Increased expression of ORMDL3 in allergic asthma: a case control and in vitro study

ORMDL3 overexpression facilitates FcεRI‐mediated transcription of proinflammatory cytokines and thapsigargin‐mediated PERK phosphorylation in RBL‐2H3 cells

(2021) Kazuhiro Ogi et al.   Immunity Inflammation and Disease

ORMDL3 regulates cigarette smoke–induced endoplasmic reticulum stress in airway smooth muscle cells

(2021) Rui Chen et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Expression quantitative trait locus fine mapping of the 17q12–21 asthma locus in African American children: a genetic association and gene expression study

(2020) Carole Ober et al.   Lancet Respiratory Medicine

Chromosome 17q21 SNP rs8076131 risk allele associates with airway smooth muscle hypertrophy in fatal asthma

(2020) Marina Miller et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Association between peripheral blood mononuclear cell ORMDL3 expression and the asthma predictive index in preschool children

(2019) Yaqin Li et al.   JOURNAL OF INTERNATIONAL MEDICAL RESEARCH

ORMDL3 knockdown in the lungs alleviates airway inflammation and airway remodeling in asthmatic mice via JNK1/2-MMP-9 pathway

(2019) Huan Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Regulation of gene expression by altered promoter methylation using a CRISPR/Cas9-mediated epigenetic editing system

(2019) Jeong Gu Kang et al.   Scientific Reports

IL-13 and IL-4, but not IL-5 nor IL-17A, induce hyperresponsiveness in isolated human small airways

(2019) Martijn L. Manson et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Orosomucoid-like 3 (ORMDL3) upregulates airway smooth muscle proliferation, contraction, and Ca 2+ oscillations in asthma

(2018) Jun Chen et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Epithelial IL-6 trans-signaling defines a new asthma phenotype with increased airway inflammation

(2018) Zala Jevnikar et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

A decade of research on the 17q12-21 asthma locus: Piecing together the puzzle

(2018) Michelle M. Stein et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Methylation status of ORMDL3 regulates cytokine production and p-ERK/MMP9 pathway expression

(2018) Xiao-Lu Wu et al.   EXPERIMENTAL CELL RESEARCH

Role of DNA methylation in expression control of the IKZF3-GSDMA region in human epithelial cells

(2017) Sanny Moussette et al.   PLoS One

Functional variants of 17q12-21 are associated with allergic asthma but not allergic rhinitis

(2016) Anand Kumar Andiappan et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Genome-wide association studies (GWAS) and their importance in asthma

(2015) A. García-Sánchez et al.   ALLERGOLOGIA ET IMMUNOPATHOLOGIA

Correlation between the genetic polymorphism of ORMDL3 gene and asthma risk: a meta-analysis

(2015) W.H. Zhai et al.   GENETICS AND MOLECULAR RESEARCH

Polymorphisms related to ORMDL3 are associated with asthma susceptibility, alterations in transcriptional regulation of ORMDL3, and changes in TH2 cytokine levels

(2015) Michaela Schedel et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Local genotype influences DNA methylation at two asthma-associated regions, 5q31 and 17q21, in a founder effect population

(2015) Abeer Al Tuwaijri et al.   JOURNAL OF MEDICAL GENETICS

The Association ofGSDMBandORMDL3Gene Polymorphisms With Asthma: A Meta-Analysis

(2015) Chun-Ni Zhao et al.   Allergy Asthma & Immunology Research

Risk of childhood asthma is associated with CpG-site polymorphisms, regional DNA methylation and mRNA levels at the GSDMB/ORMDL3 locus

(2014) Nathalie Acevedo et al.   HUMAN MOLECULAR GENETICS

ORMDL3 Transgenic Mice Have Increased Airway Remodeling and Airway Responsiveness Characteristic of Asthma

(2014) M. Miller et al.   JOURNAL OF IMMUNOLOGY

Sex- and age-dependent DNA methylation at the 17q12-q21 locus associated with childhood asthma

(2013) Anna K. Naumova et al.   HUMAN GENETICS

17q21 locus and ORMDL3: an increased risk for childhood asthma

(2013) Jennie G. Ono et al.   PEDIATRIC RESEARCH

Variants in the 17q21 asthma susceptibility locus are associated with allergic rhinitis in the Japanese population

(2012) K. Tomita et al.   ALLERGY

Interaction between genetic and epigenetic variation defines gene expression patterns at the asthma-associated locus 17q12-q21 in lymphoblastoid cell lines

(2012) Soizik Berlivet et al.   HUMAN GENETICS

Genome-wide association study to identify genetic determinants of severe asthma

(2012) Y I Wan et al.   THORAX

Epigen is induced during the interleukin-13–stimulated cell proliferation in murine primary airway epithelial cells

(2011) Kazuto Taniguchi et al.   EXPERIMENTAL LUNG RESEARCH

A Large-Scale, Consortium-Based Genomewide Association Study of Asthma

(2010) Miriam F. Moffatt et al.   NEW ENGLAND JOURNAL OF MEDICINE

17q21 variants modify the association between early respiratory infections and asthma

(2009) L. A. M. Smit et al.   EUROPEAN RESPIRATORY JOURNAL