Article
Clinical Neurology
Jessica K. Bone, Gemma Lewis, Jonathan P. Roiser, Sarah-Jayne Blakemore, Glyn Lewis
Summary: The study found that adolescents who recalled more self-referential negative words had more severe depressive symptoms, and this association was stronger in females.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Neurosciences
Nikki L. Hill, Sakshi Bhargava, Emily Bratlee-Whitaker, Jennifer R. Turner, Monique J. Brown, Jacqueline Mogle
Summary: Older adults who were more likely to report SCD had lower average objective memory (between-person associations), and depressive symptoms partially mediated this relationship in three of four datasets. However, changes in depressive symptoms did not mediate the relationship between reports of SCD and declines in objective memory in three of four datasets (within-person associations).
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Psychology, Clinical
Josephine Power, Stuart Watson, Wai Chen, Andrew Lewis, Marinus van IJzendoorn, Megan Galbally
Summary: This study finds that increasing maternal depressive symptoms during the perinatal period are associated with poorer executive function outcomes in children at the age of 4, independent of prenatal smoking, drinking, or antidepressant use. The chronicity, severity, and postpartum influences of depression may play crucial roles in determining childhood executive function outcomes.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Nursing
Sangwoo Ahn, Michelle A. Mathiason, Fang Yu
Summary: Depressive symptoms were predictive of lower episodic memory and executive function. Nurses should pay attention to depressive symptoms in older adults with SCD, as managing depressive symptoms may help prevent cognitive decline more typical of early Alzheimer's dementia.
JOURNAL OF NURSING SCHOLARSHIP
(2021)
Review
Geriatrics & Gerontology
Chen Zhu, Natalie Thomas, Shalini Arunogiri, Caroline Gurvich
Summary: This review examines the relationships between cognition, menopausal symptoms, and risk/protective factors. The findings suggest that factors associated with cognition and menopausal symptoms can be categorized into demographic, socio-economic, lifestyle, and reproductive factors.
Article
Geriatrics & Gerontology
Lin Tz-Han, Wu Wan-Ru, Chen I-Hui, Huang Hui-Chuan
Summary: This study explored the effectiveness and feasibility of a reminiscence music therapy program for older adults with dementia, aiming to improve cognition while reducing depressive and behavioral symptoms. Participants in the intervention group received 60-minute sessions of reminiscence music therapy twice a week for 4 weeks, while the control group received usual care. The results showed a significant reduction in depressive symptoms for the intervention group, but no significant effects on cognition and behavioral symptoms were observed. The high adherence and positive participation data suggested that this reminiscence music program is feasible for individuals with dementia. Healthcare professionals can consider incorporating supportive environments and regular reminiscence music activities, specifically related to festivals and memorable music, to decrease depressive symptoms in older adults with dementia.
Article
Psychology, Multidisciplinary
Mei-Lan Chen, Ying-Jung Wu, Mi-Jung Lee, Sung-Lin Hsieh, Ing-Jy Tseng, Li-Sheng Chen, Douglas S. Gardenhire
Summary: This study assessed the effects of resistance exercise training on cognitive performance and depressive symptoms in older Chinese Americans. The results showed that resistance exercise training improved cognitive performance and reduced depressive symptoms in this population.
BEHAVIORAL SCIENCES
(2023)
Article
Nursing
Lili Ji, Baoqi Zhu, Jinrong Wang, Mengshuang Ding, Yapeng Gao, Xiaoxia Qiao, Yaru Jin, Huaxin Si, Cuili Wang
Summary: This study examined the mediating effect of executive function and attentional bias in the relationship between frailty and depressive symptoms. The results showed that executive function and attentional bias act as serial mediators linking frailty to depressive symptoms.
JOURNAL OF CLINICAL NURSING
(2022)
Article
Medicine, General & Internal
Tsukasa Kato
Summary: Coping flexibility, inhibition, and set-shifting are all associated with depression, but coping flexibility has a unique relationship with depression, showing a lower risk even when controlling for inhibition and set-shifting effects. This suggests that although coping flexibility shares similarities with inhibition and set-shifting, its impact on depression differs from the other two factors.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Clinical Neurology
Benedikt Romer, Ingvild Dalen, Clive Ballard, Dag Aarsland
Summary: This study found that depressive symptoms increased continuously in patients with DLB, whereas patients with AD showed a delayed increase. The increase in depressive symptoms in DLB was mainly driven by anhedonia and retardation. Proximity to death and risk factors for depression and dementia also played a role in the course of depressive symptoms.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Psychology, Multidisciplinary
Prathima A. A. Raghavendra, Shantala Hegde, Mariamma Philip, Muralidharan Kesavan
Summary: This study explored musical and neuro-cognitive deficits in patients with mild-moderate major depressive disorder (MDD). The results showed that these patients had significant deficits in working memory, verbal learning, and memory, but no differences in music cognition. The study also found a significant relationship between music cognition and attention.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Geriatrics & Gerontology
Michelle T. Kassel, Emma Rhodes, Philip S. Insel, Kai Woodworth, Christina Garrison-Diehn, Derek D. Satre, J. Craig Nelson, Duygu Tosun, R. Scott Mackin
Summary: This study investigates the relationship between patterns of depression severity change during psychotherapy intervention for Late Life Depression (LLD) and cognitive outcomes. The results show that different patterns of improvement in depression are associated with improved cognition, specifically in areas of verbal learning, memory, and executive function. The findings suggest that the temporal pattern of depression response may have distinct impacts on specific cognitive processes.
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
(2022)
Article
Behavioral Sciences
J. Matthijs Biesbroek, Jae-Sung Lim, Nick A. Weaver, Gozdem Arikan, Yeonwook Kang, Beom Joon Kim, Hugo J. Kuijf, Albert Postma, Byung-Chul Lee, Keon-Joo Lee, Kyung-Ho Yu, Hee-Joon Bae, Geert Jan Biessels
Summary: The study identified anatomical correlates for semantic and phonemic fluency, with lower performance associated with left hemispheric frontotemporal and parietal cortical regions, and subcortical regions centered on the left thalamus. Phonemic fluency was linked to a more extensive frontoparietal white matter network, while semantic fluency was associated with disconnection of specific white matter tracts.
Article
Clinical Neurology
Jackie M. Poos, Katrina M. Moore, Jennifer Nicholas, Lucy L. Russell, Georgia Peakman, Rhian S. Convery, Lize C. Jiskoot, Emma van der Ende, Esther van den Berg, Janne M. Papma, Harro Seelaar, Yolande A. L. Pijnenburg, Fermin Moreno, Raquel Sanchez-Valle, Barbara Borroni, Robert Laforce, Mario Masellis, Carmela Tartaglia, Caroline Graff, Daniela Galimberti, James B. Rowe, Elizabeth Finger, Matthis Synofzik, Rik Vandenberghe, Alexandre de Mendonca, Pietro Tiraboschi, Isabel Santana, Simon Ducharme, Chris Butler, Alexander Gerhard, Johannes Levin, Adrian Danek, Markus Otto, Isabel Le Ber, Florence Pasquier, John C. van Swieten, Jonathan D. Rohrer
Summary: This study created cognitive composite scores for genetic frontotemporal dementia (FTD) and provided recommendations for recruitment and duration in clinical trial design.
ALZHEIMERS RESEARCH & THERAPY
(2022)
Article
Clinical Neurology
Bernice J. A. Gulpers, Frans R. J. Verhey, Simone J. P. M. Eussen, Miranda T. Schram, Bastiaan E. de Galan, Martin P. J. van Boxtel, Coen D. A. Stehouwer, S. Kohler
Summary: This study investigates the relationship between individual anxiety disorders, generalized anxiety symptoms, and multiple cognitive domains. The results show that agoraphobia is associated with worse scores on all cognitive domains and higher odds of cognitive impairment. High scores on the Generalized Anxiety Disorder 7-item scale (GAD-7) are associated with worse scores on processing speed and higher odds of cognitive impairment. Panic disorder is significantly associated with worse scores on memory tasks. These associations are stronger in younger participants and in those with type 2 diabetes.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Geriatrics & Gerontology
Andre Hajek, Elzbieta Buczak-Stec, Hendrik van den Bussche, Marion Eisele, Anke Oey, Birgitt Wiese, Siegfried Weyerer, Jochen Werle, Angela Fuchs, Michael Pentzek, Melanie Luppa, Alexander Pabst, Dagmar Weeg, Horst Bickel, Luca Kleineidam, Michael Wagner, Martin Scherer, Wolfgang Maier, Steffi G. Riedel-Heller, Hans-Helmut Koenig
Summary: This study examined the determinants of institutionalization among the oldest old longitudinally. Findings highlighted the importance of gender, age, widowhood, and functional decline for institutionalization among this population. Preventing or postponing functional decline may help delay institutionalization.
Article
Clinical Neurology
Frank Jessen, Steffen Wolfsgruber, Luca Kleineindam, Annika Spottke, Slawek Altenstein, Claudia Bartels, Moritz Berger, Frederic Brosseron, Marcel Daamen, Martin Dichgans, Laura Dobisch, Michael Ewers, Friederike Fenski, Klaus Fliessbach, Silka D. Freiesleben, Wenzel Glanz, Doreen Goerss, Selim Guersel, Daniel Janowitz, Ingo Kilimann, Xenia Kobeleva, Andrea Lohse, Franziska Maier, Coraline Metzger, Matthias Munk, Lukas Preis, Carolin Sanzenbacher, Eike Spruth, Boris Rauchmann, Ruth Vukovich, Renat Yakupov, Anne-Sophie Weyrauch, Gabriel Ziegler, Matthias Schmid, Christoph Laske, Robert Perneczky, Anja Schneider, Jens Wiltfang, Stefan Teipel, Katharina Buerger, Josef Priller, Oliver Peters, Alfredo Ramirez, Henning Boecker, Michael T. Heneka, Michael Wagner, Emrah Duezel
Summary: Research finds that subjective cognitive decline (SCD) in individuals who seek medical help may serve as an initial symptomatic stage 2 of the Alzheimer's disease (AD) continuum. The SCD group shows slightly worse cognition, as well as more subtle functional and behavioral symptoms compared to the control group (CO). It is also discovered that SCD-A+ cases (39.3% of all SCD) exhibit greater hippocampal atrophy, lower cognitive and functional performance, and more behavioral symptoms.
ALZHEIMERS & DEMENTIA
(2023)
Article
Clinical Neurology
Marios K. Georgakis, Rong Fang, Marco Duering, Frank A. Wollenweber, Felix J. Bode, Sebastian Stoesser, Christine Kindlein, Peter Hermann, Thomas G. Liman, Christian H. Nolte, Lucia Kerti, Benno Ikenberg, Kathleen Bernkopf, Holger Poppert, Wenzel Glanz, Valentina Perosa, Daniel Janowitz, Michael Wagner, Katja Neumann, Oliver Speck, Laura Dobisch, Emrah Duezel, Benno Gesierich, Anna Dewenter, Annika Spottke, Karin Waegemann, Michael Goertler, Silke Wunderlich, Matthias Endres, Inga Zerr, Gabor Petzold, Martin Dichgans
Summary: The global burden of small vessel disease (SVD) predicts cognitive and functional outcomes in stroke patients, but the current score used for assessment does not improve prediction capability. Assessing the severity of SVD lesions adds value in predicting outcomes beyond known predictors.
ALZHEIMERS & DEMENTIA
(2023)
Article
Oncology
Martine Dumont, Nana Weber-Lassalle, Charles Joly-Beauparlant, Corinna Ernst, Arnaud Droit, Bing-Jian Feng, Stephane Dubois, Annie-Claude Collin-Deschesnes, Penny Soucy, Maxime Vallee, Frederic Fournier, Audrey Lemacon, Muriel A. Adank, Jamie Allen, Janine Altmueller, Norbert Arnold, Margreet G. E. M. Ausems, Riccardo Berutti, Manjeet K. Bolla, Shelley Bull, Sara Carvalho, Sten Cornelissen, Michael R. Dufault, Alison M. Dunning, Christoph Engel, Andrea Gehrig, Willemina R. R. Geurts-Giele, Christian Gieger, Jessica Green, Karl Hackmann, Mohamed Helmy, Julia Hentschel, Frans B. L. Hogervorst, Antoinette Hollestelle, Maartje J. Hooning, Judit Horvath, M. Arf An Ikram, Silke Kaulfuss, Renske Keeman, Da Kuang, Craig Luccarini, Wolfgang Maier, John W. M. Martens, Dieter Niederacher, Peter Nurnberg, Claus-Eric Ott, Annette Peters, Paul D. P. Pharoah, Alfredo Ramirez, Juliane Ramser, Steffi Riedel-Heller, Gunnar Schmidt, Mitul Shah, Martin Scherer, Antje Stabler, Tim M. Strom, Christian Sutter, Holger Thiele, Christi J. van Asperen, Lizet van der Kolk, Rob B. van der Luijt, Alexander E. Volk, Michael Wagner, Quinten Waisfisz, Qin Wang, Shan Wang-Gohrke, Bernhard H. F. Weber, Peter Devilee, Sean Tavtigian, Gary D. Bader, Alfons Meindl, David E. Goldgar, Irene L. Andrulis, Rita K. Schmutzler, Douglas F. Easton, Marjanka K. Schmidt, Eric Hahnen, Jacques Simard
Summary: This study aimed to identify new genes associated with breast cancer risk through whole-exome sequencing. The results revealed 20 novel genes with evidence of association, but larger studies are needed for confirmation. Additionally, known genes such as BRCA1, BRCA2, PALB2, ATM, and CHEK2 were found to be associated with increased risk of breast cancer, although they only explain a fraction of the familial aggregation of the disease.
Article
Clinical Neurology
Luca Kleineidam, Michael Wagner, Jannis Guski, Steffen Wolfsgruber, Lisa Miebach, Horst Bickel, Hans-Helmut Koenig, Siegfried Weyerer, Dagmar Luehmann, Hanna Kaduszkiewicz, Melanie Luppa, Susanne Rohr, Michael Pentzek, Birgitt Wiese, Wolfgang Maier, Martin Scherer, Johannes Kornhuber, Oliver Peters, Lutz Frolich, Jens Wiltfang, Piotr Lewczuk, Michael Huell, Alfredo Ramirez, Frank Jessen, Steffi G. Riedel-Heller, Kathrin Heser
Summary: This study found that subjective cognitive decline (SCD) typically precedes depressive symptoms (DS), and individuals with SCD and high DS are at an increased risk for cognitive decline and dementia progression. Additionally, levels of CSF Ass42 can predict increasing DS.
ALZHEIMERS & DEMENTIA
(2023)
Article
Public, Environmental & Occupational Health
Felix G. Wittmann, Andrea Zuelke, Alexander Pabst, Melanie Luppa, Jochen Rene Thyrian, Anika Kaestner, Wolfgang Hoffmann, Hanna Kaduszkiewicz, Juliane Doehring, Catharina Escales, Jochen Gensichen, Isabel Zoellinger, Robert Philipp Kosilek, Birgitt Wiese, Anke Oey, Hans-Helmut Koenig, Christian Brettschneider, Thomas Frese, Steffi G. G. Riedel-Heller
Summary: This study analyzed the impact of perceived restriction due to government measures on depressive symptoms in older adults at increased risk for dementia in Germany. The results showed that feeling restricted due to COVID-19 measures was associated with higher levels of depressive symptoms, and this association was mediated by perceived stress.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Gerontology
Freya Diederich, Hans-Helmut Koenig, Christian Brettschneider
Summary: In the context of increasing demand for long-term care services in aging societies, families' provision for current and future long-term care needs has been discussed. Our study contributes to the literature by analyzing how parents transmit filial norms to their children and whether this affects their caregiving behavior when a parent needs long-term care.
Article
Clinical Neurology
Andrea E. Zuelke, Alexander Pabst, Melanie Luppa, Susanne Roehr, Hanna Seidling, Anke Oey, Maria Isabel Cardona, Iris Blotenberg, Alexander Bauer, Solveig Weise, Isabel Zoellinger, Linda Sanftenberg, Christian Brettschneider, Juliane Doehring, Laura Lunden, David Czock, Walter E. Haefeli, Birgitt Wiese, Wolfgang Hoffmann, Thomas Frese, Jochen Gensichen, Hans-Helmut Koenig, Hanna Kaduszkiewicz, Jochen Rene Thyrian, Steffi G. Riedel-Heller
Summary: In a cluster-randomized trial conducted in Germany, a multidomain intervention was found to have no effect on global cognitive performance among older adults at risk for dementia. However, it improved health-related quality of life and reduced depressive symptoms.
ALZHEIMERS & DEMENTIA
(2023)
Article
Biochemistry & Molecular Biology
Rafael Campos-Martin, Katharina Bey, Bjoern Elsner, Benedikt Reuter, Julia Klawohn, Alexandra Philipsen, Norbert Kathmann, Michael Wagner, Alfredo Ramirez
Summary: Obsessive-compulsive disorder (OCD) is a common mental disorder affecting around 2-3% of the population. This study investigated the epigenetic factors associated with OCD by analyzing DNA methylation patterns in 185 OCD patients and 199 controls. The researchers identified differentially methylated CpG positions and validated their findings using a subset of 12 CpGs. These CpGs were found to be related to genes associated with the sweet-compulsive brain hypothesis, suggesting a potential role of aberrant dopaminergic transmission in OCD pathogenesis.
