Modeling the effect of cerebral capillary blood flow on neuronal firing

Mathematical modeling of cerebral capillary blood flow heterogeneity and its effect on brain tissue oxygen levels

(2021) David Terman et al.   JOURNAL OF THEORETICAL BIOLOGY

Neurons, Glia, Extracellular Matrix and Neurovascular Unit: A Systems Biology Approach to the Complexity of Synaptic Plasticity in Health and Disease

(2020) Ciro De Luca et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Vascular physiology drives functional brain networks

(2020) Molly G. Bright et al.   NEUROIMAGE

Brain energetics plays a key role in the coordination of electrophysiology, metabolism and hemodynamics: Evidence from an integrated computational model

(2019) G. Capo Rangel et al.   JOURNAL OF THEORETICAL BIOLOGY

Fueling thought: Management of glycolysis and oxidative phosphorylation in neuronal metabolism

(2018) Gary Yellen   JOURNAL OF CELL BIOLOGY

A computational model integrating brain electrophysiology and metabolism highlights the key role of extracellular potassium and oxygen

(2018) D. Calvetti et al.   JOURNAL OF THEORETICAL BIOLOGY

Brain Energy and Oxygen Metabolism: Emerging Role in Normal Function and Disease

(2018) Michelle E. Watts et al.   Frontiers in Molecular Neuroscience

The Relation Between Capillary Transit Times and Hemoglobin Saturation Heterogeneity. Part 2: Capillary Networks

(2018) Adrien Lücker et al.   Frontiers in Physiology

Hypertension Is Associated with White Matter Disruption in Apparently Healthy Middle-Aged Individuals

(2018) Y. Hannawi et al.   AMERICAN JOURNAL OF NEURORADIOLOGY

The relative influence of hematocrit and red blood cell velocity on oxygen transport from capillaries to tissue

(2017) Adrien Lücker et al.   MICROCIRCULATION

Increased cortical capillary transit time heterogeneity in Alzheimer's disease: a DSC-MRI perfusion study

(2017) Simon F. Eskildsen et al.   NEUROBIOLOGY OF AGING

The Neurovascular Unit Coming of Age: A Journey through Neurovascular Coupling in Health and Disease

(2017) Costantino Iadecola   NEURON

Astrocytic modulation of neuronal excitability through K + spatial buffering

(2017) Alba Bellot-Saez et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Neuroprotective Role of Gap Junctions in a Neuron Astrocyte Network Model

(2016) Gemma Huguet et al.   BIOPHYSICAL JOURNAL

Computational Flux Balance Analysis Predicts that Stimulation of Energy Metabolism in Astrocytes and their Metabolic Interactions with Neurons Depend on Uptake of K+ Rather than Glutamate

(2016) Mauro DiNuzzo et al.   NEUROCHEMICAL RESEARCH

Capillary Transit Time Heterogeneity Is Associated with Modified Rankin Scale Score at Discharge in Patients with Bilateral High Grade Internal Carotid Artery Stenosis

(2016) Sibu Mundiyanapurath et al.   PLoS One

Gap junction coupling confers isopotentiality on astrocyte syncytium

(2015) Baofeng Ma et al.   GLIA

Glial cell regulation of neuronal activity and blood flow in the retina by release of gliotransmitters

(2015) Eric A. Newman   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Neurovascular coupling: a parallel implementation

(2015) Katharina Dormanns et al.   Frontiers in Computational Neuroscience

Multi-timescale Modeling of Activity-Dependent Metabolic Coupling in the Neuron-Glia-Vasculature Ensemble

(2015) Renaud Jolivet et al.   PLoS Computational Biology

Regional Heterogeneity of Cerebral Microvessels and Brain Susceptibility to Oxidative Stress

(2015) Susan A. Austin et al.   PLoS One

Unification of Neuronal Spikes, Seizures, and Spreading Depression

(2014) Y. Wei et al.   JOURNAL OF NEUROSCIENCE

Constancy and trade-offs in the neuroanatomical and metabolic design of the cerebral cortex

(2014) Jan Karbowski   Frontiers in Neural Circuits

Dynamics from Seconds to Hours in Hodgkin-Huxley Model with Time-Dependent Ion Concentrations and Buffer Reservoirs

(2014) Niklas Hübel et al.   PLoS Computational Biology

Modeling the Neuroprotective Role of Enhanced Astrocyte Mitochondrial Metabolism during Stroke

(2013) Casey O. Diekman et al.   BIOPHYSICAL JOURNAL

Potassium Buffering in the Neurovascular Unit: Models and Sensitivity Analysis

(2013) Alexandra Witthoft et al.   BIOPHYSICAL JOURNAL

A Mathematical Model of the Metabolic and Perfusion Effects on Cortical Spreading Depression

(2013) Joshua C. Chang et al.   PLoS One

Role of Mitochondrial Ca2+ in the Regulation of Cellular Energetics

(2012) Brian Glancy et al.   BIOCHEMISTRY

A bidirectional model for communication in the neurovascular unit

(2012) Alexandra Witthoft et al.   JOURNAL OF THEORETICAL BIOLOGY

Cellular Links between Neuronal Activity and Energy Homeostasis

(2012) Pavan K. Shetty et al.   Frontiers in Pharmacology

The Roles of Cerebral Blood Flow, Capillary Transit Time Heterogeneity, and Oxygen Tension in Brain Oxygenation and Metabolism

(2011) Sune N Jespersen et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

A computational model of hemodynamic parameters in cortical capillary networks

(2010) Navid Safaeian et al.   JOURNAL OF THEORETICAL BIOLOGY

Glial and neuronal control of brain blood flow

(2010) David Attwell et al.   NATURE

Neuronal activity in vitro and the in vivo reality: the role of energy homeostasis

(2010) Yuri Zilberter et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Good clinical outcome after ischemic stroke with successful revascularization is time-dependent

(2009) P. Khatri et al.   NEUROLOGY

Origins of heterogeneity in tissue perfusion and metabolism

(2008) Axel R. Pries et al.   CARDIOVASCULAR RESEARCH

Theoretical Models of Microvascular Oxygen Transport to Tissue

(2008) Daniel Goldman   MICROCIRCULATION