Review
Pharmacology & Pharmacy
Chenxi Fan, Xin Sun, Xin Wang, Hongsong Yu
Summary: This paper systematically collects and summarizes the chemical composition, pharmacological activities, and disease treatment effects of Dendrobium nobile Lindl. The research reveals that Dendrobium nobile Lindl. contains chemical components such as alkaloids, bibenzyls, sesquiterpenes, phenanthrenes, and polysaccharides, and demonstrates pharmacological activities such as anti-tumor, anti-aging, immune enhancement, hypoglycemic, and anti-cataract. Therefore, this paper provides a scientific reference for future research on the application of Dendrobium nobile Lindl. in disease treatment.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Plant Sciences
Yijun Fan, Ting Jiang, Ze Chun, Gang Wang, Kaigang Yang, Xueyan Tan, Juan Zhao, Shangrao Pu, Aoxue Luo
Summary: The study found that an appropriate amount of zinc can promote photosynthesis and the synthesis of medicinal components in Dendrobium nobile. The maximum values of photosynthetic parameters and medicinal component content were observed at a zinc concentration of 400 µmol L-1.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2021)
Article
Psychiatry
Ning Jiang, Yu-jiao Li, Meng-di Wang, Hong Huang, Shanguang Chen, Yinghui Li, Lina Qu, Fengzhong Wang, Xinmin Liu, Qiong Wang
Summary: This study found that Dendrobium nobile Lindl (DNL) can prevent and improve cognitive deficits caused by sleep deprivation, possibly through the regulation of neurotransmitters and alleviation of oxidative stress.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Plant Sciences
Xuebing Li, Yijun Fan, Jie Ma, Xiaoya Gao, Gang Wang, Shengdi Wu, Yuanyuan Liu, Kaigang Yang, Erya Xu, Shangrao Pu, Aoxue Luo
Summary: Heavy metal stress affects the quality of medicinal plants, but rare earth elements, specifically cerium, can effectively alleviate this stress. In this study, the effects of different concentrations of cerium on Dendrobium nobile Lindl. plants under copper stress were investigated. The results showed that low concentrations of cerium (10-20 mg/L) significantly improved the resistance and medicinal qualities of the plant, including polysaccharide, polyphenol, and flavonoid content. It also increased the content of photosynthetic pigment, proline, soluble sugar, and soluble protein, effectively balancing the osmotic pressure and reducing the toxic effects of copper. Overall, the optimal concentration of cerium (10-20 mg/L) shows promise in alleviating copper stress and promoting the accumulation of medicinal components in D. nobile Lindl.
JOURNAL OF PLANT PHYSIOLOGY
(2023)
Article
Nanoscience & Nanotechnology
W. Cui, Y. Wang, C. Luo, J. Xu, K. Wang, H. Han, K. Yao
Summary: Nanoceria, a nanozyme with unique auto-regenerative antioxidant capacity, shows potential in managing oxidative stress-related ocular diseases and delivering drugs to ocular tissues. This review discusses recent advances and the importance of surface modification in enhancing the safety and targeting properties of nanoceria.
MATERIALS TODAY NANO
(2022)
Article
Chemistry, Applied
Mao-Sheng Zhang, Lang Linghu, Gang Wang, Yu-Qi He, Cheng-Xin Sun, Shi-Ji Xiao
Summary: Six dendrobine-type alkaloids were isolated from Dendrobium nobile and their structures were identified using spectroscopic techniques. The cytotoxic effects of these compounds on two human tumor cell lines were evaluated.
NATURAL PRODUCT RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Yijun Fan, Xuebing Li, Gang Wang, Jie Ma, Yuanyuan Liu, Erya Xu, Aoxue Luo
Summary: This research used metabolome combined transcriptome analysis to reveal the mechanism by which Dendrobium nobile alleviates zinc stress. The results showed that zinc was mainly enriched in the roots and leaves, and the biomass of D. nobile decreased significantly under zinc stress. Metabolome analysis identified enrichment of metabolites related to secondary metabolite biosynthesis and carbohydrate metabolism, while transcriptome analysis identified differentially expressed genes involved in polysaccharide biosynthesis and glutathione metabolism. These findings provide new insights for phytoremediation and quality assurance of medicinal D. nobile.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Pharmacology & Pharmacy
Debora Santonocito, Ignazio Barbagallo, Alfio Distefano, Giuseppe Sferrazzo, Maria Vivero-Lopez, Maria Grazia Sarpietro, Carmelo Puglia
Summary: The aim of this study was to investigate the capability of MGN-NLC as a potential drug delivery system for ocular administration. The in vitro and ex vivo results showed that MGN-NLC exhibited no cytotoxic effects, maintained the antioxidant role of MGN, and could permeate and accumulate in ocular tissues. These findings suggest a potential application of MGN-NLC in the treatment of oxidative stress-related ocular diseases.
Article
Biochemistry & Molecular Biology
Yijun Fan, Jie Ma, Yuanyuan Liu, Xueyan Tan, Xuebing Li, Erya Xu, Linlong Xu, Aoxue Luo
Summary: This study investigated the relieving effect of exogenous calcium on heat stress in D. nobile and revealed its possible heat tolerance mechanism through transcriptome analysis. The results showed that a 10 mmol/L calcium treatment effectively improved the growth indicators, chlorophyll and antioxidant content of D. nobile, and reduced the yellow leaf rate and defoliation rate.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Dan Rao, Ruoxi Zhao, Yadong Hu, Hongjie Li, Ze Chun, Shigang Zheng
Summary: Thirteen new natural antioxidants were identified in the medicinal plant Dendrobium nobile using HPLC-MS/MS analysis. These compounds protected human cells from oxidative damage by increasing antioxidant enzyme activity and reducing intracellular oxidative stress levels. The results contributed to the database of safe and effective intracellular antioxidants in medicinal plants.
Article
Integrative & Complementary Medicine
Enchan Wu, Yiting Lian, Sali Zhao, Yajing Li, Lan Xiang, Jianhua Qi
Summary: This study identified the anti-aging component in the Chinese herb Dendrobium nobile and elucidated its mechanism of action. The results showed that Dendrobium nobile exerts anti-aging effects by modifying oxidative stress and autophagy through the Sch9/Rim15/Msn2 signaling pathway. This research provides a scientific basis for the development of Dendrobium nobile as an anti-aging herb.
Article
Biochemistry & Molecular Biology
Baolu Cui, Min Huang, Chongdai Guo, Ruihong Li, Yuqi Wang
Summary: The DnMSl1 gene in Dendrobium nobile Lindl was cloned and found to play a negative regulatory role in salinity-stress resistance in plants.
PLANT SIGNALING & BEHAVIOR
(2022)
Article
Plant Sciences
Ruoxi Zhao, Shigang Zheng, Yadong Hu, Hongjie Li, Yaoyi Chen, Ze Chun
Summary: In this study, high-throughput sequencing of 16S rRNA was used to explore the structure of the endophytic bacterial microbiome associated with different vegetative organs (roots, stems, and leaves) of D. nobile. The study found that the abundance and diversity of endophytes in roots were generally higher than those in stems and leaves. Most of the endophytes were involved in nutrient metabolism, and some bacterial taxa were involved in the recruitment of microorganisms from the same phylum. This study provides important insights into the interaction between medicinal plants and their endophytes and lays a theoretical foundation for further research.
SOUTH AFRICAN JOURNAL OF BOTANY
(2023)
Article
Plant Sciences
Chun Fu, MingYu Liu
Summary: In this study, the NAC gene family in Dendrobium nobile was identified and analyzed. The results showed that these genes were unevenly distributed in the chromosomes and contained multiple stress responsive elements. Phylogenetic analysis indicated the close relation between the D. nobile NAC gene family and Dendrobium catenatum and Dendrobium chrysotoxum. QRT-PCR experiment verified the response mechanism of DnoNAC gene family under stress conditions.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Biology
Ting Pan, Ning-Meng Deng, Wu-Xia Guo, Min-Zhen Wan, Yan-Tong Zheng, Song-Yi Chen, Chuan-Liang Liu, Hong-Bo Li, Shan Liang
Summary: A low temperature is required for flowering in Dendrobium nobile, but high ambient temperature can disrupt this process. Two isoforms, DnFCA gamma and DnFCA beta, were discovered to cooperatively regulate temperature-related flowering in D. nobile. They can rescue late flowering in fca-1 mutant Arabidopsis, but delay flowering and downregulate APETALA1 expression in wild-type plants. DnFCA gamma can suppress the transcription of DnAPL1 in axillary buds, while both isoforms activate DnAGL19 in seedlings.
Article
Biochemistry & Molecular Biology
Hussah Abdullah Alshwyeh, Sahar Khamees Aldosary, Muna Abdulsalam Ilowefah, Raheem Shahzad, Adeeb Shehzad, Saqib Bilal, In-Jung Lee, Jannah Ahmed Al Mater, Fatima Najf Al-Shakhoari, Waad Abdulrahman Alqahtani, Nurkhalida Kamal, Ahmed Mediani
Summary: Nigella species, particularly the roasted seeds, have been found to have various health benefits due to the presence of bioactive components. This study investigated the effect of roasting on the composition and biological activities of Nigella arvensis and Nigella sativa seed extracts. The results showed that roasted seeds exhibited strong antimicrobial activities and extracts significantly decreased cancer cell viability.
Article
Environmental Sciences
Ismail Ismail, Muhammad Hamayun, Anwar Hussain, Amjad Iqbal, Sumera Afzal Khan, Ayaz Ahmad, Sarah Gul, Ho-Youn Kim, In-Jung Lee
Summary: Endophytic fungi isolated from a wild plant species have been found to improve the physicochemical characteristics of sunflower and soybean exposed to high temperature stress, promoting chlorophyll contents, total biomass and plant height, inhibiting ROS production and lipid peroxidation, and increasing the levels of antioxidants, sugars, proteins, lipids and phenolics.
POLISH JOURNAL OF ENVIRONMENTAL STUDIES
(2022)
Article
Environmental Sciences
Raid Ali, Humaira Gul, Muhammad Hamayun, Mamoona Rauf, Amjad Iqbal, Anwar Hussain, In-Jung Lee
Summary: This study analyzed the physiological and biochemical parameters of maize plants exposed to salt stress with or without fungal association. The results showed that salinity had negative effects on maize growth and biochemical parameters, but fungal association improved growth parameters and reduced lipid-peroxidation under salt stress.
POLISH JOURNAL OF ENVIRONMENTAL STUDIES
(2022)
Article
Plant Sciences
Muhammad Junaid Yousaf, Anwar Hussain, Muhammad Hamayun, Amjad Iqbal, In-Jung Lee
Summary: Gibberellins, particularly GA4, play a significant role in the plant-pathogen interactions between Triticum aestivum and Bipolaris sorokiniana. The elevated GA4 level triggers a hypersensitive response in T. aestivum seedlings, leading to an increase in HR-inducing signaling compounds. This response also decreases the levels of IAA and TZn in the seedlings. However, the application of uniconazole inhibits GA4 biosynthesis and promotes the colonization of BIPOL in the roots of T. aestivum seedlings, resulting in enhanced seedling growth.
JOURNAL OF PLANT INTERACTIONS
(2022)
Article
Biochemistry & Molecular Biology
Sajjad Lubna, Sajjad Asaf, Rahmatullah Jan, Abdul Latif Khan, Waqar Ahmad, Saleem Asif, Ahmed Al-Harrasi, Kyung-Min Kim, In-Jung Lee
Summary: The mechanism and course of Triticum plastome evolution are still unknown, and this study aimed to investigate the evolution of Triticum plastomes during recent polyploidization. The complete plastomes of two polyploid wheat species, Triticum sphaerococcum and Triticum turgidum subsp. durum, were analyzed and compared to other Triticum plastomes. The results showed a conserved gene content in different Triticum species and a positive correlation between the number of repeats and plastome size. Additionally, a Triticum phylogeny was constructed, providing insights into the divergence time of various Triticum species.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Plant Sciences
Muhammad Junaid Yousaf, Anwar Hussain, Muhammad Humayun, Amjad Iqbal, Fawad Ali, In-Jung Lee, Ahmed M. El-Sabrout, Hosam O. Elansary
Summary: This study investigated the impact of host apoplastic nutrients on the virulence strategy of the biotroph model, E. orontii. The results showed that exogenous application of growth-promoting nutrients reduced the virulence, while stress-inducing analogs increased it.
PHYSIOLOGICAL AND MOLECULAR PLANT PATHOLOGY
(2022)
Article
Plant Sciences
Lubna, Muhammad Aaqil Khan, Sajjad Asaf, Rahmatullah Jan, Muhammad Waqas, Kyung-Min Kim, In-Jung Lee
Summary: In this study, a plant growth-promoting fungus, Bipolaris sp. CSL-1, was identified and found to enhance the growth of soybean under salt stress. The fungus produces various plant growth-promoting substances and improves the plant's resistance to salt stress. Inoculation with CSL-1 significantly increased the shoot and root length and weight of soybean, as well as the chlorophyll content. Moreover, CSL-1 inoculation regulated the endogenous hormone levels and reduced oxidative stress, resulting in improved stress tolerance in soybean.
JOURNAL OF PLANT INTERACTIONS
(2022)
Article
Plant Sciences
Abdul Latif Khan, Lucas Dantas Lopes, Saqib Bilal, Sajjad Asaf, Kerri M. Crawford, Venkatesh Balan, Ahmed Al-Rawahi, Ahmed Al-Harrasi, Daniel P. Schachtman
Summary: Microbial symbionts play a significant role in plant health and stress tolerance. This study compared the microbiome composition of the succulent dwarf shrub Zygophyllum qatarensis across different desert populations and found significant variations in the rhizospheric and endosphere microbiomes due to soil texture. Certain bacterial and fungal genera were abundantly distributed in the root and shoot endospheres. The study also analyzed major nutrients and found higher silicon content in the rhizosphere and root parts, suggesting that selective microbes may contribute to the translocation of soluble silicon to the roots.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Plant Sciences
Muhammad Ikram Khan, Niaz Ali, Gul Jan, Muhammad Hamayun, Farzana Gul Jan, Amjad Iqbal, Anwar Hussain, In-Jung Lee
Summary: The growth promoting potential of the endophytic fungus Aspergillus terreus BTK-1 in wheat under saline conditions was reported. BTK-1, isolated from the root of Chenopodium album, was identified as Aspergillus terreus through 18S rDNA sequence analysis. BTK-1 secreted indole acetic acid (IAA), exhibited aminocyclopropane-carboxylate deaminase (ACC) and siderophores activity, and solubilized phosphate. Wheat seedlings inoculated with BTK-1 showed higher concentrations of IAA and gibberellins, longer shoots and roots, higher biomass and chlorophyll contents, and lower concentrations of abscisic acid compared to non-inoculated plants. Additionally, BTK-1 inoculated wheat plants exhibited high activity of reduced glutathione and low activity of ascorbate, catalase, and peroxidase under salt stress. These findings suggest the potential use of BTK-1 as a bio-stimulator in salt affected soils.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Yi-Fen Chiang, Cheng-Pei Chung, Jing-Hui Lin, Wenchang Chiang, Hsin-Yuan Chen, Mohamed Ali, Yin-Hwa Shih, Kai-Lee Wang, Tsui-Chin Huang, Hsin-Yi Chang, Li-Chun Lin, Tzong-Ming Shieh, Shih-Min Hsia
Summary: This study investigated the effects of different fractions of adlay seed ethanolic extract on breast and cervical cancer cell lines, and found that they inhibited cell growth, induced apoptosis, and arrested the cell cycle.
Article
Biochemistry & Molecular Biology
Cheng-Pei Chung, Shih-Min Hsia, Wen-Szu Chang, Din-Wen Huang, Wen-Chang Chiang, Mohamed Ali, Ming-Yi Lee, Chi-Hao Wu
Summary: This study evaluated the antiglycation effects of adlay on protein glycation using in vitro glycation assays. The results showed that adlay extracts had the ability to inhibit glucose-mediated glycation, with ethanolic extracts from adlay testa and bran showing the strongest effects. Further investigation revealed that medium-high polarity components in the ethanolic extract of adlay testa exhibited superior antiglycation activity, which may be attributed to the presence of chlorogenic acid and ferulic acid.
Article
Microbiology
Husna, Anwar Hussain, Mohib Shah, Muhammad Hamayun, Amjad Iqbal, Muhammad Qadir, Abed Alataway, Ahmed Z. Dewidar, Hosam O. Elansary, In -Jung Lee
Summary: The aim of this research was to utilize plant growth promoting rhizobacteria for the sequestration and biotransformation of toxic forms of chromium and arsenic into non-toxic forms. The study found that the isolated rhizobacteria strains were able to tolerate high levels of chromate and arsenate, and convert them into least toxic forms. Additionally, they released stress-related metabolites and plant hormones, benefiting the soybean seedlings.
MICROBIOLOGICAL RESEARCH
(2023)
Article
Microbiology
Sang-Mo Kang, Arjun Adhikari, Yu-Na Kim, In-Jung Lee
Summary: This study investigated the effects of Paclobutrazol (PBZ) and Variovorax sp. YNA59 on Chinese cabbage. The results showed that both YNA59 and PBZ treatments significantly increased plant biomass under drought conditions. YNA59 had a more pronounced effect on the physiological attributes of the plants, especially under drought stress.
MICROBIOLOGY RESEARCH
(2023)
Correction
Plant Sciences
Lingmiao Wen, Tinglan Zhang, Fangfang Chen, Lin Hu, Chongyang Dou, Xian Ding, Alvin Altamirano, Guihua Wei, Zhiyong Yan
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Qing Tang, Mengfei Xu, Shunqin Long, Yaya Yu, Changju Ma, Rui Wang, Jing Li, Xi Wang, Fang Fang, Ling Han, Wanyin Wu, Sumei Wang
Summary: This study demonstrates that Fuzheng Kang-Ai (FZKA) decoction can inhibit the cell growth, proliferation, and invasion of lung adenocarcinoma (LUAD) and reverse the acquired resistance of gefitinib. FZKA exerts its effects by regulating the p-ERK1/2-EZH2-Snail/EGFR signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Xiang Zhao, Xianrun Hu, Qi Xie, Shenglan Qi, Zedong Xiang, Xin Sun, Zhejun Xie, Rui Dang, Limei Zhou, Wei Liu, Xuemei Cheng, Changhong Wang
Summary: This study investigated the effects of Fufangmuniziqi formula (FFMN) on Alzheimer's disease (AD) and the role of alkaloids, flavonoids, and saponins in the process. The results showed that FFMN improved cognitive and memory impairment in the AD mouse model. Alkaloids enhanced the cholinergic system, while flavonoids and saponins attenuated neuroinflammation and oxidative stress. These findings suggest that the combination of alkaloid, flavonoid, and saponin fractions derived from FFMN is a promising anti-AD agent.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Bangjian Dong, Ying Peng, Mengyue Wang, Chongsheng Peng, Xiaobo Li
Summary: This study elucidated the tissue distribution and excretion characteristics of the non-polysaccharide components of Sijunzi decoction in rats with spleen deficiency syndrome. It proposed new insights into the rationality of the compatibility of Sijunzi decoction.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jung-Seop Kim, Man-Gi Kim, Ji Eun Ryu, Ye-Been Lee, Quan Feng Liu, Kwang Ki Kim, Seung-Hun Cho, Sung Joon Shin, Byung-Soo Koo, Hyung-Kyoon Choi
Summary: Co-treatment with WCW and donepezil shows promise in improving cognitive function and serum metabolic profiles in a scopolamine-induced AD model. This combination therapy may reduce tyrosine and methionine levels, enhancing cognitive function by mitigating known risk factors for AD. The study provides a foundation for developing other bioactive compounds in AD treatment.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Kuang-Hsing Chiang, Tain-Junn Cheng, Wei-Chih Kan, Hsien-Yi Wang, Jui-Chen Li, Yan-Ling Cai, Chia-Hui Cheng, Yi-Chien Liu, Chia-Yu Chang, Jiunn-Jye Chuu
Summary: The ethanolic extract of Orthosiphon aristatus (OA) demonstrated an improving effect on memory and could serve as a potential therapeutic target for the treatment of neurodegenerative diseases like Alzheimer's disease (AD).
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Meryem Tourabi, Asmae EL Ghouizi, Ghizlane Nouioura, Khaoula Faiz, Hind Elfatemi, Karima El-yagoubi, Badiaa Lyoussi, Elhoussine Derwich
Summary: Mentha longifolia is a native plant in Morocco, traditionally used to treat various diseases. This study analyzed the phytochemical profile of the aqueous extract of M. longifolia and evaluated its acute and subacute toxicity in mice. The results showed that M. longifolia extract is rich in phenolic compounds and has no observed toxicity up to a certain dosage limit.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yue Zhang, Liang Li, Tao Chai, Han Xu, Hong-yan Du, Yan Jiang
Summary: Mulberry leaf multi-components (MMC) have hypoglycemic effects and can improve insulin resistance by activating the PI-3K/Akt signaling pathway. These findings highlight the multi-component, multi-target, and combined effects of MMC, and suggest it may be further developed as a hypoglycemic drug.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Correction
Plant Sciences
Shan Luo, Yuanchun Chen, Ruoxi Zhao, Donglai Ma, Yanmeng Zhao, Ying Zhang, Jianming Jiang, Wentao Yu
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Nittaya Chansiw, Pattranuch Chusri, Siwaporn Praman, Thaneeya Hawiset, Wannisa Sukhorum, Sorraya Champakam, Rawiwan Charoensup
Summary: This study evaluates the anti-inflammatory activity of Prabchompoothaweep (PCT) extract in an animal model. The results show that PCT significantly reduces inflammation and pro-inflammatory cytokines in acute and sub-acute inflammation. These findings suggest that PCT could be a new option for the treatment of inflammatory diseases.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yanting Wang, Guoqiang Liang, Wei Mu, Shu Sun, Xuanyi Chen, Xiaofeng Xu
Summary: Bushen Tianjing Recipe (BTR) is a tonic-kidney formula of Traditional Chinese Medicine (TCM) with good therapeutic effects in clinical settings. The aim of this study was to investigate the effect of BTR on women's reproductive system by incubating miR-23a-induced KGN cells.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jiayi Zhi, Li Yin, Zhoudong Zhang, Yaozhong Lv, Fan Wu, Yang Yang, Enming Zhang, Huanqiu Li, Ning Lu, Mengze Zhou, Qinghua Hu
Summary: This study verified the pharmacodynamics of JSW in the treatment of AD and explored its potential mechanism using network pharmacology, molecular docking, and experimental validation.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Review
Plant Sciences
Elizabeth Syowai Mutinda, Dong-Juan Zhang, Felix Wambua Muema, Elijah Mbandi Mkala, Emmanuel Nyongesa Waswa, Wyclif Ochieng Odago, Clintone Onyango Ochieng, Moses Kirega Gichua, John Kamau Muchuku, Elizabeth Kamande, Guang-Wan Hu
Summary: This article reviews the traditional uses, pharmacological properties, and phytoconstituents of Balanophora species, revealing that they contain diverse chemical compounds with interesting biological activities. However, research on many species in this genus is still lacking.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Luqi Cai, Yu Chen, Huizhong Xue, Yimeng Yang, Yuqi Wang, Junhe Xu, Chunyan Zhu, Long He, Yonghua Xiao
Summary: Salvia miltiorrhiza Bunge (SM) has been proven to have potential therapeutic effects for diabetic nephropathy (DN) through its multi-component, multi-target, and multi-pathway pharmacological effects.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Chao Wang, Rui-Jia Fu, Ding-Qiao Xu, Qian Zuo, Ji-Ping Liu, Yu-Ping Tang
Summary: This study aimed to explore the hepatoprotective effects of Shicao on CCl4-induced acute liver injury. A rat model of acute liver injury was established and liver function indices were assessed. Untargeted metabolomics was conducted to identify differential metabolites. Network pharmacology was used to construct a network of metabolite-reaction-enzyme-gene constituents, and key components and hub genes were screened. Shicao showed hepatoprotective effects against acute liver injury in rats.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
