4.6 Review

Systematic review and narrative synthesis of cognition in perimenopause: The role of risk factors and menopausal symptoms

Journal

MATURITAS
Volume 164, Issue -, Pages 76-86

Publisher

ELSEVIER IRELAND LTD
DOI: 10.1016/j.maturitas.2022.06.010

Keywords

Perimenopause; Cognition; Memory; Executive function; Lifestyle factors

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This review examines the relationships between cognition, menopausal symptoms, and risk/protective factors. The findings suggest that factors associated with cognition and menopausal symptoms can be categorized into demographic, socio-economic, lifestyle, and reproductive factors.
Objective: Many women report cognitive concerns during the menopausal transition, and cognitive testing supports objective declines in some cognitive domains for some women. Identifying risk and protective factors that mediate cognitive difficulties would help women gain better insight into how they can manage cognitive difficulties during the menopause transition. The purpose of this review was to synthesize the studies that examine the relationships between cognition, menopausal symptoms and risk/protective factors during menopause transition. Methods: A search of the literature examining cognition and risk factors in perimenopausal women between 2010 and September 2020 was performed using Ovid MEDLINE, PsychINFO, and PubMed. The results were synthesized narratively. Studies were categorized into clusters and conceptual mapping was used to illustrate the findings. Results: 33 studies were included in this review and divided into three clusters. Factors associated with cognitive and other menopausal symptoms were grouped into demographic, socio-economic, lifestyle and reproductive factors. Conclusion: The current review identified a broad range of demographic, reproductive, socio-economic, and lifestyle risk/protective factors that are associated with cognition and menopausal symptoms. Relationships were also observed between vasomotor, affective and sleep symptoms with cognition, suggesting a complex relationship, including direct and indirect effects of risk/protective factors on cognition during menopause.

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