MOLECULAR PSYCHIATRY
(2023)
Article
Multidisciplinary Sciences
Karoline Lukaschek, Carolin Haas, Andre Wannemueller, Christian Brettschneider, Tobias Dreischulte, Jurgen Margraf, Jochen Gensichen, PARADIES Study Group
Summary: A team-based exercise programme combined with cognitive behavioural therapy (CBT) and case management showed significant positive effects for patients with panic disorder. The long-term effects (>5 years) of this intervention were analysed during the Covid-19 pandemic. The intervention group had lower anxiety symptom severity compared to the control group. Both groups showed increased anxiety and depression symptoms over time, possibly due to external circumstances.
Article
Psychiatry
Katharina Isabelle Moormann, Alexander Pabst, Franziska Bleck, Margrit Loebner, Hanna Kaduszkiewicz, Carolin van der Leeden, Andre Hajek, Christian Brettschneider, Kathrin Heser, Luca Kleineidam, Jochen Werle, Angela Fuchs, Dagmar Weeg, Horst Bickel, Michael Pentzek, Siegfried Weyerer, Birgitt Wiese, Michael Wagner, Wolfgang Maier, Martin Scherer, Hans-Helmut Koenig, Steffi G. G. Riedel-Heller
Summary: This study aimed to explore the association between sociodemographic and health-related factors and social isolation in relation to family and friends among the oldest-old. The findings revealed that factors such as gender, age, functional activities of daily living, depression severity, and cognitive functioning had unequal effects on social isolation. Therefore, the social context should be considered more strongly in the detection and prevention of social isolation to maintain mental and physical health.
SOCIAL PSYCHIATRY AND PSYCHIATRIC EPIDEMIOLOGY
(2023)
Article
Medicine, General & Internal
Isabel Zoellinger, Alexander Bauer, Iris Blotenberg, Christian Brettschneider, Maresa Buchholz, David Czock, Juliane Doehring, Catharina Escales, Thomas Fankhaenel, Thomas Frese, Wolfgang Hoffmann, Hanna Kaduszkiewicz, Hans-Helmut Koenig, Melanie Luppa, Anke Oey, Alexander Pabst, Linda Sanftenberg, Jochen Rene Thyrian, Julian Weiss, Flora Wendel, Birgitt Wiese, Steffi G. Riedel-Heller, Jochen Gensichen, Piotr Galecki
Summary: In order to develop effective dementia prevention strategies, it is important to understand the risk factors, associated factors, and early signs of dementia. This study found that depressive symptoms, sleeping problems, and higher education levels are significantly associated with subjective cognitive decline (SCD), which is an early form of dementia.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Nutrition & Dietetics
Debora Melo van Lent, Sarah Egert, Steffen Wolfsgruber, Luca Kleineidam, Leonie Weinhold, Holger Wagner-Thelen, Birgit Stoffel-Wagner, Horst Bickel, Birgitt Wiese, Siegfried Weyerer, Michael Pentzek, Frank Jessen, Matthias Schmid, Wolfgang Maier, Martin Scherer, Steffi G. G. Riedel-Heller, Alfredo Ramirez, Michael Wagner
Summary: Deficiency of vitamin D increases the risk of developing Alzheimer's dementia. It is recommended to monitor vitamin D levels in the elderly and provide supplementation in cases of deficiency.
Correction
Geriatrics & Gerontology
Andre Hajek, Christian Brettschneider, Dagmar Luhmann, Hendrik van den Bussche, Birgitt Wiese, Silke Mamone, Siegfried Weyerer, Jochen Werle, Verena Leve, Angela Fuchs, Susanne Rohr, Janine Stein, Horst Bickel, Edelgard Mosch, Kathrin Heser, Michael Wagner, Martin Scherer, Wolfgang Maier, Steffi G. Riedel-Heller, Michael Pentzek, Hans-Helmut Koenig
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2022)
Article
Public, Environmental & Occupational Health
Lydia Neubert, Sophie Gottschalk, Hans-Helmut Koenig, Christian Brettschneider
Summary: Supporting informal care-giving for people with dementia has a significant impact on family life. A study revealed five types of family carers based on the quality of relationship and distribution of care-giving tasks. Carers may perceive care-giving as a joint project, cooperation with external support, cooperation within the family, disappointment, or a predicament. Focusing on the family network and promoting family unity can enhance care experiences and sustain informal dementia care.
HEALTH & SOCIAL CARE IN THE COMMUNITY
(2022)