ORMDL3 regulates cigarette smoke–induced endoplasmic reticulum stress in airway smooth muscle cells

Orosomucoid Like 3 (ORMDL3) Supports Rhinovirus Replication in Human Epithelial Cells

(2020) Yiping Liu et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Endoplasmic Reticulum Stress and Mitochondrial Function in Airway Smooth Muscle

(2020) Philippe Delmotte et al.   Frontiers in Cell and Developmental Biology

Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Lung Disease: The GOLD Science Committee Report 2019

(2019) Dave Singh et al.   EUROPEAN RESPIRATORY JOURNAL

Orosomucoid-like 3 (ORMDL3) upregulates airway smooth muscle proliferation, contraction, and Ca 2+ oscillations in asthma

(2018) Jun Chen et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Understanding the Unfolded Protein Response in the Pathogenesis of Asthma

(2018) Prabuddha S. Pathinayake et al.   Frontiers in Immunology

Roles of airway smooth muscle dysfunction in chronic obstructive pulmonary disease

(2018) Furong Yan et al.   Journal of Translational Medicine

The ORMDL3 Asthma Gene Regulates ICAM1 and has Multiple Effects on Cellular Inflammation

(2018) Youming Zhang et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Pulmonary ORMDL3 is critical for induction of Alternaria -induced allergic airways disease

(2017) Stephan Löser et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Cutting Edge: Targeting Epithelial ORMDL3 Increases, Rather than Reduces, Airway Responsiveness and Is Associated with Increased Sphingosine-1-Phosphate

(2017) Marina Miller et al.   JOURNAL OF IMMUNOLOGY

Cigarette smoke extract promotes proliferation of airway smooth muscle cells through suppressing C/EBP-α expression

(2017) Pin Guan et al.   Experimental and Therapeutic Medicine

The presence of serotonin in cigarette smoke – a possible mechanistic link to 5-HT-induced airway inflammation

(2016) Way Kwok Wai Lau et al.   FREE RADICAL RESEARCH

Mechanisms of Cigarette Smoke Effects on Human Airway Smooth Muscle

(2015) Mark E. Wylam et al.   PLoS One

Cigarette smoke-induced mitochondrial fragmentation and dysfunction in human airway smooth muscle

(2014) Bharathi Aravamudan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

ORMDL3 Transgenic Mice Have Increased Airway Remodeling and Airway Responsiveness Characteristic of Asthma

(2014) M. Miller et al.   JOURNAL OF IMMUNOLOGY

Airway smooth muscle in airway reactivity and remodeling: what have we learned?

(2013) Y. S. Prakash   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Activating Transcription Factor 4 Links Metabolic Stress to Interleukin-6 Expression in Macrophages

(2013) Y. Iwasaki et al.   DIABETES

Signal transducer and activator of transcription 6 directly regulates human ORMDL3 expression

(2013) Rongfang Qiu et al.   FEBS Journal

17q12-21 Variants are associated with asthma and interact with active smoking in an adult population from the United Kingdom

(2012) Susana Marinho et al.   ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY

Cigarette smoke induces endoplasmic reticulum stress response and proteasomal dysfunction in human alveolar epithelial cells

(2012) Anita Somborac-Bačura et al.   EXPERIMENTAL PHYSIOLOGY

ORMDL3 modulates store-operated calcium entry and lymphocyte activation

(2012) Amado Carreras-Sureda et al.   HUMAN MOLECULAR GENETICS

ER Stress Activates NF-κB by Integrating Functions of Basal IKK Activity, IRE1 and PERK

(2012) Arvin B. Tam et al.   PLoS One

ORMDL3 is an inducible lung epithelial gene regulating metalloproteases, chemokines, OAS, and ATF6

(2012) M. Miller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cigarette Smoking and Inflammation

(2011) J. Lee et al.   JOURNAL OF DENTAL RESEARCH

TGF-β regulates Nox4, MnSOD and catalase expression, and IL-6 release in airway smooth muscle cells

(2010) Charalambos Michaeloudes et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages

(2010) Fabio Martinon et al.   NATURE IMMUNOLOGY

The asthma-associated ORMDL3 gene product regulates endoplasmic reticulum-mediated calcium signaling and cellular stress

(2009) Gerard Cantero-Recasens et al.   HUMAN MOLECULAR GENETICS

Activation of the Akt-NF- B Pathway by Subtilase Cytotoxin through the ATF6 Branch of the Unfolded Protein Response

(2009) H. Yamazaki et al.   JOURNAL OF IMMUNOLOGY

Analyzing real-time PCR data by the comparative CT method

(2008) Thomas D Schmittgen et al.   Nature Protocols

Effect of 17q21 Variants and Smoking Exposure in Early-Onset Asthma

(2008) Emmanuelle Bouzigon et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cigarette Smoke Induces an Unfolded Protein Response in the Human Lung

(2007) Steven G. Kelsen et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY