Impact of physical exercise and caloric restriction in patients with type 2 diabetes: Skeletal muscle insulin resistance and mitochondrial dysfunction as ideal therapeutic targets

Genetically increasing flux through β-oxidation in skeletal muscle increases mitochondrial reductive stress and glucose intolerance

(2021) Cody D. Smith et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Experimental models of lipid overload and their relevance in understanding skeletal muscle insulin resistance and pathological changes in mitochondrial oxidative capacity

(2021) Sinenhlanhla X.H. Mthembu et al.   BIOCHIMIE

Role of skeletal muscle lipids in the pathogenesis of insulin resistance of obesity and type 2 diabetes

(2021) Marc Gilbert   Journal of Diabetes Investigation

Vitamin K: A vital micronutrient with the cardioprotective potential against diabetes-associated complications

(2021) Kabelo Mokgalaboni et al.   LIFE SCIENCES

Rooibos Flavonoids, Aspalathin, Isoorientin, and Orientin Ameliorate Antimycin A-Induced Mitochondrial Dysfunction by Improving Mitochondrial Bioenergetics in Cultured Skeletal Muscle Cells

(2021) Sinenhlanhla Mthembu et al.   MOLECULES

Antimycin A-induced mitochondrial dysfunction is consistent with impaired insulin signaling in cultured skeletal muscle cells

(2021) Sithandiwe E. Mazibuko-Mbeje et al.   TOXICOLOGY IN VITRO

Functional changes induced by caloric restriction in cardiac and skeletal muscle mitochondria

(2020) Julian David C. Serna et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Skeletal Muscle Mitochondrial Adaptations to Maximal Strength Training in Older Adults

(2020) Ole Kristian Berg et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Augmented mitochondrial energy metabolism is an early response to chronic glucose stress in human pancreatic beta cells

(2020) Isabelle Chareyron et al.   DIABETOLOGIA

Effects of intermittent fasting or calorie restriction on markers of lipid metabolism in human skeletal muscle

(2020) Bo Liu et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Mitochondrial Dysfunction in Type 2 Diabetes Mellitus: An Organ-Based Analysis

(2019) Mark V Pinti et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Elevated free fatty acid level is associated with insulin-resistant state in nondiabetic Chinese people

(2019) Yanlu Xin et al.   Diabetes Metabolic Syndrome and Obesity-Targets and Therapy

Aspalathin-Enriched Green Rooibos Extract Reduces Hepatic Insulin Resistance by Modulating PI3K/AKT and AMPK Pathways

(2019) Sithandiwe Mazibuko-Mbeje et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Calorie restriction regime enhances physical performance of trained athletes

(2018) Victoria Pons et al.   Journal of the International Society of Sports Nutrition

Skeletal muscle phosphatidylcholine and phosphatidylethanolamine respond to exercise and influence insulin sensitivity in men

(2018) Sindre Lee et al.   Scientific Reports

Exercise Response Variations in Skeletal Muscle PCr Recovery Rate and Insulin Sensitivity Relate to Muscle Epigenomic Profiles in Individuals With Type 2 Diabetes

(2018) Natalie A. Stephens et al.   DIABETES CARE

Plasma Sulphur-Containing Amino Acids, Physical Exercise and Insulin Sensitivity in Overweight Dysglycemic and Normal Weight Normoglycemic Men

(2018) Sindre Lee et al.   Nutrients

Skeletal muscle insulin resistance: role of mitochondria and other ROS sources

(2017) Sergio Di Meo et al.   JOURNAL OF ENDOCRINOLOGY

Calorie Restriction-induced Weight Loss and Exercise Have Differential Effects on Skeletal Muscle Mitochondria Despite Similar Effects on Insulin Sensitivity

(2017) Elizaveta V Menshikova et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Effect of Resistance Training and Caloric Restriction on the Metabolic Syndrome

(2017) EVE NORMANDIN et al.   MEDICINE AND SCIENCE IN SPORTS AND EXERCISE

Adaptations to Endurance and Strength Training

(2017) David C. Hughes et al.   Cold Spring Harbor Perspectives in Medicine

Effects of Exercise and Aging on Skeletal Muscle

(2017) Giovanna Distefano et al.   Cold Spring Harbor Perspectives in Medicine

Impact of Resistance Training on Skeletal Muscle Mitochondrial Biogenesis, Content, and Function

(2017) Thomas Groennebaek et al.   Frontiers in Physiology

Alterations in Mitochondrial Oxidative Stress and Mitophagy in Subjects with Prediabetes and Type 2 Diabetes Mellitus

(2017) Shipra Bhansali et al.   Frontiers in Endocrinology

Long-term moderate calorie restriction inhibits inflammation without impairing cell-mediated immunity: a randomized controlled trial in non-obese humans

(2016) Simin N. Meydani et al.   Aging-US

Influence of exercise training with resveratrol supplementation on skeletal muscle mitochondrial capacity

(2016) Kristine R. Polley et al.   Applied Physiology Nutrition and Metabolism

TGF-β Contributes to Impaired Exercise Response by Suppression of Mitochondrial Key Regulators in Skeletal Muscle

(2016) Anja Böhm et al.   DIABETES

Physical Activity/Exercise and Diabetes: A Position Statement of the American Diabetes Association

(2016) Sheri R. Colberg et al.   DIABETES CARE

High-Protein Intake during Weight Loss Therapy Eliminates the Weight-Loss-Induced Improvement in Insulin Action in Obese Postmenopausal Women

(2016) Gordon I. Smith et al.   Cell Reports

Bariatric Surgery and Long-term Durability of Weight Loss

(2016) Matthew L. Maciejewski et al.   JAMA Surgery

Roles of Reactive Oxygen Species on Insulin Resistance in Adipose Tissue

(2016) Chang Yeop Han   Diabetes & Metabolism Journal

Mitochondrial fat oxidation is essential for lipid-induced inflammation in skeletal muscle in mice

(2016) Jaycob D. Warfel et al.   Scientific Reports

The role of protein in weight loss and maintenance

(2015) Heather J Leidy et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Insulin Resistance as a Physiological Defense Against Metabolic Stress: Implications for the Management of Subsets of Type 2 Diabetes

(2015) Christopher J. Nolan et al.   DIABETES

Mechanism by which caloric restriction improves insulin sensitivity in sedentary obese adults

(2015) Matthew L. Johnson et al.   DIABETES

Defects in Mitochondrial Efficiency and H2O2Emissions in Obese Women Are Restored to a Lean Phenotype With Aerobic Exercise Training

(2015) Adam R. Konopka et al.   DIABETES

Resistance Exercise Training Alters Mitochondrial Function in Human Skeletal Muscle

(2015) CRAIG PORTER et al.   MEDICINE AND SCIENCE IN SPORTS AND EXERCISE

Strength training improves muscle aerobic capacity and glucose tolerance in elderly

(2015) P. Frank et al.   SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS

Exercise training decreases activation of the mitochondrial fission protein dynamin-related protein-1 in insulin-resistant human skeletal muscle

(2014) Ciaran E. Fealy et al.   JOURNAL OF APPLIED PHYSIOLOGY

Role of diacylglycerol activation of PKCθ in lipid-induced muscle insulin resistance in humans

(2014) Julia Szendroedi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oxygen Consumption and Usage During Physical Exercise: The Balance Between Oxidative Stress and ROS-Dependent Adaptive Signaling

(2012) Zsolt Radak et al.   ANTIOXIDANTS & REDOX SIGNALING

Chronic Caloric Restriction Preserves Mitochondrial Function in Senescence without Increasing Mitochondrial Biogenesis

(2012) Ian R. Lanza et al.   Cell Metabolism

Physical Activity Is the Key Determinant of Skeletal Muscle Mitochondrial Function in Type 2 Diabetes

(2012) F. H. J. van Tienen et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Reversal of muscle insulin resistance by weight reduction in young, lean, insulin-resistant offspring of parents with type 2 diabetes

(2012) K. F. Petersen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effects of Physical Activity and Inactivity on Muscle Fatigue

(2012) Gregory C. Bogdanis   Frontiers in Physiology

Fatty Acids, Obesity, and Insulin Resistance: Time for a Reevaluation

(2011) F. Karpe et al.   DIABETES

High-fat feeding inhibits exercise-induced increase in mitochondrial respiratory flux in skeletal muscle

(2011) Mette Skovbro et al.   JOURNAL OF APPLIED PHYSIOLOGY

Stimulation of Human Whole-Body Energy Expenditure by Salsalate Is Fueled by Higher Lipid Oxidation under Fasting Conditions and by Higher Oxidative Glucose Disposal under Insulin-Stimulated Conditions

(2011) Ruth C. R. Meex et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Effect of physical training on mitochondrial respiration and reactive oxygen species release in skeletal muscle in patients with obesity and type 2 diabetes

(2010) M. Hey-Mogensen et al.   DIABETOLOGIA

Mitochondrial adaptations in skeletal muscle to hindlimb unloading

(2010) Akira Wagatsuma et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Intramuscular triacylglycerol and insulin resistance: Guilty as charged or wrongly accused?

(2009) Deborah M. Muoio   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Restoration of Muscle Mitochondrial Function and Metabolic Flexibility in Type 2 Diabetes by Exercise Training Is Paralleled by Increased Myocellular Fat Storage and Improved Insulin Sensitivity

(2009) R. C.R. Meex et al.   DIABETES

Age, Obesity, and Sex Effects on Insulin Sensitivity and Skeletal Muscle Mitochondrial Function

(2009) H. Karakelides et al.   DIABETES

Effect of exercise intensity and volume on persistence of insulin sensitivity during training cessation

(2009) Sudip Bajpeyi et al.   JOURNAL OF APPLIED PHYSIOLOGY

Caloric Restriction with or without Exercise

(2009) D. ENETTE LARSON-MEYER et al.   MEDICINE AND SCIENCE IN SPORTS AND EXERCISE

Reduced skeletal muscle mitochondrial respiration and improved glucose metabolism in nondiabetic obese women during a very low calorie dietary intervention leading to rapid weight loss

(2009) Rasmus Rabøl et al.   METABOLISM-CLINICAL AND EXPERIMENTAL