Stimulating the Activity of Amyloid-Beta Degrading Enzymes: A Novel Approach for the Therapeutic Manipulation of Amyloid-Beta Levels

N-terminal domain of Bothrops asper Myotoxin II Enhances the Activity of Endothelin Converting Enzyme-1 and Neprilysin

(2016) A. Ian Smith et al.   Scientific Reports

Soluble Neprilysin Is Predictive of Cardiovascular Death and Heart Failure Hospitalization in Heart Failure Patients

(2015) Antoni Bayés-Genís et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Current role of neprilysin inhibitors in hypertension and heart failure

(2014) Thomas G. von Lueder et al.   PHARMACOLOGY & THERAPEUTICS

Regulation of distinct pools of amyloid β-protein by multiple cellular proteases

(2013) Malcolm A Leissring et al.   Alzheimers Research & Therapy

Mechanisms of Amyloid-β Peptide Clearance: Potential Therapeutic Targets for Alzheimer's Disease

(2012) Sang-Sun Yoon et al.   Biomolecules & Therapeutics

Are amyloid-degrading enzymes viable therapeutic targets in Alzheimer’s disease?

(2011) Natalia N. Nalivaeva et al.   JOURNAL OF NEUROCHEMISTRY

Twenty years of Alzheimer’s disease-causing mutations

(2011) Alison Goate et al.   JOURNAL OF NEUROCHEMISTRY

Aβ-Degrading Enzymes: Potential for Treatment of Alzheimer Disease

(2011) James Scott Miners et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Compounding artefacts with uncertainty, and an amyloid cascade hypothesis that is ‘too big to fail’

(2011) Rudy J Castellani et al.   JOURNAL OF PATHOLOGY

Peripheral Delivery of a CNS Targeted, Metalo-Protease Reduces Aβ Toxicity in a Mouse Model of Alzheimer's Disease

(2011) Brian Spencer et al.   PLoS One

Norepinephrine Promotes Microglia to Uptake and Degrade Amyloid   Peptide through Upregulation of Mouse Formyl Peptide Receptor 2 and Induction of Insulin-Degrading Enzyme

(2010) Y. Kong et al.   JOURNAL OF NEUROSCIENCE

Decreased Clearance of CNS  -Amyloid in Alzheimer's Disease

(2010) K. G. Mawuenyega et al.   SCIENCE

A PPARdelta Agonist Reduces Amyloid Burden and Brain Inflammation in a Transgenic Mouse Model of Alzheimers Disease

(2009) Sergey Kalinin et al.   Current Alzheimer Research

The amyloid hypothesis for Alzheimer’s disease: a critical reappraisal

(2009) John Hardy   JOURNAL OF NEUROCHEMISTRY

Neprilysin Overexpression Inhibits Plaque Formation But Fails to Reduce Pathogenic A  Oligomers and Associated Cognitive Deficits in Human Amyloid Precursor Protein Transgenic Mice

(2009) W. J. Meilandt et al.   JOURNAL OF NEUROSCIENCE

Acyl peptide hydrolase degrades monomeric and oligomeric amyloid-beta peptide

(2009) Rina Yamin et al.   Molecular Neurodegeneration

Expression of Neprilysin in Skeletal Muscle Reduces Amyloid Burden in a Transgenic Mouse Model of Alzheimer Disease

(2009) Yinxing Liu et al.   MOLECULAR THERAPY

Inhibitors of Class 1 Histone Deacetylases Reverse Contextual Memory Deficits in a Mouse Model of Alzheimer's Disease

(2009) Mark Kilgore et al.   NEUROPSYCHOPHARMACOLOGY

Small-Molecule Activators of Insulin-Degrading Enzyme Discovered through High-Throughput Compound Screening

(2009) Christelle Cabrol et al.   PLoS One

Neprilysin: An Enzyme Candidate to Slow the Progression of Alzheimer's Disease

(2008) Salim S. El-Amouri et al.   AMERICAN JOURNAL OF PATHOLOGY

Amyloid-Degrading Enzymes as Therapeutic Targets in Alzheimers Disease

(2008) Natalia Nalivaeva et al.   Current Alzheimer Research

Structure-Based Identification of Small-Molecule Angiotensin-Converting Enzyme 2 Activators as Novel Antihypertensive Agents

(2008) José A. Hernández Prada et al.   HYPERTENSION

Somatostatin: A Novel Substrate and a Modulator of Insulin-Degrading Enzyme Activity

(2008) Chiara Ciaccio et al.   JOURNAL OF MOLECULAR BIOLOGY

Clearance mechanisms of Alzheimer's amyloid-β peptide: implications for therapeutic design and diagnostic tests

(2008) K A Bates et al.   MOLECULAR PSYCHIATRY