Article
Clinical Neurology
Michael D. Oliver, Cassandra Morrison, Farooq Kamal, Jillian Graham, Mahsa Dadar
Summary: The endorsement of subjective cognitive decline (SCD) is related to the development of Alzheimer's disease (AD) and is influenced by biological sex. Individuals with SCD have poorer cognitive performance and faster decline, with females with SCD experiencing the fastest decline in cognitive domains.
ALZHEIMERS RESEARCH & THERAPY
(2022)
Article
Clinical Neurology
Olin Janssen, Willemijn J. Jansen, Stephanie J. B. Vos, Merce Boada, Lucilla Parnetti, Tomasz Gabryelewicz, Tormod Fladby, Jose Luis Molinuevo, Sylvia Villeneuve, Jakub Hort, Stephane Epelbaum, Alberto Lleo, Sebastiaan Engelborghs, Wiesje M. van der Flier, Susan Landau, Julius Popp, Anders Wallin, Philip Scheltens, Marcel Olde Rikkert, Peter J. Snyder, Chris Rowe, Gael Chetelat, Agustin Ruiz, Marta Marquie, Elena Chipi, Steffen Wolfsgruber, Michael Heneka, Henning Boecker, Oliver Peters, Jonas Jarholm, Lorena Rami, Adria Tort-Merino, Alexa Pichet Binette, Judes Poirier, Pedro Rosa-Neto, Jiri Cerman, Bruno Dubois, Marc Teichmann, Daniel Alcolea, Juan Fortea, M. Belen Sanchez-Saudinos, Jarith Ebenau, Cornelia Pocnet, Marie Eckerstrom, Louisa Thompson, Victor Villemagne, Rachel Buckley, Samantha Burnham, Marion Delarue, Yvonne Freund-Levi, Asa K. Wallin, Inez Ramakers, Magda Tsolaki, Hilkka Soininen, Harald Hampel, Luiza Spiru, Betty Tijms, Rik Ossenkoppele, Frans R. J. Verhey, Frank Jessen, Pieter Jelle Visser
Summary: In addition to age, setting, and APOE ε4 carriership, specific characteristics of subjective cognitive decline may aid in identifying individuals with amyloid positivity.
ALZHEIMERS & DEMENTIA
(2022)
Article
Neurosciences
Zhenrong Fu, Mingyan Zhao, Yuxia Li, Yirong He, Xuetong Wang, Zongkui Zhou, Ying Han, Shuyu Li
Summary: This study evaluated SCD subtypes in a Chinese cohort and examined associated neuroimaging markers, biomarkers, and clinical outcomes. Four subtypes were identified: dysexecutive/mixed SCD, neuropsychiatric SCD, amnestic SCD, and cluster-derived normal. Each subtype showed distinct patterns in gray matter volume and amplitude of low-frequency fluctuations.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Neurosciences
Zahinoor Ismail, Alexander McGirr, Sascha Gill, Sophie Hu, Nils D. Forkert, Eric E. Smith
Summary: The study showed that individuals with both MBI and SCD had the highest risk of cognitive and functional decline, suggesting that these two conditions combined can serve as a simple and scalable method to identify high-risk patients.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Geriatrics & Gerontology
Silvia Chapman, Jillian L. Joyce, Megan S. Barker, Preeti Sunderaraman, Sandra Rizer, Edward D. Huey, Jordan Dworkin, Yian Gu, Stephanie Cosentino
Summary: This study suggests that inter-individual differences in metamemory and the lack of sensitivity in clinical measures may contribute to the discrepancies between subjective cognitive decline (SCD) and objective cognitive abilities. The accuracy of metamemory can moderate the relationship between SCD and early cognitive dysfunction, highlighting the importance of considering self-referential assessment in interpreting SCD.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Review
Medicine, General & Internal
Xianfeng Yu, Kai Shao, Ke Wan, Taoran Li, Yuxia Li, Xiaoqun Zhu, Ying Han
Summary: Alzheimer's disease is a neurodegenerative disease that affects cognitive functions. Early intervention targeting subjective cognitive decline (SCD) may be the most effective in delaying or preventing cognitive decline. This review aims to summarize the current data on SCD blood biomarkers for diagnosing preclinical Alzheimer's disease and the challenges involved. Developing blood biomarkers that are sensitive, non-invasive, accessible, and cost-effective is essential for early diagnosis.
CHINESE MEDICAL JOURNAL
(2023)
Article
Clinical Neurology
Fernando Gonzalez-Ortiz, Pamela C. L. Ferreira, Armand Gonzalez-Escalante, Laia Montoliu-Gaya, Paula Ortiz-Romero, Przemyslaw R. Kac, Michael Turton, Hlin Kvartsberg, Nicholas J. Ashton, Henrik Zetterberg, Peter Harrison, Bruna Bellaver, Guilherme Povala, Victor L. Villemagne, Tharick A. Pascoal, Mary Ganguli, Anne D. Cohen, Carolina Minguillon, Jose Contador, Marc Suarez-Calvet, Thomas K. Karikari, Kaj Blennow
Summary: UGOT p-tau217 is a promising and easily accessible method for screening and monitoring individuals with suspected AD pathophysiology, even in the early stages.
ALZHEIMERS & DEMENTIA
(2023)
Article
Neurosciences
Yintong Li, Jinghua Bian, Yongna Li
Summary: This study investigated the decline in alerting, orienting, and executive control in older adults with subjective cognitive decline (SCD), as well as the difference in the proactive and reactive modes of control between SCD and healthy controls (HC). The results showed that older adults with SCD exhibited impairment in proactive control compared to HC.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Geriatrics & Gerontology
QinJie Li, Feng-Feng Pan, Qi Huang, Chun-Yi Zac Lo, Fang Xie, QiHao Guo
Summary: This study aimed to investigate metamemory alterations across the Alzheimer's continuum, the association between metamemory and cognition, and the relationship between cortical thickness in specific regions of interest and metamemory scores. Results showed that individuals with subjective cognitive decline (SCD) exhibited significantly higher degrees of confidence (DOC) in the A beta+ subgroup, and there was an increasing trend of overconfidence with cognitive decline across the AD spectrum.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Medicine, General & Internal
Miguel Angel Rivas-Fernandez, Monica Lindin, Montserrat Zurron, Fernando Diaz, Cristina Lojo-Seoane, Arturo X. Pereiro, Santiago Galdo-Alvarez
Summary: Subjective Cognitive Decline (SCD) may represent a preclinical stage of Alzheimer's disease (AD) and is associated with structural changes in the brain. However, the evidence regarding these changes remains inconsistent.
FRONTIERS IN MEDICINE
(2023)
Article
Clinical Neurology
Luca Kleineidam, Michael Wagner, Jannis Guski, Steffen Wolfsgruber, Lisa Miebach, Horst Bickel, Hans-Helmut Koenig, Siegfried Weyerer, Dagmar Luehmann, Hanna Kaduszkiewicz, Melanie Luppa, Susanne Rohr, Michael Pentzek, Birgitt Wiese, Wolfgang Maier, Martin Scherer, Johannes Kornhuber, Oliver Peters, Lutz Frolich, Jens Wiltfang, Piotr Lewczuk, Michael Huell, Alfredo Ramirez, Frank Jessen, Steffi G. Riedel-Heller, Kathrin Heser
Summary: This study found that subjective cognitive decline (SCD) typically precedes depressive symptoms (DS), and individuals with SCD and high DS are at an increased risk for cognitive decline and dementia progression. Additionally, levels of CSF Ass42 can predict increasing DS.
ALZHEIMERS & DEMENTIA
(2023)
Article
Neurosciences
Silvia Chapman, Preeti Sunderaraman, Jillian L. Joyce, Martina Azar, Leigh E. Colvin, Megan S. Barker, Ian McKeague, William C. Kreisl, Stephanie Cosentino
Summary: The study found that complaints of age-anchored SCD were less frequent when compared to age-matched peers, and this measurement method appears to be better suited for detecting early cognitive dysfunction.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Neurosciences
Laura Serra, Sabrina Bonarota, Carlotta Di Domenico, Giulia Caruso, Giovanni Giulietti, Carlo Caltagirone, Mara Cercignani, Marco Bozzali
Summary: Subjective cognitive decline (SCD) individuals show abnormalities in brain functional connectivity (FC) and AD-related biomarkers. These abnormalities may contribute to the cognitive decline experienced by SCD individuals, despite normal scores on traditional neuropsychological assessments.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Neurosciences
Xing Zhao, Wenying Du, Jiehui Jiang, Ying Han
Summary: This study investigates the effects of transcranial brain photobiomodulation therapy on sleep and cognitive function in individuals with subjective cognitive decline (SCD). The results show that after five days of treatment, the real light group had improved sleep efficiency and N-back cognitive performance.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Review
Public, Environmental & Occupational Health
Chao Xue, Juan Li, Mingqing Hao, Lihua Chen, Zuoxiu Chen, Zeli Tang, Huan Tang, Qian Fang
Summary: This study systematically evaluated the prevalence of subjective cognitive decline (SCD) among older Chinese adults. The results showed a high and widespread prevalence of SCD in this population, with variations in gender, age, BMI, geographic region, residency, occupation, education level, and marital status.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Clinical Neurology
Tingting Wang, Kevin Huynh, Corey Giles, Natalie A. Mellett, Thy Duong, Anh Nguyen, Wei Ling Florence Lim, Alex A. T. Smith, Gavriel Olshansky, Gemma Cadby, Joseph Hung, Jennie Hui, John Beilby, Gerald F. Watts, Pratishtha Chatterjee, Ian Martins, Simon M. Laws, Ashley Bush, Christopher C. Rowe, Victor L. Villemagne, David Ames, Colin L. Masters, Kevin Taddei, Vincent Dore, Juergen Fripp, Matthias Arnold, Gabi Kastenmueller, Kwangsik Nho, Andrew J. Saykin, Rebecca Baillie, Xianlin Han, Ralph N. Martins, Eric K. Moses, Rima Kaddurah-Daouk, Peter J. Meikle
Summary: The APOE genotype is strongly associated with late-onset Alzheimer's disease, with specific lipid species mediating up to 30% and 10% of the treatment effect of APOE epsilon 2 and epsilon 4, respectively. Plasma lipid species represent a potential therapeutic target for Alzheimer's disease.
ALZHEIMERS & DEMENTIA
(2022)
Article
Clinical Neurology
Duygu Tosun, Zeynep Demir, Dallas P. Veitch, Daniel Weintraub, Paul Aisen, Clifford R. Jack, William J. Jagust, Ronald C. Petersen, Andrew J. Saykin, Leslie M. Shaw, John Q. Trojanowski, Michael W. Weiner
Summary: Aβ, tau, and neurodegeneration have significant impacts on cognitive impairment and cognitive decline, while AD risk factors also play an important role in affecting disease progression.
ALZHEIMERS & DEMENTIA
(2022)
Article
Clinical Neurology
Emrin Horgusluoglu, Ryan Neff, Won-Min Song, Minghui Wang, Qian Wang, Matthias Arnold, Jan Krumsiek, Beatriz Galindo-Prieto, Chen Ming, Kwangsik Nho, Gabi Kastenmueller, Xianlin Han, Rebecca Baillie, Qi Zeng, Shea Andrews, Haoxiang Cheng, Ke Hao, Alison Goate, David A. Bennett, Andrew J. Saykin, Rima Kaddurah-Daouk, Bin Zhang
Summary: This study aims to identify AD-specific metabolomic changes and their potential upstream genetic and transcriptional regulators through an integrative systems biology framework. The findings suggest that short-chain acylcarnitines/amino acids and medium/long-chain acylcarnitines are most associated with AD clinical outcomes. Integration of gene expression data reveals ABCA1 and CPT1A are involved in regulating acylcarnitines and amino acids in AD.
ALZHEIMERS & DEMENTIA
(2022)
Article
Neurosciences
Jun Pyo Kim, Bo-Hyun Kim, Paula J. Bice, Sang Won Seo, David A. Bennett, Andrew J. Saykin, Kwangsik Nho
Summary: Through analysis of data from two independent cohorts, we found that DNA methylation alterations may be involved in Alzheimer's disease (AD), and identified 15 key CpG sites associated with AD pathology.
BIOLOGICAL PSYCHIATRY
(2023)
Article
Biochemistry & Molecular Biology
Jari Lahti, Samuli Tuominen, Qiong Yang, Giulio Pergola, Shahzad Ahmad, Najaf Amin, Nicola J. Armstrong, Alexa Beiser, Katharina Bey, Joshua C. Bis, Eric Boerwinkle, Jan Bressler, Archie Campbell, Harry Campbell, Qiang Chen, Janie Corley, Simon R. Cox, Gail Davies, Philip L. De Jager, Eske M. Derks, Jessica D. Faul, Annette L. Fitzpatrick, Alison E. Fohner, Ian Ford, Myriam Fornage, Zachary Gerring, Hans J. Grabe, Francine Grodstein, Vilmundur Gudnason, Eleanor Simonsick, Elizabeth G. Holliday, Peter K. Joshi, Eero Kajantie, Jaakko Kaprio, Pauliina Karell, Luca Kleineidam, Maria J. Knol, Nicole A. Kochan, John B. Kwok, Markus Leber, Max Lam, Teresa Lee, Shuo Li, Anu Loukola, Tobias Luck, Riccardo E. Marioni, Karen A. Mather, Sarah Medland, Saira S. Mirza, Mike A. Nalls, Kwangsik Nho, Adrienne O'Donnell, Christopher Oldmeadow, Jodie Painter, Alison Pattie, Simone Reppermund, Shannon L. Risacher, Richard J. Rose, Vijay Sadashivaiah, Markus Scholz, Claudia L. Satizabal, Peter W. Schofield, Katharina E. Schraut, Rodney J. Scott, Jeannette Simino, Albert V. Smith, Jennifer A. Smith, David J. Stott, Ida Surakka, Alexander Teumer, Anbupalam Thalamuthu, Stella Trompet, Stephen T. Turner, Sven J. van der Lee, Arno Villringer, Uwe Voelker, Robert S. Wilson, Katharina Wittfeld, Eero Vuoksimaa, Rui Xia, Kristine Yaffe, Lei Yu, Habil Zare, Wei Zhao, David Ames, John Attia, David A. Bennett, Henry Brodaty, Daniel I. Chasman, Aaron L. Goldman, Caroline Hayward, M. Arfan Ikram, J. Wouter Jukema, Sharon L. R. Kardia, Todd Lencz, Markus Loeffler, Venkata S. Mattay, Aarno Palotie, Bruce M. Psaty, Alfredo Ramirez, Paul M. Ridker, Steffi G. Riedel-Heller, Perminder S. Sachdev, Andrew J. Saykin, Martin Scherer, Peter R. Schofield, Stephen Sidney, John M. Starr, Julian Trollor, William Ulrich, Michael Wagner, David R. Weir, James F. Wilson, Margaret J. Wright, Daniel R. Weinberger, Stephanie Debette, Johan G. Eriksson, Thomas H. Mosley, Lenore J. Launer, Cornelia M. van Duijn, Ian J. Deary, Sudha Seshadri, Katri Raikkonen
Summary: This study examines the associations between genetic variants and verbal short-term memory and learning in adults, revealing several genomic loci that are implicated in these processes. Functional and bioinformatic analyses support these findings, while genetic correlations with neurocognitive and health outcomes further highlight the significance of these memory traits.
MOLECULAR PSYCHIATRY
(2022)
Article
Clinical Neurology
Mario A. Parra, Paulina Orellana, Tomas Leon, Cabello G. Victoria, Fernando Henriquez, Rodrigo Gomez, Constanza Avalos, Andres Damian, Andrea Slachevsky, Agustin Ibanez, Henrik Zetterberg, Betty M. Tijms, Jennifer S. Yokoyama, Stefanie D. Pina-Escudero, J. Nicholas Cochran, Diana L. Matallana, Daisy Acosta, Ricardo Allegri, Bianca P. Arias-Suarez, Bernardo Barra, Maria Isabel Behrens, SoniaM. D. Brucki, Geraldo Busatto, Paulo Caramelli, Sheila Castro-Suarez, Valeria Contreras, Nilton Custodio, Sergio Dansilio, Myriam De la Cruz-Puebla, Leonardo Cruz de Souza, Monica M. Diaz, Lissette Duque, Gonzalo A. Farias, Sergio T. Ferreira, Nahuel Magrath Guimet, Ana Kmaid, David Lira, Francisco Lopera, Beatriz Mar Meza, Eliane C. Miotto, Ricardo Nitrini, Alberto Nunez, Santiago O'Neill, John Ochoa, Maritza Pintado-Caipa, Elisa de Paula Franca Resende, Shannon Risacher, Luz Angela Rojas, Valentina Sabaj, Lucas Schilling, Allis F. Sellek, Ana Sosa, Leonel T. Takada, Antonio L. Teixeira, Martha Unaucho-Pilalumbo, Claudia Duran-Aniotz
Summary: Limited knowledge and funding, as well as inadequate infrastructure, present significant barriers to dementia biomarker research in Latin American and Caribbean countries. However, the region shows great potential for advancements in this field.
ALZHEIMERS & DEMENTIA
(2023)
Review
Neuroimaging
Cecily G. Swinford, Shannon L. Risacher, Yu-Chien Wu, Liana G. Apostolova, Sujuan Gao, Paula J. Bice, Andrew J. Saykin
Summary: The prevalence of Alzheimer's disease in the U.S. is expected to reach 13 million by 2050. Currently, there are no treatments available to stop or reverse the progressive cognitive decline associated with the disease. Preventive treatment before significant cognitive decline occurs may be the solution, but there is a need for a reliable biomarker to identify older adults at highest risk. Quantitative cerebral blood flow shows promise as a potential early biomarker for Alzheimer's disease, but further research is needed to fully understand the patterns of altered blood flow.
BRAIN IMAGING AND BEHAVIOR
(2023)
Letter
Clinical Neurology
Jung-Min Pyun, Young Ho Park, Jiebiao Wang, Paula J. Bice, David A. Bennett, SangYun Kim, Andrew J. Saykin, Kwangsik Nho
ANNALS OF NEUROLOGY
(2023)
Article
Oncology
Kelly Nudelman, Kwangsik Nho, Michael Zhang, Brenna C. McDonald, Wanting Zhai, Brent J. Small, Claire E. Wegel, Paul B. Jacobsen, Heather S. L. Jim, Sunita K. Patel, Deena M. A. Graham, Tim A. Ahles, James C. Root, Tatiana Foroud, Elizabeth C. Breen, Judith E. Carroll, Jeanne S. Mandelblatt, Andrew J. Saykin
Summary: This study found that genetics may play an important role in modifying risk for cognitive decline in older female breast cancer survivors. Several genetic variants and genes were identified to be associated with differences in patterns of cognitive decline in cancer patients compared to controls. Further research and validation of these findings in other cancer populations is necessary to inform therapeutic research and evaluations of risk for cognitive decline in older cancer survivors.
Article
Biophysics
Qiuting Wen, Adam Wright, Yunjie Tong, Yi Zhao, Shannon L. Risacher, Andrew J. Saykin, Yu-Chien Wu, Kaustubh Limaye, Kalen Riley
Summary: This study used dynamic diffusion-weighted imaging (dynDWI) to investigate the pulsatile dynamics of paravascular cerebrospinal fluid (pCSF) and revealed a strong correlation between pCSF pulse and finger pulse. The study also found that the time delay between pCSF and finger pulses decreased with age and shorter time delay was associated with worse cognitive function in older individuals.
NMR IN BIOMEDICINE
(2023)
Article
Cell Biology
Rafi Haque, Caroline M. Watson, Jiaqi Liu, E. Kathleen Carter, Duc M. Duong, James J. Lah, Aliza P. Wingo, Blaine R. Roberts, Erik C. B. Johnson, Andrew J. Saykin, Leslie M. Shaw, Nicholas T. Seyfried, Thomas S. Wingo, Allan I. Levey
Summary: This study developed a reliable and high-throughput mass spectrometry assay to detect 48 key proteins in cerebrospinal fluid (CSF), and found that this panel of proteins performed at least as well as existing biomarkers in predicting clinical diagnosis, brain imaging results, cognitive decline, and dementia severity in Alzheimer's disease. Combining this panel with existing biomarkers significantly improved diagnostic accuracy and prediction of disease progression.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Article
Genetics & Heredity
Thea J. Rosewood, Kwangsik Nho, Shannon L. Risacher, Sujuan Gao, Li Shen, Tatiana Foroud, Andrew J. Saykin
Summary: The genetic susceptibility for Alzheimer's disease (AD) is not fully understood. This study used an endophenotype approach to identify genetic associations and discovered novel genetic loci related to AD. These findings provide deeper insights into the genetic mechanisms underlying AD.
Article
Sport Sciences
Edward Simpson, Jill L. Reiter, Jie Ren, Zhiqi Zhang, Kelly N. Nudelman, Larry D. Riggen Jr, Michael D. Menser, Jaroslaw Harezlak, Tatiana M. Foroud, Andrew J. Saykin, Alison Brooks, Kenneth L. Cameron, Stefan M. Duma, Gerald Mcginty, Steven Rowson, Steven J. Svoboda, Steven P. Broglio, Michael A. McCrea, Paul F. Pasquina, Thomas W. Mcallister, Yunlong Liu, CARE Consortium Investigators
Summary: This study analyzed the gene expression changes in peripheral blood following concussion in collegiate athletes. The results showed immediate activation of cytokine and immune response signaling pathways, which later seemed to be suppressed. Additionally, the study found an increase in neutrophils and a decrease in natural killer cells in the blood following concussion.
Article
Clinical Neurology
Mario A. Parra, Paulina Orellana, Tomas Leon, Cabello G. Victoria, Fernando Henriquez, Rodrigo Gomez, Constanza Avalos, Andres Damian, Andrea Slachevsky, Agustin Ibanez, Henrik Zetterberg, Betty M. Tijms, Jennifer S. Yokoyama, Stefanie D. Pina-Escudero, J. Nicholas Cochran, Diana L. Matallana, Daisy Acosta, Ricardo Allegri, Bianca P. Arias-Suarez, Bernardo Barra, Maria Isabel Behrens, SoniaM. D. Brucki, Geraldo Busatto, Paulo Caramelli, Sheila Castro-Suarez, Valeria Contreras, Nilton Custodio, Sergio Dansilio, Myriam De la Cruz-Puebla, Leonardo Cruz de Souza, Monica M. Diaz, Lissette Duque, Gonzalo A. Farias, Sergio T. Ferreira, Nahuel Magrath Guimet, Ana Kmaid, David Lira, Francisco Lopera, Beatriz Mar Meza, Eliane C. Miotto, Ricardo Nitrini, Alberto Nunez, Santiago O'Neill, John Ochoa, Maritza Pintado-Caipa, Elisa de Paula Franca Resende, Shannon Risacher, Luz Angela Rojas, Valentina Sabaj, Lucas Schilling, Allis F. Sellek, Ana Sosa, Leonel T. Takada, Antonio L. Teixeira, Martha Unaucho-Pilalumbo, Claudia Duran-Aniotz
Summary: Limited knowledge on dementia biomarkers in Latin American and Caribbean countries due to lack of funding, infrastructure, and training. However, the region holds great potential to advance dementia biomarkers research and it is crucial to expand research in this field.
ALZHEIMERS & DEMENTIA
(2023)