Article
Genetics & Heredity
Yiming Sun, Yang Zeng, Hua Chen, Zhou Zhou, Jing Fu, Qing Sang, Lei Wang, Xiaoxi Sun, Biaobang Chen, Congjian Xu
Summary: This study identified a novel pathogenic variant in ZP2 that may cause thin ZP and female infertility. The variant affects the assembly of ZP2-ZP3 dimers, and further experimental results confirmed this mechanism of action.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2021)
Article
Genetics & Heredity
Weimin Jia, Qingsong Xi, Lixia Zhu, Yalin Luo, Zhou Li, Meiqi Hou, Dazhi Zhang, Xue Yang, Juan Hu, Lei Jin, Xianqin Zhang
Summary: The aim of this study was to identify disease-causing mutations in three infertile female patients diagnosed with abnormal zona pellucida and empty follicle syndrome. The study found three novel mutations in the ZP2 and ZP3 genes, expanding the spectrum of ZP gene mutations and phenotypes, which is beneficial for the genetic diagnosis of infertility in females.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2022)
Article
Reproductive Biology
Chao Lv, Hua-Lin Huang, Da-Jing Yi, Tian-Liu Peng, Hang-Jing Tan, Ru-Ping Quan, Hong-Wen Deng, Hong-Mei Xiao
Summary: This study found that a mutation in the Zp1 gene resulted in the absence of ZP in rat oocytes, leading to infertility and loss of fertilization capacity.
BIOLOGY OF REPRODUCTION
(2021)
Review
Biology
Paul M. Wassarman, Eveline S. Litscher
Summary: The presence of a zona pellucida (ZP) is essential for the fertility of female mammals, including mice and humans. It stabilizes the contacts between oocyte microvilli and follicle cell projections, supporting the development of growing oocytes and follicles. The absence of a ZP, due to gene inactivation or mutation, results in a loss of contacts and reduced production of ovulated eggs, leading to female infertility.
Article
Obstetrics & Gynecology
Ping Yang, Tailai Chen, Yuqing Liu, Zhenzhen Hou, Keliang Wu, Yongzhi Cao, Jiangtao Zhang, Zhao Wang, Han Zhao
Summary: Novel variants of ZP genes were identified in over half of the cohort with GEFS and oocyte degeneration, causing intracellular protein sequestration and failure to assemble ZP filaments, resulting in EFS and female infertility.
FERTILITY AND STERILITY
(2021)
Article
Oncology
Dominik Kraus, Alexander Glassmann, Carsten Golletz, Glen Kristiansen, Jochen Winter, Rainer Probstmeier
Summary: Our study reveals ZP2 as a new biomarker for colon cancer diagnosis, especially when used in combination with other low abundant genes. ZP2 promotes cell proliferation via the ERK1/2-cyclinD1-signaling pathway, and its specific and low-abundant expression in cancer cell lines and primary colon cancers suggests its potential as a diagnostic tool. The enhanced expression of ZP2 in colon cancer tissues and its role in cell proliferation make it a promising target for cancer therapy when used in combination with other biomarkers.
Article
Genetics & Heredity
Yongzhe Chen, Zesong Wang, Yueren Wu, Wenbin He, Juan Du, Sufen Cai, Fei Gong, Guangxiu Lu, Ge Lin, Can Dai
Summary: A novel heterozygous deletion in ZP3 was identified in an EFS patient, leading to significant degradation of the ZP3 protein. Abnormal follicular development and ZP assembly were observed in the EFS patient, providing new insights into the pathogenesis of EFS.
FRONTIERS IN GENETICS
(2021)
Article
Genetics & Heredity
Corinne Loeuillet, Magali Dhellemmes, Caroline Cazin, Zine-Eddine Kherraf, Selima Fourati Ben Mustapha, Raoudha Zouari, Nicolas Thierry-Mieg, Christophe Arnoult, Pierre F. Ray
Summary: Oocyte maturation defect (OMD) is a common cause of female factor infertility, often caused by ovulatory disorders. Several genes including PATL2, TUBB8, WEE2, and ZP1 have been associated with OMD. This study identified a new frequent ZP1 variant and found degeneration and absence of oocytes in patients with ZP1 mutations.
Article
Obstetrics & Gynecology
Liwei Sun, Keya Tong, Weiwei Liu, Yin Tian, Dongyun Liu, Guoning Huang, Jingyu Li
Summary: Whole-exome sequencing was performed in probands with empty follicle syndrome (EFS) and abnormal zona pellucida (ZP), revealing a homozygous nonsense variant in ZP1 associated with EFS, a homozygous frameshift variant in ZP2 triggering protein degradation, and a heterozygous missense variant in ZP3 linked to ZP morphological abnormalities. These findings expand the mutational spectrum of ZP1, ZP2, and ZP3, and provide new evidence for genetic diagnosis of female infertility.
REPRODUCTIVE BIOMEDICINE ONLINE
(2023)
Article
Genetics & Heredity
Dazhi Zhang, Lixia Zhu, Zhenxing Liu, Xinling Ren, Xue Yang, Dan Li, Yalin Luo, Xuejie Peng, Xiaopei Zhou, Weimin Jia, Meiqi Hou, Zhou Li, Lei Jin, Xianqin Zhang
Summary: The study aimed to identify disease-causing genes related to female infertility, and a novel mutation in the ZP3 gene was identified in a Chinese family. This mutation was found to affect the interactions between ZP3 and ZP2, expanding the mutational and phenotypical spectrum of the ZP3 gene.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2021)
Article
Obstetrics & Gynecology
Rong Hua, Rufeng Xue, Yiyuan Liu, Yuqian Li, Xuan Sha, Kuokuo Li, Yang Gao, Qunshan Shen, Mingrong Lv, Yuping Xu, Zhiguo Zhang, Xiaojin He, Yunxia Cao, Huan Wu
Summary: This study identified a novel homozygous nonsense mutation in the ACR gene leading to male infertility. This mutation caused a deficiency in ACROSIN, which impaired sperm penetration of the egg and resulted in fertilization failure. The findings expand our understanding of the genetic factors involved in human infertility and provide valuable information for genetic counseling and fertility guidance for affected individuals.
HUMAN REPRODUCTION
(2023)
Article
Reproductive Biology
Ming-Hua Zeng, Yan Wang, Hua-Lin Huang, Ru-Ping Quan, Jun-Ting Yang, Dan Guo, Ying Sun, Chao Lv, Tian-Ying Li, Le Wang, Hang-Jin Tan, Pan-Pan Long, Hong-Wen Deng, Hong-Mei Xiao
Summary: The zona pellucida (ZP) is essential for female fertility in mammals, with ZP1-3 playing important roles. However, the function of ZP4 remains poorly understood. A study on Zp4 knockout (KO) rats found that Zp4 was dispensable for female fertility, as it did not affect ZP morphology or reproductive processes.
BIOLOGY OF REPRODUCTION
(2021)
Article
Agriculture, Dairy & Animal Science
Koki Takebayashi, Manita Wittayarat, Qingyi Lin, Maki Hirata, Naoaki Yoshimura, Nanaka Torigoe, Megumi Nagahara, Lanh Thi Kim Do, Fuminori Tanihara, Takeshige Otoi
Summary: CRISPR/Cas9 technology has greatly influenced the efficiency and effectiveness of genetic modifications. The study found that electroporation alone significantly increased the frequency of biallelic mutations, while lipofection alone required the removal of the zona pellucida to enable CRISPR/Cas9-based genome editing. Additionally, additional lipofectamine treatment did not improve the mutation rates.
REPRODUCTION IN DOMESTIC ANIMALS
(2022)
Article
Genetics & Heredity
Mingzhu Huo, Yile Zhang, Senlin Shi, Hao Shi, Yidong Liu, Lingyun Zhang, Yanchi Wang, Wenbin Niu
Summary: This study examined nine patients with oocyte maturation arrest and identified nine pathogenic variants in five genes, including three novel variants. These findings expand the understanding of the gene variant spectrum and provide insights for genetic diagnosis and prediction of oocyte maturation arrest.
FRONTIERS IN GENETICS
(2022)
Review
Medicine, Research & Experimental
Naina Kumar, Namit Kant Singh
Summary: Male infertility is on the rise and the commonly used initial test of semen analysis often fails to detect the cause accurately, leading researchers to identify various sperm proteins for better detection and management in the future. Through literature review and analysis, novel sperm proteins have the potential to serve as markers of male infertility.
CURRENT MOLECULAR MEDICINE
(2021)
Article
Computer Science, Interdisciplinary Applications
Shuidong Ma, Yiming Fang, Xiaodong Zhao, Zhendong Liu
Summary: Grey Wolf Optimizer (GWO) is a swarm intelligent optimization algorithm that simulates the leadership and social behavior of grey wolves to prey. GWO is extensively used in various fields due to its simplicity and ease of implementation. However, it has shortcomings in terms of population diversity and exploration-exploitation balance. To overcome these issues, a multi-swarm improved grey wolf optimizer (MIGWO) is proposed. MIGWO utilizes mechanisms like chaotic grouping, dynamic regrouping, double adaptive weights, and dimension learning to enhance the search performance. Experimental results demonstrate the superiority of MIGWO over other metaheuristic algorithms and GWO variants.
MATHEMATICS AND COMPUTERS IN SIMULATION
(2023)
Article
Nanoscience & Nanotechnology
Zhenzhen Liu, Chongwen Wang, Shuai Zheng, Xingsheng Yang, Han Han, Yuwei Dai, Rui Xiao
Summary: In this study, a portable immunoassay based on SERS technology was proposed for simultaneous detection of multiple respiratory viruses. The method utilizes magnetic SERS tags for direct enrichment and capture of target viruses, eliminating the need for sample pretreatment and improving detection sensitivity. Experimental verification on throat swab samples demonstrated the potential of the method for early and rapid differential diagnosis of respiratory viruses.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2023)
Article
Fisheries
Huijie Lu, Wei Chen, Fengkun Liu, Minwei Huang, Kai Peng, Jichen Zhao, Xiaoying Chen, Yuping Sun, Chaozheng Li, Yihong Chen, Zhenxing Liu, Huo Li, Wen Huang
Summary: In this study, a genetic linkage map of L. vannamei was constructed using ddRAD-seq, and several quantitative trait loci related to low-temperature tolerance and growth traits were identified. A candidate gene related to growth was also discovered through genomic analysis of L. vannamei. The results provide valuable references for future genetic mapping and genomic studies.
Article
Cell Biology
Mingxi Shao, Shiyun Wang, Yani Wan, Zhenzhen Liu, Yi Ma, Wenjun Cao, Shengjie Li
Summary: This study investigated the relationship between peripheral blood total bilirubin (TBIL) levels and the risk of primary open-angle glaucoma (POAG). The results showed that high levels of TBIL may be related to the pathogenesis of POAG and that the severity of the disease is positively correlated, especially in male patients.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2023)
Article
Chemistry, Analytical
Jingfei Li, Jin Chen, Yuwei Dai, Zhenzhen Liu, Junnan Zhao, Shuchen Liu, Rui Xiao
Summary: In this study, a rapid, ultrasensitive, and quantitative lateral flow immunoassay (LFA) strip was designed for simultaneous detection of respiratory bacteria S. aureus and S. pneumoniae. The use of surface enhanced Raman scattering (SERS) tags improved the sensitivity and specificity, making it suitable for the detection of respiratory bacteria samples.
Review
Cell Biology
Hong-Jiao Liu, Hua Miao, Jun-Zheng Yang, Fei Liu, Gang Cao, Ying-Yong Zhao
Summary: Fibrosis is a common feature of chronic diseases, and ageing is a major risk factor for fibrotic diseases. However, current therapies are limited and new treatments that specifically target the pathogenesis of fibrosis are urgently needed. This review discusses the role of lipids and lipidomics in the development of renal ageing and fibrosis, as well as the potential use of dyslipidaemia as a therapeutic target. The review also highlights the progress in research on small molecule therapeutic agents that modulate lipid metabolism to prevent and treat ageing and ageing-associated renal fibrosis.
AGEING RESEARCH REVIEWS
(2023)
Article
Mathematics
Zhenhai Liu, Nikolaos S. S. Papageorgiou
Summary: This paper discusses a Dirichlet problem driven by the anisotropic p-Laplacian, with a reaction that has the competing effects of a singular term and a parametric superlinear perturbation. A bifurcation-type theorem describing the changes of the set of positive solutions as the parameter varies is proven. The existence of minimal positive solutions is also proven.
MATHEMATISCHE NACHRICHTEN
(2023)
Article
Cell Biology
Zhendong Liu, Zhehao Fan, Rui Wang, Xiaolei Li, Hui Chen, Jingcheng Wang
Summary: This study investigated the effect of IFN-alpha-2b on preventing postoperative arthrofibrosis in rats and its antiproliferation effect on fibroblasts in vitro, as well as its molecular mechanism. The results showed that IFN-alpha-2b significantly reduced arthrofibrosis by inhibiting fibroblast proliferation and migration, possibly through the regulation of STAT1/p21 signaling pathway.
MEDIATORS OF INFLAMMATION
(2023)
Article
Materials Science, Multidisciplinary
Rong Wu, Zhenzhen Liu, Hong Ning, Dingding Lu, Zhihao Liu, Ya Meng, Jinfeng Li, Ruifeng Zhang
Summary: This study analyzed the sole influence of Mg on the corrosion behavior of Al-Cu-Li-xMg alloys. The addition of Mg affects the nucleation and precipitation process of the T-1 precipitate, resulting in a potential difference between grain interior and grain boundary. The precipitation of the T-1 precipitate is promoted in a 0.7Mg alloy but impeded in a 1.1Mg alloy, due to the competition of Cu atoms and nucleation sites.
Article
Geochemistry & Geophysics
Yanbo Liang, Yuanfang Cheng, Zhongying Han, Chuanliang Yan, Zhenhai Liu, Xiufeng Zhang, Chao Wang
Summary: This paper proposes the ground fracturing technology to pre-split the high-level roof, aiming to address the frequent occurrence of mine dynamic disasters such as mine earthquake and rock burst. The FLAC numerical model is used to study the dynamic response of the roof before and after fracturing. The simulation results show that the presence of hydraulic fracture can effectively reduce the first breaking span of the roof and slow down the stress and deformation energy concentration of coal and rock mass on both sides of the goaf.
Article
Immunology
Ruolin Mao, Xiangfei Wang, Rui Long, Meng Wang, Lei Jin, Lixia Zhu
Summary: This study aimed to investigate oocyte and embryonic development, ovarian reserve, and clinical outcomes in SLE patients during IVF treatment. The results showed that SLE patients had poorer outcomes in oocyte and embryonic development, leading to compromised fertility and clinical pregnancy. Therefore, individualized fertility assessment and early fertility guidance are necessary for these special groups.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Endocrinology & Metabolism
Yuehan Li, Lei Cai, Na Guo, Chang Liu, Meng Wang, Lixia Zhu, Fei Li, Lei Jin, Cong Sui
Summary: This study aimed to investigate the influence of oviductal extracellular vesicles (oEV) from patients with endometriosis on early embryo development. In vitro experiments were conducted using human oEV and murine embryos. The results showed that oEV from endometriosis patients significantly decreased blastocyst rates and down-regulated oxidative phosphorylation in blastocysts. Additionally, embryos cultured with oEV from endometriosis patients exhibited increased oxidative stress and apoptosis levels. Overall, oEV from patients with endometriosis negatively affect early embryo development by interfering with oxidative phosphorylation.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Engineering, Electrical & Electronic
Ningqiang Shi, Ling Li, Peng Gao, Xiangqian Jiang, Jiandong Hao, Chuncheng Ban, Ruigeng Zhang, Zhenxing Liu
Summary: This review focuses on the synthesis and application of two-dimensional hexagonal boron nitride (2D h-BN) in the mid-infrared (MIR) region. The synthesis of high-quality 2D h-BN poses challenges, but is crucial for its application in MIR. Recent advancements in synthesis methods and the exploration of various potential applications in the MIR region, such as perfect absorption, photodetectors, electro-optical modulators, phonon polaritons, and plasma excitons, are discussed.
ACS APPLIED ELECTRONIC MATERIALS
(2023)
Article
Materials Science, Multidisciplinary
Zhenzhen Liu, Haibo Li
Summary: The study prepared CMO microspheres with porous core-shell structure and investigated their properties. As an electrode for capacitive deionization, the optimized AC || CMO device exhibited high salt removal capacity and current efficiency, with a relatively high capacity retention rate. It was found that the intercalation/de-intercalation of sodium ions in CMO were governed by the (103) and (221) crystal planes, which had higher adsorption energies for Na+.
ENERGY & ENVIRONMENTAL MATERIALS
(2023)
Article
Psychology, Multidisciplinary
Zhenzhen Liu, Xiaomin Sun, Yarong Guo, Shuting Yang
Summary: This study shows that mindful parenting has a positive impact on adolescents' life satisfaction, and this relationship is mediated by adolescents' coping self-efficacy. These findings highlight the importance of mindful parenting for adolescents' healthy development.
CURRENT PSYCHOLOGY
(2023)