Article
Microbiology
Sura Ali Al-Asadi, Rusul Emaduldeen S. Al-Kahachi, Wifaq M. Ali Alwattar, Jamila Bootwala, Majeed Arsheed Sabbah
Summary: Achromobacter denitrificans is an environmental opportunistic pathogen that infects immunocompromised patients. A recently identified strain, Achromobacter mucicolens, is known to induce a variety of disorders in hosts with underlying diseases. Due to its genetic constitution and acquired resistance, antibiotics face challenges in treating A. mucicolens. This study analyzed the genome of an isolated A. mucicolens strain and identified antibiotic resistance genes. In vitro studies confirmed the strain's resistance against a wide range of antibiotics. This investigation provides valuable insights for understanding the pathogenicity of A. mucicolens and offers new treatment options.
MICROBIOLOGY SPECTRUM
(2022)
Article
Infectious Diseases
Arnaud Magallon, Lucie Amoureux, Thomas Garrigos, Marine Sonois, Veronique Varin, Catherine Neuwirth, Julien Bador
Summary: The AxyABM efflux system plays a significant role in the acquired resistance of Achromobacter to commonly used antibiotics in CF patients, including ciprofloxacin, meropenem, and ceftazidime. Overproduction of AxyABM may also lead to increased minimum inhibitory concentration of the new promising antibiotic cefiderocol.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2022)
Article
Microbiology
S. M. Hossein Khademi, Migle Gabrielaite, Magnus Paulsson, Mattis Knulst, Eleni Touriki, Rasmus L. Marvig, Lisa Pahlman
Summary: Achromobacter xylosoxidans is an emerging bacterial species causing chronic airway infections in CF patients. The genomic and phenotypic analysis revealed that regulatory proteins and intergenic regions of this pathogen showed convergent evolution, leading to the development of adaptive phenotypes like antibiotic resistance and biofilm formation. The study highlights the importance of understanding bacterial pathogen adaptation for novel therapeutic interventions in chronic infections.
Article
Microbiology
Benjamin M. Bonis, Ryan C. Hunter
Summary: Achromobacter xylosoxidans is a resilient nosocomial pathogen with innate multi-drug resistance and virulence factors, leading to its persistence during long-term antibiotic therapy and association with poor clinical outcomes.
JOURNAL OF MEDICAL MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yani Liu, Fengdan Wei, Rui Xu, Tao Cheng, Yanling Ma
Summary: This study investigates the binding interaction between the crucial enzyme Catechol 1,2-dioxygenase (C12O) and the substrate catechol in Achromobacter xylosoxidans DN002. The results reveal the mechanism of the degradation pathway of polycyclic aromatic hydrocarbons and provide insights for further modifications and evolution of this enzyme.
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2023)
Article
Microbiology
Wei Wang, Hui Li, Menghan Li, Yinping Dong, Yao Bai, Fengqin Li, Jing Xiao
Summary: This study analyzed the antimicrobial resistance, biofilm formation, and genomic characteristics of ST88 MRSA collected from various foods in China and compared them with publicly available ST88 genomes worldwide. The results showed differences between ST88 MRSA in China and Africa and suggested a more recent clonal evolution in China. The molecular mechanisms of the global spread of ST88 MRSA remain unclear.
MICROBIOLOGY SPECTRUM
(2022)
Review
Infectious Diseases
Gianfranco La Bella, Francesco Salvato, Graziano Antonio Minafra, Irene Francesca Bottalico, Tiziana Rollo, Lucia Barbera, Samantha De Tullio, Gaetano Corso, Sergio Lo Caputo, Rosella De Nittis, Fabio Arena
Summary: In this study, we report a case of aortic endocarditis caused by A. xylosoxidans in a Non-Hodgkin lymphoma patient, which can cause infections in various body districts in patients with underlying diseases. The treatment of A. xylosoxidans infections is complicated by both intrinsic and acquired resistance.
Article
Oncology
Haiming Zhuang, Jigang Fan, Mingyu Li, Hao Zhang, Xiuyan Yang, Ligen Lin, Shaoyong Lu, Qing Wang, Yaqin Liu
Summary: The Y96D mutation in KRAS(G12C) causes resistance to the drug AMG510 by impairing the direct interaction between the drug and residue 96, resulting in the opening and loosening of the drug binding pocket.
