Review
Immunology
Almudena Testera-Montes, Maria Salas, Francisca Palomares, Adriana Ariza, Maria J. Torres, Carmen Rondon, Ibon Eguiluz-Gracia
Summary: Local respiratory allergy (LRA) is characterized by negative atopy tests, clinical history of airway allergy, and positive response to allergen challenge. LRA includes conditions like local allergic rhinitis (LAR) and local allergic asthma in non-atopic patients, and dual allergic rhinitis in atopic individuals. LRA is mediated through mucosal synthesis of allergen-specific IgE and can be treated effectively with allergen immunotherapy (AIT).
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Kavita Reginald, Fook Tim Chew
Summary: This review evaluates the current modes of allergen-specific immunotherapy for cockroach allergens in terms of clinical outcomes and explores future trends in research and development for a more targeted approach to cockroach immunotherapy with better efficacy and fewer adverse effects.
MOLECULAR IMMUNOLOGY
(2023)
Article
Allergy
Susan Mikkelsen, Khoa Manh Dinh, Jens Kjaergaard Boldsen, Ole Birger Pedersen, Gitte Juel Holst, Mikkel Steen Petersen, Kathrine Agergard Kaspersen, Bjarne Kuno Moller, Kaspar Rene Nielsen, Helene Martina Paarup, Klaus Rostgaard, Henrik Hjalgrim, Erik Sorensen, Linda Jenny Handgaard, Thomas Folkmann Hansen, Karina Banasik, Kristoffer Solvsten Burgdorf, Henrik Ullum, Torben Sigsgaard, Christian Erikstrup
Summary: This study found that the prevalence of allergic rhinitis, allergic conjunctivitis, and asthma is associated with allergen-specific immunoglobulin E sensitization. Individuals from younger birth cohorts have higher prevalence of symptoms, while sIgE sensitization is positively associated with male sex. Allergic predisposition and sIgE sensitization increase the risk of diseases, while farm upbringing is associated with reduced prevalence of ARC only in sIgE sensitized participants.
CLINICAL AND TRANSLATIONAL ALLERGY
(2021)
Article
Allergy
Mariana Farraia, Francisca Castro Mendes, Oksana Sokhatska, Milton Severo, Joao Cavaleiro Rufo, Henrique Barros, Andre Moreira
Summary: This study used data from a Portuguese birth cohort to identify trajectories of allergic sensitization profiles during childhood and evaluate their association with allergic outcomes. Five different trajectories were proposed, and their associations with asthma, rhinitis, and atopic dermatitis were analyzed.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2023)
Article
Allergy
Mariana Farraia, Francisca Castro Mendes, Oksana Sokhatska, Milton Severo, Joao Cavaleiro Rufo, Henrique Barros, Andre Moreira
Summary: This study analyzed data from a Portuguese birth cohort and found that the trajectories of allergic sensitization during childhood were associated with different risks of allergic diseases. These findings are important for planning effective prevention strategies.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2023)
Review
Immunology
Josh Chatelier, Samantha Chan, Ju Ann Tan, Alastair G. Stewart, Jo Anne Douglass
Summary: Epidemic thunderstorm asthma results from the interaction of environmental and immunologic factors and occurs following thunderstorms. People sensitized to RGP pollen in Australia or fungus in the UK are more prone to TA. Important risk factors include allergen sensitization and genetic factors in specific populations.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Claudia Petrarca, Davide Viola
Summary: This study conducted a post hoc analysis to investigate the effect of endogenous vitamin D on the immunological mechanism underlying effective mite allergoid immunotherapy (AIT). The results showed that AIT is able to reshape the immune response against allergens and that vitamin D plays a role in this process. Patients with lower endogenous vitamin D levels had worse symptoms and higher medication use, while those concurrently taking VD3 as a supplement showed the best treatment outcomes. This suggests that vitamin D levels affect allergy severity and the effectiveness of allergen immunotherapy.
Article
Multidisciplinary Sciences
Merlijn van Breugel, Cancan Qi, Zhongli Xu, Casper-Emil T. Pedersen, Ilya Petoukhov, Judith M. Vonk, Ulrike Gehring, Marijn Berg, Marnix Buegel, Orestes A. Carpaij, Erick Forno, Andreanne Morin, Anders U. Eliasen, Yale Jiang, Maarten Van den Berge, Martijn C. Nawijn, Yang Li, Wei Chen, Louis J. Bont, Klaus Bonnelykke, Juan C. Celedon, Gerard H. Koppelman, Cheng-Jian Xu
Summary: The study demonstrates that nasal DNA methylation is the most accurate predictor for diagnosing childhood allergic diseases, identifying multimorbidity and IgE sensitization, with findings replicated in children of different ages and ethnicities.
NATURE COMMUNICATIONS
(2022)
Article
Allergy
Sarah A. Lyons, Mareen R. Datema, Thuy-My Le, Riccardo Asero, Laura Barreales, Simona Belohlavkova, Frederic de Blay, Michael Clausen, Ruta Dubakiene, Cristina Fernandez-Perez, Philipp Fritsche, David Gislason, Karin Hoffmann-Sommergruber, Monika Jedrzejczak-Czechowicz, Laurian Jongejan, Marek L. Kowalski, Tanya Z. Kralimarkova, Jonas Lidholm, Nikolaos G. Papadopoulos, Bo Pontoppidan, Todor A. Popov, Nayade Del Prado, Ashok Purohit, Isabel Reig, Suranjith L. Seneviratne, Athanasios Sinaniotis, Emilia Vassilopoulou, Serge A. Versteeg, Stefan Vieths, Aeilko H. Zwinderman, Paco M. J. Welsing, E. N. Clare Mills, Barbara K. Ballmer-Weber, Andre C. Knulst, Montserrat Fernandez-Rivas, Ronald Van Ree
Summary: This study investigates geographical differences in walnut component sensitization and cosensitization patterns among walnut-allergic subjects in Europe. A predictive model combining results from component-based serology testing with clinical background information can effectively discriminate between mild to moderate and severe walnut allergy.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2021)
Article
Multidisciplinary Sciences
Haisheng Hu, Huimin Huang, Chenxi Liao, Aoli Li, Teng Zhang, Xueqing Liang, Baoqing Sun
Summary: This study aims to reduce the cost of allergen testing in Guangzhou, China by limiting the number of allergens tested and providing a testing panel for improved efficiency. The study found that in southern Guangzhou, dust mites, milk, German cockroaches, and Alternaria alternata were the main allergens, and suggested using these as a screening panel for allergies.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Sze Lei Pang, Sri Anusha Matta, Yang Yie Sio, Yu Ting Ng, Yee-How Say, Chyan Leong Ng, Fook Tim Chew
Summary: The study identified K44 and E46 residues as major IgE-binding residues of the Der p 23 allergen for HDM-sensitized individuals. Individuals sensitized only to HDM have a higher number of IgE-binding residues compared to polysensitized individuals. Those with allergic multimorbidity and moderate-to-severe allergic rhinitis also exhibit a higher number of IgE-binding residues.
SCIENTIFIC REPORTS
(2021)
Article
Allergy
Valerie Siroux, Anne Boudier, Jean Bousquet, Orianne Dumas, Jocelyne Just, Nicole Le Moual, Rachel Nadif, Raphaelle Varraso, Rudolf Valenta, Isabelle Pin
Summary: This study identified four molecular sensitization profiles which remained stable from childhood to adulthood, and these profiles were associated with respiratory health outcomes such as asthma and rhinitis.
Article
Otorhinolaryngology
Michael S. Benninger, Claudia Cabrera, Eulalia M. Amador, Kevin Grafmiller, Raj Sindwani
Summary: This study explores the relationship between specific allergen sensitization and asthma severity. It found that positive tests for cat dander, dog dander, certain fungi, and house dust were associated with more severe asthma.
AMERICAN JOURNAL OF RHINOLOGY & ALLERGY
(2022)
Article
Microbiology
Yu-Lun Lo, Horng-Chyuan Lin, Chun -Yu Lo, Hung -Yu Huang, Ting -Yu Lin, Chiung-Hung Lin, Meng-Heng Hsieh, Yueh-Fu Fang, Shu-Min Lin, Yu -Tung Huang, Ting -Wei Liao, Chun-Hua Wang, Chun -Yu Lin
Summary: This study aimed to investigate the clinical characteristics and outcomes of asthmatics with fungal sensitization and/or positive fungal isolates. The results showed that asthmatic patients with fungal sensitization had higher IgE levels and a higher hospitalization rate, and the clinical impact of fungi was more significant among patients with more severe disease.
MICROBIOLOGICAL RESEARCH
(2023)
Article
Otorhinolaryngology
Ying-Ying Zhang, Min Zhang, Jia-Qi Zhang, Qiu-Qi Li, Mei-Ping Lu, Lei Cheng
Summary: Combining AIT with omalizumab can significantly improve the efficacy and safety of AIT in treating allergic diseases, increasing tolerance to allergens and reducing severe systemic adverse events.
INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Chris McKennan, Katherine Naughton, Catherine Stanhope, Meyer Kattan, George T. O'Connor, Megan T. Sandel, Cynthia M. Visness, Robert A. Wood, Leonard B. Bacharier, Avraham Beigelman, Stephanie Lovinsky-Desir, Alkis Togias, James E. Gern, Dan Nicolae, Carole Ober
Summary: The study found that race-associated DNA methylation patterns at birth and age 7 are nearly identical, indicating that blood DNA methylation levels are primarily driven by genetic factors and less sensitive to environmental exposures. Up to 51% of self-reported race-associated CpGs had race-dependent DNA methylation levels mediated through local genotype, with genetic factors explaining the majority of variation in DNA methylation levels at environmentally-associated CpGs.
Article
Medicine, General & Internal
Erick Forno, Leonard B. Bacharier, Wanda Phipatanakul, Theresa W. Guilbert, Michael D. Cabana, Kristie Ross, Ronina Covar, James E. Gern, Franziska J. Rosser, Joshua Blatter, Sandy Durrani, Yueh-Ying Han, Stephen R. Wisniewski, Juan C. Celedon
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2020)
Article
Allergy
Mengdi Lu, Augusto A. Litonjua, George T. O'Connor, Robert S. Zeiger, Leonard Bacharier, Michael Schatz, Vincent J. Carey, Scott T. Weiss, Hooman Mirzakhani
Summary: Childhood asthma development is affected by a complex interplay of maternal asthma and prenatal vitamin D status. This study suggests that adequate vitamin D intake throughout pregnancy can help reduce the risk of childhood asthma exacerbated by maternal asthma.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Allergy
Maleewan Kitcharoensakkul, Leonard B. Bacharier, Toni L. Schweiger, Brad Wilson, Charles W. Goss, Daphne Lew, Kenneth B. Schechtman, Mario Castro
Summary: Children who had severe RSV bronchiolitis in infancy are at increased risk of asthma and reduced lung function in later life. This study observed longitudinal changes in lung function and bronchial hyperreactivity from early to late childhood. Lung function decline in late childhood was associated with gender, asthma diagnosis, and allergic sensitization. Methacholine PC20 levels increased with age, while the frequency of abnormal bronchial hyperreactivity decreased.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2021)
Article
Medicine, Research & Experimental
Wanda Phipatanakul, David T. Mauger, Theresa W. Guilbert, Leonard B. Bacharier, Sandy Durrani, Daniel J. Jackson, Fernando D. Martinez, Anne M. Fitzpatrick, Amparito Cunningham, Susan Kunselman, Lisa M. Wheatley, Cindy Bauer, Carla M. Davis, Bob Geng, Kirsten M. Kloepfer, Craig Lapin, Andrew H. Liu, Jacqueline A. Pongracic, Stephen J. Teach, James Chmiel, Jonathan M. Gaffin, Matthew Greenhawt, Meera R. Gupta, Peggy S. Lai, Robert F. Lemanske, Wayne J. Morgan, William J. Sheehan, Jeffrey Stokes, Peter S. Thorne, Hans C. Oettgen, Elliot Israel
Summary: Asthma in children is largely influenced by allergen sensitization, and early intervention targeting IgE and IgE-mediated responses may help prevent and reduce the severity of asthma development.
CONTEMPORARY CLINICAL TRIALS
(2021)
Article
Anesthesiology
Christopher Conley, Mark Facchin, Qingrou Gu, Shivali Mukerji, Robyn Cohen, Sharon O'Brien, Lina Nurhussien, Lynne Ferrari
Summary: The successful implementation of a virtual pediatric perioperative home at Boston Medical Center has resulted in reduced cancellation rates for pediatric patients, improving the quality of care provided to these patients.
PEDIATRIC ANESTHESIA
(2021)
Letter
Allergy
Anna Clara Rabha, Fatima Rodrigues Fernandes, Dirceu Sole, Leonard Benjamin Bacharier, Gustavo Falbo Wandalsen
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2021)
Editorial Material
Critical Care Medicine
Andrew J. Halayko, Christopher D. Pascoe, Jessica D. Gereige, Michael C. Peters, Robyn T. Cohen, Prescott G. Woodruff
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2021)
Article
Oncology
Cara S. Guenther, Victoria J. Pae, Caitlin M. Neri, Karan Barry, Molly A. Duggan, Robyn T. Cohen
Summary: The study aimed to explore the safety, feasibility, and tolerability of using BiPAP as preventative supportive care for children with sickle cell disease in a general pediatric inpatient unit. Results showed that BiPAP was safe, feasible, well tolerated, and successful in preventing acute chest syndrome in hospitalized children with SCD.
PEDIATRIC BLOOD & CANCER
(2021)
Article
Critical Care Medicine
Helen K. Reddel, Leonard B. Bacharier, Eric D. Bateman, Christopher E. Brightling, Guy G. Brusselle, Roland Buhl, Alvaro A. Cruz, Liesbeth Duijts, Jeffrey M. Drazen, J. Mark FitzGerald, Louise J. Fleming, Hiromasa Inoue, Fanny W. Ko, Jerry A. Krishnan, Mark L. Levy, Jiangtao Lin, Kevin Mortimer, Paulo M. Pitrez, Aziz Sheikh, Arzu A. Yorgancioglu, Louis-Philippe Boulet
Summary: The article summarizes key recommendations from GINA 2021 and the recent changes, highlighting the importance of not relying solely on short-acting beta(2)-agonists for asthma treatment and provides targeted treatment suggestions based on severity and age.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Editorial Material
Allergy
Leonard B. Bacharier
ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY
(2022)
Article
Respiratory System
Helen K. Reddel, Leonard B. Bacharier, Eric D. Bateman, Christopher E. Brightling, Guy G. Brusselle, Roland Buhl, Alvaro A. Cruz, Liesbeth Duijts, Jeffrey M. Drazen, J. Mark FitzGerald, Louise J. Fleming, Hiromasa Inoue, Fanny W. Ko, Jerry A. Krishnan, Mark L. Levy, Jiangtao Lin, Kevin Mortimer, Paulo M. Pitrez, Aziz Sheikh, Arzu A. Yorgancioglu, Louis-Philippe Boulet
Summary: The Global Initiative for Asthma (GINA) Strategy Report provides clinicians with an evidence-based strategy for asthma management and prevention, emphasizing the importance of regular personalized assessment, treatment of modifiable risk factors, self-management education, and appropriate medication adjustment for optimizing asthma outcomes.
ARCHIVOS DE BRONCONEUMOLOGIA
(2022)
Article
Respiratory System
Helen K. Reddel, Leonard B. Bacharier, Eric D. Bateman, Christopher E. Brightling, Guy G. Brusselle, Roland Buhl, Alvaro A. Cruz, Liesbeth Duijts, Jeffrey M. Drazen, J. Mark FitzGerald, Louise J. Fleming, Hiromasa Inoue, Fanny W. Ko, Jerry A. Krishnan, Mark L. Levy, Jiangtao Lin, Kevin Mortimer, Paulo M. Pitrez, Aziz Sheikh, Arzu A. Yorgancioglu, Louis-Philippe Boulet
Summary: The GINA Strategy Report provides clinicians with an evidence-based strategy for asthma management and prevention, with specific recommendations and treatment options for different age groups and severity levels. Regular personalized assessment, treatment of modifiable risk factors, and appropriate medication adjustment and review remain essential for optimizing asthma outcomes.
EUROPEAN RESPIRATORY JOURNAL
(2022)
Article
Allergy
Scott Bickel, Robyn T. Cohen, Joshua P. Needleman, Anna Volerman
Summary: This narrative review explores factors and solutions related to adherence to asthma inhalers using Bronfenbrenner's socio-ecological model. It provides important information for improving asthma control and morbidity for over 6 million affected children in the United States.
Article
Respiratory System
Robyn T. Cohen, Elizabeth S. Klings
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2023)