Article
Pharmacology & Pharmacy
Kamila Butowska, Xuexiang Han, Ningqiang Gong, Rakan El-Mayta, Rebecca M. Haley, Lulu Xue, Wenqun Zhong, Wei Guo, Karin Wang, Michael J. Mitchell
Summary: Evasion of apoptosis is a characteristic of cancer, and overexpression of Bcl-2 is a contributing factor. Therapeutic targeting of Bcl-2 has shown efficacy in the clinic and is being extensively tested in combination with chemotherapy. Therefore, developing co-delivery systems for Bcl-2 targeting agents and chemotherapeutics, such as LNPs, holds promise for combination cancer therapies.
ACTA PHARMACEUTICA SINICA B
(2023)
Article
Pharmacology & Pharmacy
Cansu Umran Tunc, Omer Aydin
Summary: A multifunctional carrier system based on gold nanoparticles was developed for co-delivery of siRNAs against Bcl-2 and doxorubicin to enhance treatment efficacy against advanced breast cancer. The dual delivery of gene therapy and chemotherapy agents using this system showed efficient drug internalization, enhanced apoptosis, and inhibition of cancer cell proliferation. The nano-carrier system was proven effective in reducing colony formation and cell migration of breast cancer cells.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Review
Environmental Sciences
Nasim Ebrahimi, Mahdokht Sadat Manavi, Ahmad Nazari, Amirali Momayezi, Ferdos Faghihkhorasani, Al-Hasnawi Rasool Riyadh Abdulwahid, Fatemeh Rezaei-Tazangi, Mohammed Kavei, Roya Rezaei, Halimeh Mobarak, Amir Reza Aref, Wei Fang
Summary: RNA interference (RNAi) is a treatment approach used to decrease excessive gene expression in diseases, including cancer. However, challenges such as poor cellular uptake, off-target effects, and susceptibility to destruction restrict the therapeutic potential of small interfering RNAs (siRNAs). This research focuses on sophisticated nanocarriers that aid in the transport of siRNA payloads, their combination with anticancer medications, and their use in cancer treatment. It examines molecular manifestations, transport difficulties, delivery method design and development, and the advantages and disadvantages of various nanocarriers. Challenges such as siRNA trapping in endosomes and techniques for siRNA release are also discussed. The study also provides an evaluation of the current state of siRNA treatments in clinical trials for efficient cancer therapy.
ENVIRONMENTAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Mahshid Deldar Abad Paskeh, Maliheh Entezari, Courtney Clark, Amirhossein Zabolian, Ehsan Ranjbar, Mahdi Vasheghani Farahani, Hossein Saleki, Seyed Omid Sharifzadeh, Fatemeh Bakhtiari Far, Milad Ashrafizadeh, Saeed Samarghandian, Haroon Khan, Saeid Ghavami, Ali Zarrabi, Marek J. Los
Summary: Autophagy plays a dual role in normal cells and tumors, and targeting autophagy using nanoparticles can enhance cancer therapy. Nanocarriers can deliver autophagy regulators and chemotherapeutic agents, while nanomaterials can affect key components of autophagy.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2022)
Article
Biotechnology & Applied Microbiology
Rui Wang, Changming Zhao, Shuxia Jiang, Zhaohua Zhang, Chunmei Ban, Guiping Zheng, Yan Hou, Bingjin Jin, Yannan Shi, Xin Wu, Qiangqiang Zhao
Summary: This study provides a comprehensive overview of the application of nanoparticles in leukemia research, including diagnosis, treatment, and molecular mechanisms. It offers valuable references for researchers interested in nanoparticles-leukemia.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Jie Mi, Dandan Cui, Zhenhui Zhang, Gen Mu, Yujiao Shi
Summary: This study proposes a femtosecond-laser-pumped ultrafast photoacoustic cavitation technique that relies on nanomaterials to overcome the limitations of existing methods. The experimental results demonstrate the effectiveness and precision of this method in inhibiting tumor growth, highlighting its significance in the field of photoacoustic theranostics.
Article
Chemistry, Multidisciplinary
Jie Mi, Dandan Cui, Zhenhui Zhang, Gen Mu, Yujiao Shi
Summary: This study presents a femtosecond-laser-pumped ultrafast photoacoustic cavitation technique using nanoprobes coated with polyvinylpyrrolidone-40000 (PVP). The technique allows for sustainable and highly efficient shockwave theranostics, overcoming the limitations of nanodroplets. The experiments demonstrate significant anti-tumor effects and potential clinical applications.
Review
Biochemistry & Molecular Biology
Ghazaleh Khalili-Tanha, Meysam Moghbeli
Summary: Resistance to conventional chemotherapeutic agents like DOX is a major challenge in cancer therapy, necessitating the exploration of new treatment modalities. Long non-coding RNAs play critical roles in drug resistance in tumors, with many associated with DOX resistance. This review lays the groundwork for introducing an lncRNA panel marker to predict DOX response and clinical outcomes in cancer patients.
CELLULAR & MOLECULAR BIOLOGY LETTERS
(2021)
Article
Pharmacology & Pharmacy
Chih-Peng Lin, Shu-Hui Wu, Tzu-Yin Lin, Chia-Hui Chu, Leu-Wei Lo, Ching-Chuan Kuo, Jang-Yang Chang, Szu-Chun Hsu, Bor-Sheng Ko, Ming Yao, Jong-Kai Hsiao, Shih-Wei Wang, Dong-Ming Huang
Summary: This study develops a simple and versatile biological drug delivery system (bDDS) based on human red blood cell-derived vesicles (RDVs), which shows excellent biocompatibility for cancer chemotherapy. The bDDS, named Dox-gluRDVs, effectively suppress multidrug resistance in uterine sarcoma by inducing cell death through a lysosomal-mitochondrial axis-dependent mechanism.
PHARMACOLOGICAL RESEARCH
(2023)
Review
Nanoscience & Nanotechnology
Yingli Wu, Yu Yang, Xiaolin Lv, Menghan Gao, Xujin Gong, Qingqiang Yao, Yanna Liu
Summary: Ovarian cancer is commonly treated with combination therapy, such as paclitaxel and platinum anticancer drug. Nanoparticles provide opportunities to overcome the limitations of combination therapy by improving drug properties and increasing drug accumulation in targeted tissues. This review summarizes nanoparticle-based combination therapies for ovarian cancer, highlighting the advantages of nanocarriers in combination treatment.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Review
Medicine, Research & Experimental
Mehrdad Hashemi, Rezvaneh Aparviz, Marzie Beickzade, Mahshid Deldar Abad Paskeh, Simin Khorsand Kheirabad, Zeinab Khazaei Koohpar, Amir Moravej, Hossein Dehghani, Hamidreza Saebfar, Mohammad Arad Zandieh, Shokooh Salimimoghadam, Mohsen Rashidi, Afshin Taheriazam, Maliheh Entezari, Saeed Samarghandian
Summary: This review explores the potential applications of small interfering RNA (siRNA) and short hairpin RNA (shRNA) in the treatment of gastric cancer. It highlights the ability of siRNA to reduce the proliferation and invasion of gastric cancer cells and induce chemosensitivity. However, the unmodified siRNA faces challenges in translational potential. The role of nanostructures in facilitating siRNA delivery to gastric cancer cells and suppressing tumor progression is emphasized. The translation of these findings into clinical trials holds promise for advancing the treatment of gastric cancer.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Chemistry, Multidisciplinary
Sarah J. Shepherd, Claude C. Warzecha, Sagar Yadavali, Rakan El-Mayta, Mohamad-Gabriel Alameh, Lili Wang, Drew Weissman, James M. Wilson, David Issadore, Michael J. Mitchell
Summary: The study presents a scalable, parallelized microfluidic device (PMD) that can simultaneously operate 128 mixing channels, achieving over 100 times production rate compared to traditional methods for lipid nanoparticles (LNPs). Results demonstrate superior delivery of LNPS generated using PMD in mice, showing potential for emerging clinical applications such as RNA therapeutics and vaccines.
Review
Pharmacology & Pharmacy
Chao Dong, Jiao Wu, Yin Chen, Jianyun Nie, Ceshi Chen
Summary: Hyperactivation of the PI3K/AKT/mTOR pathway is associated with drug resistance and cancer progression in breast cancer patients. Current research is focusing on developing drugs targeting this pathway to overcome acquired resistance to standard therapies.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Zhiqing Zhang, Dongyan Xu, Jiawei Wang, Ruyan Zhang, Huan Du, Ting Zhou, Xiufeng Wang, Fang Wang
Summary: This study designed a DNA nano-assembly based on rolling circle amplification that can co-deliver doxorubicin (Dox) and siRNA simultaneously, achieving a comprehensive effect in tumor treatment.
Article
Biophysics
Ganeshlenin Kandasamy, Dipak Maity
Summary: Different therapeutic practices have evolved to improve cancer treatment. Nucleic acids therapy (NAT)/gene therapy has shown potential in inhibiting tumors and preventing relapse. Effective delivery of nucleic acids, particularly RNAs, is crucial. Nanocarriers such as liposomes, polymeric nanoparticles, and exosomes have been used to deliver them and enhance stability. Recent developments in non-targeted/targeted nanocarriers have focused on silencing important genes/mRNAs for abnormal protein production. The therapeutic effects on cancer growth, invasion, and metastasis have been discussed, along with advancements in combining siRNAs with approved chemotherapeutic drugs.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Review
Biochemistry & Molecular Biology
Sepideh Mirzaei, Mohammad Hossein Gholami, Amirhossein Zabolian, Hossein Saleki, Morteza Bagherian, Seyed Mohammadreza Torabi, Seyed Omid Sharifzadeh, Kiavash Hushmandi, Kaila R. Fives, Haroon Khan, Milad Ashrafizadeh, Ali Zarrabi, Anupam Bishayee
Summary: This review focuses on the therapeutic impacts of resveratrol (Res) in enhancing the antitumor activities of doxorubicin (DOX) and cisplatin (CP) while reducing their side effects. Co-administration of Res can overcome chemoresistance, induce apoptosis and cell cycle arrest in cancer cells, and enhance the sensitivity of cancer cells to DOX and CP chemotherapy. Additionally, Res ameliorates the adverse impacts of DOX and CP on normal cells and organs, and nanoformulations have been developed to improve its bioavailability and therapeutic effects.
CURRENT MOLECULAR PHARMACOLOGY
(2023)
Review
Biotechnology & Applied Microbiology
Negin Jalilinejad, Mohammad Rabiee, Nafiseh Baheiraei, Ramin Ghahremanzadeh, Reza Salarian, Navid Rabiee, Omid Akhavan, Payam Zarrintaj, Aleksander Hejna, Mohammad Reza Saeb, Ali Zarrabi, Esmaeel Sharifi, Satar Yousefiasl, Ehsan Nazarzadeh Zare
Summary: Human cardiac tissue lacks proper self-regenerating capability, making tissue engineering critical for addressing the growing rate of deaths associated with cardiovascular disorders. Carbon-based nanomaterials, specifically their conductivity, have revolutionized tissue engineering by providing an appropriate microenvironment for cell protection against attacking mechanisms. The use of conductive biomaterials in cardiac tissue engineering, including graphene, graphene oxide, carbon nanotubes, and carbon nanofibers, has been studied extensively.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2023)
Review
Chemistry, Multidisciplinary
Afshin Taheriazam, Ghazaleh Gholamiyan Yousef Abad, Shima Hajimazdarany, Mohammad Hassan Imani, Setayesh Ziaolhagh, Mohammad Arad Zandieh, Seyedeh Delaram Bayanzadeh, Sepideh Mirzaei, Michael R. Hamblin, Maliheh Entezari, Amir Reza Aref, Ali Zarrabi, Yavuz Nuri Ertas, Jun Ren, Romina Rajabi, Mahshid Deldar Abad Paskeh, Mehrdad Hashemi, Kiavash Hushmandi
Summary: Nanotechnology offers great potential in the field of nanomedicine for the treatment of various diseases, especially cancer. Graphene oxide nanoparticles have emerged as promising carbon-based nanocarriers for drug and gene delivery, photothermal therapy, overcoming chemotherapy resistance, and imaging. This review focuses on the biological functions of graphene oxide nanoparticles as regulators of apoptosis and autophagy, and their potential toxicity in major body organs.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Psychiatry
Masoumeh Beheshti, Nikta Rabiei, Mohammad Taghizadieh, Pariya Eskandari, Samaneh Mollazadeh, Ehsan Dadgostar, Michael R. Hamblin, Arash Salmaninejad, Raziye Emadi, Amir Hossein Mohammadi, Hamed Mirazei
Summary: Obsessive-compulsive disorder (OCD) is a debilitating neuropsychiatric disorder characterized by intrusive thoughts and repetitive or ritualized actions. It is believed to have a genetic component, but the specific genetic factors involved are still unknown. This review summarizes the single nucleotide polymorphisms associated with OCD symptoms, early onset disease, neuroimaging results, and response to therapy. This information can help to understand the genetic basis of OCD, characterize individual patients, predict prognosis, and develop personalized treatment approaches.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Review
Medicine, Research & Experimental
Seyed Mohammad Reza Hashemian, Amirhossein Sheida, Mohammad Taghizadieh, Mohammad Yousef Memar, Michael R. Hamblin, Hossein Bannazadeh Baghi, Javid Sadri Nahand, Zatollah Asemi, Hamed Mirzaei
Summary: Due to the lack of effective therapies for COVID-19, patients have to rely on supportive and nonspecific treatments. Certain proteins of SARS-CoV-2, such as 3 C-like protease (3CLpro) and major protease (Mpro), have been identified as potential targets for antiviral drugs. Nirmatrelvir, combined with ritonavir, has shown potent antiviral activity against SARS-CoV-2 variants, but there are still uncertainties regarding their efficacy, safety, and side effects.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Biotechnology & Applied Microbiology
Ali Arash Anoushirvani, Arezoo Jafarian Yazdi, Sanaz Amirabadi, Sahar Ahmadi Asouri, Rana Shafabakhsh, Amirhossein Sheida, Maryam Sadat Hosseini Khabr, Ameneh Jafari, Seyed Saeed Tamehri Zadeh, Michael R. Hamblin, Leila Kalantari, Sayyed Alireza Talaei Zavareh, Hamed Mirzaei
Summary: Neuroblastoma is the most common extracranial malignancy in childhood and is derived from neural crest. Non-coding RNAs (ncRNAs) have been found to play important roles in various cancers, including glioma and gastrointestinal cancers, by regulating cancer gene networks. Recent studies have shown that ncRNA genes are deregulated in human cancers through various mechanisms, and disturbances in their expression can act as either oncogenes or tumor suppressor genes, leading to the development of cancer. Moreover, ncRNAs can be secreted from tumor cells in exosomes and transferred to other cells, exerting their functions. However, further research is needed to fully understand the roles of ncRNAs in neuroblastoma.
CANCER GENE THERAPY
(2023)
Review
Biochemistry & Molecular Biology
Nasim Ebrahimi, Elmira Fardi, Hajarossadat Ghaderi, Sahar Palizdar, Roya Khorram, Reza Vafadar, Masoud Ghanaatian, Fatemeh Rezaei-Tazangi, Payam Baziyar, Amirhossein Ahmadi, Michael R. Hamblin, Amir Reza Aref
Summary: Targeted therapy is a new approach in cancer treatment, using drugs that specifically target proteins in cancer cells. Inhibiting these proteins can impede cancer progression. Understanding the structures, activation mechanisms, and functions of receptor tyrosine kinases (RTKs) has led to the development of targeted drug therapies, including RTK inhibitors (RTKIs), some of which have been used in clinical settings. This article discusses RTKs and their role in cancer treatment, as well as the potential effects of combination drug therapy for drug resistant cancers.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Review
Chemistry, Physical
Houra Nekounam, Javad Malakootikhah, Donya Shaterabadi, Babak Negahdari, Mohammad Reza Kandi, Michael R. Hamblin
Summary: This article summarizes the advances in the preparation, optimization, and applications of silica nanoparticles in biomedical nanotechnology, as well as the inevitable human, environmental, and industrial contacts with these particles. Understanding the physicochemical properties of silica nanoparticles and their interactions with biological systems at the cellular level is crucial for the rational design of these particles. Control of toxicity risk can guide the design of silica nanoparticles for drug delivery and bioimaging systems.
Review
Microbiology
Weitao Zhu, Michael R. Hamblin, Xiang Wen
Summary: Rosacea is a chronic inflammatory skin disorder affecting the centrofacial region. Its etiology and treatment methods are still unclear. This review examines common bacterial species found in the skin and gut microbiota of rosacea patients and their role in pathogenesis. Additionally, it summarizes the impact of factors such as temperature and age on rosacea and reviews commonly used clinical treatment methods, including antibiotics and probiotics, along with their mechanisms and precautions.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Zahra Mohammadpour, Mahshid Kharaziha, Ali Zarrabi
Summary: The main challenge in extrusion 3D bioprinting is the development of bioinks with desired properties for creating complex and patient-specific scaffolds. This study focuses on non-synthetic bioinks based on alginate and silk nanofibrils (SNF) and their optimization for soft tissue engineering. The addition of SNF improved the mechanical and biological performance of the bioink, with 2 wt.% SNF showing the best results. Overall, this study highlights the favorable properties of the Alg-2SNF bioink for extrusion-based bioprinting.
Article
Materials Science, Multidisciplinary
Gokcen Yasayan, Omid Nejati, Asli F. Ceylan, Cimen Karasu, Pelin Kelicen Ugur, Ayca Bal-Ozturk, Atefeh Zarepour, Ali Zarrabi, Ebrahim Mostafavi
Summary: Chronic wounds, particularly in diabetes patients, are a major health challenge with high economic costs. Nanomaterials have shown promising results in treating chronic wounds by acting as carriers for therapeutic agents or directly as the therapeutic compound. This review provides the latest research progress and prospects on the application of different nanomaterials in chronic wound healing, with a focus on their effects on intracellular factors.
APPLIED MATERIALS TODAY
(2023)
Review
Microbiology
Hanane Joudaki, Negar Aria, Roya Moravej, Mohamadreza Rezaei Yazdi, Zarrindokht Emami-Karvani, Michael R. Hamblin
Summary: Microbial phytases are enzymes that can break down phytic acid, providing several benefits in the food industry such as improved nutrient utilization, enhanced mineral bioavailability, and improved taste and functionality of food products. Factors like enzyme production and engineering techniques play a crucial role in effectively using microbial phytases.
CURRENT MICROBIOLOGY
(2023)
Review
Oncology
Ali Zarrabi, David Perrin, Mahboubeh Kavoosi, Micah Sommer, Serap Sezen, Parvaneh Mehrbod, Bhavya Bhushan, Filip Machaj, Jakub Rosik, Philip Kawalec, Saba Afifi, Seyed Mohammadreza Bolandi, Peiman Koleini, Mohsen Taheri, Tayyebeh Madrakian, Marek J. Los, Benjamin Lindsey, Nilufer Cakir, Atefeh Zarepour, Kiavash Hushmandi, Ali Fallah, Bahattin Koc, Arezoo Khosravi, Mazaher Ahmadi, Susan Logue, Gorka Orive, Stevan Pecic, Joseph W. Gordon, Saeid Ghavami
Summary: Rhabdomyosarcoma is a rare cancer that affects skeletal muscle, primarily in children and young adults. The treatment strategies for this disease include multi-agent chemotherapies following surgical resection and radiotherapy. This review provides a detailed clinical understanding of rhabdomyosarcoma, including its classification, diagnosis, and treatment strategies. The impact of apoptosis, macro-autophagy, and the unfolded protein response on chemotherapy response is discussed. Additionally, the use of in vivo mouse and zebrafish models and in vitro three-dimensional bioengineering models for screening future therapeutic approaches and promoting muscle regeneration is explored.
Article
Biochemistry & Molecular Biology
Mahshid Deldar Abad Paskeh, Nahid Babaei, Mehrdad Hashemi, Abbas Doosti, Kiavash Hushmandi, Maliheh Entezari, Saeed Samarghandian
Summary: The combination of curcumin, vitamins D and E with Fe2O3-NPs and MnO2-NPs has shown to improve semen parameters and reduce apoptosis in germ cells in rats with testicular hyperthermia. This study suggests that this combination therapy may have a positive effect on fertility and decreasing the toxic effects of nanoparticles.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2024)
Review
Materials Science, Biomaterials
Atefeh Zarepour, Cimen Karasu, Yousof Mir, Mohammad Hadi Nematollahi, Siavash Iravani, Ali Zarrabi
Summary: MXenes and graphene have gained attention in neuroscience for their potential applications in sensing, theranostics, and biomedical engineering. They have been used to develop advanced nanosystems for diagnosis and therapy, and have shown promise in treating neurological disorders. However, there are challenges and limitations to their use, and further research is needed to optimize their properties and understand their potential in neuroscience.
BIOMATERIALS SCIENCE
(2023)
Article
Medicine, Research & Experimental
Yuwen Zhu, Yan Guo, Yujia Xue, Anqi Zhou, Ying Chen, Yifei Chen, Xiulian Miao, Fangqiao Lv
Summary: BRG1 plays an important role in HSC-myofibroblast transition and targeting it could be a reasonable strategy for liver fibrosis intervention.
Article
Medicine, Research & Experimental
Liu Ye, Beibei Liu, Jingling Huang, Xiaolin Zhao, Yuan Wang, Yungen Xu, Shuping Wang
Summary: Doublecortin-like kinase 1 (DCLK1) is a significant prooncogenic factor that is strongly associated with the malignant progression and clinical prognosis of various cancers. DCLK1 plays important roles in stem cell marker regulation, tumor cell reprogramming, and immune evasion. However, the exact biological functions of DCLK1, especially the disparities between its alpha- and beta-form transcripts in cancer progression, remain ambiguous.
Article
Medicine, Research & Experimental
Jiahui Yang, Xiaoyu Chen, Tianjing Liu, Yongyan Shi
Summary: This article reviews the role of bile acids in necrotizing enterocolitis (NEC) and their potential therapeutic value. The dysregulation of bile acids is associated with intestinal injury, and inflammatory factors in the liver also play a crucial role in regulating bile acid transport. The bile acid metabolic pathway is important for regulating intestinal microbiota, cell proliferation, and barrier protection.
Review
Medicine, Research & Experimental
Zhenzheng Zhu, Yuemiao Xu, Yuwei Xia, Xinru Jia, Yixin Chen, Yuyue Liu, Leyin Zhang, Hui Chai, Leitao Sun
Summary: Bile acid, as the final product of cholesterol breakdown, plays a complex regulatory and signaling role in human metabolism. Research suggests that it has the potential to enhance metabolism and regulate chronic metabolic diseases through various pathways. The interaction between bile acid and gut microbiota is also of great significance.
Article
Medicine, Research & Experimental
Xin He, Hong-Xu Zhou, Xian Fu, Kai-Di Ni, Ai-Zhi Lin, Ling-Tong Zhang, Hou-Hua Yin, Qing Jiang, Xue Zhou, Yi-Wen Meng, Jun-Yan Liu
Summary: DON exposure causes an increase in deoxycholic acid (DCA), which contributes to intestinal injury. DCA may be a potential therapeutic target for DON enterotoxicity.
Article
Medicine, Research & Experimental
Zhitao Wang, Heng Ma, Abdul Nasir, Sufang Liu, Zhisong Li, Feng Tao, Qian Bai
Summary: This study reveals the involvement of TET1-mediated epigenetic regulation in chronic TMJ pain through trigeminal TNF alpha signaling.
Article
Medicine, Research & Experimental
Lu Yu, Hao Ran, Yaru Lu, Qian Ma, Huan Huang, Weibin Liu
Summary: This study found that the HIF-1 alpha inhibitor BAY 87-2243 can alleviate the symptoms of the Experimental Autoimmune Myasthenia Gravis (EAMG) inflammation model. BAY 87-2243 can restore the balance of CD4(+)T cell subsets, reduce the production of pro-inflammatory cytokines, and act as both an immune imbalance regulator and anti-inflammatory.
Article
Medicine, Research & Experimental
Alex Peralvarez-Marin, Montse Sole, Judith Serrano, Alice Taddeucci, Belen Perez, Clara Penas, Gemma Manich, Marcel Jimenez, Pilar D'Ocon, Francesc Jimenez-Altayo
Summary: This study provides the first evidence that TRPV2 channels may modulate vascular tone by balancing opposing inputs from the endothelium and smooth muscle, leading to net vasodilation. The amplification of TRPV2 channel-induced activity by NO emphasizes the pathophysiological relevance of these findings.
Article
Medicine, Research & Experimental
Amin Ullah, Jing Zhao, Jiakun Li, Rajeev K. Singla, Bairong Shen
Summary: Gastric cancer is the fifth-most prevalent and second-most deadly cancer worldwide. Late onset of symptoms makes early detection important. CXC chemokines play an important role in the pathological process of gastric cancer, but their exact role in diagnosis and prognosis is not fully understood. Inhibiting CXC chemokines shows promise as a targeted therapy.
Article
Medicine, Research & Experimental
Menna S. Zeyada, Salma M. Eraky, Mamdouh M. El-Shishtawy
Summary: The current study demonstrates the prophylactic and antifibrotic effects of Trig against BLM-induced PF by targeting multiple signaling pathways. The combination of Trig and Pirf may be a promising approach to enhance Pirf's anti-fibrotic effect.