Organ and brain crosstalk: The liver-brain axis in gastrointestinal, liver, and pancreatic diseases

The gut vascular barrier: a new player in the gut–liver–brain axis

(2021) Paola Brescia et al.   TRENDS IN MOLECULAR MEDICINE

Postingestive Modulation of Food Seeking Depends on Vagus-Mediated Dopamine Neuron Activity

(2020) Ana B. Fernandes et al.   NEURON

The liver–brain–gut neural arc maintains the Treg cell niche in the gut

(2020) Toshiaki Teratani et al.   NATURE

Gut pathobionts underlie intestinal barrier dysfunction and liver T helper 17 cell immune response in primary sclerosing cholangitis

(2019) Nobuhiro Nakamoto et al.   Nature Microbiology

A Brain-Melanocortin-Vagus Axis Mediates Adipose Tissue Expansion Independently of Energy Intake

(2019) Jenna Holland et al.   Cell Reports

Vagal mechanisms as neuromodulatory targets for the treatment of metabolic disease

(2019) Hans‐Rudolf Berthoud et al.   Annals of the New York Academy of Sciences

Liver sympathetic denervation reverses obesity‐induced hepatic steatosis

(2019) Chansol Hurr et al.   JOURNAL OF PHYSIOLOGY-LONDON

Brain leptin reduces liver lipids by increasing hepatic triglyceride secretion and lowering lipogenesis

(2019) Martina Theresa Hackl et al.   Nature Communications

GLP-1 release and vagal afferent activation mediate the beneficial metabolic and chronotherapeutic effects of D-allulose

(2018) Yusaku Iwasaki et al.   Nature Communications

A Neural Circuit for Gut-Induced Reward

(2018) Wenfei Han et al.   CELL

The metabolic role of vagal afferent innervation

(2018) T. M. Zaved Waise et al.   Nature Reviews Gastroenterology & Hepatology

Human retinoic acid–regulated CD161+ regulatory T cells support wound repair in intestinal mucosa

(2018) Giovanni A. M. Povoleri et al.   NATURE IMMUNOLOGY

Vagus-macrophage-hepatocyte link promotes post-injury liver regeneration and whole-body survival through hepatic FoxM1 activation

(2018) Tomohito Izumi et al.   Nature Communications

Dysregulated bile acid signaling contributes to the neurological impairment in murine models of acute and chronic liver failure

(2018) Guoxiang Xie et al.   EBioMedicine

Liver inflammation and fibrosis

(2017) Yukinori Koyama et al.   JOURNAL OF CLINICAL INVESTIGATION

Hepatic vagus nerve regulates Kupffer cell activation via α7 nicotinic acetylcholine receptor in nonalcoholic steatohepatitis

(2017) Takahiro Nishio et al.   JOURNAL OF GASTROENTEROLOGY

Mechanisms of hepatic stellate cell activation

(2017) Takuma Tsuchida et al.   Nature Reviews Gastroenterology & Hepatology

Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes

(2016) Zobair M. Younossi et al.   HEPATOLOGY

Autonomic Nervous System and the Liver

(2016) Kei Mizuno et al.   HEPATOLOGY RESEARCH

The microbiota in adaptive immune homeostasis and disease

(2016) Kenya Honda et al.   NATURE

Central Insulin Action Activates Kupffer Cells by Suppressing Hepatic Vagal Activation via the Nicotinic Alpha 7 Acetylcholine Receptor

(2016) Kumi Kimura et al.   Cell Reports

Ammonia and Its Role in the Pathogenesis of Hepatic Encephalopathy

(2015) Parth J. Parekh et al.   Clinics in Liver Disease

Neuroepithelial circuit formed by innervation of sensory enteroendocrine cells

(2015) Diego V. Bohórquez et al.   JOURNAL OF CLINICAL INVESTIGATION

A gut-vascular barrier controls the systemic dissemination of bacteria

(2015) Ilaria Spadoni et al.   SCIENCE

A fatty acid-dependent hypothalamic–DVC neurocircuitry that regulates hepatic secretion of triglyceride-rich lipoproteins

(2015) Jessica T. Y. Yue et al.   Nature Communications

A hepatic amino acid/mTOR/S6K-dependent signalling pathway modulates systemic lipid metabolism via neuronal signals

(2015) Kenji Uno et al.   Nature Communications

Bile acids permeabilize the blood brain barrier after bile duct ligation in rats via Rac1-dependent mechanisms

(2014) Matthew Quinn et al.   DIGESTIVE AND LIVER DISEASE

Macrophages and Dendritic Cells Emerge in the Liver during Intestinal Inflammation and Predispose the Liver to Inflammation

(2014) Yohei Mikami et al.   PLoS One

The Liver May Act as a Firewall Mediating Mutualism Between the Host and Its Gut Commensal Microbiota

(2014) M. L. Balmer et al.   Science Translational Medicine

Intraportal GLP-1 stimulates insulin secretion predominantly through the hepatoportal-pancreatic vagal reflex pathways

(2013) Makoto Nishizawa et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Sleep-wake abnormalities in patients with cirrhosis

(2013) Sara Montagnese et al.   HEPATOLOGY

Update on cerebral uptake of blood ammonia

(2013) Michael Sørensen   METABOLIC BRAIN DISEASE

Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells

(2013) Yukihiro Furusawa et al.   NATURE

Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota

(2013) Koji Atarashi et al.   NATURE

A Gut Lipid Messenger Links Excess Dietary Fat to Dopamine Deficiency

(2013) L. A. Tellez et al.   SCIENCE

The Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic Treg Cell Homeostasis

(2013) P. M. Smith et al.   SCIENCE

Glycogen shortage during fasting triggers liver–brain–adipose neurocircuitry to facilitate fat utilization

(2013) Yoshihiko Izumida et al.   Nature Communications

Hepatic Glucokinase Modulates Obesity Predisposition by Regulating BAT Thermogenesis via Neural Signals

(2012) Sohei Tsukita et al.   Cell Metabolism

Hypothalamic Neuropeptide Y (NPY) Controls Hepatic VLDL-Triglyceride Secretion in Rats via the Sympathetic Nervous System

(2012) Eveline Bruinstroop et al.   DIABETES

Role of β-adrenergic receptors in regulation of hepatic fat accumulation during aging

(2012) Paramita M Ghosh et al.   JOURNAL OF ENDOCRINOLOGY

Unknown

(2011) Sanjaya Satapathy et al.   MOLECULAR MEDICINE

Bifidobacteria can protect from enteropathogenic infection through production of acetate

(2011) Shinji Fukuda et al.   NATURE

Intravascular Food Reward

(2011) Albino J. Oliveira-Maia et al.   PLoS One

Acetylcholine-Synthesizing T Cells Relay Neural Signals in a Vagus Nerve Circuit

(2011) M. Rosas-Ballina et al.   SCIENCE

Cholinergic systems mediate action from movement to higher consciousness

(2010) Nancy J. Woolf et al.   BEHAVIOURAL BRAIN RESEARCH

The role of the autonomic nervous liver innervation in the control of energy metabolism

(2010) Chun-Xia Yi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Th17 and Regulatory T Cells in Mediating and Restraining Inflammation

(2010) Dan R. Littman et al.   CELL

Basal and Insulin Mediated VLDL-Triglyceride Kinetics in Type 2 Diabetic Men

(2010) L. P. Sorensen et al.   DIABETES

Evolution of inflammation in nonalcoholic fatty liver disease: The multiple parallel hits hypothesis

(2010) Herbert Tilg et al.   HEPATOLOGY

Induction of Colonic Regulatory T Cells by Indigenous Clostridium Species

(2010) K. Atarashi et al.   SCIENCE

Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43

(2009) Kendle M. Maslowski et al.   NATURE

Lipotoxicity in nonalcoholic fatty liver disease: not all lipids are created equal

(2009) Naim Alkhouri et al.   Expert Review of Gastroenterology & Hepatology

Decreased heart rate variability in patients with cirrhosis relates to the presence and degree of hepatic encephalopathy

(2008) Ali R. Mani et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Spinal p38 MAP kinase regulates peripheral cholinergic outflow

(2008) Jean-Marc Waldburger et al.   ARTHRITIS AND RHEUMATISM

Brain cholinergic impairment in liver failure

(2008) M.-S. Garcia-Ayllon et al.   BRAIN

Toll‐like receptors and adaptor molecules in liver disease: Update

(2008) Ekihiro Seki et al.   HEPATOLOGY

Autonomic Regulation of Liver Regeneration After Partial Hepatectomy in Mice

(2008) Osamu Ikeda et al.   JOURNAL OF SURGICAL RESEARCH

Upper intestinal lipids trigger a gut–brain–liver axis to regulate glucose production

(2008) Penny Y. T. Wang et al.   NATURE

Food Reward in the Absence of Taste Receptor Signaling

(2008) Ivan E. de Araujo et al.   NEURON