Aspalathin-Enriched Green Rooibos Extract Reduces Hepatic Insulin Resistance by Modulating PI3K/AKT and AMPK Pathways

Paeoniflorin Ameliorates Fructose-Induced Insulin Resistance and Hepatic Steatosis by Activating LKB1/AMPK and AKT Pathways

(2018) Yu-Cheng Li et al.   Nutrients

Activation of AMPK by Buddleja officinalis Maxim. Flower Extract Contributes to Protecting Hepatocytes from Oxidative Stress

(2017) Ji Yun Jung et al.   Evidence-based Complementary and Alternative Medicine

Green Rooibos Extract improves plasma lipid profile and oxidative status in diabetic non-human primates

(2017) Patrick Orlando et al.   FREE RADICAL BIOLOGY AND MEDICINE

The Transcription Profile Unveils the Cardioprotective Effect of Aspalathin against Lipid Toxicity in an In Vitro H9c2 Model

(2017) Rabia Johnson et al.   MOLECULES

Hyperglycemia-induced oxidative stress and heart disease-cardioprotective effects of rooibos flavonoids and phenylpyruvic acid-2-O-β-D-glucoside

(2017) Phiwayinkosi V. Dludla et al.   Nutrition & Metabolism

Myocardial Glucose Clearance by Aspalathin Treatment in Young, Mature, and Obese Insulin-Resistant Rats

(2017) Sybrand Smit et al.   PLANTA MEDICA

Palmitate induces fat accumulation by activating C/EBPβ-mediated G0S2 expression in HepG2 cells

(2017) Nai-Qian Zhao et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Altered glucose and lipid homeostasis in liver and adipose tissue pre-dispose inducible NOS knockout mice to insulin resistance

(2017) Babu Nageswararao Kanuri et al.   Scientific Reports

Induction of miR-96 by Dietary Saturated Fatty Acids Exacerbates Hepatic Insulin Resistance through the Suppression of INSR and IRS-1

(2017) Won-Mo Yang et al.   PLoS One

Timosaponin B-II Ameliorates Palmitate-Induced Insulin Resistance and Inflammation via IRS-1/PI3K/Akt and IKK/NF-κB Pathways

(2016) Yong-Liang Yuan et al.   AMERICAN JOURNAL OF CHINESE MEDICINE

Genetic and Pharmacological Inhibition of Malonyl CoA Decarboxylase Does Not Exacerbate Age-Related Insulin Resistance in Mice

(2016) John R. Ussher et al.   DIABETES

Aspalathin, a dihydrochalconeC-glucoside, protects H9c2 cardiomyocytes against high glucose induced shifts in substrate preference and apoptosis

(2016) Rabia Johnson et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Polyphenols and Glycemic Control

(2016) Yoona Kim et al.   Nutrients

The Compound of Mangiferin-Berberine Salt Has Potent Activities in Modulating Lipid and Glucose Metabolisms in HepG2 Cells

(2016) Can Wang et al.   Biomed Research International

Ampelopsin Improves Insulin Resistance by Activating PPARγ and Subsequently Up-Regulating FGF21-AMPK Signaling Pathway

(2016) Yong Zhou et al.   PLoS One

Oligonol suppresses lipid accumulation and improves insulin resistance in a palmitate-induced in HepG2 hepatocytes as a cellular steatosis model

(2015) Jae-Yeo Park et al.   BMC Complementary and Alternative Medicine

Silibinin improves palmitate-induced insulin resistance in C2C12 myotubes by attenuating IRS-1/PI3K/Akt pathway inhibition

(2015) H.B. Li et al.   BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH

Resveratrol improves hepatic insulin signaling and reduces the inflammatory response in streptozotocin-induced diabetes

(2015) Gökhan Sadi et al.   GENE

Increasing Adipocyte Lipoprotein Lipase Improves Glucose Metabolism in High Fat Diet-induced Obesity

(2015) R. Grace Walton et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

High-Fat Diet Alters Serum Fatty Acid Profiles in Obesity Prone Rats: Implications for In Vitro Studies

(2015) Tzu-Wen Liu et al.   LIPIDS

The role of fatty acids in insulin resistance

(2015) Barry Sears et al.   Lipids in Health and Disease

Aspalathin improves glucose and lipid metabolism in 3T3-L1 adipocytes exposed to palmitate

(2015) Sithandiwe E. Mazibuko et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Short-Term and Sub-Chronic Dietary Exposure to Aspalathin-Enriched Green Rooibos (Aspalathus linearis) Extract Affects Rat Liver Function and Antioxidant Status

(2015) Johanna van der Merwe et al.   MOLECULES

Nonalcoholic fatty liver disease: A main driver of insulin resistance or a dangerous liaison?

(2014) Nanda Gruben et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Antidiabetic effect of green rooibos (Aspalathus linearis) extract in cultured cells and type 2 diabetic model KK-Ay mice

(2014) Remi Kamakura et al.   CYTOTECHNOLOGY

Decoding insulin resistance and metabolic syndrome for promising therapeutic intervention

(2014) Shaodong Guo   JOURNAL OF ENDOCRINOLOGY

Xanthene Derivatives Increase Glucose Utilization through Activation of LKB1-Dependent AMP-Activated Protein Kinase

(2014) Yonghoon Kwon et al.   PLoS One

Akt/PKB activation and insulin signaling: a novel insulin signaling pathway in the treatment of type 2 diabetes

(2014) Richard Mackenzie et al.   Diabetes Metabolic Syndrome and Obesity-Targets and Therapy

Nonalcoholic fatty liver disease, hepatic insulin resistance, and type 2 Diabetes

(2013) Andreas L. Birkenfeld et al.   HEPATOLOGY

Recent advances in understanding the anti-diabetic actions of dietary flavonoids

(2013) Pon Velayutham Anandh Babu et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Cocoa flavonoids improve insulin signalling and modulate glucose production via AKT and AMPK in HepG2 cells

(2013) Isabel Cordero-Herrera et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin

(2013) Morgan D Fullerton et al.   NATURE MEDICINE

Amelioration of palmitate-induced insulin resistance in C2C12 muscle cells by rooibos (Aspalathus linearis)

(2013) S.E. Mazibuko et al.   PHYTOMEDICINE

Effects of fermented rooibos (Aspalathus linearis) on adipocyte differentiation

(2013) Micheline Sanderson et al.   PHYTOMEDICINE

The cardioprotective effect of an aqueous extract of fermented rooibos (Aspalathus linearis) on cultured cardiomyocytes derived from diabetic rats

(2013) P.V. Dludla et al.   PHYTOMEDICINE

Diacylglycerol Activation of Protein Kinase Cε and Hepatic Insulin Resistance

(2012) François R. Jornayvaz et al.   Cell Metabolism

Aspalathin improves hyperglycemia and glucose intolerance in obese diabetic ob/ob mice

(2012) Myoung Jin Son et al.   EUROPEAN JOURNAL OF NUTRITION

Variation in Phenolic Content and Antioxidant Activity of Fermented Rooibos Herbal Tea Infusions: Role of Production Season and Quality Grade

(2012) Elizabeth Joubert et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Acute assessment of an aspalathin-enriched green rooibos (Aspalathus linearis) extract with hypoglycemic potential

(2012) C.J.F. Muller et al.   PHYTOMEDICINE

Resveratrol improves insulin sensitivity, reduces oxidative stress and activates the Akt pathway in type 2 diabetic patients

(2011) Pál Brasnyó et al.   BRITISH JOURNAL OF NUTRITION

Suppression of Free Fatty Acid-Induced Insulin Resistance by Phytopolyphenols in C2C12 Mouse Skeletal Muscle Cells

(2011) Yea-Tzy Deng et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Enhancing liver mitochondrial fatty acid oxidation capacity in obese mice improves insulin sensitivity independently of hepatic steatosis

(2011) Julia Monsénégo et al.   JOURNAL OF HEPATOLOGY

Rooibos (Aspalathus linearis) beyond the farm gate: From herbal tea to potential phytopharmaceutical

(2011) E. Joubert et al.   SOUTH AFRICAN JOURNAL OF BOTANY

Development of Glucose Intolerance in Wistar Rats Fed Low and Moderate Fat Diets Differing in Fatty Acid Profile

(2010) A. Krygsman et al.   EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES

AMP-activated Protein Kinase and FoxO Transcription Factors in Dietary Restriction-induced Longevity

(2009) Eric L. Greer et al.   Annals of the New York Academy of Sciences

FoxO1 and hepatic lipid metabolism

(2009) Janet D Sparks et al.   CURRENT OPINION IN LIPIDOLOGY