Co-component signal transduction systems: Fast-evolving virulence regulation cassettes discovered in enteric bacteria

ColabFold: making protein folding accessible to all

(2022) Milot Mirdita et al.   NATURE METHODS

PsaF is a membrane-localized pH sensor that regulates psaA expression in Y. pestis

(2021) Joshua D. Quinn et al.   JOURNAL OF BACTERIOLOGY

Highly accurate protein structure prediction with AlphaFold

(2021) John Jumper et al.   NATURE

Highly accurate protein structure prediction for the human proteome

(2021) Kathryn Tunyasuvunakool et al.   NATURE

Target classification in the 14th round of the critical assessment of protein structure prediction ( CASP14 )

(2021) Lisa N. Kinch et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Topology evaluation of models for difficult targets in the 14th round of the critical assessment of protein structure prediction

(2021) Lisa N. Kinch et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Accurate prediction of protein structures and interactions using a three-track neural network

(2021) Minkyung Baek et al.   SCIENCE

Computed structures of core eukaryotic protein complexes

(2021) Ian R. Humphreys et al.   SCIENCE

Host stimuli and operator binding sites controlling protein interactions between virulence master regulator ToxR and ToxS in Vibrio cholerae

(2020) Mareike Lembke et al.   MOLECULAR MICROBIOLOGY

A disulfide constrains the ToxR periplasmic domain structure, altering its interactions with ToxS and bile-salts

(2020) Charles R. Midgett et al.   Scientific Reports

The periplasmic domains of Vibrio cholerae ToxR and ToxS are forming a strong heterodimeric complex independent on the redox state of ToxR cysteines

(2020) Nina Gubensäk et al.   MOLECULAR MICROBIOLOGY

CDD/SPARCLE: the conserved domain database in 2020

(2019) Shennan Lu et al.   NUCLEIC ACIDS RESEARCH

DALI and the persistence of protein shape

(2019) Liisa Holm   PROTEIN SCIENCE

Proteolysis of ToxR is controlled by cysteine-thiol redox state and bile salts in Vibrio cholerae

(2018) Mareike Lembke et al.   MOLECULAR MICROBIOLOGY

Sensory Repertoire of Bacterial Chemoreceptors

(2017) Álvaro Ortega et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Bile salts and alkaline pH reciprocally modulate the interaction between the periplasmic domains of V ibrio cholerae ToxR and ToxS

(2017) Charles R. Midgett et al.   MOLECULAR MICROBIOLOGY

MMseqs2 enables sensitive protein sequence searching for the analysis of massive data sets

(2017) Martin Steinegger et al.   NATURE BIOTECHNOLOGY

Perturbation of the two-component signal transduction system, BprRS, results in attenuated virulence and motility defects in Burkholderia pseudomallei

(2016) Natalie R. Lazar Adler et al.   BMC GENOMICS

Lose to win: marT pseudogenization in Salmonella enterica serovar Typhi contributed to the surV -dependent survival to H 2 O 2 , and inside human macrophage-like cells

(2016) A.P. Ortega et al.   INFECTION GENETICS AND EVOLUTION

Bile salt receptor complex activates a pathogenic type III secretion system

(2016) Peng Li et al.   eLife

Global Regulator of Virulence A (GrvA) Coordinates Expression of Discrete Pathogenic Mechanisms in Enterohemorrhagic Escherichia coli through Interactions with GadW-GadE

(2015) Jason K. Morgan et al.   JOURNAL OF BACTERIOLOGY

Formation of an Intramolecular Periplasmic Disulfide Bond in TcpP Protects TcpP and TcpH from Degradation in Vibrio cholerae

(2015) Sarah J. Morgan et al.   JOURNAL OF BACTERIOLOGY

Structural and Functional Analysis of the Signal-Transducing Linker in the pH-Responsive One-Component System CadC of Escherichia coli

(2015) Sophie Buchner et al.   JOURNAL OF MOLECULAR BIOLOGY

Role of ToxS in the proteolytic cascade of virulence regulator ToxR inVibrio cholerae

(2015) Salvador Almagro-Moreno et al.   MOLECULAR MICROBIOLOGY

Bile salt-induced intermolecular disulfide bond formation activates Vibrio cholerae virulence

(2013) M. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Persistent Gastric Colonization with Burkholderia pseudomallei and Dissemination from the Gastrointestinal Tract following Mucosal Inoculation of Mice

(2012) Andrew Goodyear et al.   PLoS One

Detection and function of an intramolecular disulfide bond in the pH-responsive CadC of Escherichia coli

(2011) Larissa Tetsch et al.   BMC MICROBIOLOGY

Differential Gene Expression and Adherence of Escherichia coli O157:H7 In Vitro and in Ligated Pig Intestines

(2011) Xianhua Yin et al.   PLoS One

Crystal structure of the sensory domain ofEscherichia coliCadC, a member of the ToxR-like protein family

(2011) Andreas Eichinger et al.   PROTEIN SCIENCE

Hidden Markov model speed heuristic and iterative HMM search procedure

(2010) L Steven Johnson et al.   BMC BIOINFORMATICS

Evolution and phyletic distribution of two-component signal transduction systems

(2010) Kristin Wuichet et al.   CURRENT OPINION IN MICROBIOLOGY

Identification of a regulatory cascade controlling Type III Secretion System 3 gene expression in Burkholderia pseudomallei

(2010) Guang Wen Sun et al.   MOLECULAR MICROBIOLOGY

Modified Intracellular-Associated Phenotypes in a Recombinant Salmonella Typhi Expressing S. Typhimurium SPI-3 Sequences

(2010) Patricio Retamal et al.   PLoS One

Two Regulators of Vibrio parahaemolyticus Play Important Roles in Enterotoxicity by Controlling the Expression of Genes in the Vp-PAI Region

(2010) Toshio Kodama et al.   PLoS One

Structure of Vibrio cholerae ToxT reveals a mechanism for fatty acid regulation of virulence genes

(2010) M. J. Lowden et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The cad locus of Enterobacteriaceae: More than just lysine decarboxylation

(2008) Alfredo G. Torres   ANAEROBE