGF-C secreted by EMT breast cancer cells can promote proliferation, migration, and invasion of epithelial breast cancer cells through non-canonical activation of GLI signaling. Inhibiting VEGF-C in EMT cells or knocking down NRP2 in neighboring epithelial cancer cells disrupts the aggressive phenotypes induced by EMT cells, suggesting a novel therapeutic target for metastasis in breast cancer.
Article
Chemistry, Applied
Debbie C. Crans, Mark Brown, Deborah A. Roess
Summary: Membrane receptors are a class of protein-based biocatalysts that are different from enzymes. The luteinizing hormone receptor (LHR), a type of G protein-coupled receptor (GPCR), plays a crucial role in transducing signals from the membrane receptor to the signaling pathways inside living cells. Activation of LHR can be achieved through ligand binding or binding of vanadium compounds, which then activates G proteins and downstream biocatalysts in well-defined signaling pathways. Understanding GPCR-mediated signaling is important for the development of pharmacologically significant compounds, and recent studies have shown that the plasma membrane can serve as an additional target for regulating receptor activity by vanadium compounds.
Article
Biochemistry & Molecular Biology
Ke Gu, Guangmang Liu, Caimei Wu, Gang Jia, Hua Zhao, Xiaoling Chen, Gang Tian, Jingyi Cai, Ruinan Zhang, Jing Wang
Summary: This study demonstrated that tryptophan enhances cell migration in porcine intestine epithelial cells (IPEC-J2) through the CaSR/Rac1/PLC-γ1 signaling pathway.
Article
Multidisciplinary Sciences
Hualin Chen, Yang Pan, Xiaoxiang Jin, Gang Chen
Summary: By analyzing transcriptome data of BCa, a prognostic nomogram based on immune cell infiltration-related genes was successfully developed, including 5 prognostic immune cell infiltration-related module genes. This study provided potential prognostic indicators and immunotherapeutic targets for BCa.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Lilan Zhao, Anastasios D. Giannou, Yang Xu, Ahmad Mustafa Shiri, Imke Liebold, Babett Steglich, Tanja Bedke, Tao Zhang, Joean Lueke, Pasquale Scognamiglio, Jan Kempski, Anna Woestemeier, Jing Chen, Theodora Agalioti, Dimitra E. Zazara, Diana Lindner, Melanie Janning, Jan K. Hennigs, Rajesh M. Jagirdar, Ourania S. Kotsiou, Sotirios G. Zarogiannis, Yasushi Kobayashi, Jacob R. Izbicki, Sourav Ghosh, Carla V. Rothlin, Lidia Bosurgi, Samuel Huber, Nicola Gagliani
Summary: The study found that efferocytosis by pleural cavity macrophages through AXL and MERTK receptors led to the production of IL-10, which then influenced dendritic cells to produce TIMP1, thereby facilitating MPE progression. Targeting this inflammatory cascade offers potential therapeutic strategies for MPE.
Article
Endocrinology & Metabolism
Nana Zheng, Wenbo Zhang, Xiaodan Zhang, Biao Li, Zhanying Wu, Yashuang Weng, Weiyong Wang, Jingjing Miao, Jing Yang, Meijia Zhang, Wei Xia
Summary: RA-RAR signaling promotes vaginal opening by increasing ss- catenin expression and vaginal epithelial cell apoptosis.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2023)
Article
Cell Biology
Geert de Vreede, Holly A. Morrison, Alexandra M. Houser, Ryan M. Boileau, Ditte Andersen, Julien Colombani, David Bilder
DEVELOPMENTAL CELL
(2018)
Article
Multidisciplinary Sciences
Dong-Yuan Chen, Justin Crest, Sebastian J. Streichan, David Bilder
NATURE COMMUNICATIONS
(2019)
Article
Multidisciplinary Sciences
Mark J. Khoury, David Bilder
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Review
Biochemistry & Molecular Biology
Stephan U. Gerlach, Hector Herranz
Article
Cell Biology
Jung Kim, Hsiu-Chun Chuang, Natalie K. Wolf, Christopher J. Nicolai, David H. Raulet, Kaoru Saijo, David Bilder
Summary: Cancer patients often die due to systemic physiological perturbations caused by paraneoplastic syndromes, which can be explored in non-mammalian models. In a Drosophila model, malignant-tumor-produced cytokines activate JAK-STAT signaling, particularly in the cells of the blood-brain barrier, leading to premature death. Inhibiting STAT in the BBB rescues barrier function and extends the lifespan of tumor-bearing hosts, highlighting the importance of BBB alterations in tumor-host interactions and other physiological morbidities.
DEVELOPMENTAL CELL
(2021)
Article
Cell Biology
Katherine A. Sharp, Mark J. Khoury, Frederick Wirtz-Peitz, David Bilder
Summary: This study reveals a previously unknown nuclear role for Dlg in regulating chromatin and transcription by interacting with the nucleosome remodeling factor (NURF) complex. The activity of NURF is essential for the overgrowth of dlg tumors, and this growth suppression is correlated with a reduction in Hippo pathway gene expression, suggesting a new direct mechanism for Dlg in tumor suppression and epithelial polarity regulation.
MOLECULAR BIOLOGY OF THE CELL
(2021)
Article
Biology
Mark J. Khoury, David Bilder
Summary: The compartmentalized domains of polarized epithelial cells are determined by the antagonistic actions between the Scrib module and the Par complex. Scrib and Dlg proteins in Drosophila limit Lgl phosphorylation at the basolateral cortex, and this 'protection' activity is independent of PP1. The Dlg SH3 domain and the N-terminal region of the HOOK domain play important roles in Lgl protection and recruitment of Scrib to the membrane.
Article
Cell Biology
Hui-Yu Ku, Leigh K. Harris, David Bilder
Summary: The shaping of developing organs requires regulation of force and resistance, but how mechanical properties of tissues are monitored is not well understood. In developing Drosophila follicles, a pair of cells called anterior polar cells play a role in monitoring tissue elongation by secreting a matrix metalloproteinase (MMP). This MMP production is regulated by the mechanical properties of the basement membrane, which is sensed through focal adhesion signaling and contractile activity. The polar cells then reciprocally regulate basement membrane remodeling to ensure proper organ shape and reproductive success.
DEVELOPMENTAL CELL
(2023)
Article
Biology
Stephan U. Gerlach, Geert de Vreede, David Bilder
Summary: A study suggests that the receptor tyrosine phosphatase PTP10D may not be necessary for the elimination of polarity-deficient mutant cells in developing Drosophila imaginal discs.
Article
Biochemistry & Molecular Biology
Tsai-Ching Hsi, Katy L. Ong, Jorian J. Sepers, Jung Kim, David Bilder
Summary: Malignant tumors can cause complex inflammatory and wound repair responses, leading to defects in blood clotting. A new tumor model in Drosophila shows similarities to coagulopathies observed in patients. The tumor induces hypercoagulation followed by a defective wound healing state. By depleting a tumor-produced clotting factor, survival can be improved in tumor-bearing flies.
Review
Oncology
David Bilder, Katy Ong, Tsai-Ching Hsi, Kavya Adiga, Jung Kim
Summary: The Review discusses how fly tumors interact with the microenvironment and distant organs to influence disease progression and host physiology. The authors argue that the simplicity of flies and the ability to study lethality in this model provide an opportunity to address why patients ultimately die of cancer.
NATURE REVIEWS CANCER
(2021)
Article
Biology
Stephan U. Gerlach, Moritz Sander, Shilin Song, Hector Herranz
LIFE SCIENCE ALLIANCE
(2019)
