Great Expectations: recommendations for improving the methodological rigor of psychedelic clinical trials
Published 2022 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Great Expectations: recommendations for improving the methodological rigor of psychedelic clinical trials
Authors
Keywords
-
Journal
PSYCHOPHARMACOLOGY
Volume 239, Issue 6, Pages 1989-2010
Publisher
Springer Science and Business Media LLC
Online
2022-04-01
DOI
10.1007/s00213-022-06123-7
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Positive expectations predict improved mental-health outcomes linked to psychedelic microdosing
- (2021) L. S. Kaertner et al. Scientific Reports
- A placebo-controlled study of the effects of ayahuasca, set and setting on mental health of participants in ayahuasca group retreats
- (2021) M. V. Uthaug et al. PSYCHOPHARMACOLOGY
- Self-blinding citizen science to explore psychedelic microdosing
- (2021) Balázs Szigeti et al. eLife
- Registered Clinical Studies Investigating Psychedelic Drugs for Psychiatric Disorders
- (2021) Ashley N. Siegel et al. JOURNAL OF PSYCHIATRIC RESEARCH
- Cannabis-induced oceanic boundlessness
- (2021) Mitch Earleywine et al. JOURNAL OF PSYCHOPHARMACOLOGY
- Can pragmatic research, real-world data and digital technologies aid the development of psychedelic medicine?
- (2021) Robin L Carhart-Harris et al. JOURNAL OF PSYCHOPHARMACOLOGY
- Effects of psilocybin microdosing on awe and aesthetic experiences: a preregistered field and lab-based study
- (2021) Michiel van Elk et al. PSYCHOPHARMACOLOGY
- Examining changes in personality following shamanic ceremonial use of ayahuasca
- (2021) Brandon Weiss et al. Scientific Reports
- Can MDMA Change Sociopolitical Values? Insights From a Research Participant
- (2021) Harriet de Wit et al. BIOLOGICAL PSYCHIATRY
- What can be done to control the placebo response in clinical trials? A narrative review
- (2021) Kathryn Evans et al. Contemporary Clinical Trials
- Assessing the effects of methodological differences on outcomes in the use of psychedelics in the treatment of anxiety and depressive disorders: A systematic review and meta-analysis
- (2021) Robert F Leger et al. JOURNAL OF PSYCHOPHARMACOLOGY
- Cognitive therapy, mindfulness-based stress reduction, and behavior therapy for the treatment of chronic pain
- (2021) John W. Burns et al. PAIN
- A social affective neuroscience lens on placebo analgesia
- (2021) Lauren Y. Atlas TRENDS IN COGNITIVE SCIENCES
- Ten Practical Recommendations for Improving Blinding Integrity and Reporting in Psychotherapy Trials
- (2021) David Mataix-Cols et al. JAMA Psychiatry
- Blinding and expectancy confounds in psychedelic randomized controlled trials
- (2021) Suresh D. Muthukumaraswamy et al. Expert Review of Clinical Pharmacology
- Who is blind in psychedelic research? Letter to the editor regarding: blinding and expectancy confounds in psychedelic randomized controlled trials
- (2021) Eduardo Ekman Schenberg Expert Review of Clinical Pharmacology
- Systematized Review of Psychotherapeutic Components of Psilocybin-Assisted Psychotherapy
- (2021) David M. Horton et al. AMERICAN JOURNAL OF PSYCHOTHERAPY
- Caution at psychiatry’s psychedelic frontier
- (2021) Matthew J. Burke et al. NATURE MEDICINE
- Psychedelic therapy: a roadmap for wider acceptance and utilization
- (2021) Mason Marks et al. NATURE MEDICINE
- A systematic review and meta-analysis of the success of blinding in antidepressant RCTs
- (2021) Amelia J Scott et al. PSYCHIATRY RESEARCH
- Association of Single-blind Placebo Run-in Periods With the Placebo Response in Randomized Clinical Trials of Antidepressants
- (2021) Amelia J. Scott et al. JAMA Psychiatry
- A Phase 1, Dose-Ranging Study to Assess Safety and Psychoactive Effects of a Vaporized 5-Methoxy-N, N-Dimethyltryptamine Formulation (GH001) in Healthy Volunteers
- (2021) Johannes Reckweg et al. Frontiers in Pharmacology
- Magnitude of the Placebo Response Across Treatment Modalities Used for Treatment-Resistant Depression in Adults
- (2021) Brett D. M. Jones et al. JAMA Network Open
- Right-Wing Psychedelia: Case Studies in Cultural Plasticity and Political Pluripotency
- (2021) Brian A. Pace et al. Frontiers in Psychology
- Placebo and Nocebo Effects
- (2020) Luana Colloca et al. NEW ENGLAND JOURNAL OF MEDICINE
- Ayahuasca’s ‘afterglow’: improved mindfulness and cognitive flexibility in ayahuasca drinkers
- (2020) A Murphy-Beiner et al. PSYCHOPHARMACOLOGY
- Tripping on nothing: placebo psychedelics and contextual factors
- (2020) Jay A. Olson et al. PSYCHOPHARMACOLOGY
- Ethics and ego dissolution: the case of psilocybin
- (2020) William R Smith et al. JOURNAL OF MEDICAL ETHICS
- Trends in LSD use among US adults: 2015–2018
- (2020) R. Andrew Yockey et al. DRUG AND ALCOHOL DEPENDENCE
- Purpose-guided trial design in health-related behavioral intervention research.
