Selected recent advances in understanding the role of human mast cells in health and disease

Mast Cell-Specific MRGPRX2: a Key Modulator of Neuro-Immune Interaction in Allergic Diseases

(2021) Monica Thapaliya et al.   CURRENT ALLERGY AND ASTHMA REPORTS

Genetic Regulation of Tryptase Production and Clinical Impact: Hereditary Alpha Tryptasemia, Mastocytosis and Beyond

(2021) Bettina Sprinzl et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Distinct plasma biomarkers confirm the diagnosis of mastocytosis and identify increased risk of anaphylaxis

(2021) Theo Gülen et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Interleukin-33 Amplifies Human Mast Cell Activities Induced by Complement Anaphylatoxins

(2021) Peter W. West et al.   Frontiers in Immunology

COVID-19 infection in patients with mast cell disorders including mastocytosis does not impact mast cell activation symptoms

(2021) Matthew P. Giannetti et al.   Journal of Allergy and Clinical Immunology-In Practice

Human airway mast cells proliferate and acquire distinct inflammation-driven phenotypes during type 2 inflammation

(2021) Daniel F. Dwyer et al.   Science Immunology

Cytokines Stimulated by IL-33 in Human Skin Mast Cells: Involvement of NF-κB and p38 at Distinct Levels and Potent Co-Operation with FcεRI and MRGPRX2

(2021) Kristin Franke et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Use and Interpretation of Acute and Baseline Tryptase in Perioperative Hypersensitivity and Anaphylaxis

(2021) Joana Vitte et al.   Journal of Allergy and Clinical Immunology-In Practice

Effects of a topical treatment with spleen tyrosine kinase inhibitor in healthy subjects and patients with cold urticaria or chronic spontaneous urticaria: Results of a phase 1a/b randomised double‐blind placebo‐controlled study

(2021) Marion C. Dickson et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

IgE cross-linking induces activation of human and mouse mast cell progenitors

(2021) Erika Méndez-Enríquez et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Hereditary alpha tryptasemia is not associated with specific clinical phenotypes

(2021) Madeleine B. Chollet et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Mast cell chymase affects the functional properties of primary human airway fibroblasts: Implications for asthma

(2021) Xinran O. Zhao et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Cytokine Stimulation via MRGPRX2 Occurs with Lower Potency than by FcεRI-aggregation but with Similar Dependence on the ERK1/2 Module in Human Skin Mast Cells

(2021) Zhao Wang et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Fenebrutinib in H1 antihistamine-refractory chronic spontaneous urticaria: a randomized phase 2 trial

(2021) Martin Metz et al.   NATURE MEDICINE

Human Mast Cell Proteome Reveals Unique Lineage, Putative Functions, and Structural Basis for Cell Ablation

(2020) Thomas Plum et al.   IMMUNITY

Crosstalk Between Mast Cells and Adipocytes in Physiologic and Pathologic Conditions

(2020) Daniel Elieh Ali Komi et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

The role of eosinophils in chronic spontaneous urticaria

(2020) Sabine Altrichter et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

CRITICAL SIGNALING EVENTS IN THE MECHANOACTIVATION OF HUMAN MAST CELLS VIA P.C492Y-ADGRE2

(2020) Andrea N. Naranjo et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Risk and management of patients with mastocytosis and MCAS in the SARS-CoV-2 (COVID-19) pandemic: Expert opinions

(2020) Peter Valent et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Bruton’s tyrosine kinase inhibition effectively protects against human IgE-mediated anaphylaxis

(2020) Melanie C. Dispenza et al.   JOURNAL OF CLINICAL INVESTIGATION

Limited role of mast cells during infection with the parasitic nematode Litomosoides sigmodontis

(2020) Lara Christine Linnemann et al.   PLoS Neglected Tropical Diseases

Protective and pathogenic roles for mast cells during viral infections

(2020) Abhay PS Rathore et al.   CURRENT OPINION IN IMMUNOLOGY

Mas-related G protein–coupled receptor X2 and its activators in dermatologic allergies

(2020) Helen Kühn et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Anti–Siglec-8 Antibody for Eosinophilic Gastritis and Duodenitis

(2020) Evan S. Dellon et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mast Cells in Alveolar Septa of COVID-19 Patients: A Pathogenic Pathway That May Link Interstitial Edema to Immunothrombosis

(2020) Jarbas da Silva Motta Junior et al.   Frontiers in Immunology

Severe Adult Asthmas: Integrating Clinical Features, Biology and Therapeutics to Improve Outcomes

(2020) Sally E. Wenzel   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Re‐innervation of human skin by rat dorsal root ganglia permits to study interactions between sensory nerve fibres and native human dermal mast cells ex vivo

(2020) Jérémy Chéret et al.   EXPERIMENTAL DERMATOLOGY

Emerging mechanisms contributing to mast cell-mediated pathophysiology with therapeutic implications

(2020) Guido H. Falduto et al.   PHARMACOLOGY & THERAPEUTICS

Proposed Diagnostic Algorithm for Patients With Suspected Mast Cell Activation Syndrome

(2019) Peter Valent et al.   Journal of Allergy and Clinical Immunology-In Practice

Yin-yang of IL-33 in human skin mast cells: reduced degranulation, but augmented histamine synthesis through p38 activation

(2019) Magda Babina et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

The complex role of mast cells in fungal infections

(2019) Qingqing Jiao et al.   EXPERIMENTAL DERMATOLOGY

An EAACI position paper on the investigation of perioperative immediate hypersensitivity reactions

(2019) L H Garvey et al.   ALLERGY

Unique Effect of Aspirin Therapy on Biomarkers in Aspirin-Exacerbated Respiratory Disease: A Prospective Trial

(2019) Katherine N Cahill et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

GSK2646264, a spleen tyrosine kinase inhibitor, attenuates the release of histamine in ex vivo human skin

(2019) Cesar Ramirez Molina et al.   BRITISH JOURNAL OF PHARMACOLOGY

Mast Cell Cytonemes as a Defense Mechanism against Coxiella burnetii

(2019) Soraya Mezouar et al.   mBio

IL-33 and MRGPRX2-Triggered Activation of Human Skin Mast Cells—Elimination of Receptor Expression on Chronic Exposure, but Reinforced Degranulation on Acute Priming

(2019) Zhao Wang et al.   Cells

Mast Cells in Viral, Bacterial, and Fungal Infection Immunity

(2019) Adrian M. Piliponsky et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Impact of naturally forming human α/β-tryptase heterotetramers in the pathogenesis of hereditary α-tryptasemia

(2019) Quang T. Le et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Adipose Tissue Mast Cells Promote Human Adipose Beiging in Response to Cold

(2019) Brian S. Finlin et al.   Scientific Reports

Identification of two distinct pathways of human myelopoiesis

(2019) Roy Drissen et al.   Science Immunology

Demonstration of human mast cell progenitors in the bone marrow

(2019) Maya Salomonsson et al.   ALLERGY

CD203c distinguishes the erythroid and mast cell‐basophil differentiation trajectories among human FcεRI + bone marrow progenitors

(2019) Jennine Grootens et al.   ALLERGY

Mast cells are critical for controlling the bacterial burden and the healing of infected wounds

(2019) C. Zimmermann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mast Cells and Sensory Nerves Contribute to Neurogenic Inflammation and Pruritus in Chronic Skin Inflammation

(2019) Hanna Siiskonen et al.   Frontiers in Cellular Neuroscience

An Allosteric Anti-tryptase Antibody for the Treatment of Mast Cell-Mediated Severe Asthma

(2019) Henry R. Maun et al.   CELL

Genome-wide Analyses of Chromatin State in Human Mast Cells Reveal Molecular Drivers and Mediators of Allergic and Inflammatory Diseases

(2019) Gökhan Cildir et al.   IMMUNITY

AAAAI Mast Cell Disorders Committee Work Group Report: Mast cell activation syndrome (MCAS) diagnosis and management

(2019) Catherine R. Weiler et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Decoding human fetal liver haematopoiesis

(2019) Dorin-Mirel Popescu et al.   NATURE

Non-IgE mediated mast cell activation

(2018) Frank A. Redegeld et al.   IMMUNOLOGICAL REVIEWS

Mast cells as sources of cytokines, chemokines, and growth factors

(2018) Kaori Mukai et al.   IMMUNOLOGICAL REVIEWS

Human mast cells present antigen to autologous CD4 + T cells

(2018) Sahar Lotfi-Emran et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Helicobacter pylori-induced IL-33 modulates mast cell responses, benefits bacterial growth, and contributes to gastritis

(2018) Yi-pin Lv et al.   Cell Death & Disease

Mast cells and mast cell tryptase enhance migration of human lung fibroblasts through protease-activated receptor 2

(2018) Mariam Bagher et al.   Cell Communication and Signaling

Functional Inhibitory Siglec-6 Is Upregulated in Human Colorectal Cancer-Associated Mast Cells

(2018) Yingxin Yu et al.   Frontiers in Immunology

Perivascular dendritic cells elicit anaphylaxis by relaying allergens to mast cells via microvesicles

(2018) Hae Woong Choi et al.   SCIENCE

JTE-852, a novel spleen tyrosine kinase inhibitor, blocks mediator secretion from mast cells with immunoglobulin E crosslinking

(2017) Toshinobu Kato et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Mast Cells Are Crucial for Induction of Group 2 Innate Lymphoid Cells and Clearance of Helminth Infections

(2017) Chikako Shimokawa et al.   IMMUNITY

Retinoic Acid Negatively Impacts Proliferation and MCTC Specific Attributes of Human Skin Derived Mast Cells, but Reinforces Allergic Stimulability

(2017) Magda Babina et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Roles of Mast Cells in Parasitic Protozoan Infections

(2017) Fangli Lu et al.   Frontiers in Immunology

Inhibition of spleen tyrosine kinase attenuates IgE-mediated airway contraction and mediator release in human precision cut lung slices

(2016) Cynthia J Koziol-White et al.   BRITISH JOURNAL OF PHARMACOLOGY

Mast cell proteases as pharmacological targets

(2016) George H. Caughey   EUROPEAN JOURNAL OF PHARMACOLOGY

Non-IgE mediated mast cell activation

(2016) Yingxin Yu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Toll-like receptor 2-mediated MAPKs and NF-κB activation requires the GNAO1-dependent pathway in human mast cells

(2016) Meiling Jin et al.   Integrative Biology

IL-6 promotes an increase in human mast cell numbers and reactivity through suppression of suppressor of cytokine signaling 3

(2016) Avanti Desai et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Roles of Mas-related G protein–coupled receptor X2 on mast cell–mediated host defense, pseudoallergic drug reactions, and chronic inflammatory diseases

(2016) Hariharan Subramanian et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Expression profiling of constitutive mast cells reveals a unique identity within the immune system

(2016) Daniel F Dwyer et al.   NATURE IMMUNOLOGY

Vibratory Urticaria Associated with a Missense Variant in ADGRE2

(2016) Steven E. Boyden et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mast Cell-Derived Exosomes Promote Th2 Cell Differentiation via OX40L-OX40 Ligation

(2016) Fei Li et al.   Journal of Immunology Research

Lin- CD34hi CD117int/hi Fc RI+ cells in human blood constitute a rare population of mast cell progenitors

(2015) J. S. Dahlin et al.   BLOOD

Differential TLR-induced cytokine production by human mast cells is amplified by FcɛRI triggering

(2015) J. Suurmond et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Mast cells and dendritic cells form synapses that facilitate antigen transfer for T cell activation

(2015) Amanda Carroll-Portillo et al.   JOURNAL OF CELL BIOLOGY

Mast cells in the colon of Trypanosoma cruzi-infected patients: are they involved in the recruitment, survival and/or activation of eosinophils?

(2015) Patrícia Rocha Martins et al.   PARASITOLOGY RESEARCH

Redefinition of the human mast cell transcriptome by deep-CAGE sequencing

(2014) E. Motakis et al.   BLOOD

Siglec-7 is an inhibitory receptor on human mast cells and basophils

(2014) Sa'ar Mizrahi et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Expression of Mas-related gene X2 on mast cells is upregulated in the skin of patients with severe chronic urticaria

(2014) Daisuke Fujisawa et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Mast Cells Control the Expansion and Differentiation of IL-10–Competent B Cells

(2014) Francesca Mion et al.   JOURNAL OF IMMUNOLOGY

Identification of a mast-cell-specific receptor crucial for pseudo-allergic drug reactions

(2014) Benjamin D. McNeil et al.   NATURE

Central domain of IL-33 is cleaved by mast cell proteases for potent activation of group-2 innate lymphoid cells

(2014) E. Lefrancais et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interacting mast cells and eosinophils acquire an enhanced activation statein vitro

(2012) M. Elishmereni et al.   ALLERGY

Human intestinal mast cells are a potent source of multiple chemokines

(2012) Katrin Feuser et al.   CYTOKINE

Differential control of hypoxia-inducible factor 1 activity during pro-inflammatory reactions of human haematopoietic cells of myeloid lineage

(2012) Bernhard F. Gibbs et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Mast Cells in Human Adipose Tissue: Link with Morbid Obesity, Inflammatory Status, and Diabetes

(2012) Adeline Divoux et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Phenotypic Characterization of Leukocytes in Prenatal Human Dermis

(2012) Christopher Schuster et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Involvement of Hypoxia-Inducible Factor-1 in the Inflammatory Responses of Human LAD2 Mast Cells and Basophils

(2012) Vadim V. Sumbayev et al.   PLoS One

TLR signaling in mast cells: common and unique features

(2012) Hilary Sandig et al.   Frontiers in Immunology

KIT-D816V-independent oncogenic signaling in neoplastic cells in systemic mastocytosis: role of Lyn and Btk activation and disruption by dasatinib and bosutinib

(2011) K. V. Gleixner et al.   BLOOD

Mast cells promote Th1 and Th17 responses by modulating dendritic cell maturation and function

(2011) Anne Dudeck et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Definitions, Criteria and Global Classification of Mast Cell Disorders with Special Reference to Mast Cell Activation Syndromes: A Consensus Proposal

(2011) Peter Valent et al.   INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY

Inhibition of IgE-mediated secretion from human basophils with a highly selective Bruton's tyrosine kinase, Btk, inhibitor

(2011) Donald MacGlashan et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Physical interactions between mast cells and eosinophils: a novel mechanism enhancing eosinophil survival in vitro

(2010) M. Elishmereni et al.   ALLERGY

Mast cells enhance proliferation of B lymphocytes and drive their differentiation toward IgA-secreting plasma cells

(2010) S. Merluzzi et al.   BLOOD

Substance P primes lipoteichoic acid- and Pam3CysSerLys4-mediated activation of human mast cells by up-regulating Toll-like receptor 2

(2010) Brian P. Tancowny et al.   IMMUNOLOGY

Dermal mast cells reduce progressive tissue necrosis caused by subcutaneous infection with Streptococcus pyogenes in mice

(2010) H. Matsui et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Involvement of hypoxia-inducible factor-1 HiF(1α) in IgE-mediated primary human basophil responses

(2009) Vadim V. Sumbayev et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Fc RI-mediated thymic stromal lymphopoietin production by interleukin-4-primed human mast cells

(2009) Y. Okayama et al.   EUROPEAN RESPIRATORY JOURNAL

Human subjects are protected from mast cell tryptase deficiency despite frequent inheritance of loss-of-function mutations

(2009) Neil N. Trivedi et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Novel site-specific mast cell subpopulations in the human lung

(2009) C K Andersson et al.   THORAX

Phagocytosis-independent antimicrobial activity of mast cells by means of extracellular trap formation

(2008) M. von Kockritz-Blickwede et al.   BLOOD

Role of calcineurin in the regulation of human lung mast cell and basophil function by cyclosporine and FK506

(2007) C A Harrison et al.   BRITISH JOURNAL OF PHARMACOLOGY