Insights into polyketide biosynthesis gained from repurposing antibiotic-producing polyketide synthases to produce fuels and chemicals

Alteration of Polyketide Stereochemistry from anti to syn by a Ketoreductase Domain Exchange in a Type I Modular Polyketide Synthase Subunit

(2016) Clara H. Eng et al.   BIOCHEMISTRY

Substrate structure–activity relationships guide rational engineering of modular polyketide synthase ketoreductases

(2016) Constance B. Bailey et al.   CHEMICAL COMMUNICATIONS

Divergent Mechanistic Routes for the Formation ofgem-Dimethyl Groups in the Biosynthesis of Complex Polyketides

(2015) Sean Poust et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Evaluating Ketoreductase Exchanges as a Means of Rationally Altering Polyketide Stereochemistry

(2015) Thibault Annaval et al.   CHEMBIOCHEM

Engineering a Polyketide Synthase for In Vitro Production of Adipic Acid

(2015) Andrew Hagen et al.   ACS Synthetic Biology

The Structure Elucidation and Total Synthesis of β-Lipomycin

(2014) Olaf Hartmann et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

α- and β-Lipomycin: Total Syntheses by Sequential Stille Couplings and Assignment of the Absolute Configuration of All Stereogenic Centers

(2014) Max L. Hofferberth et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

In Vitro Analysis of Carboxyacyl Substrate Tolerance in the Loading and First Extension Modules of Borrelidin Polyketide Synthase

(2014) Andrew Hagen et al.   BIOCHEMISTRY

Structure of a modular polyketide synthase

(2014) Somnath Dutta et al.   NATURE

Structural rearrangements of a polyketide synthase module during its catalytic cycle

(2014) Jonathan R. Whicher et al.   NATURE

Broad Substrate Specificity of the Loading Didomain of the Lipomycin Polyketide Synthase

(2013) Satoshi Yuzawa et al.   BIOCHEMISTRY

Enzyme analysis of the polyketide synthase leads to the discovery of a novel analog of the antibiotic α-lipomycin

(2013) Satoshi Yuzawa et al.   JOURNAL OF ANTIBIOTICS

In Vitro Reconstitution and Analysis of the 6-Deoxyerythronolide B Synthase

(2013) Brian Lowry et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Beyond ethylmalonyl-CoA: The functional role of crotonyl-CoAcarboxylase/reductase homologs in expanding polyketide diversity

(2011) Micheal C. Wilson et al.   NATURAL PRODUCT REPORTS

A Polylinker Approach to Reductive Loop Swaps in Modular Polyketide Synthases

(2008) Laurenz Kellenberger et al.   CHEMBIOCHEM

Top-down mass spectrometry on low-resolution instruments: Characterization of phosphopantetheinylated carrier domains in polyketide and non-ribosomal biosynthetic pathways

(2007) Dario Meluzzi et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS