Isoflurane and Sevoflurane Induce Cognitive Impairment in Neonatal Rats by Inhibiting Neural Stem Cell Development Through Microglial Activation, Neuroinflammation, and Suppression of VEGFR2 Signaling Pathway

Recombinant fusion protein by lysozyme and antibacterial peptide enhances ischemic wound healing via angiogenesis and reduction of inflammation in diabetic db/db mice

(2021) Wei Li et al.   PeerJ

Neonatal Anesthesia by Ketamine in Neonatal Rats Inhibits the Proliferation and Differentiation of Hippocampal Neural Stem Cells and Decreases Neurocognitive Function in Adulthood via Inhibition of the Notch1 Signaling Pathway

(2021) He Huang et al.   MOLECULAR NEUROBIOLOGY

Cannabinoid receptor 2 deficiency enhances isoflurane-induced spatial cognitive impairment in adult mice by affecting neuroinflammation, neurogenesis and neuroplasticity

(2021) Chao Li et al.   Experimental and Therapeutic Medicine

Neuroprotective Effects of Dexmedetomidine on the Ketamine-Induced Disruption of the Proliferation and Differentiation of Developing Neural Stem Cells in the Subventricular Zone

(2021) Huanhuan Sha et al.   Frontiers in Pediatrics

Neuron-specific deletion of VEGF or its receptor Flk-1 impairs recognition memory

(2020) Satoshi Deyama et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

L-Theanine Attenuates Isoflurane-Induced Injury in Neural Stem Cells and Cognitive Impairment in Neonatal Mice

(2020) Yong Chen et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

The Role of Histone Acetylation in the Sevoflurane-induced Inhibition of Neurogenesis in the Hippocampi of Young Mice

(2020) Junke Jia et al.   NEUROSCIENCE

Tau Contributes to Sevoflurane-induced Neurocognitive Impairment in Neonatal Mice

(2020) Yang Yu et al.   ANESTHESIOLOGY

Neurodevelopmental outcome at 5 years of age after general anaesthesia or awake-regional anaesthesia in infancy (GAS): an international, multicentre, randomised, controlled equivalence trial

(2019) Mary Ellen McCann et al.   LANCET

17β-Estradiol Treatment Attenuates Neurogenesis Damage and Improves Behavior Performance After Ketamine Exposure in Neonatal Rats

(2019) Weisong Li et al.   Frontiers in Cellular Neuroscience

Neuropsychological and Behavioral Outcomes after Exposure of Young Children to Procedures Requiring General Anesthesia

(2018) David O. Warner et al.   ANESTHESIOLOGY

Mid-gestational sevoflurane exposure inhibits fetal neural stem cell proliferation and impairs postnatal learning and memory function in a dose-dependent manner

(2018) Yuan Wang et al.   DEVELOPMENTAL BIOLOGY

Nitric Oxide Donor Prevents Neonatal Isoflurane-induced Impairments in Synaptic Plasticity and Memory

(2018) Michele L. Schaefer et al.   ANESTHESIOLOGY

Sevoflurane suppresses microglial M2 polarization

(2017) Zengyang Pei et al.   NEUROSCIENCE LETTERS

Long-term Fate Mapping to Assess the Impact of Postnatal Isoflurane Exposure on Hippocampal Progenitor Cell Productivity

(2016) Yifei Jiang et al.   ANESTHESIOLOGY

General Anesthesia Causes Epigenetic Histone Modulation of c-Fos and Brain-derived Neurotrophic Factor, Target Genes Important for Neuronal Development in the Immature Rat Hippocampus

(2016) Lorenza Dalla Massara et al.   ANESTHESIOLOGY

Sevoflurane represses the self-renewal ability by regulating miR-7a,7b/Klf4 signalling pathway in mouse embryonic stem cells

(2016) Qimin Wang et al.   CELL PROLIFERATION

Microglia across the lifespan: from origin to function in brain development, plasticity and cognition

(2016) Tuan Leng Tay et al.   JOURNAL OF PHYSIOLOGY-LONDON

Neurodevelopmental outcome at 2 years of age after general anaesthesia and awake-regional anaesthesia in infancy (GAS): an international multicentre, randomised controlled trial

(2016) Andrew J Davidson et al.   LANCET

Neuroinflammation negatively affects adult hippocampal neurogenesis and cognition: can exercise compensate?

(2016) Sinéad M. Ryan et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Isoflurane Exposure Induces Cell Death, Microglial Activation and Modifies the Expression of Genes Supporting Neurodevelopment and Cognitive Function in the Male Newborn Piglet Brain

(2016) Kevin D. Broad et al.   PLoS One

Sequential activation of microglia and astrocyte cytokine expression precedes increased iba-1 or GFAP immunoreactivity following systemic immune challenge

(2015) Diana M. Norden et al.   GLIA

Neuroprotection induced by sevoflurane-delayed post-conditioning is attributable to increased phosphorylation of mitochondrial GSK-3β through the PI3K/Akt survival pathway

(2015) Zhi Ye et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Isoflurane suppresses the self-renewal of normal mouse neural stem cells in a p53-dependent manner by activating the Lkb1-p53-p21 signalling pathway

(2015) LENGCHEN HOU et al.   Molecular Medicine Reports

Inflammation early in life is a vulnerability factor for emotional behavior at adolescence and for lipopolysaccharide-induced spatial memory and neurogenesis alteration at adulthood

(2014) Anne-Laure Dinel et al.   Journal of Neuroinflammation

Automatic counting and positioning of 5-bromo-2-deoxyuridine (BrdU) positive cells in cortical layers of rat brain slices

(2014) Martin Schmuck et al.   NEUROTOXICOLOGY

2-Deoxy-d-glucose attenuates sevoflurane-induced neuroinflammation through nuclear factor-kappa B pathway in vitro

(2014) Qingxiu Wang et al.   TOXICOLOGY IN VITRO

Long-term effects of an acute and systemic administration of LPS on adult neurogenesis and spatial memory

(2014) Jorge Valero et al.   Frontiers in Neuroscience

Positron Emission Tomography with [18F]FLT Revealed Sevoflurane-Induced Inhibition of Neural Progenitor Cell Expansion in vivo

(2014) Shuliang Liu et al.   Frontiers in Neurology

Selective Anesthesia-induced Neuroinflammation in Developing Mouse Brain and Cognitive Impairment

(2013) Xia Shen et al.   ANESTHESIOLOGY

Effects of isoflurane or propofol on postnatal hippocampal neurogenesis in young and aged rats

(2013) Diana M. Erasso et al.   BRAIN RESEARCH

Isoflurane and sevoflurane increase interleukin-6 levels through the nuclear factor-kappa B pathway in neuroglioma cells

(2013) L. Zhang et al.   BRITISH JOURNAL OF ANAESTHESIA

Rapid task acquisition of spatial-delayed alternation in an automated T-maze by mice

(2011) Andrea T.U. Schaefers et al.   BEHAVIOURAL BRAIN RESEARCH

Chronic neuroinflammation impacts the recruitment of adult-born neurons into behaviorally relevant hippocampal networks

(2011) Karim Belarbi et al.   BRAIN BEHAVIOR AND IMMUNITY

Inhalation anesthetic-induced neuronal damage in the developing rhesus monkey

(2011) Xiaoju Zou et al.   NEUROTOXICOLOGY AND TERATOLOGY

Reversible modulations of neuronal plasticity by VEGF

(2011) T. Licht et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Xenon Pretreatment Attenuates Anesthetic-induced Apoptosis in the Developing Brain in Comparison with Nitrous Oxide and Hypoxia

(2010) Yi Shu et al.   ANESTHESIOLOGY

Isoflurane Anesthesia Induced Persistent, Progressive Memory Impairment, Caused a Loss of Neural Stem Cells, and Reduced Neurogenesis in Young, but Not Adult, Rodents

(2010) Changlian Zhu et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

The inhalation anesthetic isoflurane increases levels of proinflammatory TNF-α, IL-6, and IL-1β

(2010) Xu Wu et al.   NEUROBIOLOGY OF AGING

Brain injury activates microglia that induce neural stem cell proliferation ex vivo and promote differentiation of neurosphere-derived cells into neurons and oligodendrocytes

(2010) T. Deierborg et al.   NEUROSCIENCE

Isoflurane Inhibits Growth but Does Not Cause Cell Death in Hippocampal Neural Precursor Cells Grown in Culture

(2009) Jeffrey W. Sall et al.   ANESTHESIOLOGY

Isoflurane Differentially Affects Neurogenesis and Long-term Neurocognitive Function in 60-day-old and 7-day-old Rats

(2009) Greg Stratmann et al.   ANESTHESIOLOGY

Neonatal Exposure to Sevoflurane Induces Abnormal Social Behaviors and Deficits in Fear Conditioning in Mice

(2009) Maiko Satomoto et al.   ANESTHESIOLOGY

Effect of Hypercarbia and Isoflurane on Brain Cell Death and Neurocognitive Dysfunction in 7-day-old Rats

(2009) Greg Stratmann et al.   ANESTHESIOLOGY

Early Exposure to Anesthesia and Learning Disabilities in a Population-based Birth Cohort

(2009) Robert T. Wilder et al.   ANESTHESIOLOGY

Inflammation mediates varying effects in neurogenesis: relevance to the pathogenesis of brain injury and neurodegenerative disorders

(2009) Nicholas P. Whitney et al.   JOURNAL OF NEUROCHEMISTRY

Vascular endothelial growth factor enhances migration of astroglial cells in subventricular zone neurosphere cultures

(2009) Nina Mani et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Erythropoietin improves spatial delayed alternation in a T-maze in rats subjected to ablation of the prefrontal cortex

(2008) Jesper Mogensen et al.   BRAIN RESEARCH BULLETIN

Mechanisms and Functional Implications of Adult Neurogenesis

(2008) Chunmei Zhao et al.   CELL

In vitro neuronal and glial differentiation from embryonic or adult neural precursor cells are differently affected by chronic or acute activation of microglia

(2008) Emanuele Cacci et al.   GLIA

Suppression of Stroke-Induced Progenitor Proliferation in Adult Subventricular Zone by Tumor Necrosis Factor Receptor 1

(2008) Robert E Iosif et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Microglia: gatekeepers of central nervous system immunology

(2008) Bart R. Tambuyzer et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Brain inflammation and adult neurogenesis: The dual role of microglia

(2008) C.T. Ekdahl et al.   NEUROSCIENCE