The R262K Substitution Combined with H51Y in HIV-1 Subtype B Integrase Confers Low-Level Resistance against Dolutegravir

Resistance mutations against dolutegravir in HIV integrase impair the emergence of resistance against reverse transcriptase inhibitors

(2014) Maureen Oliveira et al.   AIDS

Development of a fluorescence-based HIV-1 integrase DNA binding assay for identification of novel HIV-1 integrase inhibitors

(2013) Ying-Shan Han et al.   ANTIVIRAL RESEARCH

What if HIV were unable to develop resistance against a new therapeutic agent?

(2013) Mark A Wainberg et al.   BMC Medicine

Dolutegravir: First Global Approval

(2013) Anita D. Ballantyne et al.   DRUGS

Dolutegravir versus raltegravir in antiretroviral-experienced, integrase-inhibitor-naive adults with HIV: week 48 results from the randomised, double-blind, non-inferiority SAILING study

(2013) Pedro Cahn et al.   LANCET

Viral fitness cost prevents HIV-1 from evading dolutegravir drug pressure

(2013) Thibault Mesplède et al.   Retrovirology

3′-Processing and strand transfer catalysed by retroviral integrasein crystallo

(2012) Stephen Hare et al.   EMBO JOURNAL

Resistance to HIV integrase inhibitors

(2012) Thibault Mesplède et al.   Current Opinion in HIV and AIDS

The development of novel HIV integrase inhibitors and the problem of drug resistance

(2012) Mark A Wainberg et al.   Current Opinion in Virology

HIV Drug Resistance and the Advent of Integrase Inhibitors

(2012) Peter K. Quashie et al.   Current Infectious Disease Reports

Dolutegravir (S/GSK1349572) Exhibits Significantly Slower Dissociation than Raltegravir and Elvitegravir from Wild-Type and Integrase Inhibitor-Resistant HIV-1 Integrase-DNA Complexes

(2011) Kendra E. Hightower et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

A protein-dependent side-chain rotamer library

(2011) Md Shariful Bhuyan et al.   BMC BIOINFORMATICS

Characterization of the R263K Mutation in HIV-1 Integrase That Confers Low-Level Resistance to the Second-Generation Integrase Strand Transfer Inhibitor Dolutegravir

(2011) P. K. Quashie et al.   JOURNAL OF VIROLOGY

Compensation by the E138K Mutation in HIV-1 Reverse Transcriptase for Deficits in Viral Replication Capacity and Enzyme Processivity Associated with the M184I/V Mutations

(2011) H.-T. Xu et al.   JOURNAL OF VIROLOGY

HIV-1 subtype B and C integrase enzymes exhibit differential patterns of resistance to integrase inhibitors in biochemical assays

(2010) Tamara Bar-Magen et al.   AIDS

Pre-calculated protein structure alignments at the RCSB PDB website: Fig. 1.

(2010) Andreas Prlić et al.   BIOINFORMATICS

Retroviral intasome assembly and inhibition of DNA strand transfer

(2010) Stephen Hare et al.   NATURE

I-TASSER: a unified platform for automated protein structure and function prediction

(2010) Ambrish Roy et al.   Nature Protocols

Dynamic patterns of human immunodeficiency virus type 1 integrase gene evolution in patients failing raltegravir-based salvage therapies

(2009) Filippo Canducci et al.   AIDS

I-TASSER server for protein 3D structure prediction

(2008) Yang Zhang   BMC BIOINFORMATICS