- (2020) Kenneth E. Freedland HEALTH PSYCHOLOGY
- Long-term effects of psychedelic drugs: A systematic review
- (2020) Jacob S. Aday et al. NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
- Interpretation of chronic pain clinical trial outcomes
- (2020) Shannon M. Smith et al. PAIN
- Placebos in chronic pain: evidence, theory, ethics, and use in clinical practice
- (2020) Ted J Kaptchuk et al. BMJ-British Medical Journal
- Placebo Response Reduction and Accurate Pain Reporting Training Reduces Placebo Responses in a Clinical Trial on Chronic Low Back Pain
- (2020) Nathalie Erpelding et al. CLINICAL JOURNAL OF PAIN
- MDMA-assisted psychotherapy for treatment of anxiety and other psychological distress related to life-threatening illnesses: a randomized pilot study
- (2020) Philip E. Wolfson et al. Scientific Reports
- Effects of Psilocybin-Assisted Therapy on Major Depressive Disorder
- (2020) Alan K. Davis et al. JAMA Psychiatry
- A randomised controlled trial of vaporised Δ9-tetrahydrocannabinol and cannabidiol alone and in combination in frequent and infrequent cannabis users: acute intoxication effects
- (2019) Nadia Solowij et al. EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
- Do natural experiments have an important future in the study of mental disorders?
- (2019) Anita Thapar et al. PSYCHOLOGICAL MEDICINE
- Association of Combined Naltrexone and Ketamine With Depressive Symptoms in a Case series of Patients With Depression and Alcohol Use Disorder
- (2019) Gihyun Yoon et al. JAMA Psychiatry
- Pain, placebo, and test of treatment efficacy: a narrative review
- (2019) Lene Vase et al. BRITISH JOURNAL OF ANAESTHESIA
- Concurrent Use of Buprenorphine, Methadone, or Naltrexone Does Not Inhibit Ketamine’s Antidepressant Activity
- (2019) Tobias Marton et al. BIOLOGICAL PSYCHIATRY
- Effects of MDMA on attention to positive social cues and pleasantness of affective touch
- (2019) Anya K. Bershad et al. NEUROPSYCHOPHARMACOLOGY
- MDMA-assisted psychotherapy for treatment of PTSD: study design and rationale for phase 3 trials based on pooled analysis of six phase 2 randomized controlled trials
- (2019) Michael C. Mithoefer et al. PSYCHOPHARMACOLOGY
- Rigorous Trial Design Is Essential to Understand the Role of Opioid Receptors in Ketamine’s Antidepressant Effect
- (2019) Boris D. Heifets et al. JAMA Psychiatry
- Microdosing psychedelics: More questions than answers? An overview and suggestions for future research
- (2019) Kim PC Kuypers et al. JOURNAL OF PSYCHOPHARMACOLOGY
- Placebo Effects in Psychotherapy: A Framework
- (2019) Paul Enck et al. Frontiers in Psychiatry
- Attenuation of antidepressant and antisuicidal effects of ketamine by opioid receptor antagonism
- (2019) Nolan R. Williams et al. MOLECULAR PSYCHIATRY
- Improving study conduct and data quality in clinical trials of chronic pain treatments: IMMPACT recommendations
- (2019) Jennifer S. Gewandter et al. JOURNAL OF PAIN
- Adaptive designs in clinical trials: why use them, and how to run and report them
- (2018) Philip Pallmann et al. BMC Medicine
- Guidelines for Inclusion of Patient-Reported Outcomes in Clinical Trial Protocols
- (2018) Melanie Calvert et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- The Meaning-Enhancing Properties of Psychedelics and Their Mediator Role in Psychedelic Therapy, Spirituality, and Creativity
- (2018) Ido Hartogsohn Frontiers in Neuroscience
- Factors shaping expectations for complete relief from symptoms during rehabilitation for patients with spine pain
- (2018) Mark D Bishop et al. PHYSIOTHERAPY THEORY AND PRACTICE
- Attenuation of Antidepressant Effects of Ketamine by Opioid Receptor Antagonism
- (2018) Nolan R. Williams et al. AMERICAN JOURNAL OF PSYCHIATRY
- Enhancing the acute psychological benefits of green exercise: An investigation of expectancy effects
- (2018) Elliott P. Flowers et al. PSYCHOLOGY OF SPORT AND EXERCISE
- Predicting Responses to Psychedelics: A Prospective Study