FRONTIERS IN ONCOLOGY
(2022)
Article
Food Science & Technology
Reem AlJindan, Doaa M. M. AlEraky, Maha Farhat, Noor B. B. Almandil, Sayed AbdulAzeez, Jesu Francis Borgio
Summary: A multidrug-resistant strain of Clostridium perfringens was isolated and identified using 16s rRNA sequencing. The strain's genome analysis revealed the presence of antibiotic susceptibility genes as well as antibiotic-resistant genes and virulence factors. This is the first report on whole genome sequencing of C. perfringens in Saudi Arabia, confirming it as a multidrug-resistant bacterium with multiple virulence factors.
Review
Immunology
Nicholas C. Poulton, Jeremy M. Rock
Summary: Tuberculosis is a challenging infection to treat and requires long-term multidrug therapy. One major difficulty is the resistance of the infecting bacterium to various classes of antimicrobials. This review discusses the gaps in our understanding of intrinsic drug resistance in tuberculosis and the potential of functional and chemical genetics to address these gaps.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Review
Medicine, General & Internal
Firdoos Ahmad Gogry, Mohammad Tahir Siddiqui, Insha Sultan, Qazi Mohd Rizwanul Haq
Summary: The global interest in colistin has risen due to the prevalence of multidrug-resistant Gram-negative Enterobacteriaceae, leading to the emergence of colistin-resistant bacteria. However, some Gram-negative species are intrinsically resistant to colistin, and most identified colistin resistance involves modification of lipid A to decrease or remove interaction with colistin. Changes in membrane structure, specifically in the outer membrane lipopolysaccharide (LPS), play a key role in colistin resistance mechanisms. New methods and approaches are being developed to detect and combat colistin resistance, with a focus on developing less toxic and more effective drugs to treat bacterial infections.
FRONTIERS IN MEDICINE
(2021)
Article
Microbiology
Dorothea K. Thompson, Stephen M. Sharkady
Summary: Cedecea, a genus in the Enterobacteriaceae family, includes opportunistic pathogens like Cedecea neteri, which is associated with bacteremia in immunocompromised hosts and shows resistance to various antibiotics. This study analyzed drug resistance genes in C. neteri using whole-genome sequence data from three environmental strains, revealing multiple beta-lactamase genes and RND-type multidrug efflux pumps. The study provides new insights into drug resistance mechanisms in environmental microorganisms with clinical relevance.
Article
Genetics & Heredity
Johann S. Hawe, Rory Wilson, Katharina T. Schmid, Li Zhou, Lakshmi Narayanan Lakshmanan, Benjamin C. Lehne, Brigitte Kuehnel, William R. Scott, Matthias Wielscher, Yik Weng Yew, Clemens Baumbach, Dominic P. Lee, Eirini Marouli, Manon Bernard, Liliane Pfeiffer, Pamela R. Matias-Garcia, Matias Autio, Stephane Bourgeois, Christian Herder, Ville Karhunen, Thomas Meitinger, Holger Prokisch, Wolfgang Rathmann, Michael Roden, Sylvain Sebert, Jean Shin, Konstantin Strauch, Weihua Zhang, Wilson L. W. Tan, Stefanie M. Hauck, Juliane Merl-Pham, Harald Grallert, Eudes G. Barbosa, Thomas Illig, Annette Peters, Tomas Paus, Zdenka Pausova, Panos Deloukas, Roger S. Y. Foo, Marjo-Riitta Jarvelin, Jaspal S. Kooner, Marie Loh, Matthias Heinig, Christian Gieger, Melanie Waldenberger, John C. Chambers
Summary: This study focuses on the relationships between DNA sequence variation and DNA methylation, using blood samples from Europeans and South Asians. The findings reveal numerous SNP-CpG associations (meQTL) that are functionally relevant and associated with gene expression, metabolic variation, and clinical traits. Molecular interaction and colocalization analyses identified regulatory pathways linking meQTL loci to phenotypic variation.
Article
Immunology
Xiaoxue Wu, Shuting Huang, Weiling He, Mei Song
Summary: HER2 is a therapeutic target in various types of cancer with HER2 overexpression or genomic alterations. Trastuzumab, a humanized monoclonal antibody targeting HER2, has improved the clinical outcomes of HER2-positive patients. However, resistance to trastuzumab poses a challenge, and this review explores the mechanisms of resistance and discusses potential strategies for improving patient outcomes through rational combinations.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
Dongya Wu, Enhui Shen, Bowen Jiang, Yu Feng, Wei Tang, Sangting Lao, Lei Jia, Han-Yang Lin, Lingjuan Xie, Xifang Weng, Chenfeng Dong, Qinghong Qian, Feng Lin, Haiming Xu, Huabing Lu, Luan Cutti, Huajun Chen, Shuiguang Deng, Longbiao Guo, Tse-Seng Chuah, Beng-Kah Song, Laura Scarabel, Jie Qiu, Qian-Hao Zhu, Qin Yu, Michael P. Timko, Hirofumi Yamaguchi, Aldo Merotto, Yingxiong Qiu, Kenneth M. Olsen, Longjiang Fan, Chu-Yu Ye
Summary: This study provides genomic insights into the dual roles of Echinochloa species as weeds and crops, revealing the complex evolution and constrained disease-related gene copy numbers in Echinochloa. The research also uncovers deep population differentiation, herbicide resistance mutations, and limited domestication of barnyard millets. These results offer essential resources for studying plant polyploidization, adaptation, precision weed control, and millet improvements.
NATURE COMMUNICATIONS
(2022)
Article
Agronomy
Xiaolu Jin, Guanggen Huang, Zheng Luo, Yongfei Hu, Dan Liu
Summary: The potential effects of oregano essential oil (OEO) on preventing necrotic enteritis (NE) caused by Clostridium perfringens (Cp) in chickens were evaluated in this study. The results showed that OEO had significant effects on increasing body weight gain and reversing the dropped feed intake. OEO also alleviated histopathological changes in the ileums of broiler chickens and had limited effects on tight junction-related gene expressions. OEO is proposed as a promising substitute for antibiotics against NE induced by Cp during poultry production.
Article
Gastroenterology & Hepatology
Na Wu, Yu-Qing Feng, Na Lyu, Di Wang, Wei-Dong Yu, Yong-Fei Hu
Summary: In this study, it was demonstrated that F. nucleatum infection altered the colon mucosal microbiota by enriching pathogens related to the development of CRC, providing new insights into the role of F. nucleatum in the oncogenic microbial environment of the colon.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Microbiology
Zijie Wang, Yifan Chen, Wenhui Wang, Caiyun Huang, Yongfei Hu, Lee Johnston, Fenglai Wang
Summary: This study investigated the effects of fine-grinding wheat bran on the body condition, lipid metabolism, inflammatory response, and gut microbiota of pregnant sows. The results showed that feeding pregnant sows with fine wheat bran improved their body condition, metabolic and inflammatory status, and reproductive performance. The supplementation of fine wheat bran also led to changes in the gut microbiota structure and increased the levels of short-chain fatty acids.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Microbiology
Chang Xu, Fuxiao Wei, Xinyue Yang, Yuqing Feng, Dan Liu, Yongfei Hu
Summary: In this study, 57 Lactobacillus strains were isolated from the gut microbiota of 17 different chicken breeds in China, and their probiotic properties were characterized. One particular strain, L. salivarius CML352, showed high acid and bile salt tolerance, hydrophobicity, auto-aggregation, and antibacterial activities. Dietary supplementation of this strain improved the gut health and production performance of late-phase laying hens, reducing abdominal fat deposition and improving egg quality.
Article
Multidisciplinary Sciences
Yuqing Feng, Dan Liu, Yan Liu, Xinyue Yang, Meihong Zhang, Fuxiao Wei, Depeng Li, Yongfei Hu, Yuming Guo
Summary: This study investigated the interactions among chicken genetics, cecal microbiota, and muscle metabolites. The results showed that different chicken breeds have distinct microbial community structures and functions, and there are significant associations between heritable microbes and metabolites.
Article
Infectious Diseases
Yuhui Dong, Yuqing Feng, Xichao Ou, Chunfa Liu, Weixing Fan, Yanlin Zhao, Yongfei Hu, Xiangmei Zhou
Summary: This study conducted a comparative and phylogenetic analysis of Mycobacterium bovis genomes to enhance our understanding of its diversity, biogeography, and drug resistance. The analysis revealed six lineages of M. bovis with strong geographical distribution patterns. Additionally, a significant percentage of M. bovis isolates in China were found to exhibit drug resistance, and genomic variations associated with increased resistance risk were identified.
TRANSBOUNDARY AND EMERGING DISEASES
(2022)
Article
Microbiology
Fuxiao Wei, Xinyue Yang, Meihong Zhang, Chang Xu, Yongfei Hu, Dan Liu
Summary: This study investigated the effects of Akkermansia muciniphila (A. muciniphila) on lipid metabolism and egg quality in laying hens. The results showed that A. muciniphila supplementation could efficiently improve lipid metabolism, decrease body weight and fat deposition, and improve yolk lipid profile in laying hens. It also suggested that different preparations of A. muciniphila, including live, pasteurized, and lyophilized, have the potential for use as additives to improve laying hen production.
FRONTIERS IN MICROBIOLOGY
(2022)
Correction
Biology
Yuqing Feng, Yanan Wang, Baoli Zhu, George Fu Gao, Yuming Guo, Yongfei Hu
COMMUNICATIONS BIOLOGY
(2022)
Editorial Material
Multidisciplinary Sciences
Yongfei Hu, Dan Liu, Xiaolu Jin, Yuqing Feng, Yuming Guo
Article
Microbiology
Fei Liu, Shi-Hui Wang, Ding-Hong Jia, Hao Tan, Bo Wang, Rui-Lin Zhao
Summary: We developed a method for identifying F. filiformis strains using MNP-seq. By screening 179 universal MNP markers and constructing an MNP sequence library, we built a neighbor-joining phylogenetic tree of 232 cultivated and wild strains. Our analysis showed that all cultivars could be accurately separated and categorized into 22 distinct evolutionary pedigrees based on genetic similarity values.
Article
Pharmacology & Pharmacy
Depeng Li, Meihong Zhang, A. La Teng Zhu La, Zhengtian Lyu, Xin Li, Yuqing Feng, Dan Liu, Yuming Guo, Yongfei Hu
Summary: The study demonstrates that quercetin can reduce serum uric acid levels and alleviate hyperuricemia by modulating the gut microbiota. It was found that quercetin alters the structure and function of chicken cecal microbiota and increases the abundance of Lactobacillus aviarius. The isolated strain, L. aviarius CML180, promotes the growth of L. aviarius and reduces uric acid levels through the degradation of purine nucleosides.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Agriculture, Dairy & Animal Science
A. La Teng Zhu La, Yuqing Feng, Die Hu, Yimei Feng, Xiaolu Jin, Dan Liu, Yuming Guo, Gong Cheng, Yongfei Hu
Summary: This study optimized the enzymatic preparation of alginate oligosaccharide (AOS) and investigated its effects on the growth performance and gut health of broiler chickens. The results showed that AOS effectively promoted broiler chicken growth performance by modulating the chicken gut microbiota structure and function.
JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY
(2023)
Article
Agriculture, Dairy & Animal Science
Xinyue Yang, Depeng Li, Meihong Zhang, Yuqing Feng, Xiaolu Jin, Dan Liu, Yuming Guo, Yongfei Hu
Summary: Ginkgo biloba extract (GBE) can alleviate fatty liver hemorrhagic syndrome (FLHS) in laying hens by reshaping the composition of gut microbiota and improving antioxidant activity. It also promotes the production of short-chain fatty acids (SCFAs) that affect overall lipid metabolism. These findings lay the foundation for the use of GBE as an additive to prevent and control FLHS in the laying hen industry.
JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Xinyue Yang, Meihong Zhang, Yan Liu, Fuxiao Wei, Xin Li, Yuqing Feng, Xiaolu Jin, Dan Liu, Yuming Guo, Yongfei Hu
Summary: Accumulated evidence supports the beneficial role of inulin in alleviating metabolic dysfunction-associated fatty liver disease by modulating gut microbiota. The study found that the inulin-enriched Megamonas genus was inversely correlated with hepatic steatosis-related parameters. The newly isolated commensal bacterium M. funiformis CML154 was able to ameliorate fatty liver disease by activating the APN-AMPK-PPAR alpha signaling pathway.
NPJ BIOFILMS AND MICROBIOMES
(2023)
Article
Microbiology
Meihong Zhang, Depeng Li, Xinyue Yang, Fuxiao Wei, Qiu Wen, Yuqing Feng, Xiaolu Jin, Dan Liu, Yuming Guo, Yongfei Hu
Summary: Growing evidence suggests a close relationship between gut microbiota and chicken growth performance. Through integrated multi-omics analyses, this study reveals differences in gut microbiota composition and host-microbiota interactions between high body weight (HBW) and low body weight chickens. The HBW microbiota contributes to chicken growth by regulating gut function and homeostasis. Additionally, a specific bacterial consortium derived from HBW chickens shows potential as a chicken growth promoter. These findings provide new insights into the potential links between gut microbiota and chicken phenotypes, with implications for improving chicken growth performance.
