Gut microbiome effects on neuronal excitability & activity: Implications for epilepsy

First evidence of altered microbiota and intestinal damage and their link to absence epilepsy in a genetic animal model, the WAG/Rij rat

(2021) Rita Citraro et al.   EPILEPSIA

Microbial Memories: Sex‐dependent Impact of the Gut Microbiome on Hippocampal Plasticity

(2021) Henry T. Darch et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Gut microbiota modulates seizure susceptibility

(2021) Francesca Mengoni et al.   EPILEPSIA

Gut metabolite S‐equol ameliorates hyperexcitability in entorhinal cortex neurons following Theiler murine encephalomyelitis virus‐induced acute seizures

(2021) Allison Gallucci et al.   EPILEPSIA

Postnatal prebiotic supplementation in rats affects adult anxious behaviour, hippocampus electrophysiology, metabolomics and gut microbiota.

(2021) Sonia O. Spitzer et al.   iScience

Antibiotic-induced gut dysbiosis leads to activation of microglia and impairment of cholinergic gamma oscillations in the hippocampus

(2021) Gürsel Çalışkan et al.   BRAIN BEHAVIOR AND IMMUNITY

Effects of probiotics on pentylenetetrazol-induced convulsions in mice

(2021) Salehe Sabouri et al.   EPILEPSY RESEARCH

Protective effects of long-term probiotic mixture supplementation against pentylenetetrazole-induced seizures, inflammation and oxidative stress in rats

(2021) Erkan Kilinc et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

The gut microbiota modulates brain network connectivity under physiological conditions and after acute brain ischemia

(2021) Markus Aswendt et al.   iScience

Probiotics and Nigella sativa extract supplementation improved behavioral and electrophysiological effects of PTZ-induced chemical kindling in rats

(2020) Saeed Tahmasebi et al.   EPILEPSY & BEHAVIOR

Protease‐dependent excitation of nodose ganglion neurons by commensal gut bacteria

(2020) Sabindra Pradhananga et al.   JOURNAL OF PHYSIOLOGY-LONDON

Neuronal programming by microbiota regulates intestinal physiology

(2020) Yuuki Obata et al.   NATURE

Clinical and experimental insight into pathophysiology, comorbidity and therapy of absence seizures

(2020) Vincenzo Crunelli et al.   BRAIN

Ketogenic Diets Alter the Gut Microbiome Resulting in Decreased Intestinal Th17 Cells

(2020) Qi Yan Ang et al.   CELL

Effects of underfeeding and oral vancomycin on gut microbiome and nutrient absorption in humans

(2020) Alessio Basolo et al.   NATURE MEDICINE

Bifidobacteria shape host neural circuits during postnatal development by promoting synapse formation and microglial function

(2020) Berkley Luck et al.   Scientific Reports

Microbiota modulate sympathetic neurons via a gut–brain circuit

(2020) Paul A. Muller et al.   NATURE

The maternal microbiome modulates fetal neurodevelopment in mice

(2020) Helen E. Vuong et al.   NATURE

Sex Differences in the Gut-Brain Axis: Implications for Mental Health

(2020) Calliope Holingue et al.   Current Psychiatry Reports

Perinatal antibiotics alter preterm infant EEG and neurobehavior in the Family Nurture Intervention trial

(2019) Morgan R. Firestein et al.   DEVELOPMENTAL PSYCHOBIOLOGY

Mid-life microbiota crises: middle age is associated with pervasive neuroimmune alterations that are reversed by targeting the gut microbiome

(2019) Marcus Boehme et al.   MOLECULAR PSYCHIATRY

Effect of probiotic supplementation on seizure activity and cognitive performance in PTZ-induced chemical kindling

(2019) Samaneh Bagheri et al.   EPILEPSY & BEHAVIOR

The gut microbiome and epilepsy

(2019) Maria Dahlin et al.   EBioMedicine

Emerging roles for the intestinal microbiome in epilepsy

(2019) Gregory R. Lum et al.   NEUROBIOLOGY OF DISEASE

The Microbiota-Gut-Brain Axis

(2019) John F. Cryan et al.   PHYSIOLOGICAL REVIEWS

The microbiota regulate neuronal function and fear extinction learning

(2019) Coco Chu et al.   NATURE

Intestinal inflammation increases convulsant activity and reduces antiepileptic drug efficacy in a mouse model of epilepsy

(2019) Carmen De Caro et al.   Scientific Reports

The gut microbiome in epilepsy

(2019) Birol Şafak et al.   MICROBIAL PATHOGENESIS

Treatment with gut bifidobacteria improves hippocampal plasticity and cognitive behavior in adult healthy rats

(2019) G. Talani et al.   NEUROPHARMACOLOGY

Antibiotic-induced microbiota perturbation causes gut endocannabinoidome changes, hippocampal neuroglial reorganization and depression in mice

(2018) F. Guida et al.   BRAIN BEHAVIOR AND IMMUNITY

The Gut Microbiota Mediates the Anti-Seizure Effects of the Ketogenic Diet

(2018) Christine A. Olson et al.   CELL

Altered gut microbiome composition in children with refractory epilepsy after ketogenic diet

(2018) Yunjian Zhang et al.   EPILEPSY RESEARCH

Small intraneuronal acidification via short-chain monocarboxylates: First evidence of an inhibitory action on over-excited human neocortical neurons

(2018) Udo Bonnet et al.   LIFE SCIENCES

Probiotic treatment reduces the autistic-like excitation/inhibition imbalance in juvenile hamsters induced by orally administered propionic acid and clindamycin

(2018) Afaf El-Ansary et al.   METABOLIC BRAIN DISEASE

Cortical drive and thalamic feed-forward inhibition control thalamic output synchrony during absence seizures

(2018) Cian McCafferty et al.   NATURE NEUROSCIENCE

Microbiome–host systems interactions: protective effects of propionate upon the blood–brain barrier

(2018) Lesley Hoyles et al.   Microbiome

Altered composition of the gut microbiome in patients with drug-resistant epilepsy

(2018) Anjiao Peng et al.   EPILEPSY RESEARCH

The beneficial effect of probiotics as a supplementary treatment in drug-resistant epilepsy: a pilot study

(2018) M. Gómez-Eguílaz et al.   Beneficial Microbes

Microbiome interactions shape host fitness

(2018) Alison L. Gould et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Probiotics and Prebiotics as a Therapeutic Strategy to Improve Memory in a Model of Middle-Aged Rats

(2018) Alejandra Romo-Araiza et al.   Frontiers in Aging Neuroscience

Protease-Mediated Suppression of DRG Neuron Excitability by Commensal Bacteria

(2017) Jessica L. Sessenwein et al.   JOURNAL OF NEUROSCIENCE

Fecal microbiota transplantation cured epilepsy in a case with Crohn’s disease: The first report

(2017) Zhi He et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Formation of propionate and butyrate by the human colonic microbiota

(2016) Petra Louis et al.   ENVIRONMENTAL MICROBIOLOGY

Adult microbiota-deficient mice have distinct dendritic morphological changes: differential effects in the amygdala and hippocampus

(2016) Pauline Luczynski et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

The effects of antibiotics on the microbiome throughout development and alternative approaches for therapeutic modulation

(2016) Amy Langdon et al.   Genome Medicine

Bifidobacterium longum 1714 as a translational psychobiotic: modulation of stress, electrophysiology and neurocognition in healthy volunteers

(2016) A P Allen et al.   Translational Psychiatry

Serotonin, tryptophan metabolism and the brain-gut-microbiome axis

(2015) S.M. O’Mahony et al.   BEHAVIOURAL BRAIN RESEARCH

The gut microbiome restores intrinsic and extrinsic nerve function in germ-free mice accompanied by changes in calbindin

(2015) K. A. McVey Neufeld et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Gamma oscillations precede interictal epileptiform spikes in the seizure onset zone

(2015) L. Ren et al.   NEUROLOGY

Fecal microbiota transplantation: in perspective

(2015) Shaan Gupta et al.   Therapeutic Advances in Gastroenterology

The gut-brain axis rewired: adding a functional vagal nicotinic “sensory synapse”

(2014) Azucena Perez-Burgos et al.   FASEB JOURNAL

Sleep and epilepsy

(2013) Christopher P. Derry et al.   EPILEPSY & BEHAVIOR

Intestinal microbiota influence the early postnatal development of the enteric nervous system

(2013) J. Collins et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Psychoactive bacteria Lactobacillus rhamnosus (JB-1) elicits rapid frequency facilitation in vagal afferents

(2012) Azucena Perez-Burgos et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour

(2012) John F. Cryan et al.   NATURE REVIEWS NEUROSCIENCE

The microbiome is essential for normal gut intrinsic primary afferent neuron excitability in the mouse

(2012) K. A. McVey Neufeld et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Effects of probiotics on gut microbiota: mechanisms of intestinal immunomodulation and neuromodulation

(2012) Peera Hemarajata et al.   Therapeutic Advances in Gastroenterology

The anxiolytic effect of Bifidobacterium longum NCC3001 involves vagal pathways for gut-brain communication

(2011) P. Bercik et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Gut microbiome-host interactions in health and disease

(2011) James M Kinross et al.   Genome Medicine

Chronic Gastrointestinal Inflammation Induces Anxiety-Like Behavior and Alters Central Nervous System Biochemistry in Mice

(2010) Premysl Bercik et al.   GASTROENTEROLOGY

Lactobacillus reuteri ingestion prevents hyperexcitability of colonic DRG neurons induced by noxious stimuli

(2009) Xuelian Ma et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Slow Oscillation State Facilitates Epileptiform Events in the Hippocampus

(2009) Farhang Nazer et al.   JOURNAL OF NEUROPHYSIOLOGY

The Effect of Diet on the Human Gut Microbiome: A Metagenomic Analysis in Humanized Gnotobiotic Mice

(2009) P. J. Turnbaugh et al.   Science Translational Medicine