Article
Biology
Rana Amini, Raimund Schluessler, Stephanie Moellmert, Archit Bhatnagar, Jochen Guck, Caren Norden
Summary: This article investigates the multipolar migration of horizontal cells in the zebrafish retina and discovers that these cells exhibit amoeboid-like characteristics, adapting to the spatial constraints of the developing retina. The study also finds that the interaction between cells and tissues is crucial for the migration and layer formation of horizontal cells.
Article
Multidisciplinary Sciences
Sithara S. Wijeratne, Shane A. Fiorenza, Alex E. Neary, Radhika Subramanian, Meredith D. Betterton
Summary: This study reports that microtubules can physically couple motor movement in the absence of detectable short-range interactions. The long-range microtubule-mediated coupling mechanism may affect the binding kinetics and mechanochemistry of motors, providing new forms of collective motor behavior.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Cell Biology
Lisa Donker, Ronja Houtekamer, Marjolein Vliem, Francois Sipieter, Helena Canever, Manuel Gomez-Gonzalez, Miquel Bosch-Padros, Willem-Jan Pannekoek, Xavier Trepat, Nicolas Borghi, Martijn Gloerich
Summary: Epithelial cells adapt their rate of cell division by sensing changes in cell number through mechanosensitive E-cadherin adhesions, which control G2/M cell-cycle progression.
Article
Multidisciplinary Sciences
Tsan-Chi Chen, Shu-Wen Chang
Summary: This study presents a more efficient method of expressing EGFP in human ocular cells using a lentiviral expression system. Cell sorting was employed to obtain homogeneous populations of EGFP-positive cells. The efficiency of EGFP expression varied among different cell types after transduction with the same amount of EGFP-encoding pseudovirions. However, repeated sorting resulted in homogeneous populations of EGFP-positive human ocular cells that could be maintained in continuous culture. Determining the IC50 for puromycin for each cell type is crucial for the isolation of homogeneous EGFP-positive cells.
Article
Engineering, Aerospace
Haoning Wang, Jie Guo, Xiao Wang, Xiang Li, Shengjing Tang
Summary: This paper proposes a time-coordination entry guidance method based on a range-determined strategy for hypersonic glide vehicles. The method reduces computational load and coupling by using longitudinal and lateral guidance algorithms to generate flight trajectories and control bank angles. The method establishes a heading error corridor based on line-of-sight to control bank angle reversal time, achieving the guidance objectives.
AEROSPACE SCIENCE AND TECHNOLOGY
(2022)
Article
Multidisciplinary Sciences
Yanbo Chen, Tong-Tong Liu, Mengxia Niu, Xiaoting Li, Xinwei Wang, Tong Liu, Yan Li
Summary: The mutation of the Drosophila prickle gene causes epileptic seizures and abnormal glial wrapping in insects, suggesting a crucial role of this gene in both neurons and glia. It regulates cell adhesion between neurons and ensheathing glia, ensuring neuron-glial interaction within neuropils. Dysregulation of this process may contribute to PRICKLE1-associated epilepsy.
Article
Immunology
Le Zhang, Xuehui Long, Yuye Yin, Jun Wang, Huamin Zhu, Jingjing Chen, Yuliang Wang, Yun Chen, Xiaoming Wang
Summary: Regulatory T cells play important roles in maintaining immune homeostasis and immune tolerance during pregnancy. This study revealed the critical role of H3K36me2 methyltransferase Nsd2 in Treg recruitment at the maternal-fetal interface. Loss of Nsd2 disrupted maternal-fetal immune tolerance, leading to severe fetal loss.
CELLULAR & MOLECULAR IMMUNOLOGY
(2022)
Article
Mathematics, Applied
W. Domgno Kuipou, A. Mohamadou
Summary: This paper investigates the contribution of long-range diffusion and diffusive stresses to cellular waves generated during an invasion in soft biological tissues. The mathematical model consists of three coupled nonlinear partial differential equations describing the spatiotemporal evolutions of cell density, extracellular matrix (ECM), and spatial displacements. The study reveals that the stability-instability transition in the system depends on the proliferation rate and long-range diffusion of cells, and the presence of temporal or spatiotemporal perturbations. Analytical solutions are constructed and their existence conditions are provided. The findings show that factors such as long-range diffusive stresses, proliferation, ECM production-degradation, and diffusion significantly modify the wave structure and the number of cells carried.
COMMUNICATIONS IN NONLINEAR SCIENCE AND NUMERICAL SIMULATION
(2022)
Article
Nanoscience & Nanotechnology
Chi Zhang, Yao Zhang, Zhishan Fang, Yuzhong Chen, Zeng Chen, Haiping He, Haiming Zhu
Summary: van der Waals heterostructures combining highly light-absorbing perovskites with two-dimensional TMDs show great potential for optoelectronic applications. Energy transfer in 3D/2D perovskite/TMD heterostructures occurs through a two-step charge transfer process, with efficient energy transfer characteristics.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Anatomy & Morphology
Xia Zhang, Min Wang, Yuanyi Zhang, Jian Yang, Wenbiao Duan
Summary: The expression of CENPU is upregulated in cervical cancer and knocking down CENPU inhibits migration and invasion of cervical cancer cells, reduces tumor stemness through the FOXM1/Wnt/8-catenin pathway. CENPU may serve as a potential target for treating cervical cancer.
Article
Cell & Tissue Engineering
Wenxiu Ning, Andrew Muroyama, Hua Li, Terry Lechler
Summary: Basal stem cells play a key role in the development, homeostasis, and regeneration of the epidermis, regulated by their microenvironment. Differentiated progeny also influence the proliferation, differentiation, and migration of basal progenitor cells.
Article
Multidisciplinary Sciences
Richard Hardstone, Michael Zhu, Adeen Flinker, Lucia Melloni, Sasha Devore, Daniel Friedman, Patricia Dugan, Werner K. Doyle, Orrin Devinsky, Biyu J. He
Summary: This passage discusses the influence of prior experiences on perception and the neural mechanisms observed in experiments. When perception is congruent with prior, there is increased top-down input, while stronger feedforward drive is observed when perception is incongruent with prior. The study results indicate a pattern of large-scale information flow change underlying the influence of long-term priors on perception.
NATURE COMMUNICATIONS
(2021)
Article
Chemistry, Inorganic & Nuclear
Younis Ahmad Pandit, Syed Jehanger Shah, Mohammad Usman, Sabyasachi Sarkar, Eugenio Garribba, Sankar Prasad Rath
Summary: Dinickel(II) and dicopper(II) porphyrin dimers with a long unconjugated dipyrrole bridge were synthesized. The bridge can be oxidized to form a fully pi-conjugated structure, leading to one- and two-electron-oxidized species with long-range charge/radical delocalization. This results in intense absorptions in the near-infrared region and electron paramagnetic resonance signals of a triplet state. Despite the large physical separation, the two metal centers behave as a single unit and efficiently share electrons between them.
INORGANIC CHEMISTRY
(2022)
Article
Oncology
Weida Chen, Chengli Miao
Summary: This study found that KRT15 is highly expressed in colorectal cancer cells and its overexpression significantly promotes the migration and invasion of these cells. It was also discovered that MMP-7 plays a crucial role in the KRT15-induced migration and invasion of colorectal cancer cells, and beta-catenin is responsible for the increased expression of MMP-7 induced by KRT15.
Article
Neurosciences
Martyna Grabowska, Tibor I. Toth, Ansgar Bueschges, Silvia Daun
Summary: In multisegmented locomotion, coordination of appendages is crucial. Sensory feedback plays a key role, but its influence on CPGs activity is not fully understood. This study demonstrates the existence of a sensory connection and shows that load is sufficient to entrain rhythmic activity in the most rostral segment.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Developmental Biology
Alexandre Souchaud, Arthur Boutillon, Gaelle Charron, Atef Asnacios, Camille Nous, Nicolas B. David, Francois Graner, Francois Gallet
Summary: Researchers have developed a pipeline of techniques based on incompressible elastic sensors to investigate the role of mechanical constraints in morphogenesis and development. The techniques can accurately measure the distribution of shear stress within a tissue.
Article
Biochemistry & Molecular Biology
Bilal Shaikh, Lucian P. Smith, Dan Vasilescu, Gnaneswara Marupilla, Michael Wilson, Eran Agmon, Henry Agnew, Steven S. Andrews, Azraf Anwar, Moritz E. Beber, Frank T. Bergmann, David Brooks, Lutz Brusch, Laurence Calzone, Kiri Choi, Joshua Cooper, John Detloff, Brian Drawert, Michel Dumontier, G. Bard Ermentrout, James R. Faeder, Andrew P. Freiburger, Fabian Frohlich, Akira Funahashi, Alan Garny, John H. Gennari, Padraig Gleeson, Anne Goelzer, Zachary Haiman, Jan Hasenauer, Joseph L. Hellerstein, Henning Hermjakob, Stefan Hoops, Jon C. Ison, Diego Jahn, Henry Jakubowski, Ryann Jordan, Matus Kalas, Matthias Koenig, Wolfram Liebermeister, Rahuman S. Malik Sheriff, Synchon Mandal, Robert McDougal, J. Kyle Medley, Pedro Mendes, Robert Mueller, Chris J. Myers, Aurelien Naldi, Tung V. N. Nguyen, David P. Nickerson, Brett G. Olivier, Drashti Patoliya, Loic Pauleve, Linda R. Petzold, Ankita Priya, Anand K. Rampadarath, Johann M. Rohwer, Ali S. Saglam, Dilawar Singh, Ankur Sinha, Jacky Snoep, Hugh Sorby, Ryan Spangler, Joern Starruss, Payton J. Thomas, David van Niekerk, Daniel Weindl, Fengkai Zhang, Anna Zhukova, Arthur P. Goldberg, James C. Schaff, Michael L. Blinov, Herbert M. Sauro, Ion I. Moraru, Jonathan R. Karr
Summary: Computational models have great potential in accelerating bioscience, bioengineering, and medicine. However, reproducing and reusing simulations is still challenging due to the different formats and methods used by different software tools. To address this issue, we developed BioSimulators, a central registry that provides consistent interfaces and recommendations for simulation tools, using standards and validation tools to ensure consistency. We anticipate that BioSimulators will facilitate the exchange, reproduction, and combination of simulations by modelers.
NUCLEIC ACIDS RESEARCH
(2022)
Article
Biology
Sebastian S. Roeder, Petra Burkardt, Fabian Rost, Julian Rode, Lutz Brusch, Roland Coras, Elisabet Englund, Karl Hakansson, Goran Possnert, Mehran Salehpour, Daniel Primetzhofer, Laszlo Csiba, Sarolta Molnar, Gabor Mehes, Anton B. Tonchev, Stefan Schwab, Olaf Bergmann, Hagen B. Huttner
Summary: Using a combination of methods, evidence for postnatal neurogenesis in the human amygdala was found. This discovery provides new insight into neuronal exchange and cell renewal.
COMMUNICATIONS BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Paula Heinke, Fabian Rost, Julian Rode, Palina Trus, Irina Simonova, Eniko Lazar, Joshua Feddema, Thilo Welsch, Kanar Alkass, Mehran Salehpour, Andrea Zimmermann, Daniel Seehofer, Goran Possnert, Georg Damm, Henrik Druid, Lutz Brusch, Olaf Bergmann
Summary: This study used retrospective radiocarbon birth dating to investigate the turnover of human liver cells. The results showed that human hepatocytes undergo continuous and lifelong renewal, which keeps the liver young. Diploid hepatocytes have a higher birth rate than polyploid hepatocytes, and the transition between diploid and polyploid cells is limited under homeostatic conditions.
Article
Optics
Julia Ferrer Ortas, Pierre Mahou, Sophie Escot, Chiara Stringari, Nicolas B. David, Laure Bally-Cuif, Nicolas Dray, Michel Negrerie, Willy Supatto, Emmanuel Beaurepaire
Summary: In this work, a novel approach based on label-free third-order sum-frequency generation (TSFG) and third-harmonic generation (THG) contrasts is introduced to map red blood cells (RBCs) flow and oxygenation. The study shows a strong three-photon (3P) resonance related to the Soret band of hemoglobin in THG and TSFG signals of zebrafish and human RBCs, which is sensitive to RBC oxygenation state. The color TSFG implementation enables specific detection of flowing RBCs with single-cell resolution and microsecond pixel times in zebrafish embryos, and provides label-free RBC-specific contrast at depths exceeding 600 μm in live adult zebrafish brain.
LIGHT-SCIENCE & APPLICATIONS
(2023)
Article
Multidisciplinary Sciences
Josephine Morizet, Nicolas Olivier, Pierre Mahou, Arthur Boutillon, Chiara Stringari, Emmanuel Beaurepaire
Summary: This study experimentally and numerically analyzed the contrast of third harmonic generation (THG) microscopy images from stretched hollow glass pipettes in different liquids. The nonlinear optical properties of 2,2'-thiodiethanol (TDE) were also characterized. The presence of index discontinuity was found to affect the THG signals, including the level, modulation amplitude, and polarization direction. The finite-difference time-domain (FDTD) modeling strategy was shown to accurately account for contrast in optically heterogeneous samples, while reference Fourier-based numerical approaches were only accurate in the absence of index mismatch. This work provides insights for interpreting THG microscopy images of tubular objects and other geometries.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Carlotta Mayer, Sophie Nehring, Michael Kuecken, Urska Repnik, Sarah Seifert, Aleksandra Sljukic, Julien Delpierre, Hernan Morales-Navarrete, Sebastian Hinz, Mario Brosch, Brian Chung, Tom Karlsen, Meritxell Huch, Yannis Kalaidzidis, Lutz Brusch, Jochen Hampe, Clemens Schafmayer, Marino Zerial
Summary: Hepatocytes dynamically respond to bile acids and bile flow, but little is known about their response to intraluminal pressure. This study reveals that hepatocytes form apical bulkheads in response to obstructed bile flow, which protect bile canaliculi against elevated pressure. The loss of apical bulkheads leads to abnormally dilated canaliculi, highlighting the importance of canalicular pressure in liver diseases.
Article
Mathematics, Interdisciplinary Applications
Robert Mueller, Arthur Boutillon, Diego Jahn, Joern Starruss, Nicolas B. David, Lutz Brusch
Summary: Collective cell migration is a crucial process in biological development and tissue repair, but it can become malignant during tumor invasion. Mathematical and computational models are essential for understanding the self-organization mechanisms that drive collective migration from individual cell interactions. This study explores how guidance stimuli are integrated when multiple cells interact simultaneously, using an individual-based model. The results show that collective cell migration remains robust and qualitatively the same regardless of the variant of stimulus integration considered. This study highlights the importance of individual-based modeling for understanding collective phenomena arising from cell-cell interactions.
FRONTIERS IN APPLIED MATHEMATICS AND STATISTICS
(2023)