- (2018) Eline C. H. M. Haijen et al. Frontiers in Pharmacology
- The Potential Role of Sensory Testing, Skin Biopsy, and Functional Brain Imaging as Biomarkers in Chronic Pain Clinical Trials: IMMPACT Considerations
- (2017) Shannon M. Smith et al. JOURNAL OF PAIN
- Efficacy of selective serotonin reuptake inhibitors in the absence of side effects: a mega-analysis of citalopram and paroxetine in adult depression
- (2017) F Hieronymus et al. MOLECULAR PSYCHIATRY
- Potential Therapeutic Effects of Psilocybin
- (2017) Matthew W. Johnson et al. Neurotherapeutics
- Double-blind comparison of the two hallucinogens psilocybin and dextromethorphan: similarities and differences in subjective experiences
- (2017) Theresa M. Carbonaro et al. PSYCHOPHARMACOLOGY
- The use of waitlists as control conditions in anxiety disorders research
- (2016) Beth Patterson et al. JOURNAL OF PSYCHIATRIC RESEARCH
- Psilocybin produces substantial and sustained decreases in depression and anxiety in patients with life-threatening cancer: A randomized double-blind trial
- (2016) Roland R Griffiths et al. JOURNAL OF PSYCHOPHARMACOLOGY
- Rapid and sustained symptom reduction following psilocybin treatment for anxiety and depression in patients with life-threatening cancer: a randomized controlled trial
- (2016) Stephen Ross et al. JOURNAL OF PSYCHOPHARMACOLOGY
- Set and setting, psychedelics and the placebo response: An extra-pharmacological perspective on psychopharmacology
- (2016) Ido Hartogsohn JOURNAL OF PSYCHOPHARMACOLOGY
- A qualitative study of changes in expectations over time among patients with chronic low back pain seeking four CAM therapies
- (2015) Emery R Eaves et al. BMC Complementary and Alternative Medicine
- Access to Investigational Drugs: FDA Expanded Access Programs or “Right-to-Try” Legislation?
- (2015) M. E. Blair Holbein et al. CTS-Clinical and Translational Science
- Can sequential parallel comparison design and two-way enriched design be useful in medical device clinical trials?
- (2015) Anastasia Ivanova et al. Journal of Biopharmaceutical Statistics
- Peak experiences and the afterglow phenomenon: When and how do therapeutic effects of hallucinogens depend on psychedelic experiences?
- (2015) Tomislav Majić et al. JOURNAL OF PSYCHOPHARMACOLOGY
- The impact of ecological momentary assessment on posttraumatic stress symptom trajectory
- (2015) Daniel Dewey et al. PSYCHIATRY RESEARCH
- Understanding the Hawthorne effect
- (2015) Philip Sedgwick et al. BMJ-British Medical Journal
- Understanding the Hawthorne effect
- (2015) Philip Sedgwick et al. BMJ-British Medical Journal
- Association Between Placebo-Activated Neural Systems and Antidepressant Responses
- (2015) Marta Peciña et al. JAMA Psychiatry
- Waiting list may be a nocebo condition in psychotherapy trials: a contribution from network meta-analysis
- (2014) T. A. Furukawa et al. ACTA PSYCHIATRICA SCANDINAVICA
- Focus Article Report of the NIH Task Force on Research Standards for Chronic Low Back Pain
- (2014) Richard A. Deyo et al. CLINICAL JOURNAL OF PAIN
- A theoretical analysis showed that blinding cannot eliminate potential for bias associated with beliefs about allocation in randomized clinical trials
- (2014) Erin Mathieu et al. JOURNAL OF CLINICAL EPIDEMIOLOGY
- Pilot study of the 5-HT2AR agonist psilocybin in the treatment of tobacco addiction
- (2014) Matthew W Johnson et al. JOURNAL OF PSYCHOPHARMACOLOGY
- Molecular mechanisms of placebo responses in humans
- (2014) M Peciña et al. MOLECULAR PSYCHIATRY
- LSD enhances suggestibility in healthy volunteers
- (2014) R. L. Carhart-Harris et al. PSYCHOPHARMACOLOGY
- A Model of Placebo Response in Antidepressant Clinical Trials
- (2013) Bret R. Rutherford et al. AMERICAN JOURNAL OF PSYCHIATRY
- Exploratory randomized controlled trial evaluating the impact of a waiting list control design
- (2013) John A Cunningham et al. BMC Medical Research Methodology
- The placebo response in medicine: minimize, maximize or personalize?
- (2013) Paul Enck et al. NATURE REVIEWS DRUG DISCOVERY
- Acute effects of ayahuasca on neuropsychological performance: differences in executive function between experienced and occasional users
- (2013) José Carlos Bouso et al. PSYCHOPHARMACOLOGY
- A Brief Intervention Reduces Hazardous and Harmful Drinking in Emergency Department Patients
- (2012) Gail D'Onofrio et al. ANNALS OF EMERGENCY MEDICINE
- Development of the Stanford Expectations of Treatment Scale (SETS): A tool for measuring patient outcome expectancy in clinical trials
- (2012) Jarred Younger et al. Clinical Trials
- A randomized, controlled pilot study of MDMA (±3,4-Methylenedioxymethamphetamine)-assisted psychotherapy for treatment of resistant, chronic Post-Traumatic Stress Disorder (PTSD)
- (2012) Peter Oehen et al. JOURNAL OF PSYCHOPHARMACOLOGY
- High doses of dextromethorphan, an NMDA antagonist, produce effects similar to classic hallucinogens
- (2012) Chad J. Reissig et al. PSYCHOPHARMACOLOGY
- Biomarkers and surrogate endpoints in clinical trials
- (2012) Thomas R. Fleming et al. STATISTICS IN MEDICINE
- The Effect of Treatment Expectation on Drug Efficacy: Imaging the Analgesic Benefit of the Opioid Remifentanil
- (2011) U. Bingel et al. Science Translational Medicine
- Pilot Study of Psilocybin Treatment for Anxiety in Patients With Advanced-Stage Cancer
- (2010) Charles S. Grob et al. ARCHIVES OF GENERAL PSYCHIATRY
- Is Ecstasy an “Empathogen”? Effects of ±3,4-Methylenedioxymethamphetamine on Prosocial Feelings and Identification of Emotional States in Others
- (2010) Gillinder Bedi et al. BIOLOGICAL PSYCHIATRY
- An introduction to adaptive designs and adaptation in CNS trials
- (2010) Vladimir Dragalin EUROPEAN NEUROPSYCHOPHARMACOLOGY
- Patient reported outcomes: looking beyond the label claim
- (2010) Lynda C Doward et al. Health and Quality of Life Outcomes
- Effect of a Symptom Diary on Symptom Frequency and Intensity in Healthy Subjects
- (2010) R. FERRARI et al. JOURNAL OF RHEUMATOLOGY
- Research design considerations for confirmatory chronic pain clinical trials: IMMPACT recommendations
- (2010) Robert H. Dworkin et al. PAIN
- Treatment Expectations and Preferences as Predictors of Outcome of Acupuncture for Chronic Back Pain
- (2010) Karen J. Sherman et al. SPINE
- What are biomarkers?
- (2010) Kyle Strimbu et al. Current Opinion in HIV and AIDS
- Towards a proposal for assessment of blinding success in clinical trials: up-to-date review
- (2009) Jafar Kolahi et al. COMMUNITY DENTISTRY AND ORAL EPIDEMIOLOGY
- Interpreting the clinical importance of group differences in chronic pain clinical trials: IMMPACT recommendations
- (2009) Robert H. Dworkin et al. PAIN
- Perceived treatment, feedback, and placebo effects in double-blind RCTs: an experimental analysis
- (2009) Ben Colagiuri et al. PSYCHOPHARMACOLOGY
- Mystical-type experiences occasioned by psilocybin mediate the attribution of personal meaning and spiritual significance 14 months later
- (2008) RR Griffiths et al. JOURNAL OF PSYCHOPHARMACOLOGY
- Interpreting the Clinical Importance of Treatment Outcomes in Chronic Pain Clinical Trials: IMMPACT Recommendations
- (2007) Robert H. Dworkin et al. JOURNAL OF PAIN
Create your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create NowAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started