High susceptibility of MDR and XDR Gram-negative pathogens to biphenyl-diacetylene-based difluoromethyl-allo-threonyl-hydroxamate LpxC inhibitors

Drug design from the cryptic inhibitor envelope

(2016) Chul-Jin Lee et al.   Nature Communications

Optimizing the Initial Amikacin Dosage in Adults

(2015) Bryan P. White et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The Challenge of Efflux-Mediated Antibiotic Resistance in Gram-Negative Bacteria

(2015) Xian-Zhi Li et al.   CLINICAL MICROBIOLOGY REVIEWS

Genomic Insights into Intrinsic and Acquired Drug Resistance Mechanisms in Achromobacter xylosoxidans

(2014) Yongfei Hu et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Treatment of bloodstream infections in ICUs

(2014) Jean-François Timsit et al.   BMC INFECTIOUS DISEASES

LpxC Inhibitors as New Antibacterial Agents and Tools for Studying Regulation of Lipid A Biosynthesis in Gram-Negative Pathogens

(2014) A. P. Tomaras et al.   mBio

Structural Basis of the Promiscuous Inhibitor Susceptibility of Escherichia coli LpxC

(2013) Chul-Jin Lee et al.   ACS Chemical Biology

Carbapenemases in Klebsiella pneumoniae and Other Enterobacteriaceae: an Evolving Crisis of Global Dimensions

(2012) L. S. Tzouvelekis et al.   CLINICAL MICROBIOLOGY REVIEWS

Mechanisms DecreasingIn VitroSusceptibility to the LpxC Inhibitor CHIR-090 in the Gram-Negative Pathogen Pseudomonas aeruginosa

(2011) Ruth E. Caughlan et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria: an international expert proposal for interim standard definitions for acquired resistance

(2011) A.-P. Magiorakos et al.   CLINICAL MICROBIOLOGY AND INFECTION

Species-Specific and Inhibitor-Dependent Conformations of LpxC: Implications for Antibiotic Design

(2010) Chul-Jin Lee et al.   CHEMISTRY & BIOLOGY

Multidrug Resistance among Gram-Negative Pathogens That Caused Healthcare-Associated Infections Reported to the National Healthcare Safety Network, 2006–2008

(2010) Alexander J. Kallen et al.   INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY

Burden of antimicrobial resistance in European hospitals: excess mortality and length of hospital stay associated with bloodstream infections due to Escherichia coli resistant to third-generation cephalosporins

(2010) M. E. A. de Kraker et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY