Identification of 1H-pyrazolo[3,4-b]pyridine derivatives as novel and potent TBK1 inhibitors: design, synthesis, biological evaluation, and molecular docking study

Design and synthesis of 1H-pyrazolo[3,4-b]pyridines targeting mitogen-activated protein kinase kinase 4 (MKK4) - A promising target for liver regeneration

(2021) Bent Pfaffenrot et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

TBK1 Inhibitor Exerts Antiproliferative Effect on Glioblastoma Multiforme Cells

(2021) Sarah A. Scuderi et al.   ONCOLOGY RESEARCH

TANK-binding kinase 1 (TBK1): An emerging therapeutic target for drug discovery

(2021) Shuang Xiang et al.   DRUG DISCOVERY TODAY

The kinase inhibitor BX795 suppresses the inflammatory response via multiple kinases

(2020) Tao Yu et al.   BIOCHEMICAL PHARMACOLOGY

Targeting TANK-binding kinase 1 (TBK1) in cancer

(2020) Or-Yam Revach et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Discovery of GSK8612, a Highly Selective and Potent TBK1 Inhibitor

(2019) Douglas W. Thomson et al.   ACS Medicinal Chemistry Letters

Expression and prognostic role of IKBKE and TBK1 in stage I non-small cell lung cancer

(2019) Xin Wang et al.   Cancer Management and Research

Ultrastructure of Human Pancreatic Cancer Cells Treated with a TBK1 Inhibitor

(2019) Linda Yasui et al.   MICROSCOPY AND MICROANALYSIS

Discovery of BAY-985, a Highly Selective TBK1/IKKε Inhibitor

(2019) Julien Lefranc et al.   JOURNAL OF MEDICINAL CHEMISTRY

TANK-Binding Kinase 1-Dependent Responses in Health and Autoimmunity

(2018) Cynthia Louis et al.   Frontiers in Immunology

Biomarker Accessible and Chemically Addressable Mechanistic Subtypes of BRAF Melanoma

(2017) Banu Eskiocak et al.   Cancer Discovery

Ex Vivo Profiling of PD-1 Blockade Using Organotypic Tumor Spheroids

(2017) Russell W. Jenkins et al.   Cancer Discovery

TBK1 Promote Bladder Cancer Cell Proliferation and Migration via Akt Signaling

(2017) Wei Chen et al.   Journal of Cancer

Regulation and function of the cGAS–STING pathway of cytosolic DNA sensing

(2016) Qi Chen et al.   NATURE IMMUNOLOGY

Autophagy Inhibition Dysregulates TBK1 Signaling and Promotes Pancreatic Inflammation

(2016) S. Yang et al.   Cancer Immunology Research

TBK1 inhibitors: a review of patent literature (2011 – 2014)

(2015) Tao Yu et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Pharmacological Inhibition of ULK1 Kinase Blocks Mammalian Target of Rapamycin (mTOR)-dependent Autophagy

(2015) Katy J. Petherick et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Evaluating TBK1 as a Therapeutic Target in Cancers with Activated IRF3

(2014) Asli Muvaffak et al.   MOLECULAR CANCER RESEARCH

Elevated expression of TANK-binding kinase 1 enhances tamoxifen resistance in breast cancer

(2014) Congwen Wei et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanism of Endogenous Regulation of the Type I Interferon Response by Suppressor of IκB Kinase ϵ (SIKE), a Novel Substrate of TANK-binding Kinase 1 (TBK1)

(2013) James D. Marion et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure and Ubiquitination-Dependent Activation of TANK-Binding Kinase 1

(2013) Daqi Tu et al.   Cell Reports

Crystal Structure and Mechanism of Activation of TANK-Binding Kinase 1

(2013) Amede Larabi et al.   Cell Reports

Novel cross-talk within the IKK family controls innate immunity

(2011) Kristopher Clark et al.   BIOCHEMICAL JOURNAL

Emerging roles for the non-canonical IKKs in cancer

(2010) R R Shen et al.   ONCOGENE

Use of the Pharmacological Inhibitor BX795 to Study the Regulation and Physiological Roles of TBK1 and IκB Kinase ϵ

(2009) Kristopher Clark et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1

(2009) David A. Barbie et al.   NATURE

Advances in Targeting IKK and IKK-Related Kinases for Cancer Therapy

(2008) D.-F. Lee et al.   CLINICAL CANCER RESEARCH