A pH-sensitive nanomedicine incorporating catalase gene and photosensitizer augments photodynamic therapy and activates antitumor immunity

Self‐Activatable Photo‐Extracellular Vesicle for Synergistic Trimodal Anticancer Therapy

(2021) Jingjing Ding et al.   ADVANCED MATERIALS

A Hypoxia Responsive Nanoassembly for Tumor Specific Oxygenation and Enhanced Sonodynamic Therapy

(2021) Kuikun Yang et al.   BIOMATERIALS

Hybrid Nanospheres to Overcome Hypoxia and Intrinsic Oxidative Resistance for Enhanced Photodynamic Therapy

(2020) Leilei Shi et al.   ACS Nano

Enhanced Ferroptosis by Oxygen-Boosted Phototherapy Based on a 2-in-1 Nanoplatform of Ferrous Hemoglobin for Tumor Synergistic Therapy

(2020) Tian Xu et al.   ACS Nano

Sequential PDT and PTT Using Dual‐Modal Single‐Walled Carbon Nanohorns Synergistically Promote Systemic Immune Responses against Tumor Metastasis and Relapse

(2020) Jingxing Yang et al.   Advanced Science

Fluorine assembly nanocluster breaks the shackles of immunosuppression to turn the cold tumor hot

(2020) Zhaoting Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanism of Iron Oxide-Induced Macrophage Activation: The Impact of Composition and the Underlying Signaling Pathway

(2019) Zhengying Gu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Redox-Activated Porphyrin-Based Liposome Remote-Loaded with Indoleamine 2,3-Dioxygenase (IDO) Inhibitor for Synergistic Photoimmunotherapy through Induction of Immunogenic Cell Death and Blockage of IDO Pathway

(2019) Dechun Liu et al.   NANO LETTERS

Eribulin Synergistically Increases Anti-Tumor Activity of an mTOR Inhibitor by Inhibiting pAKT/pS6K/pS6 in Triple Negative Breast Cancer

(2019) Wei Wen et al.   Cells

Mild photothermal therapy potentiates anti-PD-L1 treatment for immunologically cold tumors via an all-in-one and all-in-control strategy

(2019) Liping Huang et al.   Nature Communications

Intratumoral injection of the seasonal flu shot converts immunologically cold tumors to hot and serves as an immunotherapy for cancer

(2019) Jenna H. Newman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stress-induced cellular responses in immunogenic cell death: Implications for cancer immunotherapy

(2018) Flavia Radogna et al.   BIOCHEMICAL PHARMACOLOGY

Targeted, Stimuli-Responsive Delivery of Plasmid DNA and miRNAs Using a Facile Self-Assembled Supramolecular Nanoparticle System

(2018) Li-Yen Wong et al.   BIOMACROMOLECULES

Perfluorohexane-cored nanodroplets for stimulations-responsive ultrasonography and O 2 -potentiated photodynamic therapy

(2018) Meng Yu et al.   BIOMATERIALS

Tumor Cell-Intrinsic Factors Underlie Heterogeneity of Immune Cell Infiltration and Response to Immunotherapy

(2018) Jinyang Li et al.   IMMUNITY

Photothermal Therapy Generates a Thermal Window of Immunogenic Cell Death in Neuroblastoma

(2018) Elizabeth E. Sweeney et al.   Small

A Multifunctional Biomimetic Nanoplatform for Relieving Hypoxia to Enhance Chemotherapy and Inhibit the PD-1/PD-L1 Axis

(2018) Mei-Zhen Zou et al.   Small

Elimination of established tumors with nanodisc-based combination chemoimmunotherapy

(2018) Rui Kuai et al.   Science Advances

Combined local immunostimulatory radioisotope therapy and systemic immune checkpoint blockade imparts potent antitumour responses

(2018) Yu Chao et al.   Nature Biomedical Engineering

Tumor Oxygenation and Hypoxia Inducible Factor-1 Functional Inhibition via a Reactive Oxygen Species Responsive Nanoplatform for Enhancing Radiation Therapy and Abscopal Effects

(2018) Lingtong Meng et al.   ACS Nano

Binary Cooperative Prodrug Nanoparticles Improve Immunotherapy by Synergistically Modulating Immune Tumor Microenvironment

(2018) Bing Feng et al.   ADVANCED MATERIALS

Hollow MnO2 as a tumor-microenvironment-responsive biodegradable nano-platform for combination therapy favoring antitumor immune responses

(2017) Guangbao Yang et al.   Nature Communications

Long-Circulating Au-TiO2 Nanocomposite as a Sonosensitizer for ROS-Mediated Eradication of Cancer

(2016) V. G. Deepagan et al.   NANO LETTERS

Immune Checkpoint Targeting in Cancer Therapy: Toward Combination Strategies with Curative Potential

(2015) Padmanee Sharma et al.   CELL

Big opportunities for small molecules in immuno-oncology

(2015) Jerry L. Adams et al.   NATURE REVIEWS DRUG DISCOVERY

Immunological mechanisms of the antitumor effects of supplemental oxygenation

(2015) Stephen M. Hatfield et al.   Science Translational Medicine

PD-L1 is a novel direct target of HIF-1α, and its blockade under hypoxia enhanced MDSC-mediated T cell activation

(2014) Muhammad Zaeem Noman et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cancer immunotherapy comes of age

(2011) Ira Mellman et al.   NATURE

Pattern Recognition Receptors and Inflammation

(2010) Osamu Takeuchi et al.   CELL

T regulatory cells: hypoxia-adenosinergic suppression and re-direction of the immune response

(2009) Michail V. Sitkovsky   TRENDS IN IMMUNOLOGY

Targeted Therapies to Improve Tumor Immunotherapy

(2008) J. Begley et al.   CLINICAL CANCER RESEARCH