Article
Oncology
Shuyue Zheng, Xin-Yuan Guan
Summary: Ferroptosis is a cell death that occurs due to the accumulation of ferrous ions and lipid peroxidation in tumor cells. Targeting ferroptosis as a novel strategy for anti-tumor therapy involves regulating various metabolic and immune elements. This review highlights the mechanism of ferroptosis, its interaction with cancer and tumor immune microenvironment, particularly the relationship between immune cells and ferroptosis. Additionally, it discusses the latest preclinical progress in combining ferroptosis-targeted drugs with immunotherapy, and the optimal conditions for their combined use, providing insight into the potential value of ferroptosis in cancer immunotherapy.
Review
Oncology
Robin Demuynck, Iuliia Efimova, Faye Naessens, Dmitri Krysko
Summary: Ferroptosis is a newly discovered form of regulated cell death distinct from apoptosis and necroptosis, and has potential in anticancer therapy. However, ferroptotic cancer cells may pose a risk of tumor evasion due to decreased phagocytosis and antigen cross-presentation. Factors such as lactate, acidification, and hypoxia in the tumor microenvironment play a role in promoting ferroptosis resistance and affecting its immunogenicity.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Medicine, Research & Experimental
Wenqin Luo, Wenqiang Xiang, Lu Gan, Ji Che, Jing Li, Yichao Wang, Lingyu Han, Ruiqi Gu, Li Ye, Renjie Wang, Xiuping Zhang, Ye Xu, Weixing Dai, Shaobo Mo, Qingguo Li, Guoxiang Cai
Summary: The roles of necroptosis-related genes in colorectal cancer have been comprehensively explored in this study. The findings provide insights into the biological functions of necroptosis, as well as prognosis prediction, drug selection, and therapeutics development in colorectal cancer.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Shize Pan, Congkuan Song, Heng Meng, Ning Li, Donghang Li, Bo Hao, Zilong Lu, Qing Geng
Summary: The present study comprehensively examined the transcriptional and genetic alteration of cuproptosis-related genes (CRGs) in lung adenocarcinoma (LUAD), and identified their potential functions in the tumor microenvironment, clinicopathological characteristics, drug sensitivity, and prognosis. A cuproptosis-related gene score (CRG_score) was developed and validated, and its clinical application and predictive value in combination with TNM stage were established.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Immunology
Desheng Qi, Milin Peng
Summary: Cell death is a common biological process in various physiological and pathological conditions. There are multiple types of cell death, including apoptosis and the newly discovered ferroptosis. Ferroptosis has been found to have potential antitumor effects and may also impact immune cells in the tumor microenvironment.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cell Biology
Qi-Dong Xia, Jian-Xuan Sun, Chen-Qian Liu, Jin-Zhou Xu, Ye An, Meng-Yao Xu, Zheng Liu, Jia Hu, Shao-Gang Wang
Summary: In this study, different ferroptosis patterns were identified and a ferroptosis scoring system was established in bladder cancer patients. The results showed that ferroptosis patterns were closely related to clinical characteristics, prognosis, immune cell infiltration in the tumor microenvironment, and could be used to guide clinical treatment strategies.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Jun Xiao, Lingyan Zheng, Jingfeng Liu
Summary: This study systematically analyzed ferroptosis regulators in gastric cancer and identified three distinct subtypes of ferroptosis with different prognosis, hallmark pathway activity, and tumor-infiltrating immune cells. The quantification of ferroptosis levels based on prognostic signatures, along with the observed significant relationships between FPI and clinicopathological characteristics, suggests the potential of ferroptosis in guiding personalized treatment and predicting immune response.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Immunology
Ruijun Zhao, Shuanglong Chen, Weiheng Cui, Chaoyu Xie, Aiping Zhang, Li Yang, Hongmei Dong
Summary: This study found that PTPN1 is overexpressed in multiple cancers and is associated with clinical outcomes and tumor immunity, suggesting it could be a valuable potential prognostic and immunological biomarker for pan-cancer.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Yuyan Xu, Wei Liao, Qiong Luo, Dinghua Yang, Mingxin Pan
Summary: This study provides the first comprehensive analysis of 36 histone acetylation regulators in hepatocellular carcinoma (HCC). Histone acetylation patterns were found to be closely associated with tumor malignant pathways and the tumor microenvironment (TME). The therapeutic value of the HAscore in targeted therapy and immunotherapy was also analyzed.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Oncology
Zhengzhen Xia, Yi Quan
Summary: Ferroptosis is a lipid peroxidation-induced, iron-dependent programmed cell death that is closely associated with tumorigenesis, development, treatment, and tumor immune regulation. This study investigates the connection between ferroptosis and immune regulation, providing a theoretical basis for targeting ferroptosis and tumor immunotherapy.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Wei Li, Xingda Zhang, Yanbo Chen, Da Pang
Summary: This study explores the role of cuproptosis in breast cancer and its relationship with tumor microenvironment (TME) cell infiltration. Two distinct cuproptosis patterns are identified and correlated with different prognosis and TME characteristics. Evaluating cuproptosis patterns in individual tumors can help predict prognosis, immune cell infiltration, and guide more effective chemotherapeutic and immunotherapeutic strategies.
FRONTIERS IN ONCOLOGY
(2022)
Review
Immunology
Xiufang Ren, Songyi Guo, Xiaojiao Guan, Ye Kang, Jiamei Liu, Xianghong Yang
Summary: Immunity is a crucial physiological function that defends against pathogenic microorganisms. It also plays a role in monitoring and preventing cell mutations and tumor development. Immunotherapy relies on the interaction between immune cells and the tumor microenvironment and can be classified based on tumor characteristics.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Yilan Huang, Siwei Wang, Aiwu Ke, Kun Guo
Summary: Exploring effective systemic treatments for liver cancer remains a major challenge worldwide. Ferroptosis, as a novel regulated cell death, has gained increasing attention in cancer research. Targeting ferroptosis has become a promising strategy for liver cancer treatment, as it can directly kill cancer cells and improve the immunosuppressive microenvironment.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2023)
Article
Chemistry, Multidisciplinary
Huali Lei, Quguang Li, Zifan Pei, Lin Liu, Nailin Yang, Liang Cheng
Summary: Tumor immunotherapy is an important tool in oncology treatment, but the poor infiltration of pro-inflammatory immune cells in immune cold tumors and an immunosuppressive network in the tumor microenvironment limit its effectiveness. Ferroptosis has emerged as a novel strategy to enhance tumor immunotherapy. Manganese molybdate nanoparticles (MnMoOx NPs) can trigger ferroptosis, induce immune cell death, release damage-associated molecular patterns (DAMPs), and enhance tumor immunotherapy. In addition, MnMoOx NPs can suppress tumors, promote the maturation of dendritic cells (DCs), infiltrate T cells, and reverse the immunosuppressive microenvironment to make the tumor an immune hot tumor. Combination with an immune checkpoint inhibitor (ICI) (α-PD-L1) further enhances the anti-tumor effect and inhibits metastases. This work provides a new idea for the development of nonferrous inducers of ferroptosis to enhance cancer immunotherapy.
Article
Immunology
Chong Shen, Wang Chai, Jingwen Han, Zhe Zhang, Xuejing Liu, Shaobo Yang, Yinlei Wang, Donghuai Wang, Fangxin Wan, Zhenqian Fan, Hailong Hu
Summary: In this study, a prognostic model based on nine TME-associated genes was developed and validated for breast cancer patients. The model accurately predicted survival outcomes, providing guidance for individualized treatment and offering new therapeutic strategies for the disease.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Fen Wang, Nanfang Qu, Jin Peng, Chun Yue, Lingzhi Yuan, Yi Yuan
MOLECULAR MEDICINE REPORTS
(2017)
Letter
Psychology, Clinical
Ting Cai, Xiao Shi, Ling-zhi Yuan, Dan Tang, Fen Wang
INTERNATIONAL PSYCHOGERIATRICS
(2019)
Article
Microbiology
Ling-Zhi Yuan, Xiao Shi, Dan Tang, Shao-Peng Zheng, Zhi-Ming Xiao, Fen Wang
Summary: This study successfully constructed a stable, highly expressed, and pro-apoptotic VacA recombinant protein of H. pylori. The protein can be stably preserved in a specific buffer solution and is capable of inducing cell apoptosis.
Article
Gastroenterology & Hepatology
Ling-Zhi Yuan, Ping Yi, Gang-Shi Wang, Shi-Yun Tan, Guang-Ming Huang, Ling-Zhi Qi, Yan Jia, Fen Wang
THERAPEUTIC ADVANCES IN GASTROENTEROLOGY
(2019)