Article
Immunology
Sinem Nihal Esatoglu, Koray Tascilar, Hakan Babaoglu, Cemal Bes, Berna Yurttas, Servet Akar, Ozlem Pehlivan, Cansu Akleylek, Duygu Tecer, Emire Seyahi, Tuba Yuce-Inel, Nilufer Alpay-Kanitez, Erdal Bodakci, Emre Tekgoz, Seda Colak, Ertugrul Cagri Bolek, Suleyman Serdar Koca, Umut Kalyoncu, Ozan Cemal Icacan, Serdal Ugurlu, Hande Ece Oz, Vedat Hamuryudan, Gulen Hatemi
Summary: This study found that among patients with inflammatory rheumatic diseases (IRDs) and COVID-19, factors such as glucocorticoid use, chronic kidney disease, pulmonary disease, and obesity were associated with worse outcomes, while biologic disease-modifying antirheumatic drugs did not seem to be associated with worse outcomes.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Rheumatology
Charalampos Papagoras, George E. Fragoulis, Nikoleta Zioga, Theodora Simopoulou, Kleopatra Deftereou, Eleni Kalavri, Evangelia Zampeli, Nafsika Gerolymatou, Evangelia Kataxaki, Konstantinos Melissaropoulos, Stylianos Panopoulos, Kalliopi Fragiadaki, Gerasimos Evangelatos, Vasiliki-Kalliopi Bournia, Aikaterini Arida, Anastasios Karamanakos, Maria Pappa, Alexandros Panagiotopoulos, Christos Koutsianas, Georgia Mparouta, Theodoros Dimitroulas, Stamatis-Nick Liossis, Maria G. Tektonidou, Evrydiki Kravvariti, Nikolaos Kougkas, Panagiotis Georgiou, Paraskevi Voulgari, Antonia Elezoglou, Dimitrios P. Bogdanos, Dimitrios Vassilopoulos, Petros P. Sfikakis
Summary: Vaccinated patients with systemic rheumatic diseases who experience breakthrough COVID-19 have better outcomes compared to unvaccinated patients with similar disease characteristics. This highlights the importance of COVID-19 vaccination in vulnerable populations like those with SRDs.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Rheumatology
Anja Strangfeld, Martin Schafer, Milena A. Gianfrancesco, Saskia Lawson-Tovey, Jean W. Liew, Lotta Ljung, Elsa F. Mateus, Christophe Richez, Maria J. Santos, Gabriela Schmajuk, Carlo A. Scire, Emily Sirotich, Jeffrey A. Sparks, Paul Sufka, Thierry Thomas, Laura Trupin, Zachary S. Wallace, Sarah Al-Adely, Javier Bachiller-Corral, Suleman Bhana, Patrice Cacoub, Loreto Carmona, Ruth Costello, Wendy Costello, Laure Gossec, Rebecca Grainger, Eric Hachulla, Rebecca Hasseli, Jonathan S. Hausmann, Kimme L. Hyrich, Zara Izadi, Lindsay Jacobsohn, Patricia Katz, Lianne Kearsley-Fleet, Philip C. Robinson, Jinoos Yazdany, Pedro M. Machado
Summary: Factors associated with COVID-19-related death in people with rheumatic diseases include age, sex, comorbidities, disease activity, and specific medications. Adequate disease control with disease-modifying anti-rheumatic drugs (DMARDs) without increasing glucocorticoid dosages is important, while caution may be required with certain medications such as rituximab and sulfasalazine.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Review
Immunology
Katja Lakota, Katja Perdan-Pirkmajer, Alojzija Hocevar, Snezna Sodin-Semrl, Ziga Rotar, Sasa Cucnik, Polona Zigon
Summary: Patients with autoimmune diseases are more susceptible to infections, and COVID-19 may trigger autoimmune responses, but autoantibodies following SARS-CoV-2 infection are likely transient. The risk of SARS-CoV-2 infection in patients with systemic autoimmune rheumatic diseases is slightly higher, but the course of the disease seems similar to the general population.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Azam Safary, Kamal Esalatmanesh, Amir Taher Eftekharsadat, Mohammad -Reza Jafari Nakjavani, Alireza Khabbazi
Summary: Vaccination against COVID-19 is important for achieving herd immunity and controlling the pandemic. However, a small number of people may develop autoimmune rheumatic diseases (ARDs) as a rare adverse reaction to the vaccines. This study identifies individuals who developed de-novo ARDs after COVID-19 vaccination, with a higher prevalence among those who received the AstraZeneca vaccine. Prompt diagnosis and treatment can prevent irreversible organ damage.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Medicine, General & Internal
Yan Xie, Evan Xu, Ziyad Al-Aly
Summary: This study finds that survivors of the acute phase of COVID-19 are at increased risk of developing various mental health disorders, including anxiety disorders, depressive disorders, and stress and adjustment disorders. The risk is even higher among those who were hospitalized or used medication. Therefore, addressing and prioritizing the mental health issues of COVID-19 survivors are crucial.
BMJ-BRITISH MEDICAL JOURNAL
(2022)
Article
Rheumatology
Richard Conway, Elena Nikiphorou, Christiana A. Demetriou, Candice Low, Kelly Leamy, John G. Ryan, Ronan Kavanagh, Alexander D. Fraser, John J. Carey, Paul O'Connell, Rachael M. Flood, Ronan H. Mullan, David J. Kane, Nicola Ambrose, Frances Stafford, Philip C. Robinson, Jean W. Liew, Rebecca Grainger, Geraldine M. McCarthy
Summary: This study used data from the COVID-19 Global Rheumatology Alliance to describe COVID-19 outcomes for people with rheumatic disease in Ireland. The results showed that there was no temporal trend in COVID-19-related hospitalization and mortality outcomes for these patients.
Article
Rheumatology
Alla Skapenko, Hendrik Schulze-Koops
Summary: Since the start of the SARS-CoV-2 vaccination campaign, our understanding of the effects of vaccines on people with inflammatory rheumatic diseases has been limited. However, three notable papers from the past year have provided key insights and filled these knowledge gaps.
NATURE REVIEWS RHEUMATOLOGY
(2023)
Article
Clinical Neurology
Chiara Pizzamiglio, Robert D. S. Pitceathly, Michael P. Lunn, Stefen Brady, Fabiola De Marchi, Lucia Galan, Jeannine M. Heckmann, Alejandro Horga, Maria J. Molnar, Acary S. B. Oliveira, Wladimir B. V. R. Pinto, Guido Primiano, Ernestina Santos, Benedikt Schoser, Serenella Servidei, Paulo V. Sgobbi Souza, Vishnu Venugopalan, Michael G. Hanna, Mazen M. Dimachkie, Pedro M. Machado
Summary: Factors associated with the severity of COVID-19 outcomes in people with neuromuscular diseases (NMDs) include age, race/ethnicity, baseline functional status, comorbidities, history of respiratory dysfunction, obesity, number of comorbidities, glucocorticoid treatment, and Guillain-Barre syndrome.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Review
Medicine, General & Internal
Jamie Hartmann-Boyce, James Gunnell, Jonny Drake, Afolarin Otunla, Jana Suklan, Ella Schofield, Jade Kinton, Matt Inada-Kim, F. D. Richard Hobbs, Paddy Dennison
Summary: The evidence on the association between COVID-19 and asthma is limited, necessitating further research on possible interventions to support asthma care. Current consensus suggests continuing asthma medications and exploring self-management and remote interventions during disruptions in asthma care caused by the pandemic.
BMJ EVIDENCE-BASED MEDICINE
(2021)
Article
Immunology
Zixi Yi, Zhongqiang Yao, Dan Xu, Chuanhui Xu, Wenqiang Fang, Zhanfei Guo, Yong Wang, Jianlin Huang, Qin Li, Hong Zhang, Anbin Huang, Lijun Wu, Zhenbiao Wu, Huifang Guo, Fengxiao Zhang, Jing Lu, Zhenchun Zhang, Zhongming Yu, Zhanyun Da, Li Luo, Bin Wu, Henglian Wu, Lin Zeng, Rong Mu
Summary: The study highlights the intentions and actual vaccination rates among patients with rheumatic diseases in China. The majority of patients intended to get vaccinated, but the actual vaccination rate was low. Male, employed, high-income patients and those with inactive disease showed a more positive attitude towards vaccination. Concerns about adverse events and disease flare were the main factors affecting vaccination willingness. Furthermore, a significant portion of patients felt that they did not receive enough information about the COVID-19 vaccine from their doctors.
Review
Rheumatology
Bogna Grygiel-Gorniak
Summary: The medical community is actively researching new therapeutic options for combating COVID-19, including potential use of antimalarial medications. The differences in the use and dosages of chloroquine/hydroxychloroquine in treating rheumatic diseases versus viral infections have been noted, with recent studies suggesting possible interference with the efficacy of certain antiviral drugs.
CLINICAL RHEUMATOLOGY
(2022)
Article
Medicine, General & Internal
Marta Rorat, Dorota Zarebska-Michaluk, Justyna Kowalska, Krzysztof Kujawa, Magdalena Rogalska, Dorota Kozielewicz, Beata Lorenc, Katarzyna Sikorska, Piotr Czupryna, Beata Bolewska, Jadwiga Maciukajc, Tomasz Piekos, Regina Podlasin, Anna Dworzanska, Wlodzimierz Mazur, Michal Brzdek, Anna Szymanek-Pasternak, Robert Flisiak
Summary: Patients with systemic autoimmune rheumatic disease (SARD) are more susceptible to SARS-CoV-2 infection. This study compared the characteristics, severity, course, and outcomes of COVID-19 in SARD patients with the non-SARD group. Factors associated with prognosis, including remdesivir therapy efficacy, were also examined. The study found that SARD patients had longer hospital stays, higher mortality rates, and a greater need for oxygen therapy compared to the non-SARD group. Age, the presence of cardiovascular disease, severity of condition on admission, and higher inflammatory marker values were identified as risk factors for death in the SARD group. Remdesivir treatment showed a trend towards improved mortality in SARD patients but was not statistically significant. Overall, SARD patients had worse outcomes and were more likely to have other chronic diseases.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Rheumatology
Megan Rutter, Peter C. Lanyon, Matthew J. Grainge, Richard Hubbard, Emily Peach, Mary Bythell, Peter Stilwell, Jeanette Aston, Sarah Stevens, Fiona A. Pearce
Summary: During the first wave of COVID-19 in England, people with rare autoimmune rheumatic diseases (RAIRD) had a 54% increased risk of COVID-19 infection and more than twice the risk of COVID-19-related death compared with the general population.
Review
Rheumatology
Rebecca Grainger, Pedro M. Machado, Philip C. Robinson
Summary: This review discusses the risk of infection, outcomes, and risk factors for poor outcomes in patients with rheumatic disease in the context of COVID-19. It also explores data from other immune-mediated diseases, limitations of current research efforts, translation of knowledge into practice guidance, and future research agenda.
BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY
(2021)
Article
Rheumatology
Rayan Najjar, Swetha A. A. Alexander, Grant C. C. Hughes, Jinoos Yazdany, Namrata Singh
Summary: This study evaluated independent risk factors for readmission in patients with systemic lupus erythematosus (SLE) and identified the major reasons for readmission. The results showed that younger age, SLE-related manifestations, and public insurance were the strongest risk factors for 30-day readmission. These findings can help improve health outcomes for SLE patients through targeted interventions.
ARTHRITIS CARE & RESEARCH
(2023)
Article
Rheumatology
Alfredo Aguirre, Zara Izadi, Laura Trupin, Kamil E. Barbour, Kurt J. Greenlund, Patti Katz, Cristina Lanata, Lindsey Criswell, Maria Dall'Era, Jinoos Yazdany
Summary: This study analyzed racial and ethnic differences in the risk of end-organ lupus manifestations following SLE diagnosis. The results showed that Hispanic and Asian patients with SLE had heightened risks of developing renal, hematologic, and multiorgan disease.
ARTHRITIS CARE & RESEARCH
(2023)
Article
Rheumatology
Ben Darlow, Melanie Brown, Ben Hudson, Gareth Frew, Jane Clark, Loren Vincent, Rebecca Grainger, Carlo Marra, Eileen McKinlay, J. Haxby Abbott, Andrew M. Briggs
Summary: The article explores the application of a pharmacist-led service model for patients with knee osteoarthritis (OA). Through the pharmacist's professional knowledge and trustworthiness, as well as the patients' welcome and expectation of more support, better information and support can be provided for patients with knee OA.
MUSCULOSKELETAL CARE
(2023)
Article
Rheumatology
Shilpa Arora, Patricia Katz, Ailda Nika, Winston Sequeira, Joel A. A. Block, Jinoos Yazdany, Ed Yelin, Meenakshi Jolly
Summary: This study aimed to examine the association between high quality of care (QOC) and quality of life (QOL) and nonroutine health care use (HCU) in systemic lupus erythematosus. The study found that higher QOC was associated with worse scores on SF-36 domains at baseline, which was influenced by comorbidities and high disease activity. The results show that high QOC is not predictive of significant improvement in SF-36 scores and nonroutine HCU on follow-up.
ARTHRITIS CARE & RESEARCH
(2023)
Article
Rheumatology
Tiffany Taylor, Christine Anastasiou, Clairissa Ja, Stephanie Rush, Laura Trupin, Maria Dall'Era, Patricia Katz, Kamil E. Barbour, Kurt J. Greenlund, Jinoos Yazdany, Milena A. Gianfrancesco
Summary: This study found that individuals with systemic lupus erythematosus (SLE) of non-White populations, particularly Asian and Hispanic individuals, have a higher risk of cardiovascular disease (CVD) mortality compared to the general population.
ARTHRITIS CARE & RESEARCH
(2023)
Article
Rheumatology
Sinead Maguire, Samar Al-Emadi, Paula Alba, Mathia Cecilia Aguiar, Talal Al Lawati, Gelsomina Alle, Bonnie Bermas, Suleman Bhana, Anic Branimir, Inita Bulina, Megan Clowse, Karina Cogo, Iris Colunga, Claire Cook, Karen J. Cortez, Kathryn Dao, Milena Gianfrancesco, Monique Gore-Massey, Laure Gossec, Rebecca Grainger, Jonathon Hausman, Tiffany Y. T. Hsu, Kimme Hyrich, Carolina Isnardi, Yumeko Kawano, Rachael Kilding, Daria A. Kusevich, Saskia Lawson-Tovey, Jean Liew, Eoghan McCarthy, Anna Montgumery, Sebastian Moyano, Noreen Nasir, Ivan Padjen, Charalampos Papagoras, Naomi J. Patel, Mariana Pera, Cecilia Pisoni, Guillermo Pons-Estel, Antonio L. Quiambao, Rosana Quintana, Eric Ruderman, Sebastian Sattui, Veronica Savio, Savino Sciascia, Marieta Sencarova, Rosa Serrano Morales, Faizah Siddique, Emily Sirotich, Jeffrey Sparks, Anja Strangfeld, Paul Sufka, Helen Tanner, Yohana Tissera, Zachary Wallace, Marina L. Werner, Leanna Wise, Angus B. Worthing, JoAnn Zell, Julija Zepa, Pedro M. Machado, Jinoos Yazdany, Philip Robinson, Richard Conway
Summary: This study describes obstetric outcomes based on COVID-19 vaccination status in pregnant women with rheumatic and musculoskeletal diseases (RMDs). The results show that unvaccinated pregnant women have a higher rate of preterm births, and the need for COVID-19 pharmacological treatment is rare regardless of vaccination status.
Article
Medicine, General & Internal
Richard Conway, Elena Nikiphorou, Christiana A. Demetriou, Candice Low, Kelly Leamy, John G. Ryan, Ronan Kavanagh, Alexander D. Fraser, John J. Carey, Paul O'Connell, Rachael M. Flood, Ronan H. Mullan, David J. Kane, Frances Stafford, Philip C. Robinson, Jean W. Liew, Rebecca Grainger, Geraldine M. McCarthy
Summary: This study investigated the COVID-19 outcomes for individuals with rheumatic and musculoskeletal diseases in Ireland. The results showed that increasing age, gout, smoking, long-term glucocorticoid use, comorbidities, and specific comorbidities were associated with higher rates of hospitalization and mortality.
IRISH JOURNAL OF MEDICAL SCIENCE
(2023)
Article
Rheumatology
Kanon Jatuworapruk, Panchalee Satpanich, Philip C. Robinson, Rebecca Grainger
Summary: This study aimed to investigate the prevalence and outcomes of gout flare in COVID-19 hospitalized patients with comorbid gout. It was found that gout flare occurred in 18% of the hospitalized patients and added up to 3 days to the hospital length of stay.
JOURNAL OF RHEUMATOLOGY
(2023)
Article
Rheumatology
Tim McEwan, Jaspreet Bhambra, David F. Liew, Philip C. Robinson
Summary: This study aimed to identify reports of colchicine-induced neuropathy and myopathy and determine the risk factors associated with this toxicity at commonly used doses. A systematic review of case reports found 143 cases of neuromyopathy associated with the use of colchicine. Most cases presented with features of both neuropathy and myopathy, with symptoms of myopathy being predominant. Cessation of colchicine generally led to complete resolution of symptoms.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2023)
Article
Rheumatology
Rachel Ngan Kee, Valerie Milne, Nicola Dalbeth, Rebecca Grainger
Summary: This study aimed to explore the perspectives of patients with inflammatory rheumatic diseases on the important aspects of rheumatology services. The findings highlighted the importance of respecting and valuing patients' experiences and their families, providing timely and appropriate care, and supporting patient participation and education. In addition, new principles and statements were developed based on the patient-participants' feedback.
Article
Multidisciplinary Sciences
William Taylor, Robin Willink, Denise A. O'Connor, Vinay L. Patel, Allison Bourne, Ian Harris, Samuel Whittle, Bethan S. Richards, Ornella G. Clavisi, Sally Green, Rana Hinman, Chris Maher, Ainslie E. Cahill, Annie McPherson, Charlotte C. Hewson, Suzie May, Bruce Walker, Philip Robinson, Davina Ghersi, Jane Fitzpatrick, Tania Winzenberg, Kieran Fallon, Paul Glasziou, Laurent Billot, Rachelle Buchbinder
Summary: The Australia and New Zealand Musculoskeletal (ANZMUSC) Clinical Trials Network developed a Research Question Importance Tool (ANZMUSC-RQIT) to rank research projects based on their importance. The tool consists of 5 dimensions and is designed for scoring by committee consensus.
Article
Education & Educational Research
Qian Liu, Tehmina Gladman, Christina Grove, Sally Eberhard, Susan Geertshuis, Anthony Ali, Phil Blyth, Rebecca Grainger
Summary: Research shows that students use technologies beyond what institutions provide, while most studies in Internet-enabled learning focus on institutional or staff technologies. This misalignment may result in universities' online technologies being only partially relevant to student learning. By interviewing and analyzing 22 students from three New Zealand universities, the study reveals that students use non-institutional technologies to enhance institutional offerings, as they find institutional technologies overloaded with information and non-institutional technologies expedient in processing information and empowering their own learning. The study also identifies differences in technology use between high and low-achieving students, linked to motivation, technology awareness, and metacognition. It highlights the significance of non-institutional technologies in learning and has implications for future research, institutional technology design and implementation, and student preparation in technology-enhanced learning.
INTERNET AND HIGHER EDUCATION
(2023)
Article
Rheumatology
Ben Darlow, Melanie Brown, James Stanley, J. Haxby Abbott, Andrew M. Briggs, Jane Clark, Gareth Frew, Rebecca Grainger, Fiona Hood, Ben Hudson, Rawiri Keenan, Carlo Marra, Eileen McKinlay, Alison Pask, Andres Pierobon, Shirley Simmonds, Loren Vincent, Ross Wilson, Sarah Dean
Summary: The study aims to assess whether providing coordinated, community-based care through pharmacies can improve knee-related physical function and pain for patients with knee osteoarthritis. They will conduct a pragmatic randomized controlled trial and plan to perform health economic analysis and process evaluation.
MUSCULOSKELETAL CARE
(2023)
Review
Rheumatology
Brooke Conley, Samantha Bunzli, Jonathan Bullen, Penny O'Brien, Jennifer Persaud, Tilini Gunatillake, Michelle M. Dowsey, Peter F. Choong, Mandana Nikpour, Rebecca Grainger, Ivan Lin
Summary: This systematic review aims to identify Clinical Practice Guidelines (CPG) for gout management, evaluate their quality, and provide a synthesis of consistent recommendations. The findings show that for acute gout management, CPGs consistently recommend education, non-steroidal anti-inflammatories, colchicine or corticosteroids, and assessment of cardiovascular risk factors, renal function, and co-morbid conditions. For chronic gout management, consistent recommendations include urate lowering therapy (ULT) and continued prophylaxis based on individual patient characteristics. However, there are inconsistent recommendations regarding the initiation and duration of ULT, vitamin C intake, and the use of other pharmacological therapies such as pegloticase, fenofibrate, and losartan.
Article
Social Sciences, Interdisciplinary
Qian Liu, Tehmina Gladman, Julia Muir, Chen Wang, Rebecca Grainger
Summary: Researchers suggest using visualization dashboards to help educators improve learning design practice through learning analytics. This study developed a pedagogically useful and easy-to-use visualization solution for data-informed learning design, and evaluated it through interviews.
