Paired nicking-mediated COL17A1 reframing for junctional epidermolysis bullosa

Current developments in gene therapy for epidermolysis bullosa

(2022) Thomas Kocher et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Quantitative evaluation of chromosomal rearrangements in gene-edited human stem cells by CAST-Seq

(2021) Giandomenico Turchiano et al.   Cell Stem Cell

A non-viral and selection-free COL7A1 HDR approach with improved safety profile for dystrophic epidermolysis bullosa

(2021) Thomas Kocher et al.   Molecular Therapy-Nucleic Acids

Predictable CRISPR/Cas9-Mediated COL7A1 Reframing for Dystrophic Epidermolysis Bullosa

(2020) Thomas Kocher et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Context-Dependent Strategies for Enhanced Genome Editing of Genodermatoses

(2020) Oliver Patrick March et al.   Cells

Defining Epidermal Basal Cell States during Skin Homeostasis and Wound Healing Using Single-Cell Transcriptomics

(2020) Daniel Haensel et al.   Cell Reports

CRISPR Gene Therapy: Applications, Limitations, and Implications for the Future

(2020) Fathema Uddin et al.   Frontiers in Oncology

CRISPR-Cas9 genome editing induces megabase-scale chromosomal truncations

(2019) Grégoire Cullot et al.   Nature Communications

Clinically Relevant Correction of Recessive Dystrophic Epidermolysis Bullosa by Dual sgRNA CRISPR/Cas9-Mediated Gene Editing

(2019) Jose Bonafont et al.   MOLECULAR THERAPY

Efficient gene reframing therapy for recessive dystrophic epidermolysis bullosa using CRISPR/Cas9

(2019) Shota Takashima et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Gene editing-mediated disruption of epidermolytic ichthyosis-associated KRT10 alleles restores filament stability in keratinocytes

(2019) Oliver Patrick March et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Stem cell competition orchestrates skin homeostasis and ageing

(2019) Nan Liu et al.   NATURE

Microhomologies are prevalent at Cas9-induced larger deletions

(2019) Dominic D G Owens et al.   NUCLEIC ACIDS RESEARCH

Improved double-nicking strategies for COL7A1 editing by homologous recombination

(2019) Thomas Kocher et al.   Molecular Therapy-Nucleic Acids

Repair of double-strand breaks induced by CRISPR–Cas9 leads to large deletions and complex rearrangements

(2018) Michael Kosicki et al.   NATURE BIOTECHNOLOGY

The Galaxy platform for accessible, reproducible and collaborative biomedical analyses: 2018 update

(2018) Enis Afgan et al.   NUCLEIC ACIDS RESEARCH

Gene editing for skin diseases: designer nucleases as tools for gene therapy of skin fragility disorders

(2017) Oliver P. March et al.   EXPERIMENTAL PHYSIOLOGY

Cut and Paste: Efficient Homology-Directed Repair of a Dominant Negative KRT14 Mutation via CRISPR/Cas9 Nickases

(2017) Thomas Kocher et al.   MOLECULAR THERAPY

Regeneration of the entire human epidermis using transgenic stem cells

(2017) Tobias Hirsch et al.   NATURE

Type XVII collagen coordinates proliferation in the interfollicular epidermis

(2017) Mika Watanabe et al.   eLife

Traceless Targeting and Isolation of Gene-Edited Immortalized Keratinocytes from Epidermolysis Bullosa Simplex Patients

(2017) Magomet Aushev et al.   Molecular Therapy-Methods & Clinical Development

Cas-analyzer: an online tool for assessing genome editing results using NGS data

(2016) Jeongbin Park et al.   BIOINFORMATICS

Construction and validation of an RNA trans-splicing molecule suitable to repair a large number of COL7A1 mutations

(2016) B Tockner et al.   GENE THERAPY

Context-Dependent Regulation of Collagen XVII Ectodomain Shedding in Skin

(2015) Wataru Nishie et al.   AMERICAN JOURNAL OF PATHOLOGY

Error-Prone Repair of DNA Double-Strand Breaks

(2015) Kasey Rodgers et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Microhomology-Mediated End Joining: A Back-up Survival Mechanism or Dedicated Pathway?

(2015) Agnel Sfeir et al.   TRENDS IN BIOCHEMICAL SCIENCES

Cas-OFFinder: a fast and versatile algorithm that searches for potential off-target sites of Cas9 RNA-guided endonucleases

(2014) S. Bae et al.   BIOINFORMATICS

Double Nicking by RNA-Guided CRISPR Cas9 for Enhanced Genome Editing Specificity

(2013) F. Ann Ran et al.   CELL

High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells

(2013) Yanfang Fu et al.   NATURE BIOTECHNOLOGY

A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity

(2012) M. Jinek et al.   SCIENCE

Dynamic Interactions of Epidermal Collagen XVII with the Extracellular Matrix

(2011) Wataru Nishie et al.   AMERICAN JOURNAL OF PATHOLOGY