Article
Genetics & Heredity
Xinyi Peng, Zhili Xu, Yong Guo, Ying Zhu
Summary: This study aims to identify the key necroptosis-related genes in colorectal cancer and explore their role in immune activity and prognosis. Through data analysis, two molecular subgroups with different survival rates were identified, and a risk model with good potential for prognosis prediction in colorectal cancer was established. The results also indicate that necroptosis-related genes are involved in the immune microenvironment of colorectal cancer patients, providing a basis for more individualized treatment.
FRONTIERS IN GENETICS
(2022)
Article
Biochemistry & Molecular Biology
Huifang Chen, Jiameng Yao, Rujuan Bao, Yu Dong, Ting Zhang, Yanhua Du, Gaoyang Wang, Duan Ni, Zhenzhen Xun, Xiaoyin Niu, Youqiong Ye, Hua-Bing Li
Summary: Our study provides a comprehensive analysis of four RNA modifications in CRC and reveals the potential functions of these writers in TME, transcriptional and post-transcriptional events. The study also identifies the therapeutic implications of targeting these writers in cancer therapy, highlighting their potential clinical utility in targeted therapy and immunotherapy.
Article
Immunology
Ruijun Zhao, Shuanglong Chen, Weiheng Cui, Chaoyu Xie, Aiping Zhang, Li Yang, Hongmei Dong
Summary: This study found that PTPN1 is overexpressed in multiple cancers and is associated with clinical outcomes and tumor immunity, suggesting it could be a valuable potential prognostic and immunological biomarker for pan-cancer.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cell Biology
Yuan Wang, Yongbiao Huang, Chunya Li, Xi Wang, Mu Yang, Duo Xu, Bo Liu, Xianglin Yuan
Summary: This study investigated the alterations of necroptosis related genes (NRGs) in colon cancer using bioinformatics analysis, and classified colon cancer patients into two subtypes based on these genes. Furthermore, a prognostic model based on four necroptosis signature genes was constructed, which showed good predictive performance in the field of chemotherapy and immunotherapy in colon cancer.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Oncology
Miok Kim, Yong Ki Min, Jinho Jang, Hyejin Park, Semin Lee, Chang Hoon Lee
Summary: This study reveals the distinct immune modulation effects of CD73 inhibition compared to PD-1 blockade, suggesting that AB680 may serve as a novel anticancer immunotherapy for CRC with potential synergistic effects when combined with PD-1 blockers.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Cell Biology
Shilang Xiao, Xiaoming Liu, Lingzhi Yuan, Xiao Chen, Fen Wang
Summary: This study revealed that by varying the activation degrees of ferroptosis, tumor cells and their surrounding microenvironment could be shaped. Establishing ferroptosis-related subtypes would guide in predicting the biological features of individual tumors and selecting appropriate treatment protocols for patients.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Immunology
Iman M. Talaat, Noha Mousaad Elemam, Maha Saber-Ayad
Summary: Colorectal cancer is the third most common malignant tumor globally, and the complement system of the immune system plays a significant role in combating cancer. This review discusses complement system activation in CRC and its interactions with TME components, providing a framework for further understanding the potential therapies targeting complement activation in solid tumors such as CRC.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Zitao Wang, Ganhong Chen, Fangfang Dai, Shiyi Liu, Wei Hu, Yanxiang Cheng
Summary: This study identified the expression profiles of necroptosis-related genes in ovarian cancer tissues and developed a risk model consisting of 5 genes to effectively predict patient survival and prognosis. Additionally, the study explored the tumor microenvironment status of ovarian cancer patients and investigated their sensitivity to ICB immunotherapy and chemotherapy drugs.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Wei Li, Xingda Zhang, Yanbo Chen, Da Pang
Summary: This study explores the role of cuproptosis in breast cancer and its relationship with tumor microenvironment (TME) cell infiltration. Two distinct cuproptosis patterns are identified and correlated with different prognosis and TME characteristics. Evaluating cuproptosis patterns in individual tumors can help predict prognosis, immune cell infiltration, and guide more effective chemotherapeutic and immunotherapeutic strategies.
FRONTIERS IN ONCOLOGY
(2022)
Article
Immunology
Chong Shen, Wang Chai, Jingwen Han, Zhe Zhang, Xuejing Liu, Shaobo Yang, Yinlei Wang, Donghuai Wang, Fangxin Wan, Zhenqian Fan, Hailong Hu
Summary: In this study, a prognostic model based on nine TME-associated genes was developed and validated for breast cancer patients. The model accurately predicted survival outcomes, providing guidance for individualized treatment and offering new therapeutic strategies for the disease.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Yiming Ma, Lei Zhan, Jun Yang, Jingdong Zhang
Summary: SLC11A1 plays a crucial role in the tumor microenvironment of colorectal cancer and may serve as a potential biomarker for poor prognosis and immunotherapy efficacy in CRC.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, General & Internal
Rong He, Meiling Zhang, Lian He, Jiabin Huang, Changfeng Man, Xiaoyan Wang, Yakun Lang, Yu Fan
Summary: This study reveals the close relationship between necroptosis and prognosis and immune microenvironment in colon cancer. The NRS-score based on the 8-gene signature may be used to predict the sensitivity of immunotherapy and chemotherapy in colon cancer patients, and provides a foundation for future studies targeting necroptosis and its immune microenvironment.
FRONTIERS IN MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Shize Pan, Congkuan Song, Heng Meng, Ning Li, Donghang Li, Bo Hao, Zilong Lu, Qing Geng
Summary: The present study comprehensively examined the transcriptional and genetic alteration of cuproptosis-related genes (CRGs) in lung adenocarcinoma (LUAD), and identified their potential functions in the tumor microenvironment, clinicopathological characteristics, drug sensitivity, and prognosis. A cuproptosis-related gene score (CRG_score) was developed and validated, and its clinical application and predictive value in combination with TNM stage were established.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Oncology
Yuansen Li, Yi Lei, Jiaxue Sun, Wanfu Zhang, Xiaogang Li, Sijing Chen, Deshenyue Kong, Cheng Chen, Ke Bi, Xiao Luo, Hui Wang, Bo Li, Huayou Luo, Yu Xu
Summary: Colorectal cancer is a significant global cause of cancer death, and immunotherapy using CCL5 as a potential target shows promise in improving treatment outcomes for CRC patients.
FRONTIERS IN ONCOLOGY
(2022)
Review
Immunology
Yinhang Wu, Jing Zhuang, Zhanbo Qu, Xi Yang, Shuwen Han
Summary: Immunotherapy has revolutionized cancer treatment, but its effectiveness is limited in colorectal cancer patients with specific genetic characteristics. By studying the tumor immune microenvironment and genetic signatures, we can identify immune-related colorectal cancer subtypes and improve immunotherapy strategies.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cell Biology
Ji Che, Cuidi Xu, Yuanyuan Wu, Peiyu Jia, Qi Han, Yantao Ma, Xiaolei Wang, Yongjun Zheng
Summary: miR-1290 enhances myoblast differentiation and inhibits myotube atrophy through Akt/p70/FoxO3 signaling. It may be a potential therapeutic target for sarcopenia treatment.
Article
Medicine, Research & Experimental
Ji Che, Cuidi Xu, Yuanyuan Wu, Peiyu Jia, Qi Han, Yantao Ma, Xiaolei Wang, Yijie Du, Yongjun Zheng
Summary: This study demonstrated that early-senescent BMSCs accelerate the myogenic differentiation of C2C12 cells, with the transcription factor FOXO3 being the target of the senescent cells. The AKT/P70 signaling pathway mediates the effect of BMSCs on neighboring cells, as seen through the promotion of muscle differentiation by BMSC-derived exosomes.
Article
Cell Biology
Yuanyuan Wu, Ji Che, Peiyu Jia, Yantao Ma, Qi Han, Xiaolei Wang, Lei Fu, Hongjing Dou, Yongjun Zheng
Summary: Near-infrared radiation therapy, triggered by polypyrrole, can promote the differentiation of C2C12 cells and improve muscle atrophy, offering a new approach for the treatment of skeletal muscle atrophy.
CELLULAR SIGNALLING
(2022)
Article
Neurosciences
Yinying Sun, Ji Che, Jun Zhang
Summary: Microglia, as resident myeloid cells of the central nervous system, not only act as the first line of defense against foreign pathogens to limit brain injury, but also play important roles in neurodevelopmental remodeling and homeostatic maintenance. Many studies have revealed their involvement in regulating tumor growth and neural repair in disease models.
BRAIN RESEARCH BULLETIN
(2023)