Article
Cardiac & Cardiovascular Systems
Catarina Djupsjo, Jeanette Kuhl, Tomas Andersson, Magnus Lundback, Martin J. Holzmann, Thomas Nystrom
Summary: This study found that patients with disturbed blood glucose levels at emergency department admission have a higher mortality risk compared to patients with normal glucose tolerance. Patients with hyperglycemia have almost a two-fold increase in long-term mortality risk and more than a doubled risk for cardiovascular events compared to patients with normal glucose tolerance.
CARDIOVASCULAR DIABETOLOGY
(2022)
Review
Public, Environmental & Occupational Health
Rema Ramakrishnan, Jian-Rong He, Anne-Louise Ponsonby, Mark Woodward, Kazem Rahimi, Steven N. Blair, Terence Dwyer
Summary: The use of objective measures of physical activity, such as accelerometers, pedometers, and doubly labeled water method, shows a strong negative association with all cause mortality. Current physical activity recommendations based on questionnaire data may underestimate the true reduction in mortality risk associated with physical activity.
PREVENTIVE MEDICINE
(2021)
Article
Endocrinology & Metabolism
Bowen Zhu, Jian Zhang, Nana Song, Yiqin Shi, Yi Fang, Xiaoqiang Ding, Yang Li
Summary: The study found that both low and high serum uric acid levels were associated with increased mortality, supporting a U-shaped association only in non-diabetic individuals. For individuals with diabetes, declined eGFR rather than serum uric acid was identified as an independent risk factor for all-cause mortality.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Environmental Sciences
Qing Yan, Zhihao Xiao, Xianli Zhang, Gang Wang, Chunyu Zhong, Dezhi Qiu, Songming Huang, Lei Zheng, Zhe Gao
Summary: This study found that urinary levels of BCEP were positively associated with all-cause and cardiovascular mortality, while DPHP and BDCPP showed no significant associations. The economic burden associated with BCEP exposure was found to be substantial.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Infectious Diseases
Lucy McMullen, Liane Khoo, Lyndal Anderson, Simone Strasser, David M. Gracey
Summary: This article presents a rare case of post-liver transplant anaemia associated with BK viraemia. The severity of anaemia in the patient was correlated with high titres of BK virus in the serum and showed improvement with treatment.
BMC INFECTIOUS DISEASES
(2023)
Article
Medicine, General & Internal
Nicole Ruebsamen, Aleksandra Maceski, David Leppert, Pascal Benkert, Jens Kuhle, Heinz Wiendl, Annette Peters, Andre Karch, Klaus Berger
Summary: The study found that serum levels of neurofilament light chain (NfL) and tau are independently associated with all-cause mortality in elderly individuals. NfL levels are also correlated with neuropsychological test scores and brain structures.
Article
Nutrition & Dietetics
Lijing L. Yan, Chaoyun Li, Siyu Zou, Yaxi Li, Enying Gong, Zhengting He, Shuai Shao, Xurui Jin, Yechu Hua, John A. Gallis, Elizabeth L. Turner
Summary: This study analyzed the association between dietary patterns and mortality risk among Chinese adults aged 80 years and older, finding that healthier eating patterns were significantly associated with a reduced risk of all-cause mortality in this population.
INTERNATIONAL JOURNAL OF BEHAVIORAL NUTRITION AND PHYSICAL ACTIVITY
(2022)
Article
Cardiac & Cardiovascular Systems
Paddy C. Dempsey, Tessa Strain, Elisabeth A. H. Winkler, Kate Westgate, Kirsten L. Rennie, Nicholas J. Wareham, Soren Brage, Katrien Wijndaele
Summary: Accumulating sedentary behavior for longer durations is associated with higher rates of incident cancer and all-cause mortality, but not with cardiovascular disease. The findings suggest considering reducing sedentary behavior as an adjunct target for promoting less sitting and more movement.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Biochemistry & Molecular Biology
Sofia Malyutina, Vladimir Maximov, Olga Chervova, Pavel Orlov, Anastasiya Ivanova, Ekaterina Mazdorova, Andrew Ryabikov, Galina Simonova, Mikhail Voevoda
Summary: The copy number of mitochondrial DNA (mtDNA-CN) is inversely associated with all-cause natural mortality, particularly with increased risk of cardiovascular disease (CVD) and cancer-related death.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Huan Wang, Peter Donnan, E. Jane Macaskill, Lee Jordan, Alastair Thompson, Andy Evans
Summary: This study aimed to develop a pre-operative prognostic model based on known preoperative factors. A database of ultrasound (US) lesions undergoing biopsy was used to collect data, and predictive models for all-cause mortality (ACM) and breast cancer death (BCD) were built and validated. The results showed that a model based on preoperative factors, including tumor size, skin thickening, source of detection, tumor grade, ER status, pre-operative nodal metastasis, and chronic kidney disease (CKD), can predict BCD. The findings have potential implications for treatment planning and patient counselling.
Article
Cell Biology
Xu Zhang, Tak-Wah Lam, Hing-Fung Ting
Summary: By studying 397 lung adenocarcinoma patients, we identified a prognostic signature called GULPsig, which includes the genes IGF2BP1, IGF2BP3, SMC1B, CLDN6, and LY6K. Through gene expression comparison and regression analysis, we successfully predicted the prognosis of lung adenocarcinoma patients. The performance of GULPsig was validated in multiple independent datasets and found to outperform established prognostic markers.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Geriatrics & Gerontology
Xiaoyao Li, Keping Chen, Wei Hua, Yangang Su, Jiefu Yang, Zhaoguang Liang, Wei Xu, Shuang Zhao, Zeyi Li, Shu Zhang
Summary: This study examines the relationship between objective daily physical activity measured by implantable cardioverter defibrillators/cardiac resynchronization therapy defibrillators and long-term prognoses in high-risk patients above the age of 75. The results demonstrate that around 1.5 hours of daily physical activity is associated with lower all-cause mortality and cardiac death risk in these patients.
Article
Cell Biology
Kyukwang Kim, Mooyoung Kim, Andrew J. Lee, Sang-Hyun Song, Jun-Kyu Kang, Junghyun Eom, Young-Joon Kim, Gyeong Hoon Kang, Jeong Mo Bae, Sunwoo Min, Yeonsoo Kim, Yoojoo Lim, Han Sang Kim, Tae -You Kim, Inkyung Jung
Summary: This study investigates the regulatory effect of non-coding large-scale structural variations (SVs) on proto-oncogene activation by profiling 3D cancer genome maps. The analysis reveals the establishment of de novo chromatin contacts that span multiple topologically associating domains (TADs) and the occurrence of super-enhancer (SE) hijacking and its clonal characteristics. The activation of oncogenes and increased drug resistance due to SE hijacking are validated using CRISPR-Cas9. This research provides insights into the regulatory principles of large-scale SVs in oncogene activation and their clinical implications.
Article
Behavioral Sciences
Yaxi Li, Heng Jiang, Xurui Jin, Huali Wang, John S. Ji, Lijing L. Yan
Summary: There is a consistent dose-response pattern between cognitive impairment and all-cause mortality. Orientation is associated with mortality in the population without cognitive impairment.
BRAIN AND BEHAVIOR
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Matthias Eberhard, Ricarda Hinzpeter, Amadea L. N. Schoenenberger, Andre Euler, Nazar Kuzo, Kelly Reeve, Barbara E. Stahli, Albert M. Kasel, Robert Manka, Felix C. Tanner, Hatem Alkadhi
Summary: The study found that coronary artery calcium score can independently predict 30-day and 1-year mortality in patients undergoing TAVR. Adding the CAC score to the EuroSCORE II provides additional prognostic value for 1-year mortality risk.
