Article
Clinical Neurology
Christian Schwahn, Stefan Frenzel, Birte Holtfreter, Sandra van der Auwera, Christiane Pink, Robin Buelow, Nele Friedrich, Henry Voelzke, Reiner Biffar, Thomas Kocher, Hans Joergen Grabe
Summary: Through a study of 177 periodontally treated patients and 409 untreated subjects, it was found that periodontal treatment has a positive effect on AD-related brain atrophy, while the effect on brain aging remains uncertain.
ALZHEIMERS & DEMENTIA
(2022)
Article
Cell Biology
Danze Chen, Shijia Hao, Jianzhen Xu
Summary: The study explores the relationship between circRNAs in Alzheimer's disease and cancer, finding an inverse correlation in certain cancer types. CircRNAs associated with AD diagnosis and severity were negatively correlated in more cancer types, suggesting a common pathogenesis involving inflammation signaling. The study identified hub nodes in the circRNA-miRNA-target network and highlighted the relevance of inflammation signaling for potential therapeutic targeting of circRNAs in Alzheimer's disease and cancer.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Anwar T. Merchant, Longgang Zhao, Eric Mishio Bawa, Fanli Yi, Nadeesha P. Vidanapathirana, Matthew Lohman, Jiajia Zhang
Summary: Clusters of IgG antibodies against periodontal microorganisms did not predict AD mortality in this study.
JOURNAL OF PERIODONTOLOGY
(2023)
Review
Dentistry, Oral Surgery & Medicine
Luciana Solera Sales, Marina Lins Miranda, Analu Barros de Oliveira, Tulio Morandin Ferrisse, Carla Raquel Fontana, Michael Milward, Fernanda Lourencao Brighenti
Summary: This study conducted a systematic review to assess the in vitro effectiveness of photodynamic therapy against microorganisms associated with periodontal disease. The results indicated that photodynamic therapy may be a promising alternative to conventional antimicrobial approaches, but further research is needed to establish certain parameters before conducting clinical studies.
ARCHIVES OF ORAL BIOLOGY
(2022)
Article
Medicine, General & Internal
Haiyang Yu, Xuejie Song
Summary: This study used Mendelian randomization and statistical methods to find a causal association between Alzheimer disease and thyroiditis, indicating a positive correlation between the two diseases.
Review
Biochemistry & Molecular Biology
Masahiro Hatasa, Sumiko Yoshida, Hirokazu Takahashi, Kenichi Tanaka, Yoshihito Kubotsu, Yujin Ohsugi, Takaharu Katagiri, Takanori Iwata, Sayaka Katagiri
Summary: Periodontal disease is an inflammatory disease caused by oral microorganisms, with studies showing it as a risk factor for systemic diseases. The relationship between NAFLD and periodontal disease remains unclear. Epidemiological studies suggest periodontal disease as a risk factor for NAFLD, with animal models showing acceleration of NAFLD progression by periodontopathic bacteria. Th17 may play a key role in explaining the relationship between the two diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Haydar M. Al-kuraishy, Majid S. Jabir, Ali K. Albuhadily, Ali I. Al-Gareeb, Mayyadah F. Rafeeq
Summary: It has been shown that metabolic syndrome is associated with the neuropathology of Alzheimer's disease. The components of metabolic syndrome, including central obesity, hypertension, insulin resistance, and dyslipidemia, have negative effects on the pathogenesis of Alzheimer's disease through different mechanisms such as activation of the renin-angiotensin system, inflammatory signaling pathways, neuroinflammation, brain insulin resistance, mitochondrial dysfunction, and oxidative stress. Targeting these molecular pathways in metabolic syndrome could be a potential therapeutic strategy for managing Alzheimer's disease in high risk individuals, although the underlying mechanisms are not fully understood.
AGEING RESEARCH REVIEWS
(2023)
Article
Clinical Neurology
Simona I. Hategan, Sabrina A. Kamer, Ronald G. Craig, Cosmin Sinescu, Mony J. de Leon, Dragos C. Jianu, Catalin Marian, Bianca I. Bora, Traian-Flavius Dan, Claudiu D. Birdac, Anca Marcu, Angela R. Kamer, Meda Lavinia Negrutiu
Summary: The study revealed that young healthy individuals with periodontal disease may have lower cognition, and salivary IL-1 beta may play a role in this process, showing cognitive dysfunction in subjects with aggressive periodontitis for the first time.
NEUROLOGICAL SCIENCES
(2021)
Article
Clinical Neurology
Anuschka Silva-Spinola, Marisa Lima, Maria Joao Leitao, Catarina Bernardes, Joao Duraes, Diana Duro, Miguel Tabuas-Pereira, Isabel Santana, Ines Baldeiras
Summary: This study evaluated the potential of peripheral neurological biomarkers to predict progression to Alzheimer's disease in patients with mild cognitive impairment (MCI), and examined the relationship between blood and cerebrospinal fluid (CSF) markers. The results showed that levels of NfL, GFAP, and p-Tau181 in the blood were significantly higher in patients who progressed to Alzheimer's disease. Combining blood-based GFAP, NfL, and p-Tau181 may serve as a prognostic tool for MCI.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Developmental Biology
Fatma Hilal Yilmaz, Nuriye Emiroglu, Mehmet Burhan Oflaz, Mehmet Yucel, Ramazan Kececi, Hamdi Arbag, Huseyin Altunhan, Ayhan Ceri
Summary: A retrospective evaluation of 3,800 infants admitted to the NICU revealed a possible association between microbial growth related to sepsis and hearing loss, but the specific relationship could not be determined. The study highlighted potential risk factors such as low birth weight, neonatal hospitalization time, free oxygen support, intraventricular bleeding, loop diuretic use, and blood transfusion in relation to hearing loss.
BIRTH DEFECTS RESEARCH
(2021)
Article
Multidisciplinary Sciences
Wangmi Liu, Qiang Hu, Feng Zhang, Kesi Shi, Jiayan Wu
Summary: This study used Mendelian randomization methodology to investigate the causal relationship between osteocalcin and dementia. The results suggest that osteocalcin may have a protective effect against Alzheimer's disease. These findings provide important insights into the role of osteocalcin in the pathogenesis of Alzheimer's disease.
Article
Medicine, General & Internal
Fu-Mei Huang, Ci-Wen Luo, Shiuan-Shinn Lee, Yung-Chuan Ho, Yi-Ching Li, Yu-Chao Chang, Yu-Hsiang Kuan
Summary: Periodontal disease is often neglected and can lead to tooth loss and systemic diseases if its initial symptoms are overlooked. Patients with otitis media are at a higher risk of vestibular and balance dysfunction, resulting in vertigo. This study found that periodontal disease is a factor that causes dizziness.
Article
Environmental Sciences
Meiqing Jin, Jinsong Liu, Weihong Wu, Qingwei Zhou, Li Fu, Najmeh Zare, Fatemeh Karimi, Jinhong Yu, Cheng-Te Lin
Summary: This review summarizes the relationship between graphene and soils, including its applications in soil remediation, soil sensing, and effects on plant growth. Research findings suggest that graphene can alter soil physicochemical properties and microbial communities to some extent, but its impact on soil health is minimal.
Review
Biochemistry & Molecular Biology
Mattia Di Stefano, Alessandro Polizzi, Simona Santonocito, Alessandra Romano, Teresa Lombardi, Gaetano Isola
Summary: The oral cavity harbors a complex microbial community, which can lead to periodontal damage. Periodontal disease is a common chronic inflammatory condition globally, with diverse clinical manifestations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Infectious Diseases
Parichehr Hadi, Sanjiv Rampal, Vasantha Kumari Neela, Manraj Singh Cheema, Sandeep Singh Sarawan Singh, Eng Kee Tan, Ajantha Sinniah
Summary: Diabetes mellitus is a global pandemic, particularly in Southeast Asia, and diabetic foot infection is a common and serious complication of this disease. However, there is a lack of locally published data on the types of microorganisms and antibiotics prescribed. This study aims to address this gap by examining the local microorganism culture and antibiotic prescription trends among diabetic foot patients in a tertiary care hospital in central Malaysia. The findings of this study could greatly contribute to the development of empirical therapy guidelines for treating diabetic foot infections in the future.