Polymorphic substitution E157Q in HIV-1 integrase increases R263K-mediated dolutegravir resistance and decreases DNA binding activity
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Title
Polymorphic substitution E157Q in HIV-1 integrase increases R263K-mediated dolutegravir resistance and decreases DNA binding activity
Authors
Keywords
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Journal
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
Volume 71, Issue 8, Pages 2083-2088
Publisher
Oxford University Press (OUP)
Online
2016-04-16
DOI
10.1093/jac/dkw109
References
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Related references
Note: Only part of the references are listed.- Non-virological response to a dolutegravir-containing regimen in a patient harbouring a E157Q-mutated virus in the integrase region
- (2015) F. Danion et al. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
- Dolutegravir Resistance Mutation R263K Cannot Coexist in Combination with Many Classical Integrase Inhibitor Resistance Substitutions
- (2015) Kaitlin Anstett et al. JOURNAL OF VIROLOGY
- Dolutegravir-Selected HIV-1 Containing the N155H and R263K Resistance Substitutions Does Not Acquire Additional Compensatory Mutations under Drug Pressure That Lead to Higher-Level Resistance and Increased Replicative Capacity
- (2015) Kaitlin Anstett et al. JOURNAL OF VIROLOGY
- Structural Studies of the HIV-1 Integrase Protein: Compound Screening and Characterization of a DNA-Binding Inhibitor
- (2015) Peter K. Quashie et al. PLoS One
- Implications for the future of the HIV epidemic if drug resistance against dolutegravir cannot occur in first-line therapy
- (2015) Mark A Wainberg et al. Journal of the International AIDS Society
- Integrase strand transfer inhibitors in the management of HIV-positive individuals
- (2014) Thibault Mesplède et al. ANNALS OF MEDICINE
- The R262K Substitution Combined with H51Y in HIV-1 Subtype B Integrase Confers Low-Level Resistance against Dolutegravir
- (2014) Vincent Cutillas et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Addition of E138K to R263K in HIV integrase increases resistance to dolutegravir, but fails to restore activity of the HIV integrase enzyme and viral replication capacity
- (2014) T. Mesplede et al. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
- Dolutegravir in Antiretroviral-Experienced Patients With Raltegravir- and/or Elvitegravir-Resistant HIV-1: 24-Week Results of the Phase III VIKING-3 Study
- (2014) A. Castagna et al. JOURNAL OF INFECTIOUS DISEASES
- The M50I polymorphic substitution in association with the R263K mutation in HIV-1 subtype B integrase increases drug resistance but does not restore viral replicative fitness
- (2014) Melissa Wares et al. Retrovirology
- Development of a fluorescence-based HIV-1 integrase DNA binding assay for identification of novel HIV-1 integrase inhibitors
- (2013) Ying-Shan Han et al. ANTIVIRAL RESEARCH
- Resistance to HIV Integrase Strand Transfer Inhibitors Among Clinical Specimens in the United States, 2009–2012
- (2013) Christopher B. Hurt et al. CLINICAL INFECTIOUS DISEASES
- Dolutegravir versus raltegravir in antiretroviral-experienced, integrase-inhibitor-naive adults with HIV: week 48 results from the randomised, double-blind, non-inferiority SAILING study
- (2013) Pedro Cahn et al. LANCET
- Once-daily dolutegravir versus twice-daily raltegravir in antiretroviral-naive adults with HIV-1 infection (SPRING-2 study): 96 week results from a randomised, double-blind, non-inferiority trial
- (2013) François Raffi et al. LANCET INFECTIOUS DISEASES
- Viral fitness cost prevents HIV-1 from evading dolutegravir drug pressure
- (2013) Thibault Mesplède et al. Retrovirology
- HIV-1 Integrase Inhibitor Resistance and Its Clinical Implications
- (2011) Jose-Luis Blanco et al. JOURNAL OF INFECTIOUS DISEASES
- Characterization of the R263K Mutation in HIV-1 Integrase That Confers Low-Level Resistance to the Second-Generation Integrase Strand Transfer Inhibitor Dolutegravir
- (2011) P. K. Quashie et al. JOURNAL OF VIROLOGY
- Quasispecies Theory and the Behavior of RNA Viruses
- (2010) Adam S. Lauring et al. PLoS Pathogens
- Rapid selection and archiving of mutation E157Q in HIV-1 DNA during short-term low-level replication on a raltegravir-containing regimen
- (2009) J. Ghosn et al. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
- Structural effects of amino acid variations between B and CRF02-AG HIV-1 integrases
- (2008) Isabelle Malet et al. JOURNAL OF MEDICAL VIROLOGY
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