Effective targeting of breast cancer stem cells by combined inhibition of Sam68 and Rad51

PI3K-driven HER2 expression is a potential therapeutic target in colorectal cancer stem cells

(2021) Laura Rosa Mangiapane et al.   GUT

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2021) Hyuna Sung et al.   CA-A CANCER JOURNAL FOR CLINICIANS

CHK1 inhibitor sensitizes resistant colorectal cancer stem cells to nortopsentin

(2021) Simone Di Franco et al.   iScience

Cancer statistics, 2020

(2020) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Cisplatin given at three divided doses for three consecutive days in metastatic breast cancer: an alternative schedule for one full dose with comparable efficacy but less CINV and hypomagnesaemia

(2020) Jinfeng Zhang et al.   BREAST CANCER RESEARCH AND TREATMENT

Phase 1 study of CWP232291 in patients with relapsed or refractory acute myeloid leukemia and myelodysplastic syndrome

(2020) Je-Hwan Lee et al.   Blood Advances

BARD1 and Breast Cancer: The Possibility of Creating Screening Tests and New Preventive and Therapeutic Pathways for Predisposed Women

(2020) Marcin Śniadecki et al.   Genes

Inhibition of chemotherapy resistant breast cancer stem cells by a ROR1 specific antibody

(2019) Suping Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

c-MYC empowers transcription and productive splicing of the oncogenic splicing factor Sam68 in cancer

(2019) Cinzia Caggiano et al.   NUCLEIC ACIDS RESEARCH

Defining and Modulating ‘BRCAness’

(2019) Andrea K. Byrum et al.   TRENDS IN CELL BIOLOGY

The small molecule WNT/β-catenin inhibitor CWP232291 blocks the growth of castration-resistant prostate cancer by activating the endoplasmic reticulum stress pathway

(2019) Sahyun Pak et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Modeling of Cisplatin-Induced Signaling Dynamics in Triple-Negative Breast Cancer Cells Reveals Mediators of Sensitivity

(2019) Anne Margriet Heijink et al.   Cell Reports

Breast cancer

(2019) Nadia Harbeck et al.   Nature Reviews Disease Primers

RAD51 foci as a functional biomarker of homologous recombination repair and PARP inhibitor resistance in germline BRCA-mutated breast cancer

(2018) C Cruz et al.   ANNALS OF ONCOLOGY

A Living Biobank of Breast Cancer Organoids Captures Disease Heterogeneity

(2018) Norman Sachs et al.   CELL

DNA repair and cell cycle checkpoint defects in a mouse model of ‘BRCAness’ are partially rescued by 53BP1 deletion

(2018) Sarah M. Misenko et al.   CELL CYCLE

Acquired Resistance of ER-Positive Breast Cancer to Endocrine Treatment Confers an Adaptive Sensitivity to TRAIL through Posttranslational Downregulation of c-FLIP

(2018) Luke Piggott et al.   CLINICAL CANCER RESEARCH

Tamoxifen-resistant breast cancer cells are resistant to DNA-damaging chemotherapy because of upregulated BARD1 and BRCA1

(2018) Yinghua Zhu et al.   Nature Communications

MYC-driven epigenetic reprogramming favors the onset of tumorigenesis by inducing a stem cell-like state

(2018) Vittoria Poli et al.   Nature Communications

In Vivo Expansion of Cancer Stemness Affords Novel Cancer Stem Cell Targets: Malignant Rhabdoid Tumor as an Example

(2018) Hana Golan et al.   Stem Cell Reports

CHK1-targeted therapy to deplete DNA replication-stressed, p53-deficient, hyperdiploid colorectal cancer stem cells

(2017) Gwenola Manic et al.   GUT

Protein Sam68 regulates the alternative splicing of survivin DEx3

(2017) Javier Gaytan-Cervantes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RAD51 Mediates Resistance of Cancer Stem Cells to PARP Inhibition in Triple-Negative Breast Cancer

(2016) Yajing Liu et al.   CLINICAL CANCER RESEARCH

Use of poly ADP-ribose polymerase [PARP] inhibitors in cancer cells bearing DDR defects: the rationale for their inclusion in the clinic

(2016) Aniello Cerrato et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

A Myc-driven self-reinforcing regulatory network maintains mouse embryonic stem cell identity

(2016) Luca Fagnocchi et al.   Nature Communications

CDK12 Inhibition Reverses De Novo and Acquired PARP Inhibitor Resistance in BRCA Wild-Type and Mutated Models of Triple-Negative Breast Cancer

(2016) Shawn F. Johnson et al.   Cell Reports

Sam68/KHDRBS1-dependent NF-κB activation confers radioprotection to the colon epithelium in γ-irradiated mice

(2016) Kai Fu et al.   eLife

Sam68/KHDRBS1 is critical for colon tumorigenesis by regulating genotoxic stress-induced NF-κB activation

(2016) Kai Fu et al.   eLife

BRCAness Predicts Resistance to Taxane-Containing Regimens in Triple Negative Breast Cancer During Neoadjuvant Chemotherapy

(2015) Sadako Akashi-Tanaka et al.   Clinical Breast Cancer

A phase 1 study with dose expansion of the CDK inhibitor dinaciclib (SCH 727965) in combination with epirubicin in patients with metastatic triple negative breast cancer

(2015) Zahi Mitri et al.   INVESTIGATIONAL NEW DRUGS

Regulation of nucleotide metabolism by mutant p53 contributes to its gain-of-function activities

(2015) Madhusudhan Kollareddy et al.   Nature Communications

CD44v6 Is a Marker of Constitutive and Reprogrammed Cancer Stem Cells Driving Colon Cancer Metastasis

(2014) Matilde Todaro et al.   Cell Stem Cell

Analysis of TP53 Mutation Status in Human Cancer Cell Lines: A Reassessment

(2014) Bernard Leroy et al.   HUMAN MUTATION

SnapShot: Breast Cancer

(2012) Kornelia Polyak et al.   CANCER CELL

Comprehensive molecular portraits of human breast tumours

(2012) Daniel C. Koboldt et al.   NATURE

The RNA-binding protein Sam68 is a multifunctional player in human cancer

(2011) P. Bielli et al.   ENDOCRINE-RELATED CANCER

Effect of radiotherapy after breast-conserving surgery on 10-year recurrence and 15-year breast cancer death: meta-analysis of individual patient data for 10 801 women in 17 randomised trials

(2011)   LANCET

Drug Combination Studies and Their Synergy Quantification Using the Chou-Talalay Method

(2010) T.-C. Chou   CANCER RESEARCH

Biological and Molecular Heterogeneity of Breast Cancers Correlates with Their Cancer Stem Cell Content

(2010) Salvatore Pece et al.   CELL

Sam68 up-regulation correlates with, and its down-regulation inhibits, proliferation and tumourigenicity of breast cancer cells

(2010) Libing Song et al.   JOURNAL OF PATHOLOGY

Classification and prognosis of invasive breast cancer: from morphology to molecular taxonomy

(2010) Stuart J Schnitt   MODERN PATHOLOGY

The DNA Damage Response: Making It Safe to Play with Knives

(2010) Alberto Ciccia et al.   MOLECULAR CELL

Genotoxic stress causes the accumulation of the splicing regulator Sam68 in nuclear foci of transcriptionally active chromatin

(2010) Roberta Busà et al.   NUCLEIC ACIDS RESEARCH

An online survival analysis tool to rapidly assess the effect of 22,277 genes on breast cancer prognosis using microarray data of 1,809 patients

(2009) Balazs Györffy et al.   BREAST CANCER RESEARCH AND TREATMENT

Alternative Splicing of the Cyclin D1 Proto-Oncogene Is Regulated by the RNA-Binding Protein Sam68

(2009) M. P. Paronetto et al.   CANCER RESEARCH

Module Map of Stem Cell Genes Guides Creation of Epithelial Cancer Stem Cells

(2008) David J. Wong et al.   Cell Stem Cell