Antifibrotic activities of Scutellariae Radix extracts and flavonoids: Comparative proteomics reveals distinct and shared mechanisms

Drug-herb interactions between Scutellaria baicalensis and pharmaceutical drugs: Insights from experimental studies, mechanistic actions to clinical applications

(2021) Xian Zhou et al.   BIOMEDICINE & PHARMACOTHERAPY

Chronic kidney disease

(2021) Kamyar Kalantar-Zadeh et al.   LANCET

Fibrometabolism—An emerging therapeutic frontier in pulmonary fibrosis

(2021) Brintha Selvarajah et al.   Science Signaling

TGFβ2 and TGFβ3 isoforms drive fibrotic disease pathogenesis

(2021) Tianhe Sun et al.   Science Translational Medicine

HIT 2.0: an enhanced platform for Herbal Ingredients' Targets

(2021) Deyu Yan et al.   NUCLEIC ACIDS RESEARCH

Cellular uptake of collagens and implications for immune cell regulation in disease

(2020) Henrik J. Jürgensen et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Applications, phytochemistry, pharmacological effects, pharmacokinetics, toxicity of Scutellaria baicalensis Georgi. and its probably potential therapeutic effects on COVID-19: a review

(2020) Jia-Wen Song et al.   Chinese Medicine

Phase Separation in Regulation of Aggrephagy

(2019) Daxiao Sun et al.   JOURNAL OF MOLECULAR BIOLOGY

Scutellaria baicalensis Georgi. (Lamiaceae): a review of its traditional uses, botany, phytochemistry, pharmacology and toxicology

(2019) Tiantian Zhao et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

STRING v11: protein–protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets

(2018) Damian Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

NPASS: natural product activity and species source database for natural product research, discovery and tool development

(2017) Xian Zeng et al.   NUCLEIC ACIDS RESEARCH

High doses of baicalin induces kidney injury and fibrosis through regulating TGF-β/Smad signaling pathway

(2017) Yi Cai et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Synthesis and Biological Evaluation of Scutellaria Flavone Cyclaneaminol Mannich Base Derivatives as Novel CDK1 Inhibitors

(2016) Lisha Ha et al.   Anti-Cancer Agents in Medicinal Chemistry

Multiple-Ascending-Dose Pharmacokinetics and Safety Evaluation of Baicalein Chewable Tablets in Healthy Chinese Volunteers

(2016) Hongxian Pang et al.   CLINICAL DRUG INVESTIGATION

Baicalein attenuates hypertrophic scar formation via inhibition of the transforming growth factor-β/Smad2/3 signalling pathway

(2015) Y.F. Zhang et al.   BRITISH JOURNAL OF DERMATOLOGY

Smad3 plays an inhibitory role in phosphate-induced vascular smooth muscle cell calcification

(2014) Aiko Shimokado et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Safety, tolerability, and pharmacokinetics of a single ascending dose of baicalein chewable tablets in healthy subjects

(2014) Min Li et al.   JOURNAL OF ETHNOPHARMACOLOGY

Interstrain differences in the progression of nonalcoholic steatohepatitis to fibrosis in mice are associated with altered hepatic iron metabolism

(2014) Svitlana Shpyleva et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

The importance of matrix metalloproteinase-3 in respiratory disorders

(2014) Cory M Yamashita et al.   Expert Review of Respiratory Medicine

Soluble transferrin receptor in urine, a new biomarker for IgA nephropathy and Henoch–Schönlein purpura nephritis

(2013) Sigurd E. Delanghe et al.   CLINICAL BIOCHEMISTRY

Regulation of Autophagy by TGF-β: Emerging Role in Kidney Fibrosis

(2013) Yan Ding et al.   SEMINARS IN NEPHROLOGY

Next-generation sequencing identifies TGF-β1-associated gene expression profiles in renal epithelial cells reiterated in human diabetic nephropathy

(2012) Eoin P. Brennan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Physiological significance of selective degradation of p62 by autophagy

(2010) Masaaki Komatsu et al.   FEBS LETTERS

Effect of the inosine 5′-monophosphate dehydrogenase inhibitor BMS-566419 on renal fibrosis in unilateral ureteral obstruction in rats

(2010) Tomonori Nakanishi et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Kidneys of Alb/TGF-β1 Transgenic Mice Are Deficient in Retinoic Acid and Exogenous Retinoic Acid Shows Dose-Dependent Toxicity

(2010) Qihe Xu et al.   NEPHRON EXPERIMENTAL NEPHROLOGY

Mycophenolic Acid Displays IMPDH-Dependent and IMPDH-Independent Effects on Renal Fibroblast Proliferation and Function

(2010) Darinka T Petrova et al.   THERAPEUTIC DRUG MONITORING

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

(2009) Da Wei Huang et al.   Nature Protocols

In vitro anti-fibrotic activities of herbal compounds and herbs

(2009) Qin Hu et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Impacts of baicalein analogs with modification of the 6th position of A ring on the activity toward NF-κB-, AP-1-, or CREB-mediated transcription

(2008) Sheng-Teng Huang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS