Linezolid: a promising option in the treatment of Gram-positives

Surveillance for linezolid resistance via the Zyvox®Annual Appraisal of Potency and Spectrum (ZAAPS) programme (2014): evolving resistance mechanisms with stable susceptibility rates

(2016) Rodrigo E. Mendes et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Investigation of Linezolid Resistance in Staphylococci and Enterococci

(2016) Christopher D. Doern et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Emergence of linezolid resistance in hepatobiliary infections caused byEnterococcus faecium

(2016) Marc Niebel et al.   LIVER TRANSPLANTATION

Failure to decolonize mupirocin and linezolid resistant MRSA from a patient with necrotizing soft tissue infection

(2016) Sumit Rai et al.   Journal of Infection and Public Health

Dissemination of the Samecfr-Carrying Plasmid among Methicillin-Resistant Staphylococcus aureus and Coagulase-Negative Staphylococcal Isolates in China

(2015) Jia Chang Cai et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Enterococcal isolates carrying the novel oxazolidinone resistance gene optrA from hospitals in Zhejiang, Guangdong, and Henan, China, 2010–2014

(2015) J. Cai et al.   CLINICAL MICROBIOLOGY AND INFECTION

Linezolid resistance in clinical isolates of Staphylococcus epidermidis from German hospitals and characterization of two cfr-carrying plasmids

(2015) J. Bender et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

A novel gene,optrA, that confers transferable resistance to oxazolidinones and phenicols and its presence inEnterococcus faecalisandEnterococcus faeciumof human and animal origin

(2015) Yang Wang et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Incidence, management and outcomes of the first cfr-mediated linezolid-resistant Staphylococcus epidermidis outbreak in a tertiary referral centre in the Republic of Ireland

(2015) C. O'Connor et al.   JOURNAL OF HOSPITAL INFECTION

First outbreak of linezolid-resistant vancomycin-resistant Enterococcus faecium in an Irish hospital, February to September 2014

(2015) C. O'Driscoll et al.   JOURNAL OF HOSPITAL INFECTION

Linezolid Resistance in Vancomycin-Resistant Enterococcus faecalis and Enterococcus faecium Isolates in a Brazilian Hospital

(2014) L. M. de Almeida et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Linezolid update: Stable in vitro activity following more than a decade of clinical use and summary of associated resistance mechanisms

(2014) Rodrigo E. Mendes et al.   DRUG RESISTANCE UPDATES

Zyvox(R) Annual Appraisal of Potency and Spectrum (ZAAPS) Program: report of linezolid activity over 9 years (2004-12)

(2014) R. E. Mendes et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Rapid identification of linezolid resistance in Enterococcus spp. based on high-resolution melting analysis

(2014) María Alonso et al.   JOURNAL OF MICROBIOLOGICAL METHODS

Tedizolid for 6 days versus linezolid for 10 days for acute bacterial skin and skin-structure infections (ESTABLISH-2): a randomised, double-blind, phase 3, non-inferiority trial

(2014) Gregory J Moran et al.   LANCET INFECTIOUS DISEASES

Summary of Linezolid Activity and Resistance Mechanisms Detected during the 2012 LEADER Surveillance Program for the United States

(2013) Rodrigo E. Mendes et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Detection of Linezolid-Resistant Staphylococcus aureus with 23S rRNA and Novel L4 Riboprotein Mutations in a Cystic Fibrosis Patient in Spain

(2013) Federico Román et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

FDA Guidance for ABSSSI Trials: Implications for Conducting and Interpreting Clinical Trials

(2013) K. M. F. Itani et al.   CLINICAL INFECTIOUS DISEASES

Tedizolid for the Management of Human Infections: In Vitro Characteristics

(2013) Jeffrey B. Locke et al.   CLINICAL INFECTIOUS DISEASES

Linezolid resistance in Enterococcus faecium isolated in Ontario, Canada

(2013) Samir N. Patel et al.   DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE

Cfr-mediated linezolid resistance in methicillin-resistant Staphylococcus aureus and Staphylococcus haemolyticus associated with clinical infections in humans: two case reports

(2013) A. T. Fessler et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Acute Bacterial Skin Infections: Developments Since the 2005 Infectious Diseases Society of America (IDSA) Guidelines

(2013) Gregory J. Moran et al.   JOURNAL OF EMERGENCY MEDICINE

Emergence of cfr-harbouring coagulase-negative staphylococci among patients receiving linezolid therapy in two hospitals in China

(2013) X.-J. Yang et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Low Prevalence of Cfr-Mediated Linezolid Resistance among Methicillin-Resistant Staphylococcus aureus in a Spanish Hospital: Case Report on Linezolid Resistance Acquired during Linezolid Therapy

(2013) Josep M. Sierra et al.   PLoS One

Cfr-Mediated Linezolid-Resistance among Methicillin-Resistant Coagulase-Negative Staphylococci from Infections of Humans

(2013) Lanqing Cui et al.   PLoS One

Clonal Dissemination of Linezolid-Resistant Staphylococcus haemolyticus Exhibiting the G2576T Mutation in the 23S rRNA Gene in a Tertiary Care Hospital in Brazil

(2012) Lara M. de Almeida et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Linezolid Surveillance Results for the United States: LEADER Surveillance Program 2011

(2012) R. K. Flamm et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Transferable Plasmid-Mediated Resistance to Linezolid Due tocfrin a Human Clinical Isolate of Enterococcus faecalis

(2012) Lorena Diaz et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

rplCT460C Identified as a Dominant Mutation in Linezolid-Resistant Mycobacterium tuberculosis Strains

(2012) Patrick Beckert et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

LEADER Surveillance program results for 2010: an activity and spectrum analysis of linezolid using 6801 clinical isolates from the United States (61 medical centers)

(2012) Robert K. Flamm et al.   DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE

Intensive care unit dissemination of multiple clones of linezolid-resistant Enterococcus faecalis and Enterococcus faecium

(2012) E. Ntokou et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

The emerging problem of linezolid-resistant Staphylococcus

(2012) B. Gu et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Mechanisms of Linezolid Resistance among Staphylococci in a Tertiary Hospital

(2012) Inmaculada Quiles-Melero et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Linezolid-resistant clinical isolates of meticillin-resistant coagulase-negative staphylococci and Enterococcus faecium from China

(2012) J. C. Cai et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Linezolid for Treatment of Chronic Extensively Drug-Resistant Tuberculosis

(2012) Myungsun Lee et al.   NEW ENGLAND JOURNAL OF MEDICINE

Emergence of Linezolid-Resistant Mutants in a Susceptible-Cell Population of Methicillin-Resistant Staphylococcus aureus

(2011) Yurika Ikeda-Dantsuji et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Structural Basis for Methyl Transfer by a Radical SAM Enzyme

(2011) A. K. Boal et al.   SCIENCE

Stability of linezolid activity in an era of mobile oxazolidinone resistance determinants: results from the 2009 Zyvox® Annual Appraisal of Potency and Spectrum program

(2010) Douglas J. Biedenbach et al.   DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE

Higher linezolid exposure and higher frequency of thrombocytopenia in patients with renal dysfunction

(2010) Kazuaki Matsumoto et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Thrombocytopenia and anemia caused by a persistent high linezolid concentration in patients with renal dysfunction

(2010) Yasuhiro Tsuji et al.   JOURNAL OF INFECTION AND CHEMOTHERAPY

Zyvox® Annual Appraisal of Potency and Spectrum program: linezolid surveillance program results for 2008

(2009) Ronald N. Jones et al.   DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE

A retrospective TBNET assessment of linezolid safety, tolerability and efficacy in multidrug-resistant tuberculosis

(2009) G. B. Migliori et al.   EUROPEAN RESPIRATORY JOURNAL

Activity of oxazolidinone TR-700 against linezolid-susceptible and -resistant staphylococci and enterococci

(2009) D. M. Livermore et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

A T2504A mutation in the 23S rRNA gene responsible for high-level resistance to linezolid of Staphylococcus epidermidis

(2009) A. Liakopoulos et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Early and Extended Early Bactericidal Activity of Linezolid in Pulmonary Tuberculosis

(2008) Reynaldo Dietze et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

First Report of cfr-Mediated Resistance to Linezolid in Human Staphylococcal Clinical Isolates Recovered in the United States

(2008) R. E. Mendes et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Early Microbiological Response to Linezolid vs Vancomycin in Ventilator-Associated Pneumonia Due to Methicillin-Resistant Staphylococcus aureus

(2008) Richard G. Wunderink et al.   CHEST

Renal function as a predictor of linezolid-induced thrombocytopenia

(2008) Kazuaki Matsumoto et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Linezolid (ZYVOX), the First Member of a Completely New Class of Antibacterial Agents for Treatment of Serious Gram-Positive Infections

(2008) Steven J. Brickner et al.   JOURNAL OF MEDICINAL CHEMISTRY

Crystal Structure of the Oxazolidinone Antibiotic Linezolid Bound to the 50S Ribosomal Subunit∥

(2008) Joseph A. Ippolito et al.   JOURNAL OF MEDICINAL CHEMISTRY

Linezolid pharmacokinetic/pharmacodynamic profile in critically ill septic patients: intermittent versus continuous infusion

(2007) Chiara Adembri et